C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF501), putative

Species:

Leishmania mexicana

UniProt:

E9B5G3_LEIMU

TriTrypDb:

LmxM.33.3720

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5G3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.210
CLV_NRD_NRD_1	193	195	PF00675	0.631
CLV_NRD_NRD_1	204	206	PF00675	0.402
CLV_NRD_NRD_1	294	296	PF00675	0.512
CLV_PCSK_KEX2_1	204	206	PF00082	0.558
CLV_PCSK_KEX2_1	257	259	PF00082	0.397
CLV_PCSK_KEX2_1	293	295	PF00082	0.605
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.397
CLV_PCSK_SKI1_1	117	121	PF00082	0.352
CLV_PCSK_SKI1_1	280	284	PF00082	0.489
CLV_PCSK_SKI1_1	5	9	PF00082	0.618
DOC_CDC14_PxL_1	95	103	PF14671	0.280
DOC_CYCLIN_RxL_1	114	121	PF00134	0.348
DOC_MAPK_gen_1	27	36	PF00069	0.480
DOC_MAPK_MEF2A_6	280	288	PF00069	0.472
DOC_MAPK_RevD_3	245	258	PF00069	0.263
DOC_PP4_FxxP_1	245	248	PF00568	0.539
DOC_USP7_MATH_1	146	150	PF00917	0.454
DOC_USP7_MATH_1	171	175	PF00917	0.444
DOC_WW_Pin1_4	118	123	PF00397	0.485
LIG_14-3-3_CanoR_1	204	209	PF00244	0.509
LIG_14-3-3_CanoR_1	280	285	PF00244	0.444
LIG_BIR_II_1	1	5	PF00653	0.758
LIG_Clathr_ClatBox_1	285	289	PF01394	0.448
LIG_deltaCOP1_diTrp_1	213	221	PF00928	0.232
LIG_FHA_1	221	227	PF00498	0.523
LIG_FHA_1	281	287	PF00498	0.489
LIG_FHA_1	58	64	PF00498	0.401
LIG_FHA_2	35	41	PF00498	0.489
LIG_Integrin_isoDGR_2	54	56	PF01839	0.355
LIG_Integrin_isoDGR_2	57	59	PF01839	0.334
LIG_LIR_Gen_1	215	226	PF02991	0.519
LIG_LIR_Nem_3	13	19	PF02991	0.609
LIG_LIR_Nem_3	215	221	PF02991	0.522
LIG_LIR_Nem_3	235	240	PF02991	0.595
LIG_Pex14_2	128	132	PF04695	0.344
LIG_Pex14_2	221	225	PF04695	0.467
LIG_PTB_Apo_2	239	246	PF02174	0.510
LIG_SH2_NCK_1	19	23	PF00017	0.581
LIG_SH2_PTP2	179	182	PF00017	0.413
LIG_SH2_SRC	19	22	PF00017	0.595
LIG_SH2_STAP1	112	116	PF00017	0.344
LIG_SH2_STAP1	19	23	PF00017	0.581
LIG_SH2_STAT5	179	182	PF00017	0.355
LIG_SH2_STAT5	244	247	PF00017	0.444
LIG_SH3_3	165	171	PF00018	0.485
LIG_SH3_3	244	250	PF00018	0.499
LIG_SH3_4	195	202	PF00018	0.382
LIG_SUMO_SIM_par_1	283	289	PF11976	0.525
LIG_TYR_ITIM	177	182	PF00017	0.413
MOD_CK1_1	6	12	PF00069	0.561
MOD_CK2_1	34	40	PF00069	0.494
MOD_GlcNHglycan	3	8	PF01048	0.668
MOD_GlcNHglycan	91	94	PF01048	0.400
MOD_GSK3_1	204	211	PF00069	0.565
MOD_GSK3_1	212	219	PF00069	0.537
MOD_GSK3_1	265	272	PF00069	0.427
MOD_GSK3_1	5	12	PF00069	0.484
MOD_NEK2_1	212	217	PF00069	0.507
MOD_NEK2_1	34	39	PF00069	0.488
MOD_NEK2_1	47	52	PF00069	0.257
MOD_NEK2_1	68	73	PF00069	0.344
MOD_PIKK_1	265	271	PF00454	0.574
MOD_PKA_1	204	210	PF00069	0.412
MOD_PKA_2	204	210	PF00069	0.474
MOD_Plk_1	212	218	PF00069	0.522
MOD_Plk_1	265	271	PF00069	0.422
MOD_Plk_4	171	177	PF00069	0.441
MOD_Plk_4	212	218	PF00069	0.308
MOD_Plk_4	280	286	PF00069	0.378
MOD_Plk_4	63	69	PF00069	0.344
MOD_ProDKin_1	118	124	PF00069	0.485
MOD_SUMO_rev_2	149	157	PF00179	0.336
MOD_SUMO_rev_2	2	7	PF00179	0.757
TRG_ENDOCYTIC_2	179	182	PF00928	0.381
TRG_ENDOCYTIC_2	244	247	PF00928	0.338
TRG_ER_diArg_1	204	206	PF00400	0.439
TRG_ER_diArg_1	293	295	PF00400	0.524
TRG_NLS_MonoExtN_4	294	301	PF00514	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T1	Leptomonas seymouri	56%	100%
A0A1X0PAX3	Trypanosomatidae	39%	100%
A0A3Q8IIH7	Leishmania donovani	87%	100%
A0A422N2V1	Trypanosoma rangeli	40%	100%
A4HB91	Leishmania braziliensis	76%	100%
A4IAD9	Leishmania infantum	88%	100%
C9ZLV6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4Q2H2	Leishmania major	86%	100%