TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat, putative

Species:

Leishmania mexicana

UniProt:

E9B5D8_LEIMU

TriTrypDb:

LmxM.33.3490

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5D8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.443
CLV_C14_Caspase3-7	293	297	PF00656	0.355
CLV_C14_Caspase3-7	61	65	PF00656	0.703
CLV_C14_Caspase3-7	67	71	PF00656	0.684
CLV_NRD_NRD_1	10	12	PF00675	0.516
CLV_NRD_NRD_1	137	139	PF00675	0.357
CLV_NRD_NRD_1	24	26	PF00675	0.410
CLV_PCSK_KEX2_1	10	12	PF00082	0.507
CLV_PCSK_KEX2_1	194	196	PF00082	0.555
CLV_PCSK_KEX2_1	235	237	PF00082	0.437
CLV_PCSK_KEX2_1	24	26	PF00082	0.410
CLV_PCSK_KEX2_1	278	280	PF00082	0.411
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.555
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.520
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.340
CLV_PCSK_SKI1_1	138	142	PF00082	0.389
CLV_PCSK_SKI1_1	182	186	PF00082	0.521
CLV_PCSK_SKI1_1	199	203	PF00082	0.401
CLV_PCSK_SKI1_1	205	209	PF00082	0.352
CLV_PCSK_SKI1_1	308	312	PF00082	0.297
CLV_PCSK_SKI1_1	418	422	PF00082	0.526
DEG_APCC_DBOX_1	24	32	PF00400	0.677
DEG_Nend_Nbox_1	1	3	PF02207	0.697
DOC_ANK_TNKS_1	366	373	PF00023	0.502
DOC_CKS1_1	111	116	PF01111	0.597
DOC_MAPK_gen_1	199	209	PF00069	0.359
DOC_MAPK_MEF2A_6	202	210	PF00069	0.361
DOC_PP2B_LxvP_1	35	38	PF13499	0.582
DOC_USP7_MATH_1	16	20	PF00917	0.701
DOC_USP7_MATH_1	44	48	PF00917	0.628
DOC_USP7_UBL2_3	414	418	PF12436	0.518
DOC_WW_Pin1_4	110	115	PF00397	0.545
DOC_WW_Pin1_4	281	286	PF00397	0.452
DOC_WW_Pin1_4	404	409	PF00397	0.433
LIG_14-3-3_CanoR_1	27	32	PF00244	0.613
LIG_14-3-3_CanoR_1	4	8	PF00244	0.618
LIG_14-3-3_CanoR_1	49	56	PF00244	0.613
LIG_APCC_ABBA_1	175	180	PF00400	0.505
LIG_BIR_III_4	338	342	PF00653	0.357
LIG_eIF4E_1	305	311	PF01652	0.433
LIG_FHA_1	325	331	PF00498	0.251
LIG_FHA_1	7	13	PF00498	0.633
LIG_FHA_1	70	76	PF00498	0.665
LIG_FHA_2	288	294	PF00498	0.313
LIG_FHA_2	65	71	PF00498	0.525
LIG_LIR_Gen_1	101	107	PF02991	0.456
LIG_LIR_Gen_1	331	339	PF02991	0.298
LIG_LIR_Nem_3	101	106	PF02991	0.458
LIG_LIR_Nem_3	228	234	PF02991	0.512
LIG_LIR_Nem_3	331	336	PF02991	0.298
LIG_LYPXL_S_1	177	181	PF13949	0.251
LIG_LYPXL_yS_3	178	181	PF13949	0.250
LIG_SH2_CRK	161	165	PF00017	0.381
LIG_SH2_PTP2	333	336	PF00017	0.433
LIG_SH2_SRC	231	234	PF00017	0.493
LIG_SH2_SRC	353	356	PF00017	0.433
LIG_SH2_STAT3	273	276	PF00017	0.322
LIG_SH2_STAT5	333	336	PF00017	0.313
LIG_SH2_STAT5	353	356	PF00017	0.145
LIG_SH2_STAT5	382	385	PF00017	0.369
LIG_SH3_1	279	285	PF00018	0.433
LIG_SH3_3	111	117	PF00018	0.599
LIG_SH3_3	279	285	PF00018	0.433
LIG_SH3_3	405	411	PF00018	0.433
LIG_Sin3_3	391	398	PF02671	0.433
LIG_SUMO_SIM_par_1	290	296	PF11976	0.335
LIG_TRAF2_1	171	174	PF00917	0.384
LIG_TRAF2_1	274	277	PF00917	0.415
LIG_UBA3_1	80	85	PF00899	0.428
MOD_CK1_1	19	25	PF00069	0.599
MOD_CK1_1	58	64	PF00069	0.692
MOD_CK1_1	66	72	PF00069	0.725
MOD_CK2_1	271	277	PF00069	0.433
MOD_CK2_1	287	293	PF00069	0.200
MOD_CK2_1	73	79	PF00069	0.487
MOD_CK2_1	95	101	PF00069	0.496
MOD_GlcNHglycan	52	55	PF01048	0.715
MOD_GlcNHglycan	97	100	PF01048	0.489
MOD_GSK3_1	106	113	PF00069	0.479
MOD_GSK3_1	27	34	PF00069	0.525
MOD_GSK3_1	55	62	PF00069	0.677
MOD_GSK3_1	69	76	PF00069	0.572
MOD_N-GLC_1	404	409	PF02516	0.389
MOD_N-GLC_1	58	63	PF02516	0.746
MOD_NEK2_1	133	138	PF00069	0.392
MOD_NEK2_1	185	190	PF00069	0.419
MOD_NEK2_1	287	292	PF00069	0.366
MOD_NEK2_1	329	334	PF00069	0.313
MOD_PIKK_1	44	50	PF00454	0.633
MOD_PK_1	27	33	PF00069	0.519
MOD_PKA_2	3	9	PF00069	0.448
MOD_PKB_1	25	33	PF00069	0.522
MOD_Plk_1	185	191	PF00069	0.495
MOD_Plk_4	115	121	PF00069	0.487
MOD_Plk_4	287	293	PF00069	0.313
MOD_Plk_4	329	335	PF00069	0.395
MOD_ProDKin_1	110	116	PF00069	0.536
MOD_ProDKin_1	281	287	PF00069	0.445
MOD_ProDKin_1	404	410	PF00069	0.433
MOD_SUMO_for_1	171	174	PF00179	0.483
MOD_SUMO_rev_2	174	184	PF00179	0.503
TRG_ENDOCYTIC_2	130	133	PF00928	0.312
TRG_ENDOCYTIC_2	161	164	PF00928	0.370
TRG_ENDOCYTIC_2	178	181	PF00928	0.412
TRG_ENDOCYTIC_2	231	234	PF00928	0.493
TRG_ENDOCYTIC_2	333	336	PF00928	0.313
TRG_ER_diArg_1	10	12	PF00400	0.513
TRG_ER_diArg_1	23	25	PF00400	0.637
TRG_ER_diArg_1	361	364	PF00400	0.407
TRG_NES_CRM1_1	132	144	PF08389	0.362
TRG_NES_CRM1_1	180	193	PF08389	0.375
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.313
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.304
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCA8	Leptomonas seymouri	73%	96%
A0A0S4IIG6	Bodo saltans	39%	100%
A0A1X0PAU4	Trypanosomatidae	61%	100%
A0A3R7KCS2	Trypanosoma rangeli	57%	100%
A0A3S7X8G8	Leishmania donovani	94%	100%
A4HB67	Leishmania braziliensis	84%	100%
A4IAB5	Leishmania infantum	93%	100%
C9ZLY1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
Q4Q2J5	Leishmania major	92%	100%
V5DM07	Trypanosoma cruzi	61%	100%