LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B5C6_LEIMU
TriTrypDb:
LmxM.33.3370
Length:
150

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5C6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5C6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 141 143 PF00675 0.373
CLV_PCSK_KEX2_1 114 116 PF00082 0.466
CLV_PCSK_KEX2_1 141 143 PF00082 0.375
CLV_PCSK_PC1ET2_1 114 116 PF00082 0.459
CLV_PCSK_SKI1_1 33 37 PF00082 0.494
CLV_PCSK_SKI1_1 71 75 PF00082 0.503
DEG_APCC_DBOX_1 32 40 PF00400 0.294
DEG_APCC_DBOX_1 70 78 PF00400 0.365
DEG_SPOP_SBC_1 2 6 PF00917 0.625
DOC_CYCLIN_RxL_1 30 38 PF00134 0.457
DOC_MAPK_gen_1 54 61 PF00069 0.356
DOC_MAPK_MEF2A_6 132 139 PF00069 0.448
DOC_MAPK_MEF2A_6 54 61 PF00069 0.374
DOC_MAPK_MEF2A_6 71 79 PF00069 0.366
DOC_MAPK_NFAT4_5 132 140 PF00069 0.450
DOC_PP1_RVXF_1 47 53 PF00149 0.351
LIG_14-3-3_CanoR_1 17 25 PF00244 0.438
LIG_BRCT_BRCA1_1 47 51 PF00533 0.366
LIG_eIF4E_1 116 122 PF01652 0.493
LIG_EVH1_2 145 149 PF00568 0.416
LIG_LIR_Gen_1 89 98 PF02991 0.483
LIG_LIR_Nem_3 60 64 PF02991 0.341
LIG_LIR_Nem_3 89 93 PF02991 0.476
LIG_OCRL_FandH_1 50 62 PF00620 0.344
LIG_SH2_NCK_1 64 68 PF00017 0.476
LIG_SH2_STAT5 120 123 PF00017 0.376
LIG_SH2_STAT5 43 46 PF00017 0.368
LIG_SH3_1 142 148 PF00018 0.399
LIG_SH3_3 140 146 PF00018 0.381
LIG_SUMO_SIM_anti_2 72 78 PF11976 0.459
LIG_WRC_WIRS_1 83 88 PF05994 0.414
LIG_WW_1 144 147 PF00397 0.406
MOD_CK1_1 5 11 PF00069 0.551
MOD_CK2_1 62 68 PF00069 0.391
MOD_GlcNHglycan 5 8 PF01048 0.519
MOD_GSK3_1 1 8 PF00069 0.587
MOD_NEK2_1 1 6 PF00069 0.585
MOD_NEK2_1 11 16 PF00069 0.487
MOD_NEK2_1 35 40 PF00069 0.381
MOD_PKA_2 16 22 PF00069 0.506
MOD_Plk_4 82 88 PF00069 0.414
TRG_DiLeu_BaEn_1 70 75 PF01217 0.434
TRG_DiLeu_BaEn_2 81 87 PF01217 0.320
TRG_ENDOCYTIC_2 64 67 PF00928 0.470
TRG_ENDOCYTIC_2 90 93 PF00928 0.492
TRG_ER_diArg_1 141 143 PF00400 0.367
TRG_ER_diArg_1 54 57 PF00400 0.349
TRG_NES_CRM1_1 82 94 PF08389 0.458
TRG_Pf-PMV_PEXEL_1 56 60 PF00026 0.339

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5Q2 Leptomonas seymouri 80% 99%
A0A1X0PAT6 Trypanosomatidae 60% 91%
A0A3Q8IFS7 Leishmania donovani 95% 100%
A0A422NEQ0 Trypanosoma rangeli 62% 97%
A4HB56 Leishmania braziliensis 87% 100%
A4IAA3 Leishmania infantum 95% 100%
C9ZLZ0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 99%
Q4Q2K7 Leishmania major 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS