Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5C0_LEIMU

TriTrypDb:

LmxM.33.3310

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

E9B5C0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5C0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.524
CLV_NRD_NRD_1	250	252	PF00675	0.468
CLV_NRD_NRD_1	339	341	PF00675	0.395
CLV_PCSK_KEX2_1	250	252	PF00082	0.468
CLV_PCSK_KEX2_1	305	307	PF00082	0.257
CLV_PCSK_KEX2_1	339	341	PF00082	0.395
CLV_PCSK_KEX2_1	57	59	PF00082	0.616
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.257
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.495
CLV_PCSK_SKI1_1	156	160	PF00082	0.689
CLV_PCSK_SKI1_1	392	396	PF00082	0.451
CLV_PCSK_SKI1_1	397	401	PF00082	0.381
CLV_PCSK_SKI1_1	466	470	PF00082	0.547
DEG_APCC_DBOX_1	419	427	PF00400	0.306
DEG_Nend_UBRbox_2	1	3	PF02207	0.683
DOC_CDC14_PxL_1	387	395	PF14671	0.405
DOC_CKS1_1	195	200	PF01111	0.637
DOC_CYCLIN_RxL_1	392	403	PF00134	0.407
DOC_MAPK_gen_1	392	401	PF00069	0.447
DOC_MAPK_MEF2A_6	392	400	PF00069	0.415
DOC_MAPK_MEF2A_6	420	428	PF00069	0.459
DOC_PP4_FxxP_1	134	137	PF00568	0.530
DOC_PP4_FxxP_1	235	238	PF00568	0.486
DOC_PP4_FxxP_1	31	34	PF00568	0.615
DOC_SPAK_OSR1_1	104	108	PF12202	0.319
DOC_USP7_MATH_1	151	155	PF00917	0.607
DOC_USP7_MATH_1	206	210	PF00917	0.396
DOC_USP7_MATH_1	3	7	PF00917	0.622
DOC_USP7_MATH_1	381	385	PF00917	0.448
DOC_WW_Pin1_4	171	176	PF00397	0.524
DOC_WW_Pin1_4	194	199	PF00397	0.653
DOC_WW_Pin1_4	234	239	PF00397	0.216
DOC_WW_Pin1_4	261	266	PF00397	0.397
DOC_WW_Pin1_4	484	489	PF00397	0.426
LIG_14-3-3_CanoR_1	339	344	PF00244	0.370
LIG_14-3-3_CanoR_1	58	64	PF00244	0.462
LIG_14-3-3_CanoR_1	74	83	PF00244	0.574
LIG_14-3-3_CanoR_1	8	15	PF00244	0.778
LIG_14-3-3_CanoR_1	93	103	PF00244	0.323
LIG_Actin_WH2_2	461	477	PF00022	0.412
LIG_Actin_WH2_2	95	113	PF00022	0.335
LIG_BRCT_BRCA1_1	231	235	PF00533	0.471
LIG_deltaCOP1_diTrp_1	127	134	PF00928	0.420
LIG_eIF4E_1	135	141	PF01652	0.517
LIG_FHA_1	153	159	PF00498	0.694
LIG_FHA_1	195	201	PF00498	0.640
LIG_FHA_1	221	227	PF00498	0.542
LIG_FHA_1	328	334	PF00498	0.363
LIG_FHA_1	381	387	PF00498	0.455
LIG_FHA_1	419	425	PF00498	0.530
LIG_FHA_1	497	503	PF00498	0.564
LIG_FHA_2	347	353	PF00498	0.530
LIG_FHA_2	441	447	PF00498	0.493
LIG_FHA_2	508	514	PF00498	0.488
LIG_FHA_2	79	85	PF00498	0.433
LIG_FHA_2	95	101	PF00498	0.469
LIG_LIR_Apic_2	118	122	PF02991	0.411
LIG_LIR_Apic_2	131	137	PF02991	0.420
LIG_LIR_Apic_2	232	238	PF02991	0.461
LIG_LIR_Gen_1	315	326	PF02991	0.398
LIG_LIR_Gen_1	332	343	PF02991	0.398
LIG_LIR_Gen_1	354	362	PF02991	0.276
LIG_LIR_Gen_1	372	381	PF02991	0.406
LIG_LIR_Gen_1	478	488	PF02991	0.390
LIG_LIR_Gen_1	97	107	PF02991	0.425
LIG_LIR_Nem_3	193	199	PF02991	0.568
LIG_LIR_Nem_3	2	7	PF02991	0.542
LIG_LIR_Nem_3	247	252	PF02991	0.462
LIG_LIR_Nem_3	315	321	PF02991	0.368
LIG_LIR_Nem_3	332	338	PF02991	0.359
LIG_LIR_Nem_3	354	360	PF02991	0.258
LIG_LIR_Nem_3	372	378	PF02991	0.438
LIG_LIR_Nem_3	408	414	PF02991	0.464
LIG_LIR_Nem_3	469	474	PF02991	0.500
LIG_LIR_Nem_3	478	483	PF02991	0.313
LIG_LIR_Nem_3	504	509	PF02991	0.576
LIG_LIR_Nem_3	97	102	PF02991	0.459
LIG_NRBOX	292	298	PF00104	0.327
LIG_NRBOX	355	361	PF00104	0.469
LIG_NRBOX	395	401	PF00104	0.371
LIG_PCNA_PIPBox_1	465	474	PF02747	0.335
LIG_PCNA_yPIPBox_3	465	475	PF02747	0.338
LIG_Pex14_2	134	138	PF04695	0.482
LIG_Pex14_2	479	483	PF04695	0.356
LIG_PTB_Apo_2	473	480	PF02174	0.528
LIG_SH2_CRK	196	200	PF00017	0.577
LIG_SH2_CRK	375	379	PF00017	0.375
LIG_SH2_NCK_1	162	166	PF00017	0.443
LIG_SH2_STAP1	440	444	PF00017	0.492
LIG_SH2_STAT5	162	165	PF00017	0.468
LIG_SH2_STAT5	173	176	PF00017	0.482
LIG_SH2_STAT5	196	199	PF00017	0.516
LIG_SH2_STAT5	302	305	PF00017	0.441
LIG_SH2_STAT5	375	378	PF00017	0.358
LIG_SH2_STAT5	389	392	PF00017	0.340
LIG_SH2_STAT5	471	474	PF00017	0.574
LIG_SH3_3	401	407	PF00018	0.359
LIG_Sin3_3	291	298	PF02671	0.345
LIG_SUMO_SIM_anti_2	274	282	PF11976	0.409
LIG_SUMO_SIM_par_1	197	202	PF11976	0.585
LIG_SUMO_SIM_par_1	274	282	PF11976	0.558
LIG_SUMO_SIM_par_1	397	403	PF11976	0.351
LIG_TRAF2_1	124	127	PF00917	0.529
LIG_TRAF2_1	20	23	PF00917	0.685
LIG_TRAF2_1	443	446	PF00917	0.434
LIG_TYR_ITIM	316	321	PF00017	0.333
LIG_TYR_ITIM	373	378	PF00017	0.348
LIG_UBA3_1	102	109	PF00899	0.457
LIG_UBA3_1	296	305	PF00899	0.372
LIG_UBA3_1	386	395	PF00899	0.454
MOD_CDC14_SPxK_1	237	240	PF00782	0.201
MOD_CDC14_SPxK_1	487	490	PF00782	0.286
MOD_CDK_SPK_2	171	176	PF00069	0.442
MOD_CDK_SPxK_1	234	240	PF00069	0.215
MOD_CDK_SPxK_1	484	490	PF00069	0.280
MOD_CK1_1	154	160	PF00069	0.728
MOD_CK1_1	164	170	PF00069	0.510
MOD_CK1_1	276	282	PF00069	0.456
MOD_CK1_1	91	97	PF00069	0.432
MOD_CK2_1	352	358	PF00069	0.501
MOD_CK2_1	440	446	PF00069	0.497
MOD_CK2_1	94	100	PF00069	0.486
MOD_GlcNHglycan	143	146	PF01048	0.410
MOD_GlcNHglycan	163	166	PF01048	0.581
MOD_GlcNHglycan	231	234	PF01048	0.470
MOD_GlcNHglycan	271	274	PF01048	0.490
MOD_GlcNHglycan	289	292	PF01048	0.437
MOD_GlcNHglycan	378	381	PF01048	0.481
MOD_GlcNHglycan	383	386	PF01048	0.446
MOD_GlcNHglycan	407	410	PF01048	0.488
MOD_GlcNHglycan	434	437	PF01048	0.472
MOD_GSK3_1	11	18	PF00069	0.709
MOD_GSK3_1	160	167	PF00069	0.726
MOD_GSK3_1	253	260	PF00069	0.544
MOD_GSK3_1	269	276	PF00069	0.663
MOD_GSK3_1	3	10	PF00069	0.744
MOD_GSK3_1	310	317	PF00069	0.449
MOD_GSK3_1	329	336	PF00069	0.457
MOD_GSK3_1	347	354	PF00069	0.509
MOD_GSK3_1	376	383	PF00069	0.328
MOD_GSK3_1	74	81	PF00069	0.496
MOD_GSK3_1	91	98	PF00069	0.390
MOD_N-GLC_1	160	165	PF02516	0.538
MOD_N-GLC_1	475	480	PF02516	0.474
MOD_NEK2_1	110	115	PF00069	0.459
MOD_NEK2_1	160	165	PF00069	0.673
MOD_NEK2_1	229	234	PF00069	0.470
MOD_NEK2_1	314	319	PF00069	0.340
MOD_NEK2_1	321	326	PF00069	0.338
MOD_NEK2_1	329	334	PF00069	0.274
MOD_NEK2_1	371	376	PF00069	0.339
MOD_NEK2_1	495	500	PF00069	0.625
MOD_NEK2_1	88	93	PF00069	0.496
MOD_NEK2_2	3	8	PF00069	0.609
MOD_PIKK_1	206	212	PF00454	0.472
MOD_PIKK_1	327	333	PF00454	0.425
MOD_PKA_1	339	345	PF00069	0.392
MOD_PKA_2	110	116	PF00069	0.459
MOD_PKA_2	339	345	PF00069	0.376
MOD_PKA_2	7	13	PF00069	0.773
MOD_PKA_2	73	79	PF00069	0.576
MOD_Plk_1	201	207	PF00069	0.530
MOD_Plk_1	273	279	PF00069	0.528
MOD_Plk_1	314	320	PF00069	0.315
MOD_Plk_1	371	377	PF00069	0.469
MOD_Plk_1	466	472	PF00069	0.551
MOD_Plk_1	475	481	PF00069	0.531
MOD_Plk_2-3	352	358	PF00069	0.464
MOD_Plk_2-3	78	84	PF00069	0.414
MOD_Plk_4	273	279	PF00069	0.539
MOD_Plk_4	322	328	PF00069	0.387
MOD_Plk_4	352	358	PF00069	0.298
MOD_Plk_4	467	473	PF00069	0.479
MOD_Plk_4	475	481	PF00069	0.358
MOD_Plk_4	59	65	PF00069	0.469
MOD_ProDKin_1	171	177	PF00069	0.522
MOD_ProDKin_1	194	200	PF00069	0.642
MOD_ProDKin_1	234	240	PF00069	0.212
MOD_ProDKin_1	261	267	PF00069	0.403
MOD_ProDKin_1	484	490	PF00069	0.424
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.476
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.457
TRG_ENDOCYTIC_2	196	199	PF00928	0.506
TRG_ENDOCYTIC_2	318	321	PF00928	0.333
TRG_ENDOCYTIC_2	357	360	PF00928	0.330
TRG_ENDOCYTIC_2	375	378	PF00928	0.366
TRG_ENDOCYTIC_2	471	474	PF00928	0.632
TRG_ENDOCYTIC_2	506	509	PF00928	0.512
TRG_ER_diArg_1	249	251	PF00400	0.463
TRG_ER_diArg_1	338	340	PF00400	0.390
TRG_ER_diArg_1	449	452	PF00400	0.499
TRG_ER_FFAT_2	157	168	PF00635	0.445
TRG_NES_CRM1_1	388	403	PF08389	0.413
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	397	402	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I9	Leptomonas seymouri	40%	95%
A0A1X0P9X1	Trypanosomatidae	28%	100%
A0A3R7RMD9	Trypanosoma rangeli	29%	100%
A0A3S7X887	Leishmania donovani	85%	99%
A4HB50	Leishmania braziliensis	63%	99%
A4IA98	Leishmania infantum	85%	99%
C9ZLZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4Q2L3	Leishmania major	85%	100%
V5BV51	Trypanosoma cruzi	29%	100%