HECT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HECT-domain (ubiquitin-transferase), putative

Species:

Leishmania mexicana

UniProt:

E9B5C9_LEIMU

TriTrypDb:

LmxM.33.3400

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5C9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	288	290	PF00675	0.597
CLV_PCSK_KEX2_1	288	290	PF00082	0.597
CLV_PCSK_SKI1_1	263	267	PF00082	0.554
CLV_PCSK_SKI1_1	288	292	PF00082	0.567
CLV_PCSK_SKI1_1	299	303	PF00082	0.531
CLV_Separin_Metazoa	167	171	PF03568	0.723
DEG_APCC_DBOX_1	262	270	PF00400	0.544
DOC_ANK_TNKS_1	182	189	PF00023	0.645
DOC_MAPK_gen_1	176	184	PF00069	0.608
DOC_PP2B_LxvP_1	311	314	PF13499	0.769
DOC_PP4_FxxP_1	192	195	PF00568	0.628
DOC_USP7_MATH_1	121	125	PF00917	0.710
DOC_USP7_MATH_1	252	256	PF00917	0.614
DOC_WW_Pin1_4	300	305	PF00397	0.674
LIG_14-3-3_CanoR_1	151	158	PF00244	0.558
LIG_14-3-3_CanoR_1	20	29	PF00244	0.448
LIG_14-3-3_CanoR_1	214	219	PF00244	0.574
LIG_14-3-3_CanoR_1	261	269	PF00244	0.675
LIG_14-3-3_CanoR_1	92	99	PF00244	0.391
LIG_APCC_ABBA_1	198	203	PF00400	0.582
LIG_APCC_ABBA_1	312	317	PF00400	0.570
LIG_BIR_II_1	1	5	PF00653	0.461
LIG_deltaCOP1_diTrp_1	148	152	PF00928	0.501
LIG_Dynein_DLC8_1	90	96	PF01221	0.207
LIG_FHA_1	142	148	PF00498	0.648
LIG_FHA_1	197	203	PF00498	0.573
LIG_FHA_1	306	312	PF00498	0.612
LIG_FHA_1	65	71	PF00498	0.319
LIG_FHA_2	138	144	PF00498	0.505
LIG_FHA_2	189	195	PF00498	0.698
LIG_FHA_2	208	214	PF00498	0.401
LIG_Integrin_isoDGR_2	87	89	PF01839	0.509
LIG_LIR_Apic_2	189	195	PF02991	0.640
LIG_LIR_Gen_1	199	209	PF02991	0.636
LIG_LIR_Gen_1	43	51	PF02991	0.316
LIG_LIR_Gen_1	62	72	PF02991	0.211
LIG_LIR_Gen_1	80	86	PF02991	0.464
LIG_LIR_Gen_1	96	107	PF02991	0.244
LIG_LIR_Nem_3	217	222	PF02991	0.529
LIG_LIR_Nem_3	62	68	PF02991	0.353
LIG_LIR_Nem_3	71	75	PF02991	0.357
LIG_LIR_Nem_3	80	85	PF02991	0.464
LIG_LIR_Nem_3	96	102	PF02991	0.244
LIG_NRBOX	204	210	PF00104	0.498
LIG_REV1ctd_RIR_1	99	108	PF16727	0.388
LIG_SH2_CRK	109	113	PF00017	0.416
LIG_SH2_CRK	82	86	PF00017	0.352
LIG_SH2_GRB2like	109	112	PF00017	0.503
LIG_SH2_NCK_1	82	86	PF00017	0.352
LIG_SH2_STAT5	241	244	PF00017	0.551
LIG_SH3_2	165	170	PF14604	0.620
LIG_SH3_3	162	168	PF00018	0.625
LIG_SUMO_SIM_anti_2	203	211	PF11976	0.563
LIG_TRAF2_1	314	317	PF00917	0.567
LIG_TRFH_1	82	86	PF08558	0.352
MOD_CK1_1	239	245	PF00069	0.669
MOD_CK2_1	207	213	PF00069	0.485
MOD_CMANNOS	149	152	PF00535	0.500
MOD_GlcNHglycan	132	135	PF01048	0.651
MOD_GlcNHglycan	227	230	PF01048	0.753
MOD_GlcNHglycan	247	250	PF01048	0.523
MOD_GlcNHglycan	263	266	PF01048	0.774
MOD_GlcNHglycan	291	294	PF01048	0.646
MOD_GSK3_1	137	144	PF00069	0.648
MOD_GSK3_1	236	243	PF00069	0.609
MOD_GSK3_1	257	264	PF00069	0.784
MOD_GSK3_1	64	71	PF00069	0.306
MOD_GSK3_1	73	80	PF00069	0.355
MOD_N-GLC_1	77	82	PF02516	0.363
MOD_NEK2_1	130	135	PF00069	0.578
MOD_NEK2_1	137	142	PF00069	0.516
MOD_NEK2_1	150	155	PF00069	0.389
MOD_NEK2_1	269	274	PF00069	0.590
MOD_NEK2_1	68	73	PF00069	0.312
MOD_PIKK_1	119	125	PF00454	0.650
MOD_PIKK_1	21	27	PF00454	0.469
MOD_PIKK_1	252	258	PF00454	0.634
MOD_PIKK_1	91	97	PF00454	0.388
MOD_PK_1	214	220	PF00069	0.664
MOD_PKA_2	130	136	PF00069	0.577
MOD_PKA_2	137	143	PF00069	0.517
MOD_PKA_2	150	156	PF00069	0.549
MOD_PKA_2	91	97	PF00069	0.312
MOD_Plk_1	188	194	PF00069	0.644
MOD_Plk_1	236	242	PF00069	0.619
MOD_Plk_1	77	83	PF00069	0.262
MOD_Plk_2-3	143	149	PF00069	0.490
MOD_Plk_4	188	194	PF00069	0.711
MOD_Plk_4	196	202	PF00069	0.626
MOD_Plk_4	236	242	PF00069	0.546
MOD_ProDKin_1	300	306	PF00069	0.675
TRG_ENDOCYTIC_2	109	112	PF00928	0.427
TRG_ENDOCYTIC_2	82	85	PF00928	0.352
TRG_ER_diArg_1	112	115	PF00400	0.437
TRG_ER_diArg_1	126	129	PF00400	0.571
TRG_ER_diArg_1	136	139	PF00400	0.526
TRG_ER_diArg_1	175	178	PF00400	0.573
TRG_ER_diArg_1	287	289	PF00400	0.584
TRG_NES_CRM1_1	196	211	PF08389	0.504
TRG_NES_CRM1_1	66	79	PF08389	0.388
TRG_Pf-PMV_PEXEL_1	289	294	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYK9	Leptomonas seymouri	50%	97%
A0A3Q8INP3	Leishmania donovani	93%	100%
A4HB59	Leishmania braziliensis	81%	100%
A4IAA6	Leishmania infantum	93%	100%
Q4Q2K4	Leishmania major	89%	100%