Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5G2_LEIMU

TriTrypDb:

LmxM.33.3710

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5G2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5G2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.329
CLV_NRD_NRD_1	119	121	PF00675	0.473
CLV_NRD_NRD_1	77	79	PF00675	0.488
CLV_NRD_NRD_1	81	83	PF00675	0.571
CLV_PCSK_KEX2_1	119	121	PF00082	0.555
CLV_PCSK_KEX2_1	77	79	PF00082	0.502
CLV_PCSK_KEX2_1	81	83	PF00082	0.595
CLV_PCSK_PC7_1	77	83	PF00082	0.557
CLV_PCSK_SKI1_1	107	111	PF00082	0.614
CLV_PCSK_SKI1_1	148	152	PF00082	0.610
CLV_PCSK_SKI1_1	154	158	PF00082	0.531
CLV_PCSK_SKI1_1	38	42	PF00082	0.559
DOC_MAPK_gen_1	151	161	PF00069	0.637
DOC_MAPK_gen_1	81	90	PF00069	0.562
DOC_MAPK_MEF2A_6	154	161	PF00069	0.475
DOC_MAPK_RevD_3	116	130	PF00069	0.596
DOC_PP2B_LxvP_1	10	13	PF13499	0.509
DOC_USP7_MATH_1	102	106	PF00917	0.592
DOC_USP7_MATH_1	150	154	PF00917	0.462
LIG_14-3-3_CanoR_1	101	109	PF00244	0.606
LIG_14-3-3_CanoR_1	166	174	PF00244	0.496
LIG_Actin_WH2_2	114	131	PF00022	0.304
LIG_BIR_II_1	1	5	PF00653	0.711
LIG_FHA_1	106	112	PF00498	0.539
LIG_FHA_1	123	129	PF00498	0.330
LIG_FHA_1	30	36	PF00498	0.579
LIG_FHA_2	171	177	PF00498	0.464
LIG_FHA_2	39	45	PF00498	0.524
LIG_LIR_Nem_3	46	52	PF02991	0.623
LIG_PDZ_Class_2	178	183	PF00595	0.563
LIG_Rb_pABgroove_1	116	124	PF01858	0.571
LIG_SH2_PTP2	17	20	PF00017	0.333
LIG_SH2_STAP1	122	126	PF00017	0.444
LIG_SH2_STAP1	31	35	PF00017	0.561
LIG_SH2_STAT5	17	20	PF00017	0.598
LIG_SH2_STAT5	31	34	PF00017	0.563
LIG_SH3_1	48	54	PF00018	0.383
LIG_SH3_3	48	54	PF00018	0.367
LIG_SUMO_SIM_par_1	107	112	PF11976	0.374
MOD_CK1_1	100	106	PF00069	0.686
MOD_CK1_1	59	65	PF00069	0.601
MOD_CK2_1	170	176	PF00069	0.475
MOD_CK2_1	38	44	PF00069	0.503
MOD_GlcNHglycan	148	151	PF01048	0.675
MOD_GSK3_1	107	114	PF00069	0.628
MOD_GSK3_1	146	153	PF00069	0.666
MOD_GSK3_1	59	66	PF00069	0.519
MOD_GSK3_1	97	104	PF00069	0.651
MOD_LATS_1	36	42	PF00433	0.309
MOD_N-GLC_1	97	102	PF02516	0.716
MOD_NEK2_1	157	162	PF00069	0.652
MOD_NEK2_1	63	68	PF00069	0.608
MOD_NEK2_1	94	99	PF00069	0.403
MOD_NEK2_2	31	36	PF00069	0.313
MOD_PIKK_1	29	35	PF00454	0.582
MOD_PIKK_1	56	62	PF00454	0.593
MOD_PKA_2	100	106	PF00069	0.576
MOD_PKA_2	162	168	PF00069	0.595
MOD_Plk_1	114	120	PF00069	0.471
MOD_Plk_1	122	128	PF00069	0.466
MOD_Plk_1	170	176	PF00069	0.519
MOD_Plk_1	38	44	PF00069	0.512
MOD_SUMO_rev_2	145	150	PF00179	0.647
TRG_ENDOCYTIC_2	17	20	PF00928	0.375
TRG_ENDOCYTIC_2	49	52	PF00928	0.628
TRG_ER_diArg_1	118	120	PF00400	0.538
TRG_NES_CRM1_1	61	76	PF08389	0.562
TRG_NLS_Bipartite_1	119	133	PF00514	0.613
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P774	Leptomonas seymouri	61%	100%
A0A0S4J6R9	Bodo saltans	31%	98%
A0A0S4KRE5	Bodo saltans	31%	100%
A0A1X0PA28	Trypanosomatidae	38%	100%
A0A3Q8IIW0	Leishmania donovani	86%	100%
A0A3R7M5H7	Trypanosoma rangeli	39%	92%
A4HB90	Leishmania braziliensis	75%	100%
A4IAD8	Leishmania infantum	85%	100%
C9ZLV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q4Q2H3	Leishmania major	84%	100%