D-aminoacyl-tRNA deacylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

D-Tyr-tRNA(Tyr) deacylase, putative

Species:

Leishmania mexicana

UniProt:

E9B5C5_LEIMU

TriTrypDb:

LmxM.33.3360

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B5C5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5C5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006399	tRNA metabolic process	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0002161	aminoacyl-tRNA editing activity	5	11
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0051499	D-aminoacyl-tRNA deacylase activity	6	11
GO:0052689	carboxylic ester hydrolase activity	4	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140101	catalytic activity, acting on a tRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0051500	D-tyrosyl-tRNA(Tyr) deacylase activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.555
CLV_C14_Caspase3-7	63	67	PF00656	0.550
CLV_NRD_NRD_1	184	186	PF00675	0.239
CLV_PCSK_KEX2_1	184	186	PF00082	0.240
CLV_PCSK_SKI1_1	29	33	PF00082	0.309
CLV_PCSK_SKI1_1	86	90	PF00082	0.324
CLV_PCSK_SKI1_1	95	99	PF00082	0.336
DEG_APCC_DBOX_1	28	36	PF00400	0.375
DEG_Nend_UBRbox_1	1	4	PF02207	0.619
DOC_MAPK_DCC_7	2	12	PF00069	0.431
DOC_MAPK_gen_1	122	130	PF00069	0.516
DOC_MAPK_gen_1	18	28	PF00069	0.592
DOC_MAPK_gen_1	47	57	PF00069	0.579
DOC_MAPK_HePTP_8	20	32	PF00069	0.443
DOC_MAPK_MEF2A_6	21	30	PF00069	0.530
DOC_MAPK_MEF2A_6	50	59	PF00069	0.524
DOC_MAPK_MEF2A_6	76	83	PF00069	0.582
DOC_PP1_RVXF_1	124	131	PF00149	0.515
DOC_PP2B_LxvP_1	112	115	PF13499	0.492
DOC_USP7_MATH_1	115	119	PF00917	0.552
DOC_WW_Pin1_4	89	94	PF00397	0.581
LIG_APCC_ABBA_1	10	15	PF00400	0.429
LIG_BIR_III_4	162	166	PF00653	0.533
LIG_BRCT_BRCA1_1	126	130	PF00533	0.582
LIG_deltaCOP1_diTrp_1	177	182	PF00928	0.398
LIG_EH1_1	76	84	PF00400	0.550
LIG_FHA_1	204	210	PF00498	0.415
LIG_FHA_1	25	31	PF00498	0.432
LIG_LIR_Gen_1	127	138	PF02991	0.582
LIG_LIR_Gen_1	144	153	PF02991	0.522
LIG_LIR_Gen_1	177	187	PF02991	0.398
LIG_LIR_Gen_1	202	211	PF02991	0.526
LIG_LIR_Gen_1	85	96	PF02991	0.582
LIG_LIR_Nem_3	127	133	PF02991	0.582
LIG_LIR_Nem_3	14	19	PF02991	0.425
LIG_LIR_Nem_3	144	149	PF02991	0.522
LIG_LIR_Nem_3	177	182	PF02991	0.583
LIG_LIR_Nem_3	85	91	PF02991	0.582
LIG_PCNA_PIPBox_1	84	93	PF02747	0.536
LIG_PDZ_Class_2	206	211	PF00595	0.503
LIG_SH2_CRK	16	20	PF00017	0.598
LIG_SH2_STAT5	48	51	PF00017	0.509
LIG_SH2_STAT5	58	61	PF00017	0.491
LIG_SUMO_SIM_anti_2	110	115	PF11976	0.503
LIG_TRAF2_1	102	105	PF00917	0.550
LIG_TYR_ITSM	12	19	PF00017	0.428
MOD_CDC14_SPxK_1	92	95	PF00782	0.582
MOD_CDK_SPxK_1	89	95	PF00069	0.581
MOD_CK2_1	99	105	PF00069	0.537
MOD_GlcNHglycan	157	161	PF01048	0.374
MOD_GlcNHglycan	66	69	PF01048	0.414
MOD_GSK3_1	60	67	PF00069	0.611
MOD_GSK3_1	82	89	PF00069	0.539
MOD_GSK3_1	95	102	PF00069	0.461
MOD_NEK2_1	82	87	PF00069	0.582
MOD_PIKK_1	95	101	PF00454	0.480
MOD_PK_1	124	130	PF00069	0.582
MOD_PKA_2	64	70	PF00069	0.550
MOD_ProDKin_1	89	95	PF00069	0.581
MOD_SUMO_for_1	174	177	PF00179	0.573
TRG_DiLeu_BaEn_1	108	113	PF01217	0.606
TRG_ENDOCYTIC_2	143	146	PF00928	0.516
TRG_ENDOCYTIC_2	16	19	PF00928	0.601
TRG_ENDOCYTIC_2	58	61	PF00928	0.527
TRG_ER_diArg_1	184	186	PF00400	0.440
TRG_ER_diArg_1	20	23	PF00400	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKW6	Leptomonas seymouri	78%	100%
A0A0S4JLF2	Bodo saltans	40%	100%
A0A1X0P9Y0	Trypanosomatidae	52%	100%
A0A3S7X8A0	Leishmania donovani	94%	100%
A0A422NEP7	Trypanosoma rangeli	51%	100%
A4HB55	Leishmania braziliensis	79%	100%
A4IAA2	Leishmania infantum	94%	100%
C9ZLZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E1C762	Gallus gallus	32%	100%
P84066	Leishmania major	94%	100%
Q4Q2K8	Leishmania major	92%	100%
Q68EL2	Danio rerio	31%	100%
Q8BHA3	Mus musculus	30%	100%
Q96FN9	Homo sapiens	31%	100%