Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5C3_LEIMU

TriTrypDb:

LmxM.33.3340

Length:

819

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5C3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	596	600	PF00656	0.718
CLV_C14_Caspase3-7	668	672	PF00656	0.590
CLV_C14_Caspase3-7	719	723	PF00656	0.552
CLV_NRD_NRD_1	121	123	PF00675	0.532
CLV_NRD_NRD_1	292	294	PF00675	0.719
CLV_NRD_NRD_1	655	657	PF00675	0.582
CLV_NRD_NRD_1	665	667	PF00675	0.554
CLV_NRD_NRD_1	736	738	PF00675	0.763
CLV_NRD_NRD_1	800	802	PF00675	0.457
CLV_PCSK_KEX2_1	121	123	PF00082	0.809
CLV_PCSK_KEX2_1	549	551	PF00082	0.767
CLV_PCSK_KEX2_1	560	562	PF00082	0.603
CLV_PCSK_KEX2_1	655	657	PF00082	0.582
CLV_PCSK_KEX2_1	665	667	PF00082	0.554
CLV_PCSK_KEX2_1	736	738	PF00082	0.691
CLV_PCSK_KEX2_1	800	802	PF00082	0.457
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.592
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.524
CLV_PCSK_PC7_1	117	123	PF00082	0.533
CLV_PCSK_SKI1_1	155	159	PF00082	0.640
CLV_PCSK_SKI1_1	194	198	PF00082	0.644
CLV_PCSK_SKI1_1	274	278	PF00082	0.626
CLV_PCSK_SKI1_1	423	427	PF00082	0.551
CLV_PCSK_SKI1_1	550	554	PF00082	0.667
CLV_PCSK_SKI1_1	655	659	PF00082	0.576
DEG_SPOP_SBC_1	46	50	PF00917	0.498
DEG_SPOP_SBC_1	637	641	PF00917	0.532
DEG_SPOP_SBC_1	768	772	PF00917	0.518
DOC_CKS1_1	168	173	PF01111	0.654
DOC_CKS1_1	518	523	PF01111	0.502
DOC_CKS1_1	651	656	PF01111	0.703
DOC_CYCLIN_RxL_1	653	663	PF00134	0.703
DOC_CYCLIN_yCln2_LP_2	28	31	PF00134	0.523
DOC_MAPK_gen_1	190	199	PF00069	0.637
DOC_MAPK_gen_1	549	555	PF00069	0.774
DOC_MAPK_MEF2A_6	3	12	PF00069	0.511
DOC_MAPK_MEF2A_6	702	710	PF00069	0.732
DOC_PP1_RVXF_1	583	589	PF00149	0.580
DOC_PP1_RVXF_1	654	661	PF00149	0.625
DOC_PP2B_LxvP_1	28	31	PF13499	0.523
DOC_PP4_FxxP_1	157	160	PF00568	0.710
DOC_USP7_MATH_1	138	142	PF00917	0.717
DOC_USP7_MATH_1	298	302	PF00917	0.763
DOC_USP7_MATH_1	31	35	PF00917	0.566
DOC_USP7_MATH_1	421	425	PF00917	0.572
DOC_USP7_MATH_1	475	479	PF00917	0.676
DOC_USP7_MATH_1	482	486	PF00917	0.788
DOC_USP7_MATH_1	587	591	PF00917	0.705
DOC_WW_Pin1_4	133	138	PF00397	0.719
DOC_WW_Pin1_4	167	172	PF00397	0.707
DOC_WW_Pin1_4	206	211	PF00397	0.762
DOC_WW_Pin1_4	260	265	PF00397	0.777
DOC_WW_Pin1_4	294	299	PF00397	0.662
DOC_WW_Pin1_4	440	445	PF00397	0.665
DOC_WW_Pin1_4	47	52	PF00397	0.499
DOC_WW_Pin1_4	517	522	PF00397	0.523
DOC_WW_Pin1_4	573	578	PF00397	0.712
DOC_WW_Pin1_4	613	618	PF00397	0.692
DOC_WW_Pin1_4	650	655	PF00397	0.653
DOC_WW_Pin1_4	697	702	PF00397	0.695
DOC_WW_Pin1_4	757	762	PF00397	0.642
LIG_14-3-3_CanoR_1	112	119	PF00244	0.740
LIG_14-3-3_CanoR_1	200	210	PF00244	0.731
LIG_14-3-3_CanoR_1	468	474	PF00244	0.816
LIG_14-3-3_CanoR_1	561	571	PF00244	0.567
LIG_14-3-3_CanoR_1	60	69	PF00244	0.552
LIG_14-3-3_CanoR_1	7	11	PF00244	0.594
LIG_14-3-3_CanoR_1	736	742	PF00244	0.681
LIG_14-3-3_CanoR_1	754	759	PF00244	0.545
LIG_Actin_WH2_2	261	276	PF00022	0.663
LIG_Actin_WH2_2	97	114	PF00022	0.748
LIG_BIR_II_1	1	5	PF00653	0.569
LIG_BIR_III_2	356	360	PF00653	0.762
LIG_BRCT_BRCA1_1	780	784	PF00533	0.660
LIG_BRCT_BRCA1_2	780	786	PF00533	0.665
LIG_deltaCOP1_diTrp_1	149	158	PF00928	0.590
LIG_deltaCOP1_diTrp_1	310	319	PF00928	0.666
LIG_FAT_LD_1	809	817	PF03623	0.504
LIG_FHA_1	101	107	PF00498	0.661
LIG_FHA_1	142	148	PF00498	0.643
LIG_FHA_1	161	167	PF00498	0.762
LIG_FHA_1	275	281	PF00498	0.659
LIG_FHA_1	311	317	PF00498	0.746
LIG_FHA_1	490	496	PF00498	0.521
LIG_FHA_1	726	732	PF00498	0.795
LIG_FHA_1	738	744	PF00498	0.550
LIG_FHA_1	761	767	PF00498	0.665
LIG_FHA_1	77	83	PF00498	0.579
LIG_FHA_2	351	357	PF00498	0.682
LIG_FHA_2	629	635	PF00498	0.708
LIG_FHA_2	638	644	PF00498	0.535
LIG_FHA_2	717	723	PF00498	0.543
LIG_LIR_Apic_2	472	477	PF02991	0.740
LIG_LIR_Apic_2	756	761	PF02991	0.576
LIG_LIR_Gen_1	239	246	PF02991	0.669
LIG_LIR_Gen_1	37	46	PF02991	0.520
LIG_LIR_Gen_1	410	420	PF02991	0.526
LIG_LIR_Gen_1	548	559	PF02991	0.691
LIG_LIR_Gen_1	738	749	PF02991	0.724
LIG_LIR_Gen_1	781	791	PF02991	0.660
LIG_LIR_Nem_3	180	184	PF02991	0.508
LIG_LIR_Nem_3	239	243	PF02991	0.665
LIG_LIR_Nem_3	37	41	PF02991	0.507
LIG_LIR_Nem_3	395	401	PF02991	0.498
LIG_LIR_Nem_3	4	8	PF02991	0.492
LIG_LIR_Nem_3	410	415	PF02991	0.627
LIG_LIR_Nem_3	548	554	PF02991	0.772
LIG_LIR_Nem_3	738	744	PF02991	0.651
LIG_LIR_Nem_3	781	787	PF02991	0.734
LIG_MYND_1	697	701	PF01753	0.584
LIG_MYND_3	507	511	PF01753	0.496
LIG_SH2_CRK	551	555	PF00017	0.773
LIG_SH2_STAP1	346	350	PF00017	0.727
LIG_SH2_STAP1	551	555	PF00017	0.773
LIG_SH2_STAT3	732	735	PF00017	0.779
LIG_SH2_STAT5	113	116	PF00017	0.602
LIG_SH2_STAT5	75	78	PF00017	0.568
LIG_SH3_3	165	171	PF00018	0.701
LIG_SH3_3	683	689	PF00018	0.753
LIG_SH3_3	698	704	PF00018	0.479
LIG_Sin3_3	626	633	PF02671	0.486
LIG_SUMO_SIM_anti_2	261	269	PF11976	0.742
LIG_SUMO_SIM_anti_2	37	43	PF11976	0.483
LIG_SUMO_SIM_par_1	195	201	PF11976	0.661
LIG_SUMO_SIM_par_1	590	596	PF11976	0.556
LIG_SUMO_SIM_par_1	68	73	PF11976	0.492
LIG_SUMO_SIM_par_1	738	746	PF11976	0.538
LIG_TRFH_1	157	161	PF08558	0.633
MOD_CDK_SPK_2	650	655	PF00069	0.623
MOD_CDK_SPK_2	697	702	PF00069	0.775
MOD_CDK_SPxK_1	440	446	PF00069	0.643
MOD_CDK_SPxK_1	650	656	PF00069	0.699
MOD_CK1_1	126	132	PF00069	0.677
MOD_CK1_1	136	142	PF00069	0.773
MOD_CK1_1	162	168	PF00069	0.748
MOD_CK1_1	201	207	PF00069	0.797
MOD_CK1_1	208	214	PF00069	0.725
MOD_CK1_1	263	269	PF00069	0.720
MOD_CK1_1	34	40	PF00069	0.536
MOD_CK1_1	453	459	PF00069	0.772
MOD_CK1_1	478	484	PF00069	0.809
MOD_CK1_1	573	579	PF00069	0.634
MOD_CK1_1	621	627	PF00069	0.573
MOD_CK1_1	638	644	PF00069	0.727
MOD_CK1_1	713	719	PF00069	0.606
MOD_CK1_1	739	745	PF00069	0.461
MOD_CK1_1	760	766	PF00069	0.708
MOD_CK1_1	81	87	PF00069	0.594
MOD_CK2_1	169	175	PF00069	0.719
MOD_CK2_1	628	634	PF00069	0.708
MOD_CK2_1	637	643	PF00069	0.544
MOD_CK2_1	712	718	PF00069	0.419
MOD_GlcNHglycan	140	143	PF01048	0.721
MOD_GlcNHglycan	200	203	PF01048	0.712
MOD_GlcNHglycan	205	208	PF01048	0.715
MOD_GlcNHglycan	232	236	PF01048	0.696
MOD_GlcNHglycan	31	34	PF01048	0.607
MOD_GlcNHglycan	339	342	PF01048	0.620
MOD_GlcNHglycan	404	407	PF01048	0.672
MOD_GlcNHglycan	423	426	PF01048	0.707
MOD_GlcNHglycan	480	483	PF01048	0.677
MOD_GlcNHglycan	527	531	PF01048	0.595
MOD_GlcNHglycan	557	560	PF01048	0.623
MOD_GlcNHglycan	572	575	PF01048	0.718
MOD_GlcNHglycan	589	592	PF01048	0.769
MOD_GlcNHglycan	65	68	PF01048	0.538
MOD_GlcNHglycan	712	715	PF01048	0.586
MOD_GlcNHglycan	722	726	PF01048	0.676
MOD_GSK3_1	113	120	PF00069	0.653
MOD_GSK3_1	141	148	PF00069	0.642
MOD_GSK3_1	162	169	PF00069	0.641
MOD_GSK3_1	201	208	PF00069	0.714
MOD_GSK3_1	241	248	PF00069	0.662
MOD_GSK3_1	259	266	PF00069	0.500
MOD_GSK3_1	294	301	PF00069	0.682
MOD_GSK3_1	335	342	PF00069	0.674
MOD_GSK3_1	346	353	PF00069	0.615
MOD_GSK3_1	449	456	PF00069	0.786
MOD_GSK3_1	478	485	PF00069	0.753
MOD_GSK3_1	498	505	PF00069	0.648
MOD_GSK3_1	562	569	PF00069	0.719
MOD_GSK3_1	587	594	PF00069	0.757
MOD_GSK3_1	609	616	PF00069	0.715
MOD_GSK3_1	665	672	PF00069	0.661
MOD_GSK3_1	712	719	PF00069	0.660
MOD_GSK3_1	721	728	PF00069	0.686
MOD_GSK3_1	73	80	PF00069	0.568
MOD_GSK3_1	735	742	PF00069	0.637
MOD_GSK3_1	753	760	PF00069	0.651
MOD_GSK3_1	764	771	PF00069	0.760
MOD_GSK3_1	82	89	PF00069	0.758
MOD_LATS_1	115	121	PF00433	0.628
MOD_LATS_1	664	670	PF00433	0.626
MOD_N-GLC_1	327	332	PF02516	0.468
MOD_N-GLC_1	478	483	PF02516	0.759
MOD_NEK2_1	1	6	PF00069	0.549
MOD_NEK2_1	111	116	PF00069	0.722
MOD_NEK2_1	198	203	PF00069	0.672
MOD_NEK2_1	502	507	PF00069	0.724
MOD_NEK2_1	572	577	PF00069	0.527
MOD_NEK2_1	660	665	PF00069	0.543
MOD_NEK2_1	710	715	PF00069	0.599
MOD_NEK2_1	77	82	PF00069	0.561
MOD_PIKK_1	327	333	PF00454	0.620
MOD_PIKK_1	438	444	PF00454	0.726
MOD_PIKK_1	90	96	PF00454	0.549
MOD_PKA_1	560	566	PF00069	0.613
MOD_PKA_1	665	671	PF00069	0.579
MOD_PKA_1	736	742	PF00069	0.753
MOD_PKA_2	111	117	PF00069	0.817
MOD_PKA_2	230	236	PF00069	0.702
MOD_PKA_2	241	247	PF00069	0.529
MOD_PKA_2	254	260	PF00069	0.571
MOD_PKA_2	560	566	PF00069	0.672
MOD_PKA_2	6	12	PF00069	0.592
MOD_PKA_2	665	671	PF00069	0.633
MOD_PKA_2	735	741	PF00069	0.755
MOD_PKA_2	753	759	PF00069	0.472
MOD_PKA_2	778	784	PF00069	0.456
MOD_PKB_1	229	237	PF00069	0.702
MOD_Plk_1	148	154	PF00069	0.513
MOD_Plk_1	231	237	PF00069	0.708
MOD_Plk_1	310	316	PF00069	0.665
MOD_Plk_1	327	333	PF00069	0.468
MOD_Plk_1	394	400	PF00069	0.764
MOD_Plk_4	263	269	PF00069	0.751
MOD_Plk_4	34	40	PF00069	0.604
MOD_Plk_4	394	400	PF00069	0.662
MOD_Plk_4	469	475	PF00069	0.791
MOD_Plk_4	490	496	PF00069	0.682
MOD_Plk_4	498	504	PF00069	0.591
MOD_Plk_4	6	12	PF00069	0.592
MOD_Plk_4	747	753	PF00069	0.735
MOD_Plk_4	78	84	PF00069	0.580
MOD_Plk_4	808	814	PF00069	0.420
MOD_ProDKin_1	133	139	PF00069	0.717
MOD_ProDKin_1	167	173	PF00069	0.702
MOD_ProDKin_1	206	212	PF00069	0.761
MOD_ProDKin_1	260	266	PF00069	0.775
MOD_ProDKin_1	294	300	PF00069	0.661
MOD_ProDKin_1	440	446	PF00069	0.669
MOD_ProDKin_1	47	53	PF00069	0.502
MOD_ProDKin_1	517	523	PF00069	0.522
MOD_ProDKin_1	573	579	PF00069	0.712
MOD_ProDKin_1	613	619	PF00069	0.696
MOD_ProDKin_1	650	656	PF00069	0.651
MOD_ProDKin_1	697	703	PF00069	0.688
MOD_ProDKin_1	757	763	PF00069	0.644
MOD_SUMO_rev_2	581	587	PF00179	0.581
TRG_DiLeu_BaEn_2	518	524	PF01217	0.719
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.615
TRG_DiLeu_BaLyEn_6	694	699	PF01217	0.713
TRG_DiLeu_BaLyEn_6	703	708	PF01217	0.609
TRG_ENDOCYTIC_2	551	554	PF00928	0.770
TRG_ER_diArg_1	654	656	PF00400	0.587
TRG_ER_diArg_1	800	802	PF00400	0.457
TRG_Pf-PMV_PEXEL_1	655	659	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	729	734	PF00026	0.714
TRG_Pf-PMV_PEXEL_1	800	804	PF00026	0.736

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q0	Leptomonas seymouri	31%	100%
A0A3S7X8B8	Leishmania donovani	82%	100%
A4HB53	Leishmania braziliensis	64%	99%
E9AHT9	Leishmania infantum	82%	100%
Q4Q2L0	Leishmania major	81%	100%