ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies)/Ankyrin repeats (many copies), putative

Species:

Leishmania mexicana

UniProt:

E9B5E5_LEIMU

TriTrypDb:

LmxM.33.3560

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 15
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5E5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.378
CLV_NRD_NRD_1	235	237	PF00675	0.697
CLV_NRD_NRD_1	262	264	PF00675	0.705
CLV_NRD_NRD_1	90	92	PF00675	0.441
CLV_PCSK_KEX2_1	235	237	PF00082	0.700
CLV_PCSK_KEX2_1	262	264	PF00082	0.721
CLV_PCSK_SKI1_1	16	20	PF00082	0.476
CLV_PCSK_SKI1_1	196	200	PF00082	0.468
DEG_COP1_1	250	259	PF00400	0.685
DOC_CKS1_1	136	141	PF01111	0.366
DOC_MAPK_gen_1	132	142	PF00069	0.392
DOC_MAPK_gen_1	179	188	PF00069	0.295
DOC_MAPK_MEF2A_6	148	156	PF00069	0.417
DOC_MAPK_MEF2A_6	179	188	PF00069	0.287
DOC_MAPK_MEF2A_6	247	256	PF00069	0.553
DOC_MAPK_MEF2A_6	44	51	PF00069	0.221
DOC_USP7_MATH_1	212	216	PF00917	0.524
DOC_USP7_MATH_1	274	278	PF00917	0.509
DOC_USP7_MATH_1	45	49	PF00917	0.459
DOC_WW_Pin1_4	135	140	PF00397	0.295
DOC_WW_Pin1_4	168	173	PF00397	0.339
DOC_WW_Pin1_4	282	287	PF00397	0.683
DOC_WW_Pin1_4	68	73	PF00397	0.357
LIG_14-3-3_CanoR_1	235	244	PF00244	0.617
LIG_Actin_WH2_2	111	126	PF00022	0.164
LIG_Actin_WH2_2	180	198	PF00022	0.399
LIG_BIR_II_1	1	5	PF00653	0.512
LIG_FHA_1	149	155	PF00498	0.391
LIG_FHA_1	304	310	PF00498	0.643
LIG_FHA_2	123	129	PF00498	0.234
LIG_FHA_2	189	195	PF00498	0.201
LIG_FHA_2	310	316	PF00498	0.582
LIG_FHA_2	65	71	PF00498	0.368
LIG_LIR_Apic_2	280	286	PF02991	0.506
LIG_LIR_Apic_2	333	338	PF02991	0.556
LIG_LIR_Gen_1	150	160	PF02991	0.366
LIG_LIR_Gen_1	2	8	PF02991	0.404
LIG_LIR_Gen_1	71	82	PF02991	0.417
LIG_LIR_LC3C_4	306	310	PF02991	0.475
LIG_LIR_Nem_3	150	156	PF02991	0.324
LIG_LIR_Nem_3	178	184	PF02991	0.417
LIG_LIR_Nem_3	2	6	PF02991	0.382
LIG_LIR_Nem_3	71	77	PF02991	0.417
LIG_NRBOX	118	124	PF00104	0.370
LIG_SH2_CRK	283	287	PF00017	0.619
LIG_SH2_NCK_1	283	287	PF00017	0.559
LIG_SH2_PTP2	335	338	PF00017	0.424
LIG_SH2_PTP2	35	38	PF00017	0.305
LIG_SH2_PTP2	74	77	PF00017	0.417
LIG_SH2_SRC	335	338	PF00017	0.535
LIG_SH2_SRC	87	90	PF00017	0.276
LIG_SH2_STAT5	141	144	PF00017	0.343
LIG_SH2_STAT5	153	156	PF00017	0.348
LIG_SH2_STAT5	174	177	PF00017	0.321
LIG_SH2_STAT5	335	338	PF00017	0.621
LIG_SH2_STAT5	35	38	PF00017	0.338
LIG_SH2_STAT5	39	42	PF00017	0.312
LIG_SH2_STAT5	74	77	PF00017	0.311
LIG_SH2_STAT5	87	90	PF00017	0.264
LIG_SH3_1	283	289	PF00018	0.416
LIG_SH3_3	253	259	PF00018	0.546
LIG_SH3_3	283	289	PF00018	0.557
LIG_SH3_3	95	101	PF00018	0.276
LIG_TRAF2_1	134	137	PF00917	0.375
LIG_TRAF2_1	277	280	PF00917	0.531
MOD_CK2_1	174	180	PF00069	0.445
MOD_CK2_1	274	280	PF00069	0.573
MOD_CK2_1	309	315	PF00069	0.678
MOD_CK2_1	64	70	PF00069	0.406
MOD_GlcNHglycan	237	240	PF01048	0.572
MOD_GSK3_1	197	204	PF00069	0.511
MOD_GSK3_1	64	71	PF00069	0.343
MOD_NEK2_1	122	127	PF00069	0.365
MOD_NEK2_1	188	193	PF00069	0.249
MOD_NEK2_1	73	78	PF00069	0.370
MOD_PK_1	323	329	PF00069	0.538
MOD_PKA_1	235	241	PF00069	0.566
MOD_PKA_2	102	108	PF00069	0.443
MOD_PKA_2	234	240	PF00069	0.678
MOD_PKA_2	298	304	PF00069	0.567
MOD_PKA_2	64	70	PF00069	0.396
MOD_Plk_4	148	154	PF00069	0.417
MOD_Plk_4	304	310	PF00069	0.624
MOD_ProDKin_1	135	141	PF00069	0.295
MOD_ProDKin_1	168	174	PF00069	0.339
MOD_ProDKin_1	282	288	PF00069	0.683
MOD_ProDKin_1	68	74	PF00069	0.357
MOD_SUMO_rev_2	167	172	PF00179	0.275
MOD_SUMO_rev_2	177	184	PF00179	0.272
MOD_SUMO_rev_2	250	257	PF00179	0.670
TRG_DiLeu_BaEn_4	53	59	PF01217	0.387
TRG_ENDOCYTIC_2	153	156	PF00928	0.285
TRG_ENDOCYTIC_2	181	184	PF00928	0.358
TRG_ENDOCYTIC_2	35	38	PF00928	0.336
TRG_ENDOCYTIC_2	74	77	PF00928	0.417
TRG_ER_diArg_1	206	209	PF00400	0.517
TRG_ER_diArg_1	261	263	PF00400	0.748
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB55	Leptomonas seymouri	66%	99%
A0A0S4IZ37	Bodo saltans	27%	93%
A0A1X0PAB8	Trypanosomatidae	46%	100%
A0A3Q8IFT3	Leishmania donovani	92%	100%
A0A3R7KWY8	Trypanosoma rangeli	25%	82%
A0A3R7N419	Trypanosoma rangeli	28%	86%
A0A3R7RA24	Trypanosoma rangeli	43%	100%
A0A3S7WRN0	Leishmania donovani	25%	100%
A4HB74	Leishmania braziliensis	85%	100%
A4IAC2	Leishmania infantum	92%	100%
C9ZLX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B1A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	83%
Q4Q2I8	Leishmania major	93%	100%
Q4QH09	Leishmania major	27%	100%
V5B6C0	Trypanosoma cruzi	48%	93%