Inositol-pentakisphosphate 2-kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol-pentakisphosphate 2-kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B5G1_LEIMU

TriTrypDb:

LmxM.33.3700

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B5G1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5G1

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0044237	cellular metabolic process	2	12
GO:0005975	carbohydrate metabolic process	3	1
GO:0006020	inositol metabolic process	4	1
GO:0006066	alcohol metabolic process	3	1
GO:0009058	biosynthetic process	2	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019751	polyol metabolic process	4	1
GO:0032958	inositol phosphate biosynthetic process	5	1
GO:0043647	inositol phosphate metabolic process	4	1
GO:0044238	primary metabolic process	2	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046165	alcohol biosynthetic process	4	1
GO:0046173	polyol biosynthetic process	5	1
GO:0046835	carbohydrate phosphorylation	4	1
GO:0052746	obsolete inositol phosphorylation	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901617	organic hydroxy compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035299	inositol pentakisphosphate 2-kinase activity	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.546
CLV_C14_Caspase3-7	285	289	PF00656	0.373
CLV_NRD_NRD_1	241	243	PF00675	0.391
CLV_NRD_NRD_1	413	415	PF00675	0.325
CLV_NRD_NRD_1	69	71	PF00675	0.376
CLV_PCSK_KEX2_1	413	415	PF00082	0.390
CLV_PCSK_KEX2_1	455	457	PF00082	0.637
CLV_PCSK_KEX2_1	68	70	PF00082	0.376
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.728
CLV_PCSK_SKI1_1	213	217	PF00082	0.203
CLV_PCSK_SKI1_1	251	255	PF00082	0.348
CLV_PCSK_SKI1_1	42	46	PF00082	0.494
DEG_APCC_DBOX_1	218	226	PF00400	0.562
DEG_Nend_UBRbox_2	1	3	PF02207	0.580
DOC_CDC14_PxL_1	296	304	PF14671	0.373
DOC_MAPK_gen_1	68	74	PF00069	0.414
DOC_MAPK_MEF2A_6	13	22	PF00069	0.474
DOC_MAPK_MEF2A_6	374	382	PF00069	0.501
DOC_SPAK_OSR1_1	366	370	PF12202	0.517
DOC_USP7_MATH_1	215	219	PF00917	0.557
DOC_USP7_MATH_1	291	295	PF00917	0.430
DOC_USP7_MATH_1	443	447	PF00917	0.466
DOC_USP7_MATH_1	450	454	PF00917	0.577
DOC_USP7_MATH_1	81	85	PF00917	0.546
DOC_WW_Pin1_4	287	292	PF00397	0.561
DOC_WW_Pin1_4	347	352	PF00397	0.544
DOC_WW_Pin1_4	400	405	PF00397	0.480
LIG_14-3-3_CanoR_1	213	222	PF00244	0.528
LIG_14-3-3_CanoR_1	366	376	PF00244	0.494
LIG_Actin_WH2_2	218	236	PF00022	0.537
LIG_BIR_III_2	288	292	PF00653	0.581
LIG_BIR_III_4	122	126	PF00653	0.525
LIG_BRCT_BRCA1_1	4	8	PF00533	0.433
LIG_Clathr_ClatBox_1	113	117	PF01394	0.547
LIG_eIF4E_1	206	212	PF01652	0.483
LIG_FHA_1	1	7	PF00498	0.287
LIG_FHA_1	129	135	PF00498	0.508
LIG_FHA_1	250	256	PF00498	0.565
LIG_FHA_2	189	195	PF00498	0.503
LIG_FHA_2	252	258	PF00498	0.581
LIG_FHA_2	324	330	PF00498	0.525
LIG_FHA_2	336	342	PF00498	0.491
LIG_FHA_2	370	376	PF00498	0.481
LIG_LIR_Apic_2	138	143	PF02991	0.562
LIG_LIR_Apic_2	350	356	PF02991	0.505
LIG_LIR_Gen_1	318	328	PF02991	0.505
LIG_LIR_Gen_1	77	87	PF02991	0.530
LIG_LIR_Nem_3	318	324	PF02991	0.505
LIG_LIR_Nem_3	433	438	PF02991	0.415
LIG_LIR_Nem_3	56	62	PF02991	0.503
LIG_LIR_Nem_3	77	82	PF02991	0.514
LIG_SH2_CRK	59	63	PF00017	0.454
LIG_SH2_CRK	79	83	PF00017	0.579
LIG_SH2_CRK	90	94	PF00017	0.532
LIG_SH2_NCK_1	79	83	PF00017	0.562
LIG_SH2_PTP2	353	356	PF00017	0.562
LIG_SH2_SRC	353	356	PF00017	0.425
LIG_SH2_STAP1	130	134	PF00017	0.540
LIG_SH2_STAP1	167	171	PF00017	0.581
LIG_SH2_STAP1	360	364	PF00017	0.566
LIG_SH2_STAP1	79	83	PF00017	0.581
LIG_SH2_STAT5	130	133	PF00017	0.549
LIG_SH2_STAT5	206	209	PF00017	0.468
LIG_SH2_STAT5	210	213	PF00017	0.464
LIG_SH2_STAT5	353	356	PF00017	0.528
LIG_SH2_STAT5	368	371	PF00017	0.420
LIG_SH3_3	15	21	PF00018	0.458
LIG_SH3_3	244	250	PF00018	0.543
LIG_SH3_3	267	273	PF00018	0.552
LIG_SH3_3	69	75	PF00018	0.572
LIG_SH3_5	356	360	PF00018	0.581
LIG_SUMO_SIM_anti_2	375	380	PF11976	0.487
LIG_SUMO_SIM_par_1	251	257	PF11976	0.581
LIG_SUMO_SIM_par_1	377	383	PF11976	0.502
LIG_SUMO_SIM_par_1	422	427	PF11976	0.501
LIG_TRAF2_1	254	257	PF00917	0.581
LIG_TRAF2_1	290	293	PF00917	0.525
LIG_TYR_ITIM	171	176	PF00017	0.581
MOD_CDK_SPK_2	347	352	PF00069	0.525
MOD_CK1_1	186	192	PF00069	0.560
MOD_CK1_1	27	33	PF00069	0.707
MOD_CK1_1	333	339	PF00069	0.586
MOD_CK1_1	347	353	PF00069	0.380
MOD_CK1_1	98	104	PF00069	0.581
MOD_CK2_1	251	257	PF00069	0.560
MOD_CK2_1	287	293	PF00069	0.517
MOD_CK2_1	308	314	PF00069	0.475
MOD_CK2_1	323	329	PF00069	0.512
MOD_Cter_Amidation	66	69	PF01082	0.359
MOD_GlcNHglycan	137	140	PF01048	0.376
MOD_GlcNHglycan	188	191	PF01048	0.353
MOD_GlcNHglycan	197	200	PF01048	0.371
MOD_GlcNHglycan	202	205	PF01048	0.346
MOD_GlcNHglycan	285	288	PF01048	0.335
MOD_GlcNHglycan	30	33	PF01048	0.713
MOD_GlcNHglycan	445	448	PF01048	0.299
MOD_GSK3_1	234	241	PF00069	0.539
MOD_GSK3_1	24	31	PF00069	0.530
MOD_GSK3_1	283	290	PF00069	0.528
MOD_GSK3_1	291	298	PF00069	0.522
MOD_GSK3_1	33	40	PF00069	0.684
MOD_GSK3_1	380	387	PF00069	0.518
MOD_GSK3_1	94	101	PF00069	0.582
MOD_N-GLC_1	104	109	PF02516	0.342
MOD_N-GLC_1	400	405	PF02516	0.380
MOD_N-GLC_1	95	100	PF02516	0.325
MOD_NEK2_1	1	6	PF00069	0.531
MOD_NEK2_1	330	335	PF00069	0.434
MOD_NEK2_1	367	372	PF00069	0.476
MOD_PIKK_1	265	271	PF00454	0.373
MOD_PIKK_1	291	297	PF00454	0.442
MOD_PIKK_1	37	43	PF00454	0.624
MOD_PIKK_1	384	390	PF00454	0.525
MOD_PKA_1	242	248	PF00069	0.525
MOD_Plk_1	1	7	PF00069	0.579
MOD_Plk_1	128	134	PF00069	0.565
MOD_Plk_1	265	271	PF00069	0.574
MOD_Plk_1	291	297	PF00069	0.472
MOD_Plk_1	374	380	PF00069	0.476
MOD_Plk_1	98	104	PF00069	0.542
MOD_Plk_4	2	8	PF00069	0.504
MOD_Plk_4	374	380	PF00069	0.482
MOD_Plk_4	430	436	PF00069	0.446
MOD_Plk_4	81	87	PF00069	0.566
MOD_Plk_4	98	104	PF00069	0.520
MOD_ProDKin_1	287	293	PF00069	0.561
MOD_ProDKin_1	347	353	PF00069	0.544
MOD_ProDKin_1	400	406	PF00069	0.480
MOD_SUMO_rev_2	129	136	PF00179	0.505
MOD_SUMO_rev_2	425	430	PF00179	0.518
TRG_ENDOCYTIC_2	167	170	PF00928	0.537
TRG_ENDOCYTIC_2	173	176	PF00928	0.537
TRG_ENDOCYTIC_2	59	62	PF00928	0.554
TRG_ENDOCYTIC_2	79	82	PF00928	0.532
TRG_ENDOCYTIC_2	90	93	PF00928	0.487
TRG_ER_diArg_1	412	414	PF00400	0.525
TRG_ER_diArg_1	45	48	PF00400	0.489
TRG_ER_diArg_1	68	70	PF00400	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDW9	Leptomonas seymouri	55%	100%
A0A0S4KLU4	Bodo saltans	28%	92%
A0A1X0PAD2	Trypanosomatidae	31%	100%
A0A3Q8IEN4	Leishmania donovani	88%	100%
A0A3R7K0N1	Trypanosoma rangeli	32%	99%
A4HB89	Leishmania braziliensis	74%	100%
A4IAD7	Leishmania infantum	87%	100%
C9ZLV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	99%
Q4Q2H4	Leishmania major	88%	100%
V5B6A7	Trypanosoma cruzi	31%	90%