Glucose-6-phosphate 1-epimerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldose 1-epimerase-like protein

Species:

Leishmania mexicana

UniProt:

E9B5C7_LEIMU

TriTrypDb:

LmxM.33.3380

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5C7

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0016853	isomerase activity	2	12
GO:0016854	racemase and epimerase activity	3	12
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	4	12
GO:0030246	carbohydrate binding	2	12
GO:0047938	glucose-6-phosphate 1-epimerase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.497
CLV_PCSK_SKI1_1	270	274	PF00082	0.282
CLV_PCSK_SKI1_1	56	60	PF00082	0.325
DEG_APCC_DBOX_1	102	110	PF00400	0.497
DOC_CKS1_1	190	195	PF01111	0.344
DOC_MAPK_gen_1	39	47	PF00069	0.560
DOC_MAPK_gen_1	9	16	PF00069	0.526
DOC_MAPK_MEF2A_6	60	67	PF00069	0.458
DOC_USP7_MATH_1	111	115	PF00917	0.497
DOC_USP7_MATH_1	244	248	PF00917	0.497
DOC_USP7_MATH_1	279	283	PF00917	0.533
DOC_USP7_MATH_1	296	300	PF00917	0.672
DOC_USP7_MATH_1	31	35	PF00917	0.554
DOC_USP7_UBL2_3	138	142	PF12436	0.533
DOC_USP7_UBL2_3	270	274	PF12436	0.503
DOC_WW_Pin1_4	116	121	PF00397	0.534
DOC_WW_Pin1_4	175	180	PF00397	0.506
DOC_WW_Pin1_4	189	194	PF00397	0.463
DOC_WW_Pin1_4	2	7	PF00397	0.543
DOC_WW_Pin1_4	230	235	PF00397	0.533
DOC_WW_Pin1_4	292	297	PF00397	0.627
DOC_WW_Pin1_4	45	50	PF00397	0.458
LIG_14-3-3_CanoR_1	103	107	PF00244	0.382
LIG_14-3-3_CanoR_1	84	89	PF00244	0.550
LIG_14-3-3_CanoR_1	9	15	PF00244	0.474
LIG_Actin_WH2_2	259	275	PF00022	0.508
LIG_BRCT_BRCA1_1	150	154	PF00533	0.553
LIG_BRCT_BRCA1_1	176	180	PF00533	0.344
LIG_BRCT_BRCA1_1	78	82	PF00533	0.493
LIG_FHA_1	226	232	PF00498	0.450
LIG_FHA_1	284	290	PF00498	0.525
LIG_FHA_1	97	103	PF00498	0.390
LIG_FHA_2	144	150	PF00498	0.536
LIG_FHA_2	23	29	PF00498	0.517
LIG_HCF-1_HBM_1	43	46	PF13415	0.533
LIG_IRF3_LxIS_1	227	232	PF10401	0.344
LIG_LIR_Apic_2	43	49	PF02991	0.458
LIG_LIR_Gen_1	79	90	PF02991	0.496
LIG_LIR_Nem_3	160	164	PF02991	0.447
LIG_LIR_Nem_3	258	263	PF02991	0.450
LIG_LIR_Nem_3	79	85	PF02991	0.462
LIG_PDZ_Class_1	296	301	PF00595	0.646
LIG_Pex14_2	154	158	PF04695	0.458
LIG_SH2_CRK	73	77	PF00017	0.525
LIG_SH2_STAP1	128	132	PF00017	0.458
LIG_SH2_STAT3	211	214	PF00017	0.458
LIG_SH2_STAT5	128	131	PF00017	0.452
LIG_SH2_STAT5	161	164	PF00017	0.437
LIG_SH2_STAT5	46	49	PF00017	0.458
LIG_SH2_STAT6	259	263	PF00017	0.472
LIG_SH3_1	187	193	PF00018	0.413
LIG_SH3_3	187	193	PF00018	0.493
LIG_SH3_3	272	278	PF00018	0.471
LIG_SH3_3	72	78	PF00018	0.496
LIG_TRAF2_1	146	149	PF00917	0.552
LIG_WRC_WIRS_1	97	102	PF05994	0.367
MOD_CDK_SPxxK_3	2	9	PF00069	0.493
MOD_CK1_1	114	120	PF00069	0.497
MOD_CK1_1	165	171	PF00069	0.552
MOD_CK1_1	22	28	PF00069	0.474
MOD_CK1_1	281	287	PF00069	0.533
MOD_CK1_1	35	41	PF00069	0.464
MOD_CK2_1	102	108	PF00069	0.512
MOD_CK2_1	130	136	PF00069	0.501
MOD_CK2_1	143	149	PF00069	0.441
MOD_CK2_1	192	198	PF00069	0.552
MOD_CK2_1	22	28	PF00069	0.516
MOD_CK2_1	292	298	PF00069	0.660
MOD_GlcNHglycan	148	153	PF01048	0.328
MOD_GlcNHglycan	172	175	PF01048	0.297
MOD_GlcNHglycan	94	97	PF01048	0.256
MOD_GSK3_1	112	119	PF00069	0.468
MOD_GSK3_1	126	133	PF00069	0.476
MOD_GSK3_1	144	151	PF00069	0.405
MOD_GSK3_1	170	177	PF00069	0.344
MOD_GSK3_1	225	232	PF00069	0.458
MOD_GSK3_1	244	251	PF00069	0.443
MOD_GSK3_1	279	286	PF00069	0.532
MOD_GSK3_1	292	299	PF00069	0.622
MOD_GSK3_1	31	38	PF00069	0.441
MOD_GSK3_1	92	99	PF00069	0.458
MOD_LATS_1	17	23	PF00433	0.344
MOD_N-GLC_1	144	149	PF02516	0.319
MOD_N-GLC_1	175	180	PF02516	0.251
MOD_N-GLC_1	234	239	PF02516	0.297
MOD_NEK2_1	102	107	PF00069	0.509
MOD_NEK2_1	126	131	PF00069	0.454
MOD_NEK2_1	141	146	PF00069	0.425
MOD_NEK2_1	229	234	PF00069	0.535
MOD_NEK2_2	98	103	PF00069	0.497
MOD_PIKK_1	165	171	PF00454	0.399
MOD_PIKK_1	283	289	PF00454	0.465
MOD_PKA_2	10	16	PF00069	0.233
MOD_PKA_2	102	108	PF00069	0.527
MOD_Plk_1	111	117	PF00069	0.554
MOD_Plk_1	54	60	PF00069	0.497
MOD_Plk_2-3	112	118	PF00069	0.427
MOD_Plk_4	157	163	PF00069	0.439
MOD_Plk_4	167	173	PF00069	0.445
MOD_ProDKin_1	116	122	PF00069	0.534
MOD_ProDKin_1	175	181	PF00069	0.506
MOD_ProDKin_1	189	195	PF00069	0.463
MOD_ProDKin_1	2	8	PF00069	0.550
MOD_ProDKin_1	230	236	PF00069	0.533
MOD_ProDKin_1	292	298	PF00069	0.634
MOD_ProDKin_1	45	51	PF00069	0.458
MOD_SUMO_rev_2	133	139	PF00179	0.533
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.533
TRG_ENDOCYTIC_2	161	164	PF00928	0.447
TRG_ENDOCYTIC_2	260	263	PF00928	0.447
TRG_ENDOCYTIC_2	73	76	PF00928	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6S8	Leptomonas seymouri	70%	100%
A0A0S4IIG2	Bodo saltans	36%	100%
A0A1X0P9Y8	Trypanosomatidae	50%	100%
A0A3S5H7X6	Leishmania donovani	93%	100%
A0A422NEP9	Trypanosoma rangeli	47%	100%
A4HB57	Leishmania braziliensis	80%	100%
A4IAA4	Leishmania infantum	93%	100%
C9ZLY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
P39173	Escherichia coli (strain K12)	33%	100%
P44160	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	29%	100%
Q03161	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q40784	Cenchrus ciliaris	30%	91%
Q4Q2K6	Leishmania major	93%	100%
Q8ZPV9	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	35%	100%
V5BV57	Trypanosoma cruzi	49%	100%