LeishMANIAdb
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ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
ANK_REP_REGION domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B5E6_LEIMU
TriTrypDb:
LmxM.33.3570
Length:
1010

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 5, no: 0
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5E6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5E6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 112 116 PF00656 0.671
CLV_C14_Caspase3-7 573 577 PF00656 0.593
CLV_C14_Caspase3-7 580 584 PF00656 0.513
CLV_MEL_PAP_1 540 546 PF00089 0.656
CLV_NRD_NRD_1 138 140 PF00675 0.742
CLV_NRD_NRD_1 149 151 PF00675 0.651
CLV_NRD_NRD_1 287 289 PF00675 0.600
CLV_NRD_NRD_1 342 344 PF00675 0.552
CLV_NRD_NRD_1 354 356 PF00675 0.708
CLV_NRD_NRD_1 420 422 PF00675 0.517
CLV_NRD_NRD_1 439 441 PF00675 0.649
CLV_NRD_NRD_1 457 459 PF00675 0.372
CLV_NRD_NRD_1 471 473 PF00675 0.488
CLV_NRD_NRD_1 506 508 PF00675 0.628
CLV_NRD_NRD_1 725 727 PF00675 0.661
CLV_NRD_NRD_1 917 919 PF00675 0.766
CLV_NRD_NRD_1 992 994 PF00675 0.840
CLV_PCSK_FUR_1 723 727 PF00082 0.663
CLV_PCSK_KEX2_1 138 140 PF00082 0.742
CLV_PCSK_KEX2_1 149 151 PF00082 0.651
CLV_PCSK_KEX2_1 266 268 PF00082 0.700
CLV_PCSK_KEX2_1 354 356 PF00082 0.689
CLV_PCSK_KEX2_1 420 422 PF00082 0.517
CLV_PCSK_KEX2_1 439 441 PF00082 0.649
CLV_PCSK_KEX2_1 444 446 PF00082 0.566
CLV_PCSK_KEX2_1 457 459 PF00082 0.372
CLV_PCSK_KEX2_1 506 508 PF00082 0.647
CLV_PCSK_KEX2_1 725 727 PF00082 0.661
CLV_PCSK_KEX2_1 917 919 PF00082 0.766
CLV_PCSK_KEX2_1 991 993 PF00082 0.870
CLV_PCSK_PC1ET2_1 266 268 PF00082 0.700
CLV_PCSK_PC1ET2_1 444 446 PF00082 0.566
CLV_PCSK_PC7_1 145 151 PF00082 0.649
CLV_PCSK_PC7_1 440 446 PF00082 0.468
CLV_PCSK_SKI1_1 13 17 PF00082 0.693
CLV_PCSK_SKI1_1 473 477 PF00082 0.644
CLV_PCSK_SKI1_1 579 583 PF00082 0.388
CLV_PCSK_SKI1_1 800 804 PF00082 0.647
CLV_Separin_Metazoa 546 550 PF03568 0.391
DEG_APCC_DBOX_1 12 20 PF00400 0.576
DEG_SPOP_SBC_1 693 697 PF00917 0.783
DOC_CKS1_1 104 109 PF01111 0.546
DOC_CKS1_1 729 734 PF01111 0.629
DOC_CKS1_1 941 946 PF01111 0.761
DOC_CYCLIN_yCln2_LP_2 61 67 PF00134 0.796
DOC_MAPK_gen_1 79 87 PF00069 0.748
DOC_MAPK_MEF2A_6 81 89 PF00069 0.828
DOC_PP2B_LxvP_1 61 64 PF13499 0.801
DOC_PP2B_LxvP_1 905 908 PF13499 0.723
DOC_PP2B_LxvP_1 961 964 PF13499 0.670
DOC_PP4_FxxP_1 968 971 PF00568 0.705
DOC_USP7_MATH_1 128 132 PF00917 0.606
DOC_USP7_MATH_1 202 206 PF00917 0.740
DOC_USP7_MATH_1 209 213 PF00917 0.706
DOC_USP7_MATH_1 221 225 PF00917 0.559
DOC_USP7_MATH_1 230 234 PF00917 0.723
DOC_USP7_MATH_1 291 295 PF00917 0.766
DOC_USP7_MATH_1 450 454 PF00917 0.483
DOC_USP7_MATH_1 581 585 PF00917 0.667
DOC_USP7_MATH_1 684 688 PF00917 0.624
DOC_USP7_MATH_1 700 704 PF00917 0.718
DOC_USP7_MATH_1 816 820 PF00917 0.664
DOC_USP7_MATH_1 873 877 PF00917 0.787
DOC_USP7_UBL2_3 474 478 PF12436 0.390
DOC_USP7_UBL2_3 517 521 PF12436 0.498
DOC_WW_Pin1_4 103 108 PF00397 0.545
DOC_WW_Pin1_4 224 229 PF00397 0.639
DOC_WW_Pin1_4 239 244 PF00397 0.559
DOC_WW_Pin1_4 29 34 PF00397 0.755
DOC_WW_Pin1_4 662 667 PF00397 0.686
DOC_WW_Pin1_4 710 715 PF00397 0.676
DOC_WW_Pin1_4 717 722 PF00397 0.603
DOC_WW_Pin1_4 728 733 PF00397 0.538
DOC_WW_Pin1_4 800 805 PF00397 0.785
DOC_WW_Pin1_4 812 817 PF00397 0.700
DOC_WW_Pin1_4 831 836 PF00397 0.571
DOC_WW_Pin1_4 844 849 PF00397 0.642
DOC_WW_Pin1_4 852 857 PF00397 0.667
DOC_WW_Pin1_4 869 874 PF00397 0.753
DOC_WW_Pin1_4 888 893 PF00397 0.550
DOC_WW_Pin1_4 921 926 PF00397 0.724
DOC_WW_Pin1_4 937 942 PF00397 0.606
DOC_WW_Pin1_4 950 955 PF00397 0.637
DOC_WW_Pin1_4 969 974 PF00397 0.621
DOC_WW_Pin1_4 982 987 PF00397 0.667
LIG_14-3-3_CanoR_1 13 23 PF00244 0.475
LIG_14-3-3_CanoR_1 467 476 PF00244 0.562
LIG_14-3-3_CanoR_1 485 493 PF00244 0.442
LIG_14-3-3_CanoR_1 549 555 PF00244 0.418
LIG_14-3-3_CanoR_1 897 905 PF00244 0.582
LIG_14-3-3_CterR_2 1008 1010 PF00244 0.724
LIG_Actin_WH2_2 533 551 PF00022 0.394
LIG_BIR_III_4 115 119 PF00653 0.502
LIG_BRCT_BRCA1_1 206 210 PF00533 0.791
LIG_BRCT_BRCA1_1 899 903 PF00533 0.572
LIG_EH_1 1002 1006 PF12763 0.815
LIG_EVH1_2 835 839 PF00568 0.554
LIG_FHA_1 190 196 PF00498 0.670
LIG_FHA_1 580 586 PF00498 0.379
LIG_FHA_1 663 669 PF00498 0.789
LIG_FHA_1 693 699 PF00498 0.623
LIG_FHA_1 766 772 PF00498 0.656
LIG_FHA_1 801 807 PF00498 0.766
LIG_FHA_1 921 927 PF00498 0.774
LIG_FHA_2 135 141 PF00498 0.655
LIG_FHA_2 35 41 PF00498 0.826
LIG_FHA_2 493 499 PF00498 0.607
LIG_FHA_2 537 543 PF00498 0.364
LIG_FHA_2 617 623 PF00498 0.461
LIG_FHA_2 644 650 PF00498 0.711
LIG_FHA_2 796 802 PF00498 0.783
LIG_GBD_Chelix_1 511 519 PF00786 0.677
LIG_MYND_1 666 670 PF01753 0.659
LIG_NRBOX 20 26 PF00104 0.695
LIG_Pex14_2 1005 1009 PF04695 0.807
LIG_PTAP_UEV_1 701 706 PF05743 0.754
LIG_RPA_C_Fungi 127 139 PF08784 0.485
LIG_RPA_C_Fungi 453 465 PF08784 0.478
LIG_SH2_PTP2 70 73 PF00017 0.636
LIG_SH2_SRC 70 73 PF00017 0.714
LIG_SH2_STAP1 746 750 PF00017 0.553
LIG_SH2_STAT5 70 73 PF00017 0.714
LIG_SH3_1 70 76 PF00018 0.636
LIG_SH3_1 930 936 PF00018 0.559
LIG_SH3_2 941 946 PF14604 0.761
LIG_SH3_3 45 51 PF00018 0.623
LIG_SH3_3 650 656 PF00018 0.819
LIG_SH3_3 664 670 PF00018 0.609
LIG_SH3_3 673 679 PF00018 0.704
LIG_SH3_3 699 705 PF00018 0.544
LIG_SH3_3 70 76 PF00018 0.780
LIG_SH3_3 708 714 PF00018 0.655
LIG_SH3_3 86 92 PF00018 0.561
LIG_SH3_3 907 913 PF00018 0.824
LIG_SH3_3 929 935 PF00018 0.757
LIG_SH3_3 938 944 PF00018 0.660
LIG_SH3_3 968 974 PF00018 0.781
LIG_SH3_CIN85_PxpxPR_1 892 897 PF14604 0.560
LIG_SUMO_SIM_par_1 82 88 PF11976 0.774
LIG_TRAF2_1 164 167 PF00917 0.638
LIG_TRAF2_1 196 199 PF00917 0.637
LIG_TRAF2_1 253 256 PF00917 0.666
LIG_TRAF2_1 429 432 PF00917 0.498
LIG_TRAF2_1 495 498 PF00917 0.601
LIG_TRAF2_1 736 739 PF00917 0.564
MOD_CDC14_SPxK_1 720 723 PF00782 0.550
MOD_CDC14_SPxK_1 815 818 PF00782 0.740
MOD_CDC14_SPxK_1 855 858 PF00782 0.545
MOD_CDK_SPK_2 710 715 PF00069 0.777
MOD_CDK_SPxK_1 717 723 PF00069 0.556
MOD_CDK_SPxK_1 812 818 PF00069 0.744
MOD_CDK_SPxK_1 844 850 PF00069 0.568
MOD_CDK_SPxK_1 852 858 PF00069 0.539
MOD_CDK_SPxK_1 940 946 PF00069 0.762
MOD_CDK_SPxxK_3 890 897 PF00069 0.757
MOD_CDK_SPxxK_3 952 959 PF00069 0.756
MOD_CK1_1 188 194 PF00069 0.730
MOD_CK1_1 224 230 PF00069 0.677
MOD_CK1_1 31 37 PF00069 0.754
MOD_CK1_1 550 556 PF00069 0.542
MOD_CK1_1 669 675 PF00069 0.636
MOD_CK1_1 742 748 PF00069 0.716
MOD_CK1_1 812 818 PF00069 0.791
MOD_CK1_1 834 840 PF00069 0.845
MOD_CK1_1 874 880 PF00069 0.829
MOD_CK1_1 940 946 PF00069 0.768
MOD_CK2_1 117 123 PF00069 0.486
MOD_CK2_1 193 199 PF00069 0.852
MOD_CK2_1 230 236 PF00069 0.688
MOD_CK2_1 250 256 PF00069 0.613
MOD_CK2_1 291 297 PF00069 0.705
MOD_CK2_1 492 498 PF00069 0.596
MOD_CK2_1 574 580 PF00069 0.595
MOD_CK2_1 643 649 PF00069 0.700
MOD_CK2_1 854 860 PF00069 0.715
MOD_CK2_1 942 948 PF00069 0.768
MOD_GlcNHglycan 204 207 PF01048 0.687
MOD_GlcNHglycan 211 214 PF01048 0.698
MOD_GlcNHglycan 452 455 PF01048 0.559
MOD_GlcNHglycan 502 505 PF01048 0.668
MOD_GlcNHglycan 702 705 PF01048 0.809
MOD_GlcNHglycan 785 788 PF01048 0.806
MOD_GlcNHglycan 812 815 PF01048 0.759
MOD_GlcNHglycan 822 825 PF01048 0.812
MOD_GlcNHglycan 860 863 PF01048 0.846
MOD_GlcNHglycan 873 876 PF01048 0.657
MOD_GlcNHglycan 976 979 PF01048 0.722
MOD_GSK3_1 185 192 PF00069 0.711
MOD_GSK3_1 463 470 PF00069 0.368
MOD_GSK3_1 548 555 PF00069 0.521
MOD_GSK3_1 662 669 PF00069 0.834
MOD_GSK3_1 770 777 PF00069 0.603
MOD_GSK3_1 796 803 PF00069 0.769
MOD_GSK3_1 808 815 PF00069 0.727
MOD_GSK3_1 816 823 PF00069 0.620
MOD_GSK3_1 831 838 PF00069 0.803
MOD_GSK3_1 854 861 PF00069 0.693
MOD_GSK3_1 865 872 PF00069 0.748
MOD_GSK3_1 886 893 PF00069 0.571
MOD_GSK3_1 921 928 PF00069 0.779
MOD_GSK3_1 936 943 PF00069 0.709
MOD_GSK3_1 946 953 PF00069 0.677
MOD_N-GLC_1 844 849 PF02516 0.568
MOD_N-GLC_1 946 951 PF02516 0.578
MOD_NEK2_1 28 33 PF00069 0.674
MOD_NEK2_1 302 307 PF00069 0.666
MOD_NEK2_1 547 552 PF00069 0.542
MOD_NEK2_2 333 338 PF00069 0.438
MOD_PIKK_1 173 179 PF00454 0.671
MOD_PIKK_1 492 498 PF00454 0.596
MOD_PIKK_1 552 558 PF00454 0.607
MOD_PIKK_1 634 640 PF00454 0.504
MOD_PIKK_1 865 871 PF00454 0.855
MOD_PKA_2 193 199 PF00069 0.778
MOD_PKA_2 542 548 PF00069 0.502
MOD_PKA_2 808 814 PF00069 0.687
MOD_PKB_1 483 491 PF00069 0.578
MOD_Plk_1 122 128 PF00069 0.720
MOD_Plk_1 333 339 PF00069 0.439
MOD_Plk_1 369 375 PF00069 0.492
MOD_Plk_1 387 393 PF00069 0.491
MOD_Plk_1 405 411 PF00069 0.517
MOD_Plk_1 742 748 PF00069 0.820
MOD_Plk_1 85 91 PF00069 0.821
MOD_Plk_1 946 952 PF00069 0.588
MOD_Plk_2-3 117 123 PF00069 0.486
MOD_Plk_2-3 739 745 PF00069 0.563
MOD_Plk_4 117 123 PF00069 0.486
MOD_Plk_4 230 236 PF00069 0.703
MOD_Plk_4 31 37 PF00069 0.798
MOD_ProDKin_1 103 109 PF00069 0.544
MOD_ProDKin_1 224 230 PF00069 0.635
MOD_ProDKin_1 239 245 PF00069 0.561
MOD_ProDKin_1 29 35 PF00069 0.761
MOD_ProDKin_1 662 668 PF00069 0.689
MOD_ProDKin_1 710 716 PF00069 0.675
MOD_ProDKin_1 717 723 PF00069 0.605
MOD_ProDKin_1 728 734 PF00069 0.539
MOD_ProDKin_1 800 806 PF00069 0.784
MOD_ProDKin_1 812 818 PF00069 0.701
MOD_ProDKin_1 831 837 PF00069 0.575
MOD_ProDKin_1 844 850 PF00069 0.642
MOD_ProDKin_1 852 858 PF00069 0.665
MOD_ProDKin_1 869 875 PF00069 0.753
MOD_ProDKin_1 888 894 PF00069 0.547
MOD_ProDKin_1 921 927 PF00069 0.725
MOD_ProDKin_1 937 943 PF00069 0.606
MOD_ProDKin_1 950 956 PF00069 0.628
MOD_ProDKin_1 969 975 PF00069 0.616
MOD_ProDKin_1 982 988 PF00069 0.668
MOD_SUMO_for_1 38 41 PF00179 0.540
MOD_SUMO_rev_2 292 302 PF00179 0.709
MOD_SUMO_rev_2 466 475 PF00179 0.443
MOD_SUMO_rev_2 498 503 PF00179 0.428
MOD_SUMO_rev_2 514 523 PF00179 0.561
TRG_DiLeu_BaEn_1 878 883 PF01217 0.572
TRG_DiLeu_BaEn_4 297 303 PF01217 0.677
TRG_DiLeu_LyEn_5 878 883 PF01217 0.572
TRG_ER_diArg_1 149 151 PF00400 0.651
TRG_ER_diArg_1 420 422 PF00400 0.517
TRG_ER_diArg_1 483 486 PF00400 0.550
TRG_ER_diArg_1 724 726 PF00400 0.694
TRG_ER_diArg_1 917 919 PF00400 0.763
TRG_ER_diArg_1 991 993 PF00400 0.735
TRG_NES_CRM1_1 529 542 PF08389 0.381
TRG_Pf-PMV_PEXEL_1 300 304 PF00026 0.678
TRG_Pf-PMV_PEXEL_1 420 425 PF00026 0.504
TRG_Pf-PMV_PEXEL_1 726 730 PF00026 0.658
TRG_Pf-PMV_PEXEL_1 881 885 PF00026 0.572

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X8C0 Leishmania donovani 74% 100%
A4HB75 Leishmania braziliensis 54% 99%
A4IAC3 Leishmania infantum 73% 100%
Q4Q2I7 Leishmania major 73% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS