PDCD2_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Programmed cell death protein 2, C-terminal putative domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B5E4_LEIMU

TriTrypDb:

LmxM.33.3550

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9B5E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5E4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	95	97	PF00675	0.485
CLV_PCSK_KEX2_1	95	97	PF00082	0.485
CLV_PCSK_SKI1_1	16	20	PF00082	0.486
CLV_PCSK_SKI1_1	233	237	PF00082	0.507
CLV_PCSK_SKI1_1	240	244	PF00082	0.445
DEG_SCF_FBW7_1	319	326	PF00400	0.327
DOC_CKS1_1	11	16	PF01111	0.394
DOC_CYCLIN_yCln2_LP_2	355	361	PF00134	0.266
DOC_MAPK_gen_1	259	266	PF00069	0.580
DOC_MAPK_MEF2A_6	325	333	PF00069	0.428
DOC_MAPK_RevD_3	248	262	PF00069	0.312
DOC_PP2B_LxvP_1	338	341	PF13499	0.457
DOC_PP2B_LxvP_1	355	358	PF13499	0.270
DOC_PP4_FxxP_1	57	60	PF00568	0.319
DOC_USP7_MATH_1	127	131	PF00917	0.531
DOC_USP7_MATH_1	137	141	PF00917	0.263
DOC_USP7_MATH_1	229	233	PF00917	0.576
DOC_USP7_MATH_1	26	30	PF00917	0.434
DOC_USP7_MATH_1	272	276	PF00917	0.533
DOC_USP7_MATH_1	66	70	PF00917	0.441
DOC_USP7_MATH_1	99	103	PF00917	0.595
DOC_WW_Pin1_4	10	15	PF00397	0.401
DOC_WW_Pin1_4	218	223	PF00397	0.659
DOC_WW_Pin1_4	307	312	PF00397	0.414
DOC_WW_Pin1_4	319	324	PF00397	0.291
LIG_14-3-3_CanoR_1	129	135	PF00244	0.526
LIG_14-3-3_CanoR_1	201	208	PF00244	0.467
LIG_14-3-3_CanoR_1	233	238	PF00244	0.543
LIG_14-3-3_CanoR_1	325	333	PF00244	0.307
LIG_14-3-3_CanoR_1	98	104	PF00244	0.569
LIG_APCC_ABBA_1	250	255	PF00400	0.370
LIG_BIR_II_1	1	5	PF00653	0.563
LIG_BRCT_BRCA1_1	132	136	PF00533	0.300
LIG_BRCT_BRCA1_1	139	143	PF00533	0.314
LIG_BRCT_BRCA1_1	53	57	PF00533	0.430
LIG_deltaCOP1_diTrp_1	180	190	PF00928	0.652
LIG_FHA_1	234	240	PF00498	0.494
LIG_FHA_1	243	249	PF00498	0.376
LIG_FHA_1	26	32	PF00498	0.334
LIG_FHA_1	324	330	PF00498	0.352
LIG_FHA_1	354	360	PF00498	0.267
LIG_FHA_1	362	368	PF00498	0.267
LIG_FHA_1	63	69	PF00498	0.410
LIG_FHA_2	161	167	PF00498	0.594
LIG_FHA_2	17	23	PF00498	0.534
LIG_FHA_2	219	225	PF00498	0.659
LIG_LIR_Apic_2	251	256	PF02991	0.405
LIG_LIR_Apic_2	54	60	PF02991	0.333
LIG_LIR_Gen_1	146	155	PF02991	0.505
LIG_LIR_Gen_1	401	409	PF02991	0.286
LIG_LIR_Gen_1	79	88	PF02991	0.349
LIG_LIR_Nem_3	146	151	PF02991	0.468
LIG_LIR_Nem_3	401	405	PF02991	0.286
LIG_LIR_Nem_3	79	84	PF02991	0.376
LIG_MLH1_MIPbox_1	53	57	PF16413	0.457
LIG_PDZ_Class_3	404	409	PF00595	0.404
LIG_SH2_CRK	81	85	PF00017	0.305
LIG_SH2_NCK_1	253	257	PF00017	0.482
LIG_SH2_PTP2	402	405	PF00017	0.394
LIG_SH2_SRC	253	256	PF00017	0.536
LIG_SH2_STAP1	27	31	PF00017	0.355
LIG_SH2_STAP1	81	85	PF00017	0.305
LIG_SH2_STAT5	147	150	PF00017	0.486
LIG_SH2_STAT5	244	247	PF00017	0.497
LIG_SH2_STAT5	27	30	PF00017	0.362
LIG_SH2_STAT5	362	365	PF00017	0.347
LIG_SH2_STAT5	37	40	PF00017	0.341
LIG_SH2_STAT5	383	386	PF00017	0.306
LIG_SH2_STAT5	398	401	PF00017	0.198
LIG_SH2_STAT5	402	405	PF00017	0.140
LIG_SH2_STAT5	56	59	PF00017	0.222
LIG_SH2_STAT5	86	89	PF00017	0.295
LIG_SH3_1	223	229	PF00018	0.423
LIG_SH3_3	104	110	PF00018	0.567
LIG_SH3_3	223	229	PF00018	0.535
LIG_SH3_3	337	343	PF00018	0.313
LIG_SH3_3	394	400	PF00018	0.394
LIG_SH3_3	71	77	PF00018	0.377
LIG_SUMO_SIM_par_1	248	255	PF11976	0.399
LIG_SUMO_SIM_par_1	76	82	PF11976	0.357
LIG_SxIP_EBH_1	325	335	PF03271	0.218
LIG_TRAF2_1	265	268	PF00917	0.564
MOD_CDK_SPK_2	218	223	PF00069	0.502
MOD_CDK_SPxK_1	10	16	PF00069	0.454
MOD_CDK_SPxK_1	319	325	PF00069	0.327
MOD_CK1_1	117	123	PF00069	0.715
MOD_CK1_1	130	136	PF00069	0.414
MOD_CK2_1	160	166	PF00069	0.625
MOD_CK2_1	218	224	PF00069	0.630
MOD_CK2_1	262	268	PF00069	0.540
MOD_CK2_1	283	289	PF00069	0.500
MOD_CK2_1	40	46	PF00069	0.498
MOD_GlcNHglycan	1	4	PF01048	0.645
MOD_GlcNHglycan	119	122	PF01048	0.730
MOD_GlcNHglycan	245	248	PF01048	0.427
MOD_GlcNHglycan	284	288	PF01048	0.623
MOD_GlcNHglycan	48	51	PF01048	0.555
MOD_GSK3_1	110	117	PF00069	0.732
MOD_GSK3_1	137	144	PF00069	0.377
MOD_GSK3_1	229	236	PF00069	0.489
MOD_GSK3_1	272	279	PF00069	0.579
MOD_GSK3_1	319	326	PF00069	0.375
MOD_GSK3_1	62	69	PF00069	0.385
MOD_GSK3_1	99	106	PF00069	0.595
MOD_N-GLC_1	141	146	PF02516	0.471
MOD_N-GLC_1	333	338	PF02516	0.295
MOD_NEK2_1	103	108	PF00069	0.660
MOD_NEK2_1	243	248	PF00069	0.418
MOD_NEK2_1	276	281	PF00069	0.596
MOD_NEK2_1	283	288	PF00069	0.636
MOD_NEK2_1	324	329	PF00069	0.317
MOD_NEK2_1	353	358	PF00069	0.246
MOD_NEK2_1	375	380	PF00069	0.283
MOD_NEK2_1	381	386	PF00069	0.267
MOD_NEK2_1	40	45	PF00069	0.480
MOD_NEK2_2	272	277	PF00069	0.483
MOD_PIKK_1	137	143	PF00454	0.315
MOD_PIKK_1	16	22	PF00454	0.519
MOD_PIKK_1	309	315	PF00454	0.251
MOD_PK_1	262	268	PF00069	0.604
MOD_PKA_2	160	166	PF00069	0.495
MOD_PKA_2	200	206	PF00069	0.471
MOD_PKA_2	324	330	PF00069	0.307
MOD_Plk_1	262	268	PF00069	0.592
MOD_Plk_1	295	301	PF00069	0.412
MOD_Plk_2-3	189	195	PF00069	0.578
MOD_Plk_4	272	278	PF00069	0.529
MOD_Plk_4	66	72	PF00069	0.305
MOD_ProDKin_1	10	16	PF00069	0.419
MOD_ProDKin_1	218	224	PF00069	0.656
MOD_ProDKin_1	307	313	PF00069	0.414
MOD_ProDKin_1	319	325	PF00069	0.291
MOD_SUMO_rev_2	366	373	PF00179	0.313
TRG_ENDOCYTIC_2	37	40	PF00928	0.500
TRG_ENDOCYTIC_2	402	405	PF00928	0.285
TRG_ENDOCYTIC_2	75	78	PF00928	0.304
TRG_ENDOCYTIC_2	81	84	PF00928	0.296
TRG_ER_diArg_1	95	98	PF00400	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYV7	Leptomonas seymouri	63%	100%
A0A0S4JQH8	Bodo saltans	30%	100%
A0A1X0PA07	Trypanosomatidae	36%	100%
A0A3R7N1R1	Trypanosoma rangeli	36%	100%
A0A3S7X8B9	Leishmania donovani	92%	100%
A4HB73	Leishmania braziliensis	79%	98%
A4IAC1	Leishmania infantum	92%	100%
C9ZLX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
P87156	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q4Q2I9	Leishmania major	92%	100%
Q5ZID2	Gallus gallus	23%	100%
Q8C5N5	Mus musculus	25%	100%
V5DMW4	Trypanosoma cruzi	34%	100%