LeishMANIAdb
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Transmembrane 9 superfamily member

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane 9 superfamily member
Gene product:
transmembrane/endomembrane-like protein
Species:
Leishmania mexicana
UniProt:
E9B5F7_LEIMU
TriTrypDb:
LmxM.33.3660
Length:
637

Annotations

LeishMANIAdb annotations

A compact protein with N-terminal signal peptide and 9 TM segments at the C-terminus. related to other Eukaryotic proteins of the same superfamily, sugguested to regulate vesicular pH. Localization: Endosomal (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 10, no: 1
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
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Expansion

Sequence features

E9B5F7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5F7

Function

Biological processes
TermNameLevelCount
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0033036 macromolecule localization 2 1
GO:0051179 localization 1 1
GO:0051641 cellular localization 2 1
GO:0051668 localization within membrane 3 1
GO:0070727 cellular macromolecule localization 3 1
GO:0072657 protein localization to membrane 4 1
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Could not find GO molecular_function term for this entry.

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 236 240 PF00656 0.231
CLV_MEL_PAP_1 475 481 PF00089 0.231
CLV_NRD_NRD_1 126 128 PF00675 0.528
CLV_NRD_NRD_1 272 274 PF00675 0.520
CLV_NRD_NRD_1 301 303 PF00675 0.238
CLV_NRD_NRD_1 82 84 PF00675 0.483
CLV_PCSK_KEX2_1 126 128 PF00082 0.493
CLV_PCSK_KEX2_1 272 274 PF00082 0.438
CLV_PCSK_KEX2_1 586 588 PF00082 0.516
CLV_PCSK_KEX2_1 82 84 PF00082 0.542
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P948 Leptomonas seymouri 28% 96%
A0A0N1I2B1 Leptomonas seymouri 30% 100%
A0A0N1I6Y7 Leptomonas seymouri 56% 100%
A0A0N1IME8 Leptomonas seymouri 22% 100%
A0A0S4IV41 Bodo saltans 29% 100%
A0A0S4J9X2 Bodo saltans 28% 98%
A0A0S4JBB1 Bodo saltans 32% 100%
A0A0S4JCH7 Bodo saltans 27% 93%
A0A0S4JEU5 Bodo saltans 25% 99%
A0A0S4JIF4 Bodo saltans 33% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS