Metallophos domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5F2_LEIMU

TriTrypDb:

LmxM.33.3630

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 14, no: 2
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14

Expansion

Sequence features

E9B5F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5F2

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0016787	hydrolase activity	2	14
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	1
GO:0004564	beta-fructofuranosidase activity	5	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	338	342	PF00656	0.341
CLV_NRD_NRD_1	2	4	PF00675	0.495
CLV_PCSK_KEX2_1	2	4	PF00082	0.495
CLV_PCSK_KEX2_1	230	232	PF00082	0.523
CLV_PCSK_KEX2_1	249	251	PF00082	0.396
CLV_PCSK_KEX2_1	392	394	PF00082	0.633
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.543
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.543
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.550
CLV_PCSK_PC7_1	226	232	PF00082	0.543
CLV_PCSK_SKI1_1	113	117	PF00082	0.533
CLV_PCSK_SKI1_1	2	6	PF00082	0.558
CLV_PCSK_SKI1_1	292	296	PF00082	0.443
CLV_PCSK_SKI1_1	351	355	PF00082	0.576
CLV_PCSK_SKI1_1	382	386	PF00082	0.547
CLV_PCSK_SKI1_1	43	47	PF00082	0.535
CLV_PCSK_SKI1_1	485	489	PF00082	0.424
DEG_APCC_DBOX_1	218	226	PF00400	0.288
DEG_Nend_UBRbox_1	1	4	PF02207	0.577
DEG_SPOP_SBC_1	18	22	PF00917	0.358
DOC_MAPK_gen_1	2	9	PF00069	0.564
DOC_MAPK_gen_1	274	284	PF00069	0.337
DOC_MAPK_gen_1	401	411	PF00069	0.321
DOC_MAPK_gen_1	440	449	PF00069	0.143
DOC_MAPK_MEF2A_6	277	284	PF00069	0.328
DOC_MAPK_MEF2A_6	298	306	PF00069	0.359
DOC_MAPK_MEF2A_6	440	449	PF00069	0.251
DOC_PP2B_LxvP_1	200	203	PF13499	0.311
DOC_PP2B_LxvP_1	294	297	PF13499	0.353
DOC_USP7_MATH_1	168	172	PF00917	0.332
DOC_USP7_MATH_1	203	207	PF00917	0.274
DOC_USP7_MATH_1	433	437	PF00917	0.431
DOC_USP7_MATH_1	73	77	PF00917	0.342
DOC_USP7_UBL2_3	401	405	PF12436	0.418
DOC_USP7_UBL2_3	43	47	PF12436	0.291
DOC_WW_Pin1_4	307	312	PF00397	0.264
DOC_WW_Pin1_4	50	55	PF00397	0.265
DOC_WW_Pin1_4	60	65	PF00397	0.240
LIG_14-3-3_CanoR_1	113	118	PF00244	0.332
LIG_14-3-3_CanoR_1	2	9	PF00244	0.526
LIG_14-3-3_CanoR_1	336	344	PF00244	0.236
LIG_14-3-3_CanoR_1	367	373	PF00244	0.353
LIG_14-3-3_CanoR_1	382	387	PF00244	0.356
LIG_14-3-3_CanoR_1	91	101	PF00244	0.267
LIG_BRCT_BRCA1_1	108	112	PF00533	0.336
LIG_BRCT_BRCA1_1	287	291	PF00533	0.209
LIG_BRCT_BRCA1_1	309	313	PF00533	0.370
LIG_deltaCOP1_diTrp_1	376	387	PF00928	0.328
LIG_deltaCOP1_diTrp_1	88	94	PF00928	0.324
LIG_EH1_1	298	306	PF00400	0.161
LIG_FHA_1	18	24	PF00498	0.567
LIG_FHA_1	439	445	PF00498	0.401
LIG_FHA_1	493	499	PF00498	0.739
LIG_FHA_2	336	342	PF00498	0.373
LIG_FHA_2	69	75	PF00498	0.288
LIG_LIR_Apic_2	53	59	PF02991	0.282
LIG_LIR_Gen_1	266	276	PF02991	0.274
LIG_LIR_Gen_1	377	387	PF02991	0.322
LIG_LIR_LC3C_4	278	281	PF02991	0.288
LIG_LIR_Nem_3	109	115	PF02991	0.299
LIG_LIR_Nem_3	244	248	PF02991	0.311
LIG_LIR_Nem_3	266	272	PF02991	0.243
LIG_LIR_Nem_3	275	279	PF02991	0.239
LIG_LIR_Nem_3	288	294	PF02991	0.233
LIG_LIR_Nem_3	310	316	PF02991	0.223
LIG_LIR_Nem_3	33	39	PF02991	0.300
LIG_LIR_Nem_3	377	383	PF02991	0.302
LIG_MYND_1	394	398	PF01753	0.229
LIG_NRBOX	190	196	PF00104	0.308
LIG_PDZ_Class_1	505	510	PF00595	0.663
LIG_Pex14_1	261	265	PF04695	0.244
LIG_Pex14_1	484	488	PF04695	0.570
LIG_Pex14_2	324	328	PF04695	0.390
LIG_Pex14_2	383	387	PF04695	0.362
LIG_PTB_Apo_2	254	261	PF02174	0.143
LIG_SH2_CRK	429	433	PF00017	0.393
LIG_SH2_CRK	56	60	PF00017	0.251
LIG_SH2_PTP2	408	411	PF00017	0.352
LIG_SH2_STAP1	179	183	PF00017	0.324
LIG_SH2_STAP1	265	269	PF00017	0.338
LIG_SH2_STAT5	179	182	PF00017	0.274
LIG_SH2_STAT5	319	322	PF00017	0.250
LIG_SH2_STAT5	337	340	PF00017	0.213
LIG_SH2_STAT5	408	411	PF00017	0.343
LIG_SH3_3	199	205	PF00018	0.299
LIG_SUMO_SIM_anti_2	278	283	PF11976	0.356
LIG_SUMO_SIM_par_1	187	193	PF11976	0.241
LIG_SUMO_SIM_par_1	27	33	PF11976	0.143
LIG_SUMO_SIM_par_1	352	358	PF11976	0.397
LIG_SUMO_SIM_par_1	446	452	PF11976	0.350
LIG_SUMO_SIM_par_1	462	468	PF11976	0.562
LIG_TRAF2_1	147	150	PF00917	0.335
LIG_TRAF2_1	489	492	PF00917	0.686
LIG_TRFH_1	198	202	PF08558	0.232
LIG_WW_2	202	205	PF00397	0.222
MOD_CK1_1	142	148	PF00069	0.277
MOD_CK1_1	206	212	PF00069	0.277
MOD_CK1_1	335	341	PF00069	0.381
MOD_CK1_1	346	352	PF00069	0.333
MOD_CK1_1	355	361	PF00069	0.368
MOD_CK1_1	436	442	PF00069	0.470
MOD_CK1_1	468	474	PF00069	0.620
MOD_CK1_1	486	492	PF00069	0.708
MOD_CK1_1	50	56	PF00069	0.265
MOD_CK1_1	95	101	PF00069	0.194
MOD_CK2_1	145	151	PF00069	0.325
MOD_CK2_1	163	169	PF00069	0.186
MOD_CK2_1	410	416	PF00069	0.332
MOD_CK2_1	486	492	PF00069	0.682
MOD_GlcNHglycan	126	129	PF01048	0.537
MOD_GlcNHglycan	165	168	PF01048	0.421
MOD_GlcNHglycan	345	348	PF01048	0.586
MOD_GlcNHglycan	455	458	PF01048	0.363
MOD_GlcNHglycan	467	470	PF01048	0.425
MOD_GlcNHglycan	479	482	PF01048	0.480
MOD_GlcNHglycan	74	78	PF01048	0.521
MOD_GlcNHglycan	85	88	PF01048	0.458
MOD_GSK3_1	113	120	PF00069	0.295
MOD_GSK3_1	213	220	PF00069	0.333
MOD_GSK3_1	332	339	PF00069	0.285
MOD_GSK3_1	355	362	PF00069	0.307
MOD_GSK3_1	368	375	PF00069	0.306
MOD_GSK3_1	449	456	PF00069	0.421
MOD_GSK3_1	46	53	PF00069	0.289
MOD_GSK3_1	465	472	PF00069	0.631
MOD_GSK3_1	473	480	PF00069	0.536
MOD_N-GLC_1	113	118	PF02516	0.410
MOD_N-GLC_1	206	211	PF02516	0.488
MOD_N-GLC_1	322	327	PF02516	0.564
MOD_N-GLC_1	417	422	PF02516	0.574
MOD_N-GLC_1	427	432	PF02516	0.625
MOD_N-GLC_1	493	498	PF02516	0.441
MOD_N-GLC_1	50	55	PF02516	0.473
MOD_NEK2_1	285	290	PF00069	0.282
MOD_NEK2_1	39	44	PF00069	0.348
MOD_NEK2_1	453	458	PF00069	0.391
MOD_NEK2_1	46	51	PF00069	0.352
MOD_NEK2_1	465	470	PF00069	0.596
MOD_NEK2_1	473	478	PF00069	0.479
MOD_NEK2_1	68	73	PF00069	0.236
MOD_NEK2_1	94	99	PF00069	0.292
MOD_NEK2_2	483	488	PF00069	0.520
MOD_PIKK_1	433	439	PF00454	0.414
MOD_PKA_1	2	8	PF00069	0.370
MOD_PKA_2	2	8	PF00069	0.370
MOD_PKA_2	335	341	PF00069	0.390
MOD_PKB_1	111	119	PF00069	0.332
MOD_Plk_1	113	119	PF00069	0.243
MOD_Plk_1	168	174	PF00069	0.304
MOD_Plk_1	265	271	PF00069	0.288
MOD_Plk_1	427	433	PF00069	0.423
MOD_Plk_1	492	498	PF00069	0.574
MOD_Plk_4	168	174	PF00069	0.361
MOD_Plk_4	190	196	PF00069	0.243
MOD_Plk_4	241	247	PF00069	0.297
MOD_Plk_4	268	274	PF00069	0.306
MOD_Plk_4	315	321	PF00069	0.252
MOD_Plk_4	382	388	PF00069	0.309
MOD_Plk_4	410	416	PF00069	0.271
MOD_Plk_4	427	433	PF00069	0.367
MOD_Plk_4	449	455	PF00069	0.323
MOD_Plk_4	483	489	PF00069	0.739
MOD_Plk_4	493	499	PF00069	0.705
MOD_Plk_4	78	84	PF00069	0.300
MOD_ProDKin_1	307	313	PF00069	0.269
MOD_ProDKin_1	50	56	PF00069	0.265
MOD_ProDKin_1	60	66	PF00069	0.240
MOD_SUMO_rev_2	270	279	PF00179	0.333
TRG_DiLeu_BaEn_1	275	280	PF01217	0.340
TRG_ENDOCYTIC_2	245	248	PF00928	0.302
TRG_ENDOCYTIC_2	269	272	PF00928	0.258
TRG_ENDOCYTIC_2	276	279	PF00928	0.248
TRG_ENDOCYTIC_2	408	411	PF00928	0.343
TRG_ENDOCYTIC_2	429	432	PF00928	0.425
TRG_ER_diArg_1	1	3	PF00400	0.380
TRG_NES_CRM1_1	107	118	PF08389	0.330
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYJ4	Leptomonas seymouri	53%	100%
A0A0S4IUW2	Bodo saltans	21%	97%
A0A0S4JMD5	Bodo saltans	30%	100%
A0A0S4JQJ5	Bodo saltans	35%	90%
A0A1X0PA11	Trypanosomatidae	28%	100%
A0A1X0PAC3	Trypanosomatidae	33%	98%
A0A3Q8IHH9	Leishmania donovani	81%	100%
A0A3R7K6I9	Trypanosoma rangeli	31%	100%
A0A3R7KT12	Trypanosoma rangeli	27%	99%
A4HB81	Leishmania braziliensis	64%	100%
A4IAC9	Leishmania infantum	82%	100%
C9ZLW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZLW5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AHU3	Leishmania infantum	37%	100%
P70158	Mus musculus	22%	100%
Q10916	Caenorhabditis elegans	20%	90%
Q4Q2I1	Leishmania major	81%	100%
Q55C09	Dictyostelium discoideum	22%	87%
Q641Z7	Rattus norvegicus	21%	100%
V5DMV6	Trypanosoma cruzi	27%	100%