Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5D7_LEIMU

TriTrypDb:

LmxM.33.3480

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

E9B5D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5D7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.446
CLV_NRD_NRD_1	16	18	PF00675	0.569
CLV_NRD_NRD_1	216	218	PF00675	0.561
CLV_NRD_NRD_1	48	50	PF00675	0.409
CLV_PCSK_KEX2_1	16	18	PF00082	0.569
CLV_PCSK_KEX2_1	216	218	PF00082	0.561
CLV_PCSK_KEX2_1	48	50	PF00082	0.409
CLV_PCSK_PC7_1	12	18	PF00082	0.572
CLV_PCSK_SKI1_1	12	16	PF00082	0.575
CLV_PCSK_SKI1_1	192	196	PF00082	0.428
CLV_PCSK_SKI1_1	96	100	PF00082	0.452
DOC_CYCLIN_RxL_1	114	124	PF00134	0.471
DOC_CYCLIN_RxL_1	9	18	PF00134	0.580
DOC_MAPK_MEF2A_6	128	136	PF00069	0.406
DOC_PP1_RVXF_1	115	122	PF00149	0.455
DOC_PP1_RVXF_1	126	132	PF00149	0.388
DOC_USP7_MATH_1	103	107	PF00917	0.480
DOC_USP7_MATH_1	233	237	PF00917	0.724
DOC_WW_Pin1_4	194	199	PF00397	0.446
DOC_WW_Pin1_4	227	232	PF00397	0.585
DOC_WW_Pin1_4	35	40	PF00397	0.505
LIG_14-3-3_CanoR_1	16	26	PF00244	0.565
LIG_14-3-3_CanoR_1	192	198	PF00244	0.461
LIG_14-3-3_CanoR_1	66	72	PF00244	0.475
LIG_14-3-3_CanoR_1	77	86	PF00244	0.351
LIG_14-3-3_CanoR_1	96	101	PF00244	0.334
LIG_Actin_WH2_2	38	56	PF00022	0.371
LIG_BIR_II_1	1	5	PF00653	0.628
LIG_BRCT_BRCA1_1	19	23	PF00533	0.501
LIG_CSL_BTD_1	130	133	PF09270	0.404
LIG_FHA_1	213	219	PF00498	0.471
LIG_FHA_1	9	15	PF00498	0.585
LIG_FHA_2	1	7	PF00498	0.644
LIG_LIR_Gen_1	95	105	PF02991	0.399
LIG_LIR_Nem_3	20	26	PF02991	0.510
LIG_LIR_Nem_3	73	78	PF02991	0.443
LIG_LIR_Nem_3	95	100	PF02991	0.399
LIG_NRBOX	157	163	PF00104	0.408
LIG_Pex14_1	131	135	PF04695	0.394
LIG_SH2_CRK	43	47	PF00017	0.410
LIG_SH2_CRK	97	101	PF00017	0.357
LIG_SH2_NCK_1	97	101	PF00017	0.390
LIG_SH2_PTP2	50	53	PF00017	0.431
LIG_SH2_STAP1	43	47	PF00017	0.453
LIG_SH2_STAT5	125	128	PF00017	0.470
LIG_SH2_STAT5	50	53	PF00017	0.431
LIG_SH2_STAT5	75	78	PF00017	0.443
LIG_SH2_STAT5	90	93	PF00017	0.284
LIG_SH3_3	36	42	PF00018	0.506
LIG_SUMO_SIM_anti_2	155	163	PF11976	0.413
LIG_SUMO_SIM_par_1	23	29	PF11976	0.599
LIG_TRAF2_1	2	5	PF00917	0.656
LIG_TYR_ITIM	41	46	PF00017	0.460
LIG_TYR_ITSM	93	100	PF00017	0.371
LIG_UBA3_1	190	195	PF00899	0.382
MOD_CK1_1	148	154	PF00069	0.342
MOD_CK1_1	196	202	PF00069	0.446
MOD_GlcNHglycan	105	108	PF01048	0.483
MOD_GlcNHglycan	176	180	PF01048	0.539
MOD_GlcNHglycan	61	64	PF01048	0.550
MOD_GSK3_1	143	150	PF00069	0.484
MOD_GSK3_1	194	201	PF00069	0.439
MOD_GSK3_1	229	236	PF00069	0.747
MOD_GSK3_1	67	74	PF00069	0.306
MOD_GSK3_1	92	99	PF00069	0.366
MOD_NEK2_1	143	148	PF00069	0.449
MOD_NEK2_1	15	20	PF00069	0.558
MOD_NEK2_1	162	167	PF00069	0.377
MOD_NEK2_1	175	180	PF00069	0.338
MOD_NEK2_1	193	198	PF00069	0.273
MOD_NEK2_1	65	70	PF00069	0.388
MOD_PIKK_1	148	154	PF00454	0.359
MOD_PIKK_1	198	204	PF00454	0.446
MOD_PKA_2	15	21	PF00069	0.558
MOD_PKA_2	65	71	PF00069	0.488
MOD_Plk_1	8	14	PF00069	0.464
MOD_Plk_4	121	127	PF00069	0.543
MOD_Plk_4	71	77	PF00069	0.443
MOD_ProDKin_1	194	200	PF00069	0.441
MOD_ProDKin_1	227	233	PF00069	0.592
MOD_ProDKin_1	35	41	PF00069	0.487
TRG_DiLeu_BaEn_1	9	14	PF01217	0.467
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.499
TRG_DiLeu_LyEn_5	9	14	PF01217	0.467
TRG_ENDOCYTIC_2	43	46	PF00928	0.453
TRG_ENDOCYTIC_2	50	53	PF00928	0.431
TRG_ENDOCYTIC_2	75	78	PF00928	0.443
TRG_ENDOCYTIC_2	97	100	PF00928	0.438
TRG_ER_diArg_1	15	17	PF00400	0.572
TRG_ER_diArg_1	216	218	PF00400	0.476
TRG_ER_diArg_1	47	49	PF00400	0.425
TRG_NES_CRM1_1	59	73	PF08389	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X8B4	Leishmania donovani	91%	100%
A4HB66	Leishmania braziliensis	76%	100%
A4IAB4	Leishmania infantum	91%	100%
Q4Q2J6	Leishmania major	89%	100%