PNPLA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF3336)/Patatin-like phospholipase, putative

Species:

Leishmania mexicana

UniProt:

E9B5F1_LEIMU

TriTrypDb:

LmxM.33.3620

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9B5F1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5F1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	14
GO:0008152	metabolic process	1	14
GO:0044238	primary metabolic process	2	14
GO:0071704	organic substance metabolic process	2	14
GO:0009056	catabolic process	2	3
GO:0016042	lipid catabolic process	4	3
GO:1901575	organic substance catabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0004806	triglyceride lipase activity	5	13
GO:0016298	lipase activity	4	13
GO:0016787	hydrolase activity	2	14
GO:0016788	hydrolase activity, acting on ester bonds	3	13
GO:0052689	carboxylic ester hydrolase activity	4	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.460
CLV_C14_Caspase3-7	310	314	PF00656	0.476
CLV_NRD_NRD_1	182	184	PF00675	0.333
CLV_NRD_NRD_1	217	219	PF00675	0.325
CLV_NRD_NRD_1	371	373	PF00675	0.330
CLV_PCSK_FUR_1	315	319	PF00082	0.307
CLV_PCSK_KEX2_1	182	184	PF00082	0.297
CLV_PCSK_KEX2_1	217	219	PF00082	0.409
CLV_PCSK_KEX2_1	317	319	PF00082	0.245
CLV_PCSK_KEX2_1	371	373	PF00082	0.294
CLV_PCSK_KEX2_1	613	615	PF00082	0.369
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.329
CLV_PCSK_PC1ET2_1	613	615	PF00082	0.369
CLV_PCSK_SKI1_1	224	228	PF00082	0.331
CLV_PCSK_SKI1_1	424	428	PF00082	0.363
CLV_PCSK_SKI1_1	468	472	PF00082	0.287
CLV_PCSK_SKI1_1	546	550	PF00082	0.348
DEG_APCC_DBOX_1	223	231	PF00400	0.547
DEG_APCC_DBOX_1	483	491	PF00400	0.509
DOC_ANK_TNKS_1	42	49	PF00023	0.293
DOC_CYCLIN_RxL_1	421	430	PF00134	0.494
DOC_MAPK_DCC_7	356	365	PF00069	0.365
DOC_MAPK_gen_1	353	362	PF00069	0.411
DOC_MAPK_gen_1	371	378	PF00069	0.463
DOC_MAPK_gen_1	466	475	PF00069	0.568
DOC_MAPK_MEF2A_6	353	362	PF00069	0.511
DOC_MAPK_MEF2A_6	371	380	PF00069	0.404
DOC_MAPK_MEF2A_6	577	584	PF00069	0.401
DOC_MAPK_RevD_3	358	372	PF00069	0.408
DOC_MAPK_RevD_3	600	614	PF00069	0.372
DOC_PP1_RVXF_1	525	532	PF00149	0.551
DOC_PP2B_LxvP_1	358	361	PF13499	0.512
DOC_PP2B_LxvP_1	90	93	PF13499	0.619
DOC_SPAK_OSR1_1	474	478	PF12202	0.542
DOC_USP7_MATH_1	117	121	PF00917	0.499
DOC_USP7_MATH_1	361	365	PF00917	0.511
DOC_USP7_MATH_1	407	411	PF00917	0.688
DOC_USP7_MATH_1	49	53	PF00917	0.277
DOC_USP7_MATH_1	561	565	PF00917	0.497
DOC_WW_Pin1_4	13	18	PF00397	0.317
DOC_WW_Pin1_4	363	368	PF00397	0.424
DOC_WW_Pin1_4	383	388	PF00397	0.494
DOC_WW_Pin1_4	412	417	PF00397	0.600
DOC_WW_Pin1_4	538	543	PF00397	0.580
LIG_14-3-3_CanoR_1	429	439	PF00244	0.637
LIG_14-3-3_CanoR_1	511	515	PF00244	0.617
LIG_14-3-3_CanoR_1	599	605	PF00244	0.500
LIG_14-3-3_CanoR_1	614	619	PF00244	0.550
LIG_Actin_WH2_2	142	158	PF00022	0.408
LIG_BRCT_BRCA1_1	136	140	PF00533	0.512
LIG_BRCT_BRCA1_1	248	252	PF00533	0.389
LIG_BRCT_BRCA1_1	76	80	PF00533	0.429
LIG_deltaCOP1_diTrp_1	508	514	PF00928	0.548
LIG_eIF4E_1	234	240	PF01652	0.433
LIG_FHA_1	189	195	PF00498	0.415
LIG_FHA_1	221	227	PF00498	0.532
LIG_FHA_1	235	241	PF00498	0.395
LIG_FHA_1	323	329	PF00498	0.501
LIG_FHA_1	352	358	PF00498	0.420
LIG_FHA_1	431	437	PF00498	0.533
LIG_FHA_1	511	517	PF00498	0.606
LIG_FHA_1	66	72	PF00498	0.329
LIG_FHA_2	108	114	PF00498	0.430
LIG_FHA_2	119	125	PF00498	0.409
LIG_FHA_2	146	152	PF00498	0.512
LIG_FHA_2	20	26	PF00498	0.331
LIG_FHA_2	344	350	PF00498	0.419
LIG_FHA_2	545	551	PF00498	0.714
LIG_GBD_Chelix_1	71	79	PF00786	0.282
LIG_LIR_Apic_2	410	416	PF02991	0.552
LIG_LIR_Gen_1	197	206	PF02991	0.447
LIG_LIR_Gen_1	563	573	PF02991	0.528
LIG_LIR_Nem_3	113	118	PF02991	0.424
LIG_LIR_Nem_3	137	142	PF02991	0.435
LIG_LIR_Nem_3	197	201	PF02991	0.423
LIG_LIR_Nem_3	228	234	PF02991	0.519
LIG_LIR_Nem_3	313	319	PF02991	0.494
LIG_LIR_Nem_3	33	37	PF02991	0.403
LIG_LIR_Nem_3	508	512	PF02991	0.518
LIG_LIR_Nem_3	563	569	PF02991	0.522
LIG_LIR_Nem_3	68	73	PF02991	0.343
LIG_MLH1_MIPbox_1	136	140	PF16413	0.512
LIG_NRBOX	318	324	PF00104	0.336
LIG_NRBOX	486	492	PF00104	0.505
LIG_Pex14_2	471	475	PF04695	0.550
LIG_PTB_Apo_2	356	363	PF02174	0.429
LIG_SH2_CRK	198	202	PF00017	0.458
LIG_SH2_CRK	413	417	PF00017	0.552
LIG_SH2_CRK	534	538	PF00017	0.567
LIG_SH2_CRK	76	80	PF00017	0.442
LIG_SH2_CRK	99	103	PF00017	0.496
LIG_SH2_NCK_1	534	538	PF00017	0.567
LIG_SH2_SRC	439	442	PF00017	0.503
LIG_SH2_STAP1	112	116	PF00017	0.432
LIG_SH2_STAP1	448	452	PF00017	0.548
LIG_SH2_STAP1	512	516	PF00017	0.496
LIG_SH2_STAP1	534	538	PF00017	0.539
LIG_SH2_STAP1	76	80	PF00017	0.282
LIG_SH2_STAT3	486	489	PF00017	0.471
LIG_SH2_STAT5	139	142	PF00017	0.472
LIG_SH2_STAT5	185	188	PF00017	0.423
LIG_SH2_STAT5	383	386	PF00017	0.422
LIG_SH2_STAT5	486	489	PF00017	0.585
LIG_SH2_STAT5	512	515	PF00017	0.524
LIG_SH2_STAT5	568	571	PF00017	0.559
LIG_SH2_STAT5	70	73	PF00017	0.326
LIG_SH3_2	367	372	PF14604	0.408
LIG_SH3_3	364	370	PF00018	0.567
LIG_SH3_3	457	463	PF00018	0.539
LIG_SH3_3	7	13	PF00018	0.328
LIG_SUMO_SIM_par_1	150	157	PF11976	0.472
LIG_SUMO_SIM_par_1	581	586	PF11976	0.464
LIG_SUMO_SIM_par_1	88	95	PF11976	0.583
LIG_TRAF2_1	111	114	PF00917	0.476
LIG_TRAF2_1	148	151	PF00917	0.496
LIG_TYR_ITIM	456	461	PF00017	0.702
LIG_TYR_ITIM	74	79	PF00017	0.282
LIG_UBA3_1	164	170	PF00899	0.460
LIG_WRC_WIRS_1	139	144	PF05994	0.512
LIG_WRC_WIRS_1	31	36	PF05994	0.316
LIG_WRC_WIRS_1	545	550	PF05994	0.687
MOD_CK1_1	157	163	PF00069	0.522
MOD_CK1_1	16	22	PF00069	0.328
MOD_CK1_1	197	203	PF00069	0.470
MOD_CK1_1	23	29	PF00069	0.320
MOD_CK1_1	294	300	PF00069	0.479
MOD_CK1_1	409	415	PF00069	0.635
MOD_CK1_1	479	485	PF00069	0.478
MOD_CK1_1	541	547	PF00069	0.696
MOD_CK1_1	564	570	PF00069	0.542
MOD_CK2_1	107	113	PF00069	0.453
MOD_CK2_1	145	151	PF00069	0.501
MOD_CK2_1	19	25	PF00069	0.332
MOD_CK2_1	296	302	PF00069	0.502
MOD_CK2_1	343	349	PF00069	0.407
MOD_CK2_1	544	550	PF00069	0.693
MOD_GlcNHglycan	159	162	PF01048	0.208
MOD_GlcNHglycan	248	251	PF01048	0.325
MOD_GlcNHglycan	270	273	PF01048	0.308
MOD_GlcNHglycan	294	297	PF01048	0.273
MOD_GlcNHglycan	392	395	PF01048	0.226
MOD_GlcNHglycan	493	496	PF01048	0.436
MOD_GlcNHglycan	51	54	PF01048	0.538
MOD_GSK3_1	130	137	PF00069	0.522
MOD_GSK3_1	16	23	PF00069	0.328
MOD_GSK3_1	186	193	PF00069	0.498
MOD_GSK3_1	282	289	PF00069	0.420
MOD_GSK3_1	290	297	PF00069	0.491
MOD_GSK3_1	307	314	PF00069	0.392
MOD_GSK3_1	427	434	PF00069	0.579
MOD_GSK3_1	444	451	PF00069	0.660
MOD_GSK3_1	540	547	PF00069	0.679
MOD_GSK3_1	560	567	PF00069	0.427
MOD_NEK2_1	186	191	PF00069	0.471
MOD_NEK2_1	246	251	PF00069	0.392
MOD_NEK2_1	276	281	PF00069	0.408
MOD_NEK2_1	290	295	PF00069	0.426
MOD_NEK2_1	306	311	PF00069	0.433
MOD_NEK2_1	338	343	PF00069	0.469
MOD_NEK2_1	390	395	PF00069	0.447
MOD_NEK2_1	427	432	PF00069	0.530
MOD_NEK2_1	491	496	PF00069	0.645
MOD_NEK2_1	598	603	PF00069	0.518
MOD_NEK2_2	30	35	PF00069	0.347
MOD_PKA_1	613	619	PF00069	0.421
MOD_PKA_2	430	436	PF00069	0.582
MOD_PKA_2	510	516	PF00069	0.616
MOD_PKA_2	598	604	PF00069	0.487
MOD_PKA_2	613	619	PF00069	0.560
MOD_PKB_1	429	437	PF00069	0.485
MOD_Plk_1	134	140	PF00069	0.512
MOD_Plk_1	343	349	PF00069	0.410
MOD_Plk_1	479	485	PF00069	0.485
MOD_Plk_4	135	141	PF00069	0.512
MOD_Plk_4	190	196	PF00069	0.441
MOD_Plk_4	197	203	PF00069	0.411
MOD_Plk_4	276	282	PF00069	0.331
MOD_Plk_4	286	292	PF00069	0.478
MOD_Plk_4	296	302	PF00069	0.462
MOD_Plk_4	432	438	PF00069	0.577
MOD_Plk_4	544	550	PF00069	0.616
MOD_Plk_4	561	567	PF00069	0.517
MOD_Plk_4	66	72	PF00069	0.236
MOD_ProDKin_1	13	19	PF00069	0.319
MOD_ProDKin_1	363	369	PF00069	0.424
MOD_ProDKin_1	383	389	PF00069	0.494
MOD_ProDKin_1	412	418	PF00069	0.600
MOD_ProDKin_1	538	544	PF00069	0.576
TRG_DiLeu_BaEn_4	150	156	PF01217	0.512
TRG_DiLeu_BaLyEn_6	318	323	PF01217	0.476
TRG_DiLeu_BaLyEn_6	524	529	PF01217	0.623
TRG_ENDOCYTIC_2	139	142	PF00928	0.450
TRG_ENDOCYTIC_2	198	201	PF00928	0.432
TRG_ENDOCYTIC_2	458	461	PF00928	0.700
TRG_ENDOCYTIC_2	534	537	PF00928	0.637
TRG_ENDOCYTIC_2	568	571	PF00928	0.563
TRG_ENDOCYTIC_2	76	79	PF00928	0.260
TRG_ENDOCYTIC_2	99	102	PF00928	0.548
TRG_ER_diArg_1	182	184	PF00400	0.533
TRG_ER_diArg_1	217	219	PF00400	0.584
TRG_ER_diArg_1	221	224	PF00400	0.533
TRG_ER_diArg_1	370	372	PF00400	0.527
TRG_ER_diArg_1	429	432	PF00400	0.516
TRG_ER_diArg_1	500	503	PF00400	0.632
TRG_NES_CRM1_1	465	480	PF08389	0.485
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.273
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P1	Leptomonas seymouri	28%	75%
A0A0N1P9M9	Leptomonas seymouri	59%	100%
A0A0S4JME6	Bodo saltans	29%	100%
A0A0S4JR20	Bodo saltans	27%	100%
A0A1X0PA17	Trypanosomatidae	34%	100%
A0A3Q8INR2	Leishmania donovani	93%	100%
A0A422N5R5	Trypanosoma rangeli	34%	100%
A1CRG6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	23%	87%
A1D4C8	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	24%	87%
A2Q8F7	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	24%	83%
A4HB80	Leishmania braziliensis	85%	100%
A4HIE6	Leishmania braziliensis	29%	81%
A4IAC8	Leishmania infantum	93%	100%
A4R8V2	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	24%	79%
A5DIR3	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	26%	86%
A5DUA8	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	25%	76%
O14115	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	98%
P0C584	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	71%
P0CP52	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	26%	71%
P0CP53	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	26%	71%
P0CT18	Magnaporthe oryzae (strain Y34)	24%	79%
Q0CUP0	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	24%	87%
Q12043	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	83%
Q1DXR6	Coccidioides immitis (strain RS)	24%	85%
Q2HA54	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	26%	72%
Q4Q2I2	Leishmania major	91%	100%
Q4WJS4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	87%
Q5AM72	Candida albicans (strain SC5314 / ATCC MYA-2876)	24%	73%
Q5BGC2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	83%
Q6BXC8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	25%	79%
Q9LZA6	Arabidopsis thaliana	25%	75%
Q9M1I6	Arabidopsis thaliana	25%	77%
Q9Y7P3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
V5BW64	Trypanosoma cruzi	34%	100%