LeishMANIAdb
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ATPase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ATPase-like protein
Gene product:
ATPase-like protein
Species:
Leishmania mexicana
UniProt:
E9B5C4_LEIMU
TriTrypDb:
LmxM.33.3350
Length:
537

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0010008 endosome membrane 5 11
GO:0012506 vesicle membrane 4 11
GO:0016020 membrane 2 12
GO:0030659 cytoplasmic vesicle membrane 5 11
GO:0031090 organelle membrane 3 11
GO:0031902 late endosome membrane 6 11
GO:0098588 bounding membrane of organelle 4 11
GO:0110165 cellular anatomical entity 1 15
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 4
GO:0005838 proteasome regulatory particle 2 1
GO:0008540 proteasome regulatory particle, base subcomplex 2 1
GO:0032991 protein-containing complex 1 3
GO:0000502 proteasome complex 3 2
GO:0140535 intracellular protein-containing complex 2 2
GO:1902494 catalytic complex 2 2
GO:1905368 peptidase complex 3 2
GO:1905369 endopeptidase complex 4 2

Expansion

Sequence features

E9B5C4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5C4

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006807 nitrogen compound metabolic process 2 3
GO:0008152 metabolic process 1 3
GO:0009056 catabolic process 2 3
GO:0009057 macromolecule catabolic process 4 3
GO:0009987 cellular process 1 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0019538 protein metabolic process 3 3
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0030163 protein catabolic process 4 3
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 1
GO:0043170 macromolecule metabolic process 3 3
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 3
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:0071704 organic substance metabolic process 2 3
GO:1901564 organonitrogen compound metabolic process 3 3
GO:1901565 organonitrogen compound catabolic process 4 3
GO:1901575 organic substance catabolic process 3 3
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 17
GO:0003824 catalytic activity 1 17
GO:0005488 binding 1 17
GO:0005524 ATP binding 5 17
GO:0016462 pyrophosphatase activity 5 17
GO:0016787 hydrolase activity 2 17
GO:0016817 hydrolase activity, acting on acid anhydrides 3 17
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 17
GO:0016887 ATP hydrolysis activity 7 17
GO:0017076 purine nucleotide binding 4 17
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 17
GO:0030554 adenyl nucleotide binding 5 17
GO:0032553 ribonucleotide binding 3 17
GO:0032555 purine ribonucleotide binding 4 17
GO:0032559 adenyl ribonucleotide binding 5 17
GO:0035639 purine ribonucleoside triphosphate binding 4 17
GO:0036094 small molecule binding 2 17
GO:0043167 ion binding 2 17
GO:0043168 anion binding 3 17
GO:0097159 organic cyclic compound binding 2 17
GO:0097367 carbohydrate derivative binding 2 17
GO:1901265 nucleoside phosphate binding 3 17
GO:1901363 heterocyclic compound binding 2 17
GO:0036402 proteasome-activating activity 2 3
GO:0140657 ATP-dependent activity 1 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 115 119 PF00656 0.484
CLV_C14_Caspase3-7 260 264 PF00656 0.307
CLV_C14_Caspase3-7 95 99 PF00656 0.523
CLV_NRD_NRD_1 194 196 PF00675 0.359
CLV_NRD_NRD_1 279 281 PF00675 0.240
CLV_NRD_NRD_1 314 316 PF00675 0.280
CLV_NRD_NRD_1 331 333 PF00675 0.428
CLV_NRD_NRD_1 366 368 PF00675 0.379
CLV_PCSK_KEX2_1 194 196 PF00082 0.360
CLV_PCSK_KEX2_1 279 281 PF00082 0.240
CLV_PCSK_KEX2_1 314 316 PF00082 0.258
CLV_PCSK_KEX2_1 330 332 PF00082 0.399
CLV_PCSK_KEX2_1 366 368 PF00082 0.379
CLV_PCSK_PC1ET2_1 330 332 PF00082 0.534
CLV_PCSK_PC7_1 190 196 PF00082 0.402
CLV_PCSK_SKI1_1 173 177 PF00082 0.402
CLV_PCSK_SKI1_1 194 198 PF00082 0.307
CLV_PCSK_SKI1_1 242 246 PF00082 0.296
CLV_PCSK_SKI1_1 254 258 PF00082 0.171
CLV_PCSK_SKI1_1 26 30 PF00082 0.460
CLV_PCSK_SKI1_1 279 283 PF00082 0.310
CLV_PCSK_SKI1_1 331 335 PF00082 0.384
CLV_PCSK_SKI1_1 366 370 PF00082 0.347
CLV_PCSK_SKI1_1 452 456 PF00082 0.700
CLV_PCSK_SKI1_1 50 54 PF00082 0.395
CLV_PCSK_SKI1_1 526 530 PF00082 0.607
DEG_APCC_DBOX_1 49 57 PF00400 0.542
DEG_Kelch_Keap1_1 392 397 PF01344 0.466
DEG_Nend_UBRbox_1 1 4 PF02207 0.505
DOC_CKS1_1 126 131 PF01111 0.525
DOC_CYCLIN_RxL_1 328 337 PF00134 0.383
DOC_CYCLIN_yClb5_NLxxxL_5 299 308 PF00134 0.331
DOC_CYCLIN_yCln2_LP_2 133 139 PF00134 0.449
DOC_MAPK_gen_1 279 289 PF00069 0.251
DOC_MAPK_gen_1 314 324 PF00069 0.309
DOC_MAPK_HePTP_8 277 289 PF00069 0.257
DOC_MAPK_MEF2A_6 280 289 PF00069 0.273
DOC_MAPK_MEF2A_6 315 324 PF00069 0.261
DOC_MAPK_NFAT4_5 282 290 PF00069 0.273
DOC_PP1_RVXF_1 252 259 PF00149 0.273
DOC_PP2B_LxvP_1 133 136 PF13499 0.505
DOC_PP2B_PxIxI_1 57 63 PF00149 0.314
DOC_PP4_FxxP_1 186 189 PF00568 0.451
DOC_SPAK_OSR1_1 359 363 PF12202 0.336
DOC_USP7_MATH_1 120 124 PF00917 0.700
DOC_USP7_MATH_1 152 156 PF00917 0.556
DOC_USP7_MATH_1 248 252 PF00917 0.260
DOC_USP7_MATH_1 264 268 PF00917 0.323
DOC_USP7_MATH_1 424 428 PF00917 0.542
DOC_USP7_MATH_1 468 472 PF00917 0.737
DOC_USP7_MATH_1 517 521 PF00917 0.542
DOC_WW_Pin1_4 125 130 PF00397 0.653
DOC_WW_Pin1_4 458 463 PF00397 0.747
DOC_WW_Pin1_4 464 469 PF00397 0.786
LIG_14-3-3_CanoR_1 160 164 PF00244 0.477
LIG_14-3-3_CanoR_1 173 179 PF00244 0.391
LIG_14-3-3_CanoR_1 2 10 PF00244 0.558
LIG_14-3-3_CanoR_1 279 289 PF00244 0.273
LIG_14-3-3_CanoR_1 359 363 PF00244 0.336
LIG_14-3-3_CanoR_1 366 376 PF00244 0.317
LIG_14-3-3_CanoR_1 382 388 PF00244 0.484
LIG_14-3-3_CanoR_1 526 531 PF00244 0.630
LIG_Actin_WH2_2 326 341 PF00022 0.544
LIG_APCC_ABBAyCdc20_2 254 260 PF00400 0.256
LIG_FHA_1 128 134 PF00498 0.644
LIG_FHA_1 175 181 PF00498 0.400
LIG_FHA_1 281 287 PF00498 0.234
LIG_FHA_1 376 382 PF00498 0.470
LIG_FHA_1 4 10 PF00498 0.645
LIG_FHA_1 442 448 PF00498 0.589
LIG_FHA_1 73 79 PF00498 0.485
LIG_FHA_2 113 119 PF00498 0.542
LIG_FHA_2 211 217 PF00498 0.275
LIG_FHA_2 342 348 PF00498 0.493
LIG_FHA_2 385 391 PF00498 0.603
LIG_FHA_2 427 433 PF00498 0.703
LIG_FHA_2 517 523 PF00498 0.575
LIG_FHA_2 93 99 PF00498 0.437
LIG_GBD_Chelix_1 277 285 PF00786 0.257
LIG_LIR_Apic_2 184 189 PF02991 0.375
LIG_LIR_Gen_1 317 325 PF02991 0.390
LIG_LIR_Gen_1 357 368 PF02991 0.412
LIG_LIR_Gen_1 378 388 PF02991 0.393
LIG_LIR_Gen_1 67 78 PF02991 0.550
LIG_LIR_Nem_3 317 322 PF02991 0.390
LIG_LIR_Nem_3 357 363 PF02991 0.392
LIG_LIR_Nem_3 378 383 PF02991 0.525
LIG_LIR_Nem_3 499 505 PF02991 0.513
LIG_LIR_Nem_3 67 73 PF02991 0.533
LIG_Pex14_1 159 163 PF04695 0.481
LIG_Pex14_2 312 316 PF04695 0.296
LIG_PTAP_UEV_1 128 133 PF05743 0.503
LIG_RPA_C_Fungi 14 26 PF08784 0.334
LIG_SH2_CRK 199 203 PF00017 0.336
LIG_SH2_CRK 31 35 PF00017 0.422
LIG_SH2_CRK 70 74 PF00017 0.693
LIG_SH2_STAP1 66 70 PF00017 0.527
LIG_SH2_STAP1 76 80 PF00017 0.508
LIG_SH2_STAT5 70 73 PF00017 0.524
LIG_SH3_2 189 194 PF14604 0.454
LIG_SH3_2 473 478 PF14604 0.547
LIG_SH3_3 126 132 PF00018 0.546
LIG_SH3_3 186 192 PF00018 0.432
LIG_SH3_3 31 37 PF00018 0.518
LIG_SH3_3 319 325 PF00018 0.320
LIG_SH3_3 370 376 PF00018 0.373
LIG_SH3_3 467 473 PF00018 0.547
LIG_Sin3_3 18 25 PF02671 0.320
LIG_SUMO_SIM_anti_2 403 410 PF11976 0.530
LIG_TRAF2_1 520 523 PF00917 0.510
LIG_TYR_ITIM 29 34 PF00017 0.418
MOD_CK1_1 127 133 PF00069 0.647
MOD_CK1_1 155 161 PF00069 0.366
MOD_CK1_1 184 190 PF00069 0.440
MOD_CK1_1 392 398 PF00069 0.682
MOD_CK1_1 412 418 PF00069 0.487
MOD_CK1_1 453 459 PF00069 0.673
MOD_CK1_1 460 466 PF00069 0.663
MOD_CK1_1 481 487 PF00069 0.718
MOD_CK2_1 210 216 PF00069 0.300
MOD_CK2_1 426 432 PF00069 0.699
MOD_CK2_1 453 459 PF00069 0.571
MOD_CK2_1 516 522 PF00069 0.506
MOD_CK2_1 71 77 PF00069 0.639
MOD_GlcNHglycan 121 125 PF01048 0.641
MOD_GlcNHglycan 224 227 PF01048 0.299
MOD_GlcNHglycan 250 253 PF01048 0.263
MOD_GlcNHglycan 266 269 PF01048 0.451
MOD_GlcNHglycan 394 397 PF01048 0.742
MOD_GlcNHglycan 411 414 PF01048 0.491
MOD_GlcNHglycan 455 458 PF01048 0.571
MOD_GlcNHglycan 519 522 PF01048 0.599
MOD_GlcNHglycan 533 536 PF01048 0.622
MOD_GlcNHglycan 80 83 PF01048 0.668
MOD_GSK3_1 120 127 PF00069 0.595
MOD_GSK3_1 155 162 PF00069 0.410
MOD_GSK3_1 354 361 PF00069 0.408
MOD_GSK3_1 424 431 PF00069 0.711
MOD_GSK3_1 453 460 PF00069 0.728
MOD_GSK3_1 464 471 PF00069 0.748
MOD_GSK3_1 478 485 PF00069 0.651
MOD_GSK3_1 513 520 PF00069 0.613
MOD_GSK3_1 58 65 PF00069 0.486
MOD_GSK3_1 68 75 PF00069 0.546
MOD_NEK2_1 220 225 PF00069 0.275
MOD_NEK2_1 299 304 PF00069 0.360
MOD_NEK2_1 381 386 PF00069 0.562
MOD_NEK2_1 409 414 PF00069 0.494
MOD_NEK2_1 78 83 PF00069 0.587
MOD_PIKK_1 3 9 PF00454 0.487
MOD_PIKK_1 381 387 PF00454 0.524
MOD_PK_1 434 440 PF00069 0.544
MOD_PKA_2 159 165 PF00069 0.473
MOD_PKA_2 358 364 PF00069 0.546
MOD_PKA_2 381 387 PF00069 0.468
MOD_PKA_2 390 396 PF00069 0.603
MOD_Plk_1 120 126 PF00069 0.583
MOD_Plk_1 68 74 PF00069 0.483
MOD_Plk_1 76 82 PF00069 0.415
MOD_Plk_1 93 99 PF00069 0.686
MOD_Plk_2-3 358 364 PF00069 0.475
MOD_Plk_4 181 187 PF00069 0.624
MOD_Plk_4 294 300 PF00069 0.356
MOD_Plk_4 68 74 PF00069 0.560
MOD_Plk_4 86 92 PF00069 0.517
MOD_ProDKin_1 125 131 PF00069 0.649
MOD_ProDKin_1 458 464 PF00069 0.743
MOD_ProDKin_1 469 475 PF00069 0.808
MOD_SUMO_for_1 281 284 PF00179 0.234
MOD_SUMO_rev_2 8 15 PF00179 0.432
TRG_DiLeu_BaEn_1 17 22 PF01217 0.446
TRG_DiLeu_BaEn_2 99 105 PF01217 0.454
TRG_DiLeu_BaLyEn_6 192 197 PF01217 0.344
TRG_DiLeu_BaLyEn_6 329 334 PF01217 0.460
TRG_DiLeu_BaLyEn_6 364 369 PF01217 0.468
TRG_DiLeu_BaLyEn_6 416 421 PF01217 0.589
TRG_ENDOCYTIC_2 217 220 PF00928 0.257
TRG_ENDOCYTIC_2 31 34 PF00928 0.560
TRG_ENDOCYTIC_2 505 508 PF00928 0.489
TRG_ENDOCYTIC_2 70 73 PF00928 0.516
TRG_ER_diArg_1 193 195 PF00400 0.387
TRG_ER_diArg_1 279 281 PF00400 0.241
TRG_ER_diArg_1 313 315 PF00400 0.259
TRG_ER_diArg_1 331 333 PF00400 0.542
TRG_ER_diArg_1 365 367 PF00400 0.338
TRG_ER_diArg_1 530 533 PF00400 0.540
TRG_NES_CRM1_1 276 290 PF08389 0.331
TRG_NLS_Bipartite_1 314 334 PF00514 0.328
TRG_Pf-PMV_PEXEL_1 279 284 PF00026 0.390
TRG_Pf-PMV_PEXEL_1 332 337 PF00026 0.477
TRG_Pf-PMV_PEXEL_1 39 44 PF00026 0.520

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P643 Leptomonas seymouri 47% 100%
A0A0S4JUG1 Bodo saltans 32% 67%
A0A1X0P9Z1 Trypanosomatidae 41% 100%
A0A3Q8IIF1 Leishmania donovani 91% 99%
A0A3Q8IJS0 Leishmania donovani 31% 100%
A0A3R7KPY1 Trypanosoma rangeli 31% 100%
A0A422NNS9 Trypanosoma rangeli 45% 100%
A4HB54 Leishmania braziliensis 76% 100%
A4HME8 Leishmania braziliensis 35% 100%
A4IAA1 Leishmania infantum 91% 99%
A4IE38 Leishmania infantum 31% 100%
C9ZLZ3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
Q4Q0X8 Leishmania major 31% 100%
Q4Q2K9 Leishmania major 92% 100%
V5B5D2 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS