A very conserved eukaryotic enzyme involved in sphingolipid biosynthesis. Localization: ER (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 9 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 7 |
| GO:0110165 | cellular anatomical entity | 1 | 8 |
| GO:0005783 | endoplasmic reticulum | 5 | 1 |
| GO:0043226 | organelle | 2 | 1 |
| GO:0043227 | membrane-bounded organelle | 3 | 1 |
| GO:0043229 | intracellular organelle | 3 | 1 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 1 |
Related structures:
AlphaFold database: E9B5G5
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0008152 | metabolic process | 1 | 12 |
| GO:0009058 | biosynthetic process | 2 | 12 |
| GO:0006066 | alcohol metabolic process | 3 | 1 |
| GO:0006629 | lipid metabolic process | 3 | 1 |
| GO:0006643 | membrane lipid metabolic process | 4 | 1 |
| GO:0006665 | sphingolipid metabolic process | 4 | 1 |
| GO:0006670 | sphingosine metabolic process | 6 | 1 |
| GO:0006672 | ceramide metabolic process | 4 | 1 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 1 |
| GO:0008610 | lipid biosynthetic process | 4 | 1 |
| GO:0009987 | cellular process | 1 | 1 |
| GO:0019751 | polyol metabolic process | 4 | 1 |
| GO:0030148 | sphingolipid biosynthetic process | 5 | 1 |
| GO:0034311 | diol metabolic process | 5 | 1 |
| GO:0034312 | diol biosynthetic process | 6 | 1 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 1 |
| GO:0043603 | amide metabolic process | 3 | 1 |
| GO:0043604 | amide biosynthetic process | 4 | 1 |
| GO:0044237 | cellular metabolic process | 2 | 1 |
| GO:0044238 | primary metabolic process | 2 | 1 |
| GO:0044249 | cellular biosynthetic process | 3 | 1 |
| GO:0044255 | cellular lipid metabolic process | 3 | 1 |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 4 | 1 |
| GO:0044281 | small molecule metabolic process | 2 | 1 |
| GO:0044283 | small molecule biosynthetic process | 3 | 1 |
| GO:0046165 | alcohol biosynthetic process | 4 | 1 |
| GO:0046173 | polyol biosynthetic process | 5 | 1 |
| GO:0046467 | membrane lipid biosynthetic process | 4 | 1 |
| GO:0046512 | sphingosine biosynthetic process | 5 | 1 |
| GO:0046513 | ceramide biosynthetic process | 5 | 1 |
| GO:0046519 | sphingoid metabolic process | 5 | 1 |
| GO:0046520 | sphingoid biosynthetic process | 6 | 1 |
| GO:0071704 | organic substance metabolic process | 2 | 1 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 1 |
| GO:1901566 | organonitrogen compound biosynthetic process | 4 | 1 |
| GO:1901576 | organic substance biosynthetic process | 3 | 1 |
| GO:1901615 | organic hydroxy compound metabolic process | 3 | 1 |
| GO:1901617 | organic hydroxy compound biosynthetic process | 4 | 1 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 12 |
| GO:0004758 | serine C-palmitoyltransferase activity | 7 | 8 |
| GO:0005488 | binding | 1 | 12 |
| GO:0016408 | C-acyltransferase activity | 5 | 8 |
| GO:0016409 | palmitoyltransferase activity | 5 | 8 |
| GO:0016454 | C-palmitoyltransferase activity | 6 | 8 |
| GO:0016740 | transferase activity | 2 | 12 |
| GO:0016746 | acyltransferase activity | 3 | 8 |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 4 | 8 |
| GO:0019842 | vitamin binding | 3 | 12 |
| GO:0030170 | pyridoxal phosphate binding | 4 | 12 |
| GO:0036094 | small molecule binding | 2 | 12 |
| GO:0043167 | ion binding | 2 | 12 |
| GO:0043168 | anion binding | 3 | 12 |
| GO:0070279 | vitamin B6 binding | 3 | 12 |
| GO:0097159 | organic cyclic compound binding | 2 | 12 |
| GO:1901363 | heterocyclic compound binding | 2 | 12 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 246 | 248 | PF00675 | 0.241 |
| CLV_NRD_NRD_1 | 381 | 383 | PF00675 | 0.307 |
| CLV_NRD_NRD_1 | 39 | 41 | PF00675 | 0.406 |
| CLV_NRD_NRD_1 | 59 | 61 | PF00675 | 0.360 |
| CLV_PCSK_FUR_1 | 379 | 383 | PF00082 | 0.239 |
| CLV_PCSK_KEX2_1 | 246 | 248 | PF00082 | 0.238 |
| CLV_PCSK_KEX2_1 | 378 | 380 | PF00082 | 0.264 |
| CLV_PCSK_KEX2_1 | 381 | 383 | PF00082 | 0.241 |
| CLV_PCSK_KEX2_1 | 39 | 41 | PF00082 | 0.400 |
| CLV_PCSK_KEX2_1 | 59 | 61 | PF00082 | 0.360 |
| CLV_PCSK_PC1ET2_1 | 378 | 380 | PF00082 | 0.239 |
| CLV_PCSK_PC7_1 | 374 | 380 | PF00082 | 0.239 |
| CLV_PCSK_SKI1_1 | 165 | 169 | PF00082 | 0.307 |
| CLV_PCSK_SKI1_1 | 247 | 251 | PF00082 | 0.200 |
| CLV_PCSK_SKI1_1 | 277 | 281 | PF00082 | 0.231 |
| CLV_PCSK_SKI1_1 | 444 | 448 | PF00082 | 0.236 |
| DEG_APCC_DBOX_1 | 417 | 425 | PF00400 | 0.439 |
| DEG_COP1_1 | 74 | 84 | PF00400 | 0.643 |
| DOC_AGCK_PIF_2 | 114 | 119 | PF00069 | 0.398 |
| DOC_CYCLIN_RxL_1 | 272 | 283 | PF00134 | 0.480 |
| DOC_CYCLIN_yClb5_NLxxxL_5 | 44 | 52 | PF00134 | 0.516 |
| DOC_MAPK_gen_1 | 273 | 280 | PF00069 | 0.443 |
| DOC_PP4_FxxP_1 | 300 | 303 | PF00568 | 0.442 |
| DOC_USP7_MATH_1 | 103 | 107 | PF00917 | 0.638 |
| DOC_USP7_MATH_1 | 16 | 20 | PF00917 | 0.195 |
| DOC_USP7_MATH_1 | 326 | 330 | PF00917 | 0.519 |
| DOC_USP7_MATH_1 | 354 | 358 | PF00917 | 0.460 |
| DOC_USP7_MATH_1 | 63 | 67 | PF00917 | 0.575 |
| DOC_USP7_MATH_1 | 71 | 75 | PF00917 | 0.572 |
| DOC_WW_Pin1_4 | 293 | 298 | PF00397 | 0.484 |
| DOC_WW_Pin1_4 | 401 | 406 | PF00397 | 0.417 |
| DOC_WW_Pin1_4 | 50 | 55 | PF00397 | 0.529 |
| LIG_14-3-3_CanoR_1 | 102 | 112 | PF00244 | 0.566 |
| LIG_14-3-3_CanoR_1 | 247 | 255 | PF00244 | 0.417 |
| LIG_14-3-3_CanoR_1 | 336 | 344 | PF00244 | 0.428 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.390 |
| LIG_BIR_III_2 | 402 | 406 | PF00653 | 0.439 |
| LIG_BRCT_BRCA1_1 | 282 | 286 | PF00533 | 0.417 |
| LIG_BRCT_BRCA1_1 | 65 | 69 | PF00533 | 0.540 |
| LIG_Clathr_ClatBox_1 | 408 | 412 | PF01394 | 0.385 |
| LIG_eIF4E_1 | 274 | 280 | PF01652 | 0.439 |
| LIG_FHA_1 | 249 | 255 | PF00498 | 0.417 |
| LIG_FHA_1 | 256 | 262 | PF00498 | 0.417 |
| LIG_FHA_1 | 302 | 308 | PF00498 | 0.460 |
| LIG_FHA_1 | 338 | 344 | PF00498 | 0.450 |
| LIG_FHA_1 | 351 | 357 | PF00498 | 0.376 |
| LIG_FHA_1 | 471 | 477 | PF00498 | 0.502 |
| LIG_FHA_1 | 74 | 80 | PF00498 | 0.611 |
| LIG_FHA_1 | 86 | 92 | PF00498 | 0.535 |
| LIG_FHA_2 | 122 | 128 | PF00498 | 0.434 |
| LIG_FHA_2 | 294 | 300 | PF00498 | 0.374 |
| LIG_FHA_2 | 446 | 452 | PF00498 | 0.481 |
| LIG_FHA_2 | 466 | 472 | PF00498 | 0.323 |
| LIG_Integrin_RGD_1 | 192 | 194 | PF01839 | 0.260 |
| LIG_LIR_Apic_2 | 239 | 244 | PF02991 | 0.475 |
| LIG_LIR_Apic_2 | 298 | 303 | PF02991 | 0.417 |
| LIG_LIR_Gen_1 | 116 | 126 | PF02991 | 0.421 |
| LIG_LIR_Gen_1 | 176 | 186 | PF02991 | 0.442 |
| LIG_LIR_Gen_1 | 22 | 33 | PF02991 | 0.167 |
| LIG_LIR_Nem_3 | 113 | 117 | PF02991 | 0.418 |
| LIG_LIR_Nem_3 | 118 | 122 | PF02991 | 0.423 |
| LIG_LIR_Nem_3 | 148 | 153 | PF02991 | 0.519 |
| LIG_LIR_Nem_3 | 176 | 182 | PF02991 | 0.442 |
| LIG_LIR_Nem_3 | 194 | 198 | PF02991 | 0.453 |
| LIG_LIR_Nem_3 | 22 | 28 | PF02991 | 0.167 |
| LIG_LIR_Nem_3 | 283 | 289 | PF02991 | 0.434 |
| LIG_LIR_Nem_3 | 83 | 87 | PF02991 | 0.632 |
| LIG_PDZ_Class_3 | 483 | 488 | PF00595 | 0.509 |
| LIG_PTB_Apo_2 | 11 | 18 | PF02174 | 0.241 |
| LIG_SH2_CRK | 150 | 154 | PF00017 | 0.417 |
| LIG_SH2_CRK | 179 | 183 | PF00017 | 0.519 |
| LIG_SH2_CRK | 241 | 245 | PF00017 | 0.475 |
| LIG_SH2_GRB2like | 415 | 418 | PF00017 | 0.341 |
| LIG_SH2_NCK_1 | 179 | 183 | PF00017 | 0.519 |
| LIG_SH2_SRC | 198 | 201 | PF00017 | 0.466 |
| LIG_SH2_STAP1 | 175 | 179 | PF00017 | 0.460 |
| LIG_SH2_STAT5 | 195 | 198 | PF00017 | 0.435 |
| LIG_SH2_STAT5 | 31 | 34 | PF00017 | 0.324 |
| LIG_SH2_STAT5 | 310 | 313 | PF00017 | 0.417 |
| LIG_SH2_STAT5 | 342 | 345 | PF00017 | 0.417 |
| LIG_SH2_STAT5 | 351 | 354 | PF00017 | 0.417 |
| LIG_SH2_STAT5 | 415 | 418 | PF00017 | 0.455 |
| LIG_SH3_3 | 76 | 82 | PF00018 | 0.591 |
| LIG_SUMO_SIM_anti_2 | 359 | 364 | PF11976 | 0.519 |
| LIG_SUMO_SIM_anti_2 | 404 | 410 | PF11976 | 0.436 |
| LIG_SUMO_SIM_anti_2 | 96 | 102 | PF11976 | 0.618 |
| LIG_SUMO_SIM_par_1 | 407 | 412 | PF11976 | 0.385 |
| LIG_TRAF2_1 | 227 | 230 | PF00917 | 0.519 |
| LIG_TRAF2_1 | 296 | 299 | PF00917 | 0.341 |
| LIG_TRAF2_1 | 53 | 56 | PF00917 | 0.523 |
| LIG_TYR_ITIM | 29 | 34 | PF00017 | 0.397 |
| LIG_UBA3_1 | 267 | 275 | PF00899 | 0.428 |
| LIG_WRC_WIRS_1 | 119 | 124 | PF05994 | 0.426 |
| LIG_WRC_WIRS_1 | 174 | 179 | PF05994 | 0.433 |
| LIG_WRC_WIRS_1 | 397 | 402 | PF05994 | 0.341 |
| MOD_CK1_1 | 121 | 127 | PF00069 | 0.417 |
| MOD_CK1_1 | 187 | 193 | PF00069 | 0.448 |
| MOD_CK1_1 | 2 | 8 | PF00069 | 0.422 |
| MOD_CK1_1 | 224 | 230 | PF00069 | 0.487 |
| MOD_CK1_1 | 313 | 319 | PF00069 | 0.419 |
| MOD_CK1_1 | 465 | 471 | PF00069 | 0.472 |
| MOD_CK1_1 | 50 | 56 | PF00069 | 0.649 |
| MOD_CK1_1 | 74 | 80 | PF00069 | 0.632 |
| MOD_CK1_1 | 96 | 102 | PF00069 | 0.541 |
| MOD_CK2_1 | 103 | 109 | PF00069 | 0.578 |
| MOD_CK2_1 | 121 | 127 | PF00069 | 0.463 |
| MOD_CK2_1 | 16 | 22 | PF00069 | 0.178 |
| MOD_CK2_1 | 202 | 208 | PF00069 | 0.507 |
| MOD_CK2_1 | 224 | 230 | PF00069 | 0.442 |
| MOD_CK2_1 | 293 | 299 | PF00069 | 0.341 |
| MOD_CK2_1 | 445 | 451 | PF00069 | 0.428 |
| MOD_CK2_1 | 465 | 471 | PF00069 | 0.323 |
| MOD_CK2_1 | 50 | 56 | PF00069 | 0.561 |
| MOD_GlcNHglycan | 18 | 21 | PF01048 | 0.406 |
| MOD_GlcNHglycan | 189 | 192 | PF01048 | 0.305 |
| MOD_GlcNHglycan | 291 | 294 | PF01048 | 0.275 |
| MOD_GlcNHglycan | 344 | 347 | PF01048 | 0.237 |
| MOD_GlcNHglycan | 456 | 459 | PF01048 | 0.257 |
| MOD_GSK3_1 | 145 | 152 | PF00069 | 0.526 |
| MOD_GSK3_1 | 2 | 9 | PF00069 | 0.364 |
| MOD_GSK3_1 | 289 | 296 | PF00069 | 0.419 |
| MOD_GSK3_1 | 310 | 317 | PF00069 | 0.428 |
| MOD_GSK3_1 | 350 | 357 | PF00069 | 0.417 |
| MOD_N-GLC_1 | 454 | 459 | PF02516 | 0.307 |
| MOD_NEK2_1 | 149 | 154 | PF00069 | 0.425 |
| MOD_NEK2_1 | 280 | 285 | PF00069 | 0.428 |
| MOD_NEK2_1 | 289 | 294 | PF00069 | 0.439 |
| MOD_NEK2_1 | 314 | 319 | PF00069 | 0.428 |
| MOD_PIKK_1 | 354 | 360 | PF00454 | 0.505 |
| MOD_PKA_2 | 335 | 341 | PF00069 | 0.443 |
| MOD_Plk_1 | 365 | 371 | PF00069 | 0.428 |
| MOD_Plk_1 | 71 | 77 | PF00069 | 0.651 |
| MOD_Plk_2-3 | 113 | 119 | PF00069 | 0.426 |
| MOD_Plk_4 | 181 | 187 | PF00069 | 0.437 |
| MOD_Plk_4 | 202 | 208 | PF00069 | 0.519 |
| MOD_Plk_4 | 365 | 371 | PF00069 | 0.486 |
| MOD_ProDKin_1 | 293 | 299 | PF00069 | 0.484 |
| MOD_ProDKin_1 | 401 | 407 | PF00069 | 0.417 |
| MOD_ProDKin_1 | 50 | 56 | PF00069 | 0.521 |
| MOD_SUMO_for_1 | 483 | 486 | PF00179 | 0.559 |
| TRG_DiLeu_BaEn_1 | 392 | 397 | PF01217 | 0.484 |
| TRG_DiLeu_BaLyEn_6 | 274 | 279 | PF01217 | 0.451 |
| TRG_ENDOCYTIC_2 | 150 | 153 | PF00928 | 0.417 |
| TRG_ENDOCYTIC_2 | 179 | 182 | PF00928 | 0.496 |
| TRG_ENDOCYTIC_2 | 31 | 34 | PF00928 | 0.381 |
| TRG_ENDOCYTIC_2 | 84 | 87 | PF00928 | 0.640 |
| TRG_ER_diArg_1 | 246 | 248 | PF00400 | 0.440 |
| TRG_ER_diArg_1 | 379 | 382 | PF00400 | 0.457 |
| TRG_ER_diArg_1 | 39 | 42 | PF00400 | 0.605 |
| TRG_ER_diArg_1 | 59 | 61 | PF00400 | 0.542 |
| TRG_NLS_MonoExtC_3 | 377 | 382 | PF00514 | 0.439 |
| TRG_Pf-PMV_PEXEL_1 | 226 | 230 | PF00026 | 0.176 |
| TRG_Pf-PMV_PEXEL_1 | 277 | 281 | PF00026 | 0.208 |
| TRG_Pf-PMV_PEXEL_1 | 382 | 386 | PF00026 | 0.345 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0H3C7E9 | Caulobacter vibrioides (strain NA1000 / CB15N) | 28% | 100% |
| A0A0N1HYL3 | Leptomonas seymouri | 74% | 99% |
| A0A0S4KPJ9 | Bodo saltans | 45% | 96% |
| A0A1X0PAD7 | Trypanosomatidae | 49% | 99% |
| A0A3R7KRA6 | Trypanosoma rangeli | 49% | 99% |
| A0A3S7X8D9 | Leishmania donovani | 92% | 100% |
| A0A422NN79 | Trypanosoma rangeli | 28% | 87% |
| A4HB93 | Leishmania braziliensis | 83% | 100% |
| A4IAE1 | Leishmania infantum | 93% | 100% |
| A4VR87 | Pseudomonas stutzeri (strain A1501) | 26% | 100% |
| A6UYW1 | Pseudomonas aeruginosa (strain PA7) | 26% | 100% |
| A9HJ57 | Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / CCUG 37298 / CIP 103539 / LMG 7603 / PAl5) | 28% | 100% |
| B3PI88 | Cellvibrio japonicus (strain Ueda107) | 27% | 100% |
| B7K0L9 | Rippkaea orientalis (strain PCC 8801) | 27% | 100% |
| B7V486 | Pseudomonas aeruginosa (strain LESB58) | 27% | 100% |
| B8GTH6 | Thioalkalivibrio sulfidiphilus (strain HL-EbGR7) | 26% | 100% |
| C4LK80 | Corynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717) | 27% | 68% |
| C8V1D1 | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) | 23% | 100% |
| C9ZLV5 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 51% | 100% |
| D4A2H2 | Rattus norvegicus | 33% | 100% |
| O15269 | Homo sapiens | 34% | 100% |
| O35704 | Mus musculus | 34% | 100% |
| O54695 | Cricetulus griseus | 33% | 100% |
| O59682 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 33% | 96% |
| P18080 | Gallus gallus | 28% | 95% |
| P25045 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 29% | 87% |
| P91079 | Caenorhabditis elegans | 32% | 100% |
| P97363 | Mus musculus | 29% | 87% |
| Q02TR5 | Pseudomonas aeruginosa (strain UCBPP-PA14) | 27% | 100% |
| Q10P01 | Oryza sativa subsp. japonica | 32% | 100% |
| Q12F38 | Polaromonas sp. (strain JS666 / ATCC BAA-500) | 26% | 100% |
| Q1GZA7 | Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) | 27% | 100% |
| Q20375 | Caenorhabditis elegans | 27% | 87% |
| Q31E54 | Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2) | 25% | 100% |
| Q3B7D2 | Rattus norvegicus | 29% | 87% |
| Q3MHG1 | Bos taurus | 36% | 100% |
| Q3SLX9 | Thiobacillus denitrificans (strain ATCC 25259) | 28% | 100% |
| Q48CS2 | Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) | 26% | 100% |
| Q55FL5 | Dictyostelium discoideum | 33% | 100% |
| Q5KY23 | Geobacillus kaustophilus (strain HTA426) | 25% | 100% |
| Q5R9T5 | Pongo abelii | 34% | 100% |
| Q60HD1 | Macaca fascicularis | 34% | 100% |
| Q6FXE3 | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) | 24% | 92% |
| Q6LPR3 | Photobacterium profundum (strain SS9) | 24% | 100% |
| Q6XFB3 | Leishmania major | 93% | 100% |
| Q7VWP1 | Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) | 26% | 100% |
| Q7W9I4 | Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) | 26% | 100% |
| Q7WH76 | Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) | 26% | 100% |
| Q88A97 | Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) | 25% | 100% |
| Q9I617 | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 27% | 100% |
| Q9KM65 | Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) | 22% | 100% |
| V5BLV3 | Trypanosoma cruzi | 51% | 99% |