Amidinotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Amidinotransferase

Gene product:

amidinotransferase, putative

Species:

Leishmania mexicana

UniProt:

E9B5D6_LEIMU

TriTrypDb:

LmxM.33.3470

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0030863	cortical cytoskeleton	6	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5D6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	2
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	320	322	PF00675	0.363
CLV_PCSK_KEX2_1	320	322	PF00082	0.367
CLV_PCSK_SKI1_1	126	130	PF00082	0.325
CLV_PCSK_SKI1_1	197	201	PF00082	0.308
CLV_PCSK_SKI1_1	298	302	PF00082	0.378
CLV_Separin_Metazoa	350	354	PF03568	0.582
DOC_CYCLIN_RxL_1	194	204	PF00134	0.382
DOC_CYCLIN_RxL_1	295	303	PF00134	0.394
DOC_CYCLIN_yCln2_LP_2	265	271	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.468
DOC_MAPK_gen_1	67	76	PF00069	0.556
DOC_MAPK_JIP1_4	186	192	PF00069	0.472
DOC_PP2B_LxvP_1	190	193	PF13499	0.329
DOC_PP2B_LxvP_1	265	268	PF13499	0.472
DOC_USP7_MATH_1	223	227	PF00917	0.486
DOC_USP7_MATH_1	341	345	PF00917	0.618
DOC_USP7_UBL2_3	122	126	PF12436	0.266
DOC_WW_Pin1_4	159	164	PF00397	0.411
DOC_WW_Pin1_4	5	10	PF00397	0.291
LIG_14-3-3_CanoR_1	321	327	PF00244	0.398
LIG_APCC_ABBA_1	143	148	PF00400	0.472
LIG_BRCT_BRCA1_1	157	161	PF00533	0.450
LIG_BRCT_BRCA1_1	225	229	PF00533	0.450
LIG_FHA_1	207	213	PF00498	0.323
LIG_FHA_1	346	352	PF00498	0.517
LIG_FHA_1	58	64	PF00498	0.456
LIG_FHA_2	44	50	PF00498	0.507
LIG_LIR_Nem_3	49	54	PF02991	0.515
LIG_PCNA_yPIPBox_3	53	62	PF02747	0.321
LIG_REV1ctd_RIR_1	49	57	PF16727	0.533
LIG_SH2_CRK	169	173	PF00017	0.352
LIG_SH2_CRK	246	250	PF00017	0.352
LIG_SH2_CRK	72	76	PF00017	0.456
LIG_SH2_PTP2	281	284	PF00017	0.472
LIG_SH2_SRC	152	155	PF00017	0.415
LIG_SH2_STAP1	239	243	PF00017	0.392
LIG_SH2_STAP1	246	250	PF00017	0.362
LIG_SH2_STAT5	152	155	PF00017	0.394
LIG_SH2_STAT5	167	170	PF00017	0.307
LIG_SH2_STAT5	281	284	PF00017	0.472
LIG_SH2_STAT5	334	337	PF00017	0.524
LIG_SH3_2	110	115	PF14604	0.391
LIG_SH3_3	104	110	PF00018	0.395
LIG_SH3_3	265	271	PF00018	0.455
LIG_SH3_3	337	343	PF00018	0.542
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.452
LIG_SUMO_SIM_anti_2	347	353	PF11976	0.573
LIG_SUMO_SIM_par_1	2	8	PF11976	0.342
LIG_SUMO_SIM_par_1	247	254	PF11976	0.450
LIG_SUMO_SIM_par_1	281	288	PF11976	0.472
LIG_TRAF2_1	131	134	PF00917	0.484
LIG_TRAF2_1	145	148	PF00917	0.327
LIG_TRAF2_1	75	78	PF00917	0.579
LIG_TYR_ITIM	312	317	PF00017	0.355
LIG_WRC_WIRS_1	48	53	PF05994	0.500
LIG_WW_2	340	343	PF00397	0.528
MOD_CDK_SPxxK_3	159	166	PF00069	0.418
MOD_CK1_1	173	179	PF00069	0.329
MOD_CK1_1	325	331	PF00069	0.429
MOD_CK1_1	344	350	PF00069	0.368
MOD_CK2_1	250	256	PF00069	0.415
MOD_CK2_1	260	266	PF00069	0.370
MOD_CK2_1	344	350	PF00069	0.532
MOD_CK2_1	43	49	PF00069	0.525
MOD_GlcNHglycan	154	158	PF01048	0.418
MOD_GlcNHglycan	203	206	PF01048	0.331
MOD_GlcNHglycan	262	265	PF01048	0.428
MOD_GlcNHglycan	274	277	PF01048	0.459
MOD_GSK3_1	155	162	PF00069	0.409
MOD_GSK3_1	321	328	PF00069	0.451
MOD_GSK3_1	341	348	PF00069	0.263
MOD_GSK3_1	43	50	PF00069	0.451
MOD_NEK2_1	153	158	PF00069	0.348
MOD_NEK2_1	170	175	PF00069	0.242
MOD_NEK2_1	23	28	PF00069	0.526
MOD_NEK2_1	260	265	PF00069	0.472
MOD_NEK2_1	36	41	PF00069	0.491
MOD_NEK2_1	85	90	PF00069	0.378
MOD_OFUCOSY	322	329	PF10250	0.501
MOD_PIKK_1	170	176	PF00454	0.404
MOD_PIKK_1	341	347	PF00454	0.578
MOD_PIKK_1	36	42	PF00454	0.447
MOD_PK_1	79	85	PF00069	0.498
MOD_Plk_1	36	42	PF00069	0.488
MOD_Plk_4	155	161	PF00069	0.450
MOD_Plk_4	223	229	PF00069	0.482
MOD_Plk_4	47	53	PF00069	0.473
MOD_ProDKin_1	159	165	PF00069	0.411
MOD_ProDKin_1	5	11	PF00069	0.295
MOD_SUMO_rev_2	147	153	PF00179	0.418
MOD_SUMO_rev_2	66	71	PF00179	0.510
TRG_DiLeu_BaEn_4	148	154	PF01217	0.433
TRG_ENDOCYTIC_2	167	170	PF00928	0.324
TRG_ENDOCYTIC_2	239	242	PF00928	0.375
TRG_ENDOCYTIC_2	246	249	PF00928	0.258
TRG_ENDOCYTIC_2	281	284	PF00928	0.450
TRG_ENDOCYTIC_2	314	317	PF00928	0.438
TRG_Pf-PMV_PEXEL_1	298	303	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q5	Leptomonas seymouri	66%	100%
A0A0N1IKG5	Leptomonas seymouri	39%	99%
A0A0S4JAZ5	Bodo saltans	28%	93%
A0A1X0PAA5	Trypanosomatidae	37%	95%
A0A3R7KYJ2	Trypanosoma rangeli	38%	95%
A0A3S7X8B2	Leishmania donovani	92%	100%
A4HB65	Leishmania braziliensis	84%	100%
A4IAB3	Leishmania infantum	93%	100%
C9ZLY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	96%
Q4Q2J7	Leishmania major	93%	100%
V5B5E2	Trypanosoma cruzi	38%	95%