Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5C8_LEIMU

TriTrypDb:

LmxM.33.3390

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5C8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5C8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.485
CLV_NRD_NRD_1	241	243	PF00675	0.766
CLV_NRD_NRD_1	653	655	PF00675	0.642
CLV_NRD_NRD_1	71	73	PF00675	0.603
CLV_PCSK_KEX2_1	118	120	PF00082	0.507
CLV_PCSK_KEX2_1	241	243	PF00082	0.766
CLV_PCSK_KEX2_1	29	31	PF00082	0.610
CLV_PCSK_KEX2_1	525	527	PF00082	0.543
CLV_PCSK_KEX2_1	652	654	PF00082	0.680
CLV_PCSK_KEX2_1	71	73	PF00082	0.603
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.507
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.610
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.522
CLV_PCSK_PC7_1	649	655	PF00082	0.685
CLV_PCSK_SKI1_1	138	142	PF00082	0.461
CLV_PCSK_SKI1_1	202	206	PF00082	0.618
CLV_PCSK_SKI1_1	307	311	PF00082	0.553
CLV_PCSK_SKI1_1	35	39	PF00082	0.583
CLV_PCSK_SKI1_1	42	46	PF00082	0.551
CLV_PCSK_SKI1_1	584	588	PF00082	0.611
CLV_PCSK_SKI1_1	642	646	PF00082	0.648
CLV_Separin_Metazoa	39	43	PF03568	0.682
CLV_Separin_Metazoa	608	612	PF03568	0.710
DEG_APCC_DBOX_1	312	320	PF00400	0.362
DEG_APCC_DBOX_1	34	42	PF00400	0.576
DEG_APCC_DBOX_1	651	659	PF00400	0.686
DEG_APCC_KENBOX_2	335	339	PF00400	0.694
DEG_Nend_Nbox_1	1	3	PF02207	0.635
DEG_SCF_FBW7_1	372	378	PF00400	0.709
DOC_CKS1_1	372	377	PF01111	0.703
DOC_CKS1_1	410	415	PF01111	0.559
DOC_CKS1_1	417	422	PF01111	0.554
DOC_CKS1_1	702	707	PF01111	0.521
DOC_CYCLIN_RxL_1	135	144	PF00134	0.508
DOC_MAPK_gen_1	564	573	PF00069	0.749
DOC_MAPK_gen_1	642	650	PF00069	0.666
DOC_MAPK_gen_1	652	660	PF00069	0.534
DOC_MAPK_HePTP_8	650	662	PF00069	0.693
DOC_MAPK_MEF2A_6	653	662	PF00069	0.601
DOC_PP1_RVXF_1	482	489	PF00149	0.576
DOC_PP2B_LxvP_1	720	723	PF13499	0.730
DOC_PP4_FxxP_1	436	439	PF00568	0.535
DOC_PP4_FxxP_1	488	491	PF00568	0.537
DOC_PP4_FxxP_1	692	695	PF00568	0.623
DOC_PP4_FxxP_1	84	87	PF00568	0.445
DOC_USP7_MATH_1	173	177	PF00917	0.598
DOC_USP7_MATH_1	259	263	PF00917	0.644
DOC_USP7_MATH_1	273	277	PF00917	0.686
DOC_USP7_MATH_1	31	35	PF00917	0.569
DOC_USP7_MATH_1	375	379	PF00917	0.722
DOC_USP7_MATH_1	427	431	PF00917	0.600
DOC_USP7_MATH_1	630	634	PF00917	0.682
DOC_USP7_MATH_1	65	69	PF00917	0.551
DOC_USP7_MATH_1	700	704	PF00917	0.735
DOC_WW_Pin1_4	103	108	PF00397	0.465
DOC_WW_Pin1_4	152	157	PF00397	0.479
DOC_WW_Pin1_4	246	251	PF00397	0.787
DOC_WW_Pin1_4	296	301	PF00397	0.651
DOC_WW_Pin1_4	371	376	PF00397	0.760
DOC_WW_Pin1_4	409	414	PF00397	0.557
DOC_WW_Pin1_4	416	421	PF00397	0.582
DOC_WW_Pin1_4	602	607	PF00397	0.741
DOC_WW_Pin1_4	701	706	PF00397	0.800
DOC_WW_Pin1_4	709	714	PF00397	0.707
DOC_WW_Pin1_4	723	728	PF00397	0.720
LIG_14-3-3_CanoR_1	119	124	PF00244	0.353
LIG_14-3-3_CanoR_1	223	228	PF00244	0.616
LIG_14-3-3_CanoR_1	30	38	PF00244	0.576
LIG_14-3-3_CanoR_1	311	317	PF00244	0.350
LIG_14-3-3_CanoR_1	611	617	PF00244	0.706
LIG_APCC_ABBA_1	207	212	PF00400	0.426
LIG_APCC_ABBAyCdc20_2	291	297	PF00400	0.662
LIG_BIR_III_4	383	387	PF00653	0.660
LIG_BRCT_BRCA1_1	291	295	PF00533	0.359
LIG_Clathr_ClatBox_1	195	199	PF01394	0.582
LIG_Clathr_ClatBox_1	207	211	PF01394	0.406
LIG_deltaCOP1_diTrp_1	674	680	PF00928	0.817
LIG_eIF4E_1	110	116	PF01652	0.420
LIG_FAT_LD_1	15	23	PF03623	0.525
LIG_FHA_1	153	159	PF00498	0.560
LIG_FHA_1	184	190	PF00498	0.446
LIG_FHA_1	199	205	PF00498	0.523
LIG_FHA_1	374	380	PF00498	0.551
LIG_FHA_1	508	514	PF00498	0.656
LIG_FHA_1	549	555	PF00498	0.767
LIG_FHA_1	568	574	PF00498	0.489
LIG_FHA_1	594	600	PF00498	0.611
LIG_FHA_1	685	691	PF00498	0.660
LIG_FHA_1	715	721	PF00498	0.730
LIG_FHA_2	273	279	PF00498	0.723
LIG_FHA_2	450	456	PF00498	0.628
LIG_FHA_2	475	481	PF00498	0.597
LIG_Integrin_isoDGR_2	338	340	PF01839	0.711
LIG_Integrin_isoDGR_2	502	504	PF01839	0.577
LIG_IRF3_LxIS_1	137	144	PF10401	0.455
LIG_LIR_Apic_2	186	190	PF02991	0.545
LIG_LIR_Apic_2	434	439	PF02991	0.536
LIG_LIR_Apic_2	691	695	PF02991	0.623
LIG_LIR_Gen_1	131	142	PF02991	0.384
LIG_LIR_Gen_1	177	188	PF02991	0.473
LIG_LIR_Gen_1	283	290	PF02991	0.635
LIG_LIR_Gen_1	494	501	PF02991	0.551
LIG_LIR_Gen_1	646	655	PF02991	0.683
LIG_LIR_Gen_1	679	688	PF02991	0.798
LIG_LIR_Nem_3	131	137	PF02991	0.503
LIG_LIR_Nem_3	152	157	PF02991	0.581
LIG_LIR_Nem_3	177	183	PF02991	0.490
LIG_LIR_Nem_3	283	288	PF02991	0.650
LIG_LIR_Nem_3	302	308	PF02991	0.309
LIG_LIR_Nem_3	494	500	PF02991	0.544
LIG_LIR_Nem_3	565	571	PF02991	0.719
LIG_LIR_Nem_3	646	650	PF02991	0.688
LIG_LIR_Nem_3	679	683	PF02991	0.808
LIG_NRBOX	14	20	PF00104	0.527
LIG_NRBOX	226	232	PF00104	0.555
LIG_PCNA_yPIPBox_3	359	367	PF02747	0.529
LIG_Pex14_1	617	621	PF04695	0.617
LIG_Pex14_2	324	328	PF04695	0.531
LIG_PTB_Apo_2	148	155	PF02174	0.498
LIG_PTB_Phospho_1	148	154	PF10480	0.602
LIG_RPA_C_Fungi	649	661	PF08784	0.691
LIG_SH2_CRK	120	124	PF00017	0.591
LIG_SH2_CRK	134	138	PF00017	0.356
LIG_SH2_CRK	154	158	PF00017	0.217
LIG_SH2_CRK	187	191	PF00017	0.552
LIG_SH2_CRK	497	501	PF00017	0.536
LIG_SH2_GRB2like	366	369	PF00017	0.530
LIG_SH2_GRB2like	629	632	PF00017	0.667
LIG_SH2_NCK_1	187	191	PF00017	0.552
LIG_SH2_NCK_1	497	501	PF00017	0.536
LIG_SH2_NCK_1	629	633	PF00017	0.749
LIG_SH2_SRC	629	632	PF00017	0.667
LIG_SH2_STAP1	55	59	PF00017	0.547
LIG_SH2_STAT5	154	157	PF00017	0.551
LIG_SH2_STAT5	2	5	PF00017	0.695
LIG_SH2_STAT5	216	219	PF00017	0.479
LIG_SH2_STAT5	308	311	PF00017	0.503
LIG_SH2_STAT5	366	369	PF00017	0.552
LIG_SH2_STAT5	519	522	PF00017	0.635
LIG_SH2_STAT5	647	650	PF00017	0.564
LIG_SH2_STAT5	83	86	PF00017	0.446
LIG_SH3_3	197	203	PF00018	0.608
LIG_SH3_3	391	397	PF00018	0.782
LIG_SH3_3	417	423	PF00018	0.840
LIG_SH3_3	666	672	PF00018	0.786
LIG_SH3_3	679	685	PF00018	0.480
LIG_SH3_3	699	705	PF00018	0.579
LIG_SH3_CIN85_PxpxPR_1	409	414	PF14604	0.557
LIG_SUMO_SIM_par_1	569	575	PF11976	0.552
LIG_SUMO_SIM_par_1	585	591	PF11976	0.673
LIG_TRAF2_1	275	278	PF00917	0.638
LIG_TRAF2_1	605	608	PF00917	0.570
LIG_TRFH_1	497	501	PF08558	0.536
LIG_UBA3_1	195	202	PF00899	0.311
LIG_WRC_WIRS_1	10	15	PF05994	0.603
LIG_WRC_WIRS_1	59	64	PF05994	0.485
LIG_WW_3	423	427	PF00397	0.755
MOD_CDC14_SPxK_1	254	257	PF00782	0.638
MOD_CDK_SPK_2	409	414	PF00069	0.557
MOD_CDK_SPxK_1	251	257	PF00069	0.637
MOD_CK1_1	152	158	PF00069	0.574
MOD_CK1_1	229	235	PF00069	0.701
MOD_CK1_1	249	255	PF00069	0.473
MOD_CK1_1	262	268	PF00069	0.576
MOD_CK1_1	271	277	PF00069	0.653
MOD_CK1_1	378	384	PF00069	0.758
MOD_CK1_1	602	608	PF00069	0.736
MOD_CK2_1	271	277	PF00069	0.731
MOD_CK2_1	296	302	PF00069	0.538
MOD_CK2_1	460	466	PF00069	0.670
MOD_CK2_1	474	480	PF00069	0.510
MOD_CK2_1	602	608	PF00069	0.671
MOD_CK2_1	700	706	PF00069	0.734
MOD_GlcNHglycan	143	146	PF01048	0.541
MOD_GlcNHglycan	251	254	PF01048	0.711
MOD_GlcNHglycan	261	264	PF01048	0.688
MOD_GlcNHglycan	271	274	PF01048	0.590
MOD_GlcNHglycan	389	393	PF01048	0.781
MOD_GlcNHglycan	433	436	PF01048	0.690
MOD_GlcNHglycan	530	533	PF01048	0.660
MOD_GlcNHglycan	545	548	PF01048	0.533
MOD_GlcNHglycan	696	699	PF01048	0.533
MOD_GSK3_1	198	205	PF00069	0.585
MOD_GSK3_1	226	233	PF00069	0.655
MOD_GSK3_1	245	252	PF00069	0.462
MOD_GSK3_1	265	272	PF00069	0.657
MOD_GSK3_1	371	378	PF00069	0.677
MOD_GSK3_1	427	434	PF00069	0.727
MOD_GSK3_1	456	463	PF00069	0.683
MOD_GSK3_1	5	12	PF00069	0.536
MOD_GSK3_1	543	550	PF00069	0.704
MOD_GSK3_1	588	595	PF00069	0.591
MOD_N-GLC_1	150	155	PF02516	0.607
MOD_N-GLC_1	5	10	PF02516	0.534
MOD_N-GLC_1	630	635	PF02516	0.681
MOD_NEK2_1	149	154	PF00069	0.597
MOD_NEK2_1	183	188	PF00069	0.549
MOD_NEK2_1	230	235	PF00069	0.606
MOD_NEK2_1	312	317	PF00069	0.352
MOD_NEK2_1	599	604	PF00069	0.631
MOD_NEK2_1	9	14	PF00069	0.504
MOD_NEK2_2	449	454	PF00069	0.633
MOD_NEK2_2	55	60	PF00069	0.550
MOD_PIKK_1	126	132	PF00454	0.636
MOD_PIKK_1	167	173	PF00454	0.603
MOD_PIKK_1	314	320	PF00454	0.667
MOD_PIKK_1	404	410	PF00454	0.682
MOD_PIKK_1	44	50	PF00454	0.581
MOD_PIKK_1	466	472	PF00454	0.692
MOD_PIKK_1	610	616	PF00454	0.713
MOD_PIKK_1	721	727	PF00454	0.748
MOD_PK_1	119	125	PF00069	0.308
MOD_PK_1	654	660	PF00069	0.695
MOD_PKA_2	312	318	PF00069	0.356
MOD_PKA_2	474	480	PF00069	0.613
MOD_PKA_2	610	616	PF00069	0.678
MOD_PKB_1	652	660	PF00069	0.695
MOD_Plk_1	150	156	PF00069	0.598
MOD_Plk_1	320	326	PF00069	0.664
MOD_Plk_1	456	462	PF00069	0.657
MOD_Plk_1	5	11	PF00069	0.580
MOD_Plk_2-3	588	594	PF00069	0.698
MOD_Plk_4	119	125	PF00069	0.376
MOD_Plk_4	14	20	PF00069	0.429
MOD_Plk_4	175	181	PF00069	0.597
MOD_Plk_4	226	232	PF00069	0.656
MOD_Plk_4	456	462	PF00069	0.711
MOD_Plk_4	5	11	PF00069	0.594
MOD_Plk_4	643	649	PF00069	0.626
MOD_ProDKin_1	103	109	PF00069	0.460
MOD_ProDKin_1	152	158	PF00069	0.473
MOD_ProDKin_1	246	252	PF00069	0.790
MOD_ProDKin_1	296	302	PF00069	0.640
MOD_ProDKin_1	371	377	PF00069	0.768
MOD_ProDKin_1	409	415	PF00069	0.559
MOD_ProDKin_1	416	422	PF00069	0.579
MOD_ProDKin_1	602	608	PF00069	0.736
MOD_ProDKin_1	701	707	PF00069	0.801
MOD_ProDKin_1	709	715	PF00069	0.707
MOD_ProDKin_1	723	729	PF00069	0.720
MOD_SUMO_rev_2	521	527	PF00179	0.556
TRG_DiLeu_BaEn_2	336	342	PF01217	0.716
TRG_DiLeu_BaLyEn_6	646	651	PF01217	0.682
TRG_ENDOCYTIC_2	110	113	PF00928	0.469
TRG_ENDOCYTIC_2	120	123	PF00928	0.491
TRG_ENDOCYTIC_2	134	137	PF00928	0.388
TRG_ENDOCYTIC_2	154	157	PF00928	0.220
TRG_ENDOCYTIC_2	216	219	PF00928	0.479
TRG_ENDOCYTIC_2	497	500	PF00928	0.521
TRG_ENDOCYTIC_2	647	650	PF00928	0.584
TRG_ENDOCYTIC_2	83	86	PF00928	0.446
TRG_ER_diArg_1	240	242	PF00400	0.746
TRG_ER_diArg_1	310	313	PF00400	0.532
TRG_ER_diArg_1	651	654	PF00400	0.674
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I561	Leptomonas seymouri	45%	99%
A0A3S7X8F7	Leishmania donovani	93%	100%
A4HB58	Leishmania braziliensis	78%	100%
A4IAA5	Leishmania infantum	93%	100%
Q4Q2K5	Leishmania major	90%	100%