HECT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5E7_LEIMU

TriTrypDb:

LmxM.33.3580

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B5E7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5E7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	244	246	PF00675	0.501
CLV_NRD_NRD_1	359	361	PF00675	0.281
CLV_NRD_NRD_1	732	734	PF00675	0.540
CLV_NRD_NRD_1	783	785	PF00675	0.517
CLV_NRD_NRD_1	795	797	PF00675	0.506
CLV_PCSK_KEX2_1	359	361	PF00082	0.281
CLV_PCSK_KEX2_1	732	734	PF00082	0.540
CLV_PCSK_KEX2_1	785	787	PF00082	0.546
CLV_PCSK_KEX2_1	795	797	PF00082	0.522
CLV_PCSK_PC1ET2_1	785	787	PF00082	0.544
CLV_PCSK_SKI1_1	10	14	PF00082	0.573
CLV_PCSK_SKI1_1	263	267	PF00082	0.422
CLV_PCSK_SKI1_1	343	347	PF00082	0.453
CLV_PCSK_SKI1_1	359	363	PF00082	0.402
CLV_PCSK_SKI1_1	376	380	PF00082	0.578
CLV_PCSK_SKI1_1	796	800	PF00082	0.607
CLV_Separin_Metazoa	21	25	PF03568	0.553
DEG_APCC_DBOX_1	631	639	PF00400	0.351
DEG_COP1_1	749	758	PF00400	0.537
DEG_MDM2_SWIB_1	468	475	PF02201	0.605
DEG_SCF_FBW7_1	550	557	PF00400	0.522
DEG_SCF_FBW7_1	614	621	PF00400	0.496
DOC_CDC14_PxL_1	773	781	PF14671	0.535
DOC_CKS1_1	551	556	PF01111	0.518
DOC_CYCLIN_RxL_1	729	740	PF00134	0.555
DOC_MAPK_gen_1	732	738	PF00069	0.518
DOC_MAPK_MEF2A_6	394	402	PF00069	0.510
DOC_MAPK_MEF2A_6	556	564	PF00069	0.504
DOC_PP1_RVXF_1	312	319	PF00149	0.275
DOC_PP1_RVXF_1	641	648	PF00149	0.508
DOC_PP1_RVXF_1	8	14	PF00149	0.556
DOC_PP2B_LxvP_1	513	516	PF13499	0.504
DOC_PP2B_LxvP_1	605	608	PF13499	0.443
DOC_PP2B_LxvP_1	809	812	PF13499	0.646
DOC_PP2B_LxvP_1	863	866	PF13499	0.660
DOC_PP4_FxxP_1	195	198	PF00568	0.435
DOC_USP7_MATH_1	111	115	PF00917	0.619
DOC_USP7_MATH_1	422	426	PF00917	0.621
DOC_USP7_MATH_1	446	450	PF00917	0.620
DOC_USP7_MATH_1	489	493	PF00917	0.487
DOC_USP7_MATH_1	554	558	PF00917	0.503
DOC_USP7_MATH_1	692	696	PF00917	0.749
DOC_USP7_MATH_1	737	741	PF00917	0.505
DOC_USP7_MATH_1	80	84	PF00917	0.713
DOC_USP7_MATH_2	2	8	PF00917	0.507
DOC_WW_Pin1_4	301	306	PF00397	0.558
DOC_WW_Pin1_4	426	431	PF00397	0.541
DOC_WW_Pin1_4	442	447	PF00397	0.659
DOC_WW_Pin1_4	550	555	PF00397	0.425
DOC_WW_Pin1_4	592	597	PF00397	0.515
DOC_WW_Pin1_4	614	619	PF00397	0.527
DOC_WW_Pin1_4	759	764	PF00397	0.659
DOC_WW_Pin1_4	810	815	PF00397	0.691
LIG_14-3-3_CanoR_1	145	155	PF00244	0.397
LIG_14-3-3_CanoR_1	252	256	PF00244	0.486
LIG_14-3-3_CanoR_1	27	35	PF00244	0.460
LIG_14-3-3_CanoR_1	343	352	PF00244	0.390
LIG_14-3-3_CanoR_1	376	381	PF00244	0.529
LIG_14-3-3_CanoR_1	486	492	PF00244	0.515
LIG_14-3-3_CanoR_1	60	68	PF00244	0.461
LIG_14-3-3_CanoR_1	632	641	PF00244	0.521
LIG_14-3-3_CanoR_1	78	83	PF00244	0.532
LIG_14-3-3_CanoR_1	795	803	PF00244	0.603
LIG_14-3-3_CanoR_1	829	837	PF00244	0.541
LIG_14-3-3_CanoR_1	85	90	PF00244	0.627
LIG_14-3-3_CanoR_1	95	99	PF00244	0.528
LIG_Actin_WH2_2	709	727	PF00022	0.288
LIG_Actin_WH2_2	8	26	PF00022	0.558
LIG_ActinCP_TwfCPI_2	195	202	PF01115	0.418
LIG_APCC_ABBA_1	330	335	PF00400	0.455
LIG_BIR_III_2	264	268	PF00653	0.407
LIG_BRCT_BRCA1_1	128	132	PF00533	0.466
LIG_BRCT_BRCA1_1	148	152	PF00533	0.238
LIG_BRCT_BRCA1_1	430	434	PF00533	0.651
LIG_BRCT_BRCA1_1	83	87	PF00533	0.644
LIG_BRCT_BRCA1_1	99	103	PF00533	0.477
LIG_CaM_NSCaTE_8	33	40	PF13499	0.515
LIG_deltaCOP1_diTrp_1	31	36	PF00928	0.511
LIG_deltaCOP1_diTrp_1	4	13	PF00928	0.440
LIG_EH1_1	229	237	PF00400	0.432
LIG_EVH1_1	817	821	PF00568	0.705
LIG_FHA_1	183	189	PF00498	0.545
LIG_FHA_1	236	242	PF00498	0.492
LIG_FHA_1	273	279	PF00498	0.532
LIG_FHA_1	317	323	PF00498	0.463
LIG_FHA_1	327	333	PF00498	0.502
LIG_FHA_1	344	350	PF00498	0.412
LIG_FHA_1	593	599	PF00498	0.509
LIG_FHA_1	609	615	PF00498	0.440
LIG_FHA_1	704	710	PF00498	0.388
LIG_FHA_1	795	801	PF00498	0.622
LIG_FHA_1	854	860	PF00498	0.401
LIG_FHA_2	437	443	PF00498	0.749
LIG_FHA_2	453	459	PF00498	0.409
LIG_FHA_2	569	575	PF00498	0.705
LIG_FHA_2	619	625	PF00498	0.496
LIG_LIR_Apic_2	194	198	PF02991	0.476
LIG_LIR_Gen_1	133	142	PF02991	0.383
LIG_LIR_Gen_1	149	157	PF02991	0.337
LIG_LIR_Gen_1	31	40	PF02991	0.474
LIG_LIR_Gen_1	315	326	PF02991	0.429
LIG_LIR_Gen_1	374	385	PF02991	0.466
LIG_LIR_Gen_1	469	476	PF02991	0.608
LIG_LIR_Gen_1	671	680	PF02991	0.615
LIG_LIR_Gen_1	704	713	PF02991	0.393
LIG_LIR_Gen_1	767	778	PF02991	0.529
LIG_LIR_Gen_1	840	851	PF02991	0.642
LIG_LIR_Nem_3	129	135	PF02991	0.381
LIG_LIR_Nem_3	149	155	PF02991	0.252
LIG_LIR_Nem_3	264	269	PF02991	0.345
LIG_LIR_Nem_3	31	36	PF02991	0.421
LIG_LIR_Nem_3	315	321	PF02991	0.434
LIG_LIR_Nem_3	374	380	PF02991	0.469
LIG_LIR_Nem_3	386	391	PF02991	0.446
LIG_LIR_Nem_3	469	475	PF02991	0.611
LIG_LIR_Nem_3	47	53	PF02991	0.328
LIG_LIR_Nem_3	553	558	PF02991	0.477
LIG_LIR_Nem_3	6	12	PF02991	0.431
LIG_LIR_Nem_3	671	675	PF02991	0.585
LIG_LIR_Nem_3	704	708	PF02991	0.404
LIG_LIR_Nem_3	767	773	PF02991	0.534
LIG_LIR_Nem_3	832	837	PF02991	0.657
LIG_LIR_Nem_3	840	846	PF02991	0.653
LIG_LYPXL_S_1	387	391	PF13949	0.522
LIG_LYPXL_yS_3	388	391	PF13949	0.525
LIG_PAM2_1	657	669	PF00658	0.484
LIG_Pex14_1	647	651	PF04695	0.337
LIG_Pex14_1	9	13	PF04695	0.409
LIG_Pex14_2	195	199	PF04695	0.522
LIG_Pex14_2	468	472	PF04695	0.593
LIG_SH2_CRK	377	381	PF00017	0.464
LIG_SH2_NCK_1	190	194	PF00017	0.349
LIG_SH2_NCK_1	247	251	PF00017	0.409
LIG_SH2_NCK_1	377	381	PF00017	0.555
LIG_SH2_STAP1	333	337	PF00017	0.487
LIG_SH2_STAT3	339	342	PF00017	0.456
LIG_SH2_STAT5	190	193	PF00017	0.407
LIG_SH2_STAT5	258	261	PF00017	0.316
LIG_SH2_STAT5	372	375	PF00017	0.594
LIG_SH2_STAT5	778	781	PF00017	0.615
LIG_SH3_1	725	731	PF00018	0.325
LIG_SH3_2	728	733	PF14604	0.552
LIG_SH3_3	302	308	PF00018	0.361
LIG_SH3_3	334	340	PF00018	0.511
LIG_SH3_3	414	420	PF00018	0.789
LIG_SH3_3	512	518	PF00018	0.434
LIG_SH3_3	597	603	PF00018	0.510
LIG_SH3_3	725	731	PF00018	0.432
LIG_SH3_3	812	818	PF00018	0.600
LIG_SUMO_SIM_par_1	168	177	PF11976	0.387
LIG_SUMO_SIM_par_1	323	329	PF11976	0.372
LIG_SUMO_SIM_par_1	50	55	PF11976	0.504
LIG_TRAF2_1	271	274	PF00917	0.442
LIG_UBA3_1	240	246	PF00899	0.430
LIG_WRC_WIRS_1	349	354	PF05994	0.429
LIG_WRC_WIRS_1	693	698	PF05994	0.615
LIG_WRC_WIRS_1	702	707	PF05994	0.358
LIG_WW_2	818	821	PF00397	0.650
LIG_WW_3	601	605	PF00397	0.412
MOD_CDK_SPxK_1	550	556	PF00069	0.517
MOD_CK1_1	312	318	PF00069	0.517
MOD_CK1_1	366	372	PF00069	0.296
MOD_CK1_1	429	435	PF00069	0.633
MOD_CK1_1	487	493	PF00069	0.527
MOD_CK1_1	625	631	PF00069	0.580
MOD_CK1_1	678	684	PF00069	0.690
MOD_CK1_1	694	700	PF00069	0.570
MOD_CK1_1	81	87	PF00069	0.645
MOD_CK1_1	813	819	PF00069	0.776
MOD_CK1_1	94	100	PF00069	0.496
MOD_CK2_1	15	21	PF00069	0.433
MOD_CK2_1	158	164	PF00069	0.441
MOD_CK2_1	348	354	PF00069	0.397
MOD_CK2_1	436	442	PF00069	0.755
MOD_CK2_1	470	476	PF00069	0.622
MOD_CK2_1	568	574	PF00069	0.661
MOD_CK2_1	59	65	PF00069	0.532
MOD_CK2_1	692	698	PF00069	0.644
MOD_CK2_1	799	805	PF00069	0.611
MOD_GlcNHglycan	105	108	PF01048	0.653
MOD_GlcNHglycan	113	116	PF01048	0.567
MOD_GlcNHglycan	121	124	PF01048	0.465
MOD_GlcNHglycan	132	135	PF01048	0.299
MOD_GlcNHglycan	168	171	PF01048	0.566
MOD_GlcNHglycan	176	179	PF01048	0.460
MOD_GlcNHglycan	38	41	PF01048	0.433
MOD_GlcNHglycan	577	580	PF01048	0.644
MOD_GlcNHglycan	623	627	PF01048	0.674
MOD_GlcNHglycan	635	638	PF01048	0.471
MOD_GlcNHglycan	687	690	PF01048	0.742
MOD_GlcNHglycan	746	749	PF01048	0.615
MOD_GlcNHglycan	99	102	PF01048	0.589
MOD_GSK3_1	103	110	PF00069	0.711
MOD_GSK3_1	126	133	PF00069	0.454
MOD_GSK3_1	146	153	PF00069	0.237
MOD_GSK3_1	184	191	PF00069	0.441
MOD_GSK3_1	312	319	PF00069	0.472
MOD_GSK3_1	418	425	PF00069	0.787
MOD_GSK3_1	429	436	PF00069	0.699
MOD_GSK3_1	442	449	PF00069	0.651
MOD_GSK3_1	463	470	PF00069	0.628
MOD_GSK3_1	550	557	PF00069	0.487
MOD_GSK3_1	575	582	PF00069	0.638
MOD_GSK3_1	608	615	PF00069	0.542
MOD_GSK3_1	618	625	PF00069	0.643
MOD_GSK3_1	737	744	PF00069	0.532
MOD_GSK3_1	746	753	PF00069	0.571
MOD_GSK3_1	81	88	PF00069	0.727
MOD_GSK3_1	829	836	PF00069	0.733
MOD_GSK3_1	90	97	PF00069	0.748
MOD_N-GLC_1	107	112	PF02516	0.744
MOD_N-GLC_1	684	689	PF02516	0.753
MOD_N-GLC_2	478	480	PF02516	0.491
MOD_NEK2_1	103	108	PF00069	0.724
MOD_NEK2_1	184	189	PF00069	0.434
MOD_NEK2_1	235	240	PF00069	0.448
MOD_NEK2_1	299	304	PF00069	0.545
MOD_NEK2_1	326	331	PF00069	0.470
MOD_NEK2_1	36	41	PF00069	0.423
MOD_NEK2_1	42	47	PF00069	0.446
MOD_NEK2_1	484	489	PF00069	0.557
MOD_NEK2_1	631	636	PF00069	0.369
MOD_NEK2_1	676	681	PF00069	0.618
MOD_NEK2_1	736	741	PF00069	0.571
MOD_NEK2_1	799	804	PF00069	0.622
MOD_NEK2_2	383	388	PF00069	0.466
MOD_NEK2_2	463	468	PF00069	0.470
MOD_NEK2_2	608	613	PF00069	0.422
MOD_PIKK_1	146	152	PF00454	0.384
MOD_PIKK_1	206	212	PF00454	0.539
MOD_PIKK_1	484	490	PF00454	0.419
MOD_PIKK_1	829	835	PF00454	0.551
MOD_PK_1	78	84	PF00069	0.457
MOD_PKA_1	786	792	PF00069	0.575
MOD_PKA_2	118	124	PF00069	0.624
MOD_PKA_2	150	156	PF00069	0.424
MOD_PKA_2	174	180	PF00069	0.506
MOD_PKA_2	251	257	PF00069	0.444
MOD_PKA_2	26	32	PF00069	0.430
MOD_PKA_2	59	65	PF00069	0.432
MOD_PKA_2	631	637	PF00069	0.373
MOD_PKA_2	794	800	PF00069	0.594
MOD_PKA_2	94	100	PF00069	0.539
MOD_PKB_1	784	792	PF00069	0.492
MOD_Plk_1	312	318	PF00069	0.274
MOD_Plk_1	4	10	PF00069	0.577
MOD_Plk_1	470	476	PF00069	0.638
MOD_Plk_4	191	197	PF00069	0.443
MOD_Plk_4	306	312	PF00069	0.628
MOD_Plk_4	326	332	PF00069	0.218
MOD_Plk_4	383	389	PF00069	0.480
MOD_Plk_4	429	435	PF00069	0.600
MOD_Plk_4	463	469	PF00069	0.507
MOD_Plk_4	522	528	PF00069	0.494
MOD_Plk_4	608	614	PF00069	0.426
MOD_Plk_4	711	717	PF00069	0.353
MOD_Plk_4	838	844	PF00069	0.624
MOD_Plk_4	94	100	PF00069	0.584
MOD_ProDKin_1	301	307	PF00069	0.551
MOD_ProDKin_1	426	432	PF00069	0.540
MOD_ProDKin_1	442	448	PF00069	0.660
MOD_ProDKin_1	550	556	PF00069	0.428
MOD_ProDKin_1	592	598	PF00069	0.513
MOD_ProDKin_1	614	620	PF00069	0.536
MOD_ProDKin_1	759	765	PF00069	0.656
MOD_ProDKin_1	810	816	PF00069	0.694
TRG_DiLeu_BaEn_1	179	184	PF01217	0.631
TRG_DiLeu_BaLyEn_6	601	606	PF01217	0.407
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.558
TRG_ENDOCYTIC_2	258	261	PF00928	0.456
TRG_ENDOCYTIC_2	377	380	PF00928	0.458
TRG_ENDOCYTIC_2	388	391	PF00928	0.464
TRG_ENDOCYTIC_2	669	672	PF00928	0.533
TRG_ENDOCYTIC_2	770	773	PF00928	0.599
TRG_ENDOCYTIC_2	834	837	PF00928	0.630
TRG_ER_diArg_1	731	733	PF00400	0.547
TRG_NES_CRM1_1	137	150	PF08389	0.490
TRG_NES_CRM1_1	320	336	PF08389	0.488
TRG_NES_CRM1_1	707	719	PF08389	0.464
TRG_NLS_MonoExtN_4	784	789	PF00514	0.547
TRG_Pf-PMV_PEXEL_1	556	561	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W8	Leptomonas seymouri	44%	99%
A0A1X0PA03	Trypanosomatidae	27%	100%
A0A3R7K2U6	Trypanosoma rangeli	28%	100%
A0A3S5H7X7	Leishmania donovani	89%	100%
A4HB76	Leishmania braziliensis	75%	100%
A4IAC4	Leishmania infantum	89%	100%
C9ZLW8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4Q2I6	Leishmania major	88%	100%
V5BW70	Trypanosoma cruzi	27%	100%