Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5G7_LEIMU

TriTrypDb:

LmxM.33.3750

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5G7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5G7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.457
CLV_C14_Caspase3-7	319	323	PF00656	0.609
CLV_C14_Caspase3-7	443	447	PF00656	0.744
CLV_C14_Caspase3-7	85	89	PF00656	0.623
CLV_NRD_NRD_1	306	308	PF00675	0.587
CLV_NRD_NRD_1	353	355	PF00675	0.726
CLV_NRD_NRD_1	382	384	PF00675	0.833
CLV_NRD_NRD_1	421	423	PF00675	0.729
CLV_NRD_NRD_1	425	427	PF00675	0.695
CLV_NRD_NRD_1	5	7	PF00675	0.657
CLV_NRD_NRD_1	71	73	PF00675	0.734
CLV_PCSK_KEX2_1	185	187	PF00082	0.521
CLV_PCSK_KEX2_1	198	200	PF00082	0.630
CLV_PCSK_KEX2_1	306	308	PF00082	0.587
CLV_PCSK_KEX2_1	353	355	PF00082	0.726
CLV_PCSK_KEX2_1	384	386	PF00082	0.839
CLV_PCSK_KEX2_1	425	427	PF00082	0.629
CLV_PCSK_KEX2_1	5	7	PF00082	0.657
CLV_PCSK_KEX2_1	527	529	PF00082	0.461
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.631
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.630
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.839
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.461
CLV_PCSK_SKI1_1	103	107	PF00082	0.630
CLV_PCSK_SKI1_1	115	119	PF00082	0.764
CLV_PCSK_SKI1_1	451	455	PF00082	0.558
CLV_PCSK_SKI1_1	528	532	PF00082	0.498
CLV_PCSK_SKI1_1	60	64	PF00082	0.786
DEG_Nend_UBRbox_3	1	3	PF02207	0.673
DEG_SPOP_SBC_1	129	133	PF00917	0.598
DOC_CKS1_1	61	66	PF01111	0.764
DOC_CYCLIN_yCln2_LP_2	432	438	PF00134	0.748
DOC_MAPK_JIP1_4	345	351	PF00069	0.728
DOC_PP2B_LxvP_1	288	291	PF13499	0.536
DOC_PP2B_LxvP_1	362	365	PF13499	0.510
DOC_USP7_MATH_1	116	120	PF00917	0.682
DOC_USP7_MATH_1	129	133	PF00917	0.587
DOC_USP7_MATH_1	232	236	PF00917	0.706
DOC_USP7_MATH_1	253	257	PF00917	0.622
DOC_USP7_MATH_1	47	51	PF00917	0.729
DOC_USP7_UBL2_3	245	249	PF12436	0.540
DOC_USP7_UBL2_3	419	423	PF12436	0.719
DOC_USP7_UBL2_3	527	531	PF12436	0.556
DOC_WW_Pin1_4	175	180	PF00397	0.530
DOC_WW_Pin1_4	228	233	PF00397	0.727
DOC_WW_Pin1_4	26	31	PF00397	0.540
DOC_WW_Pin1_4	332	337	PF00397	0.732
DOC_WW_Pin1_4	386	391	PF00397	0.799
DOC_WW_Pin1_4	466	471	PF00397	0.608
DOC_WW_Pin1_4	488	493	PF00397	0.651
DOC_WW_Pin1_4	60	65	PF00397	0.769
LIG_14-3-3_CanoR_1	115	124	PF00244	0.726
LIG_14-3-3_CanoR_1	199	207	PF00244	0.430
LIG_14-3-3_CanoR_1	425	433	PF00244	0.630
LIG_14-3-3_CanoR_1	5	14	PF00244	0.571
LIG_14-3-3_CanoR_1	516	520	PF00244	0.613
LIG_AP2alpha_2	167	169	PF02296	0.393
LIG_APCC_Cbox_2	15	21	PF00515	0.483
LIG_BRCT_BRCA1_1	210	214	PF00533	0.438
LIG_BRCT_BRCA1_1	449	453	PF00533	0.488
LIG_CtBP_PxDLS_1	493	497	PF00389	0.350
LIG_FHA_1	151	157	PF00498	0.813
LIG_FHA_1	216	222	PF00498	0.565
LIG_FHA_1	390	396	PF00498	0.603
LIG_FHA_1	405	411	PF00498	0.716
LIG_FHA_2	401	407	PF00498	0.751
LIG_FHA_2	443	449	PF00498	0.521
LIG_FHA_2	470	476	PF00498	0.645
LIG_FHA_2	510	516	PF00498	0.590
LIG_LIR_Gen_1	15	24	PF02991	0.518
LIG_LIR_Nem_3	15	20	PF02991	0.507
LIG_LIR_Nem_3	178	184	PF02991	0.586
LIG_LIR_Nem_3	202	207	PF02991	0.437
LIG_SH2_CRK	181	185	PF00017	0.600
LIG_SH2_CRK	265	269	PF00017	0.279
LIG_SH2_NCK_1	301	305	PF00017	0.445
LIG_SH2_SRC	181	184	PF00017	0.592
LIG_SH2_SRC	301	304	PF00017	0.441
LIG_SH2_STAP1	24	28	PF00017	0.601
LIG_SH2_STAP1	464	468	PF00017	0.591
LIG_SH2_STAT5	503	506	PF00017	0.492
LIG_SH3_3	325	331	PF00018	0.807
LIG_SH3_3	340	346	PF00018	0.599
LIG_SH3_3	432	438	PF00018	0.709
LIG_SH3_3	486	492	PF00018	0.581
LIG_SH3_3	58	64	PF00018	0.772
LIG_TRAF2_1	438	441	PF00917	0.767
LIG_TRAF2_1	472	475	PF00917	0.657
LIG_TRAF2_2	438	443	PF00917	0.648
LIG_TYR_ITSM	200	207	PF00017	0.355
MOD_CDC14_SPxK_1	29	32	PF00782	0.574
MOD_CDK_SPK_2	332	337	PF00069	0.732
MOD_CDK_SPK_2	466	471	PF00069	0.608
MOD_CDK_SPxK_1	26	32	PF00069	0.584
MOD_CDK_SPxxK_3	332	339	PF00069	0.734
MOD_CDK_SPxxK_3	60	67	PF00069	0.767
MOD_CK1_1	123	129	PF00069	0.667
MOD_CK1_1	133	139	PF00069	0.784
MOD_CK1_1	316	322	PF00069	0.680
MOD_CK1_1	389	395	PF00069	0.622
MOD_CK1_1	417	423	PF00069	0.555
MOD_CK1_1	48	54	PF00069	0.742
MOD_CK1_1	56	62	PF00069	0.683
MOD_CK2_1	159	165	PF00069	0.602
MOD_CK2_1	459	465	PF00069	0.520
MOD_CK2_1	469	475	PF00069	0.624
MOD_DYRK1A_RPxSP_1	26	30	PF00069	0.585
MOD_DYRK1A_RPxSP_1	60	64	PF00069	0.771
MOD_GlcNHglycan	118	121	PF01048	0.737
MOD_GlcNHglycan	132	135	PF01048	0.594
MOD_GlcNHglycan	161	164	PF01048	0.743
MOD_GlcNHglycan	234	237	PF01048	0.686
MOD_GlcNHglycan	251	254	PF01048	0.586
MOD_GlcNHglycan	257	260	PF01048	0.571
MOD_GlcNHglycan	427	430	PF01048	0.748
MOD_GlcNHglycan	47	50	PF01048	0.640
MOD_GlcNHglycan	7	10	PF01048	0.642
MOD_GSK3_1	1	8	PF00069	0.579
MOD_GSK3_1	103	110	PF00069	0.775
MOD_GSK3_1	111	118	PF00069	0.574
MOD_GSK3_1	129	136	PF00069	0.539
MOD_GSK3_1	20	27	PF00069	0.486
MOD_GSK3_1	226	233	PF00069	0.655
MOD_GSK3_1	249	256	PF00069	0.586
MOD_GSK3_1	312	319	PF00069	0.608
MOD_GSK3_1	400	407	PF00069	0.760
MOD_GSK3_1	488	495	PF00069	0.642
MOD_GSK3_1	50	57	PF00069	0.759
MOD_GSK3_1	95	102	PF00069	0.696
MOD_N-GLC_1	1	6	PF02516	0.586
MOD_N-GLC_1	103	108	PF02516	0.531
MOD_N-GLC_1	404	409	PF02516	0.823
MOD_NEK2_1	1	6	PF00069	0.617
MOD_NEK2_1	20	25	PF00069	0.489
MOD_NEK2_1	227	232	PF00069	0.504
MOD_NEK2_1	313	318	PF00069	0.517
MOD_NEK2_1	496	501	PF00069	0.537
MOD_PIKK_1	150	156	PF00454	0.811
MOD_PIKK_1	321	327	PF00454	0.735
MOD_PIKK_1	459	465	PF00454	0.374
MOD_PKA_1	425	431	PF00069	0.632
MOD_PKA_1	5	11	PF00069	0.644
MOD_PKA_2	305	311	PF00069	0.679
MOD_PKA_2	425	431	PF00069	0.564
MOD_PKA_2	5	11	PF00069	0.586
MOD_PKA_2	515	521	PF00069	0.621
MOD_PKA_2	53	59	PF00069	0.820
MOD_Plk_1	137	143	PF00069	0.576
MOD_Plk_1	447	453	PF00069	0.492
MOD_Plk_2-3	281	287	PF00069	0.617
MOD_Plk_4	234	240	PF00069	0.689
MOD_ProDKin_1	175	181	PF00069	0.523
MOD_ProDKin_1	228	234	PF00069	0.729
MOD_ProDKin_1	26	32	PF00069	0.539
MOD_ProDKin_1	332	338	PF00069	0.733
MOD_ProDKin_1	386	392	PF00069	0.801
MOD_ProDKin_1	466	472	PF00069	0.612
MOD_ProDKin_1	488	494	PF00069	0.646
MOD_ProDKin_1	60	66	PF00069	0.766
MOD_SUMO_for_1	239	242	PF00179	0.571
MOD_SUMO_for_1	438	441	PF00179	0.767
MOD_SUMO_rev_2	242	251	PF00179	0.653
MOD_SUMO_rev_2	83	91	PF00179	0.621
TRG_DiLeu_BaEn_2	164	170	PF01217	0.410
TRG_DiLeu_BaEn_4	151	157	PF01217	0.811
TRG_ENDOCYTIC_2	181	184	PF00928	0.592
TRG_ENDOCYTIC_2	204	207	PF00928	0.649
TRG_ENDOCYTIC_2	301	304	PF00928	0.441
TRG_ER_diArg_1	260	263	PF00400	0.363
TRG_ER_diArg_1	424	426	PF00400	0.622
TRG_ER_diArg_1	5	7	PF00400	0.657
TRG_NLS_MonoCore_2	382	387	PF00514	0.838
TRG_NLS_MonoExtC_3	382	387	PF00514	0.838
TRG_NLS_MonoExtC_3	421	426	PF00514	0.734
TRG_NLS_MonoExtN_4	383	389	PF00514	0.812
TRG_NLS_MonoExtN_4	419	426	PF00514	0.727
TRG_Pf-PMV_PEXEL_1	26	31	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8INS4	Leishmania donovani	79%	100%
A4HB95	Leishmania braziliensis	60%	100%
A4IAE3	Leishmania infantum	79%	100%
Q4Q2G8	Leishmania major	78%	100%