Lactamase_B domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-beta-lactamase superfamily, putative

Species:

Leishmania mexicana

UniProt:

E9B5D1_LEIMU

TriTrypDb:

LmxM.33.3420

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9B5D1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5D1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004416	hydroxyacylglutathione hydrolase activity	5	3
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016790	thiolester hydrolase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	421	425	PF00656	0.624
CLV_NRD_NRD_1	511	513	PF00675	0.401
CLV_PCSK_KEX2_1	510	512	PF00082	0.368
CLV_PCSK_SKI1_1	158	162	PF00082	0.199
CLV_PCSK_SKI1_1	427	431	PF00082	0.375
DOC_CKS1_1	127	132	PF01111	0.334
DOC_CYCLIN_yClb3_PxF_3	63	71	PF00134	0.598
DOC_CYCLIN_yCln2_LP_2	206	212	PF00134	0.535
DOC_MAPK_DCC_7	158	167	PF00069	0.500
DOC_MAPK_MEF2A_6	158	167	PF00069	0.483
DOC_MAPK_MEF2A_6	203	212	PF00069	0.535
DOC_MAPK_MEF2A_6	471	479	PF00069	0.459
DOC_PP1_RVXF_1	259	265	PF00149	0.446
DOC_PP2B_LxvP_1	206	209	PF13499	0.535
DOC_PP4_FxxP_1	456	459	PF00568	0.621
DOC_USP7_MATH_1	457	461	PF00917	0.541
DOC_USP7_MATH_2	343	349	PF00917	0.604
DOC_USP7_UBL2_3	488	492	PF12436	0.549
DOC_WW_Pin1_4	115	120	PF00397	0.412
DOC_WW_Pin1_4	126	131	PF00397	0.426
DOC_WW_Pin1_4	280	285	PF00397	0.535
DOC_WW_Pin1_4	339	344	PF00397	0.426
DOC_WW_Pin1_4	406	411	PF00397	0.612
DOC_WW_Pin1_4	491	496	PF00397	0.472
LIG_14-3-3_CanoR_1	158	163	PF00244	0.542
LIG_14-3-3_CanoR_1	356	360	PF00244	0.539
LIG_14-3-3_CanoR_1	364	369	PF00244	0.530
LIG_14-3-3_CanoR_1	402	410	PF00244	0.692
LIG_14-3-3_CanoR_1	451	459	PF00244	0.570
LIG_14-3-3_CanoR_1	512	518	PF00244	0.667
LIG_Actin_WH2_2	107	125	PF00022	0.422
LIG_Actin_WH2_2	425	442	PF00022	0.635
LIG_Actin_WH2_2	472	490	PF00022	0.508
LIG_APCC_ABBA_1	165	170	PF00400	0.564
LIG_BIR_II_1	1	5	PF00653	0.622
LIG_BIR_III_2	281	285	PF00653	0.478
LIG_BRCT_BRCA1_1	1	5	PF00533	0.697
LIG_BRCT_BRCA1_1	282	286	PF00533	0.535
LIG_BRCT_BRCA1_1	306	310	PF00533	0.431
LIG_BRCT_BRCA1_1	66	70	PF00533	0.625
LIG_BRCT_BRCA1_1	71	75	PF00533	0.608
LIG_Clathr_ClatBox_1	476	480	PF01394	0.571
LIG_EH_1	61	65	PF12763	0.572
LIG_FHA_1	151	157	PF00498	0.626
LIG_FHA_1	179	185	PF00498	0.501
LIG_FHA_1	211	217	PF00498	0.453
LIG_FHA_1	344	350	PF00498	0.551
LIG_FHA_1	387	393	PF00498	0.506
LIG_FHA_2	356	362	PF00498	0.518
LIG_FHA_2	369	375	PF00498	0.635
LIG_FHA_2	407	413	PF00498	0.709
LIG_FHA_2	476	482	PF00498	0.567
LIG_LIR_Apic_2	35	40	PF02991	0.472
LIG_LIR_Apic_2	454	459	PF02991	0.497
LIG_LIR_Apic_2	6	10	PF02991	0.478
LIG_LIR_Gen_1	170	179	PF02991	0.432
LIG_LIR_Gen_1	2	13	PF02991	0.599
LIG_LIR_Gen_1	283	293	PF02991	0.478
LIG_LIR_Gen_1	342	352	PF02991	0.531
LIG_LIR_Nem_3	170	175	PF02991	0.432
LIG_LIR_Nem_3	342	347	PF02991	0.544
LIG_LIR_Nem_3	43	49	PF02991	0.382
LIG_LIR_Nem_3	72	78	PF02991	0.472
LIG_MYND_1	256	260	PF01753	0.478
LIG_Pex14_2	135	139	PF04695	0.406
LIG_Pex14_2	64	68	PF04695	0.583
LIG_SH2_CRK	172	176	PF00017	0.498
LIG_SH2_CRK	37	41	PF00017	0.495
LIG_SH2_CRK	46	50	PF00017	0.417
LIG_SH2_CRK	89	93	PF00017	0.406
LIG_SH2_NCK_1	140	144	PF00017	0.331
LIG_SH2_SRC	174	177	PF00017	0.535
LIG_SH2_SRC	19	22	PF00017	0.331
LIG_SH2_SRC	85	88	PF00017	0.210
LIG_SH2_STAP1	172	176	PF00017	0.431
LIG_SH2_STAP1	19	23	PF00017	0.355
LIG_SH2_STAP1	388	392	PF00017	0.482
LIG_SH2_STAT5	174	177	PF00017	0.431
LIG_SH2_STAT5	383	386	PF00017	0.460
LIG_SH2_STAT5	388	391	PF00017	0.485
LIG_SH2_STAT5	418	421	PF00017	0.552
LIG_SH2_STAT5	46	49	PF00017	0.343
LIG_SH2_STAT5	506	509	PF00017	0.520
LIG_SH2_STAT5	82	85	PF00017	0.321
LIG_SH3_1	121	127	PF00018	0.465
LIG_SH3_1	237	243	PF00018	0.542
LIG_SH3_3	121	127	PF00018	0.384
LIG_SH3_3	160	166	PF00018	0.494
LIG_SH3_3	186	192	PF00018	0.436
LIG_SH3_3	236	242	PF00018	0.520
LIG_SH3_3	250	256	PF00018	0.424
LIG_SH3_3	407	413	PF00018	0.630
LIG_SH3_3	57	63	PF00018	0.576
LIG_SH3_3	88	94	PF00018	0.550
LIG_SH3_3	97	103	PF00018	0.362
LIG_SH3_5	103	107	PF00018	0.258
LIG_SUMO_SIM_anti_2	395	401	PF11976	0.589
LIG_SUMO_SIM_par_1	395	401	PF11976	0.589
LIG_SUMO_SIM_par_1	475	482	PF11976	0.521
LIG_TRAF2_1	243	246	PF00917	0.446
LIG_TRAF2_1	314	317	PF00917	0.478
LIG_TRAF2_1	371	374	PF00917	0.594
LIG_TYR_ITIM	44	49	PF00017	0.331
LIG_TYR_ITIM	87	92	PF00017	0.399
LIG_UBA3_1	175	183	PF00899	0.535
LIG_UBA3_1	74	80	PF00899	0.411
LIG_WRC_WIRS_1	231	236	PF05994	0.360
LIG_WRC_WIRS_1	65	70	PF05994	0.587
LIG_WW_3	241	245	PF00397	0.401
MOD_CDC14_SPxK_1	118	121	PF00782	0.461
MOD_CDK_SPxK_1	115	121	PF00069	0.446
MOD_CK1_1	178	184	PF00069	0.431
MOD_CK1_1	3	9	PF00069	0.537
MOD_CK1_1	334	340	PF00069	0.421
MOD_CK2_1	232	238	PF00069	0.485
MOD_CK2_1	311	317	PF00069	0.478
MOD_CK2_1	339	345	PF00069	0.458
MOD_CK2_1	355	361	PF00069	0.509
MOD_CK2_1	368	374	PF00069	0.652
MOD_DYRK1A_RPxSP_1	406	410	PF00069	0.621
MOD_GlcNHglycan	26	29	PF01048	0.650
MOD_GlcNHglycan	313	316	PF01048	0.309
MOD_GlcNHglycan	32	35	PF01048	0.698
MOD_GlcNHglycan	336	339	PF01048	0.241
MOD_GlcNHglycan	435	438	PF01048	0.296
MOD_GlcNHglycan	55	58	PF01048	0.325
MOD_GSK3_1	210	217	PF00069	0.433
MOD_GSK3_1	339	346	PF00069	0.455
MOD_GSK3_1	364	371	PF00069	0.559
MOD_GSK3_1	398	405	PF00069	0.634
MOD_GSK3_1	459	466	PF00069	0.505
MOD_NEK2_1	175	180	PF00069	0.442
MOD_NEK2_1	230	235	PF00069	0.447
MOD_NEK2_1	69	74	PF00069	0.571
MOD_NEK2_1	81	86	PF00069	0.266
MOD_NEK2_2	40	45	PF00069	0.331
MOD_PIKK_1	364	370	PF00454	0.665
MOD_PIKK_1	404	410	PF00454	0.581
MOD_PIKK_1	451	457	PF00454	0.540
MOD_PKA_2	355	361	PF00069	0.588
MOD_PKA_2	401	407	PF00069	0.645
MOD_PKB_1	510	518	PF00069	0.485
MOD_Plk_4	13	19	PF00069	0.260
MOD_Plk_4	152	158	PF00069	0.550
MOD_Plk_4	304	310	PF00069	0.437
MOD_Plk_4	331	337	PF00069	0.535
MOD_Plk_4	355	361	PF00069	0.588
MOD_Plk_4	395	401	PF00069	0.545
MOD_Plk_4	64	70	PF00069	0.648
MOD_ProDKin_1	115	121	PF00069	0.419
MOD_ProDKin_1	126	132	PF00069	0.418
MOD_ProDKin_1	280	286	PF00069	0.535
MOD_ProDKin_1	339	345	PF00069	0.427
MOD_ProDKin_1	406	412	PF00069	0.603
MOD_ProDKin_1	491	497	PF00069	0.471
TRG_DiLeu_BaEn_1	377	382	PF01217	0.554
TRG_DiLeu_BaEn_1	395	400	PF01217	0.644
TRG_DiLeu_BaEn_4	268	274	PF01217	0.439
TRG_DiLeu_BaEn_4	377	383	PF01217	0.543
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.478
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.536
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.482
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.535
TRG_ENDOCYTIC_2	172	175	PF00928	0.498
TRG_ENDOCYTIC_2	46	49	PF00928	0.430
TRG_ENDOCYTIC_2	89	92	PF00928	0.429
TRG_ER_diArg_1	363	366	PF00400	0.560
TRG_ER_diArg_1	510	512	PF00400	0.516
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD83	Leptomonas seymouri	66%	99%
A0A0S4IM37	Bodo saltans	33%	100%
A0A1X0PA00	Trypanosomatidae	37%	100%
A0A3R7K9K9	Trypanosoma rangeli	39%	100%
A0A3S7X8A7	Leishmania donovani	90%	100%
A4HB60	Leishmania braziliensis	82%	100%
A4IAA8	Leishmania infantum	91%	100%
C9ZLY8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4Q2K2	Leishmania major	91%	100%
V5B5D7	Trypanosoma cruzi	40%	100%