Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5B8_LEIMU

TriTrypDb:

LmxM.33.3290

Length:

477

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5B8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5B8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.464
CLV_NRD_NRD_1	165	167	PF00675	0.620
CLV_NRD_NRD_1	205	207	PF00675	0.565
CLV_PCSK_KEX2_1	165	167	PF00082	0.583
CLV_PCSK_KEX2_1	205	207	PF00082	0.553
CLV_PCSK_KEX2_1	469	471	PF00082	0.511
CLV_PCSK_PC1ET2_1	469	471	PF00082	0.511
CLV_PCSK_SKI1_1	108	112	PF00082	0.603
CLV_PCSK_SKI1_1	123	127	PF00082	0.543
CLV_PCSK_SKI1_1	166	170	PF00082	0.589
CLV_PCSK_SKI1_1	179	183	PF00082	0.621
CLV_PCSK_SKI1_1	256	260	PF00082	0.599
DEG_APCC_DBOX_1	178	186	PF00400	0.467
DOC_ANK_TNKS_1	323	330	PF00023	0.436
DOC_CYCLIN_yCln2_LP_2	181	184	PF00134	0.378
DOC_PP1_RVXF_1	233	240	PF00149	0.484
DOC_PP1_RVXF_1	360	366	PF00149	0.411
DOC_PP2B_LxvP_1	126	129	PF13499	0.428
DOC_PP2B_LxvP_1	181	184	PF13499	0.378
DOC_USP7_MATH_1	155	159	PF00917	0.402
DOC_USP7_MATH_1	216	220	PF00917	0.406
DOC_USP7_MATH_1	458	462	PF00917	0.589
DOC_USP7_MATH_1	87	91	PF00917	0.525
DOC_WW_Pin1_4	173	178	PF00397	0.435
DOC_WW_Pin1_4	401	406	PF00397	0.599
DOC_WW_Pin1_4	434	439	PF00397	0.669
DOC_WW_Pin1_4	83	88	PF00397	0.488
LIG_14-3-3_CanoR_1	200	207	PF00244	0.451
LIG_14-3-3_CanoR_1	290	295	PF00244	0.405
LIG_14-3-3_CanoR_1	324	328	PF00244	0.395
LIG_14-3-3_CanoR_1	347	357	PF00244	0.437
LIG_14-3-3_CanoR_1	36	44	PF00244	0.429
LIG_14-3-3_CanoR_1	362	368	PF00244	0.341
LIG_14-3-3_CanoR_1	387	396	PF00244	0.695
LIG_14-3-3_CanoR_1	459	467	PF00244	0.602
LIG_14-3-3_CanoR_1	76	80	PF00244	0.364
LIG_Actin_WH2_2	382	399	PF00022	0.685
LIG_BIR_II_1	1	5	PF00653	0.387
LIG_BRCT_BRCA1_1	305	309	PF00533	0.494
LIG_Clathr_ClatBox_1	110	114	PF01394	0.419
LIG_CtBP_PxDLS_1	438	442	PF00389	0.687
LIG_deltaCOP1_diTrp_1	104	113	PF00928	0.343
LIG_FHA_1	249	255	PF00498	0.319
LIG_FHA_1	25	31	PF00498	0.505
LIG_FHA_1	349	355	PF00498	0.455
LIG_FHA_1	425	431	PF00498	0.655
LIG_FHA_1	446	452	PF00498	0.647
LIG_FHA_1	65	71	PF00498	0.313
LIG_FHA_2	421	427	PF00498	0.706
LIG_FHA_2	49	55	PF00498	0.452
LIG_LIR_Gen_1	190	197	PF02991	0.471
LIG_LIR_Gen_1	199	207	PF02991	0.452
LIG_LIR_Gen_1	236	246	PF02991	0.368
LIG_LIR_Gen_1	366	375	PF02991	0.358
LIG_LIR_Gen_1	426	436	PF02991	0.681
LIG_LIR_Gen_1	43	49	PF02991	0.365
LIG_LIR_Nem_3	190	194	PF02991	0.458
LIG_LIR_Nem_3	199	204	PF02991	0.441
LIG_LIR_Nem_3	236	242	PF02991	0.397
LIG_LIR_Nem_3	366	370	PF02991	0.346
LIG_LIR_Nem_3	426	432	PF02991	0.686
LIG_LIR_Nem_3	43	47	PF02991	0.361
LIG_MLH1_MIPbox_1	306	310	PF16413	0.490
LIG_MYND_3	379	383	PF01753	0.676
LIG_Pex14_1	109	113	PF04695	0.262
LIG_Pex14_1	453	457	PF04695	0.623
LIG_Pex14_2	194	198	PF04695	0.398
LIG_REV1ctd_RIR_1	157	166	PF16727	0.363
LIG_SH2_STAP1	44	48	PF00017	0.444
LIG_SH2_STAT5	44	47	PF00017	0.454
LIG_SH3_3	374	380	PF00018	0.358
LIG_SUMO_SIM_anti_2	217	227	PF11976	0.390
LIG_SUMO_SIM_anti_2	67	72	PF11976	0.273
LIG_SUMO_SIM_par_1	114	122	PF11976	0.427
LIG_SUMO_SIM_par_1	26	31	PF11976	0.499
LIG_SUMO_SIM_par_1	356	361	PF11976	0.311
LIG_SUMO_SIM_par_1	437	443	PF11976	0.538
LIG_TRAF2_1	412	415	PF00917	0.681
LIG_TRAF2_1	423	426	PF00917	0.722
LIG_TRAF2_1	61	64	PF00917	0.434
LIG_UBA3_1	37	46	PF00899	0.431
LIG_WRC_WIRS_1	156	161	PF05994	0.402
MOD_CDK_SPxK_1	173	179	PF00069	0.441
MOD_CK1_1	199	205	PF00069	0.447
MOD_CK1_1	248	254	PF00069	0.328
MOD_CK1_1	302	308	PF00069	0.443
MOD_CK1_1	90	96	PF00069	0.536
MOD_CK2_1	418	424	PF00069	0.718
MOD_CK2_1	437	443	PF00069	0.527
MOD_CK2_1	90	96	PF00069	0.405
MOD_CMANNOS	106	109	PF00535	0.535
MOD_CMANNOS	364	367	PF00535	0.411
MOD_GlcNHglycan	145	148	PF01048	0.622
MOD_GlcNHglycan	313	317	PF01048	0.637
MOD_GlcNHglycan	38	41	PF01048	0.662
MOD_GlcNHglycan	391	394	PF01048	0.442
MOD_GlcNHglycan	414	419	PF01048	0.542
MOD_GlcNHglycan	445	448	PF01048	0.449
MOD_GlcNHglycan	56	60	PF01048	0.576
MOD_GlcNHglycan	92	95	PF01048	0.752
MOD_GSK3_1	173	180	PF00069	0.438
MOD_GSK3_1	248	255	PF00069	0.329
MOD_GSK3_1	297	304	PF00069	0.437
MOD_GSK3_1	36	43	PF00069	0.440
MOD_GSK3_1	401	408	PF00069	0.653
MOD_GSK3_1	414	421	PF00069	0.756
MOD_GSK3_1	439	446	PF00069	0.681
MOD_GSK3_1	468	475	PF00069	0.571
MOD_GSK3_1	48	55	PF00069	0.428
MOD_GSK3_1	83	90	PF00069	0.504
MOD_N-GLC_1	297	302	PF02516	0.607
MOD_NEK2_1	187	192	PF00069	0.357
MOD_NEK2_1	259	264	PF00069	0.456
MOD_NEK2_1	363	368	PF00069	0.478
MOD_NEK2_1	382	387	PF00069	0.519
MOD_NEK2_1	389	394	PF00069	0.632
MOD_NEK2_2	155	160	PF00069	0.401
MOD_PIKK_1	112	118	PF00454	0.380
MOD_PIKK_1	297	303	PF00454	0.433
MOD_PK_1	136	142	PF00069	0.340
MOD_PKA_2	199	205	PF00069	0.429
MOD_PKA_2	323	329	PF00069	0.400
MOD_PKA_2	458	464	PF00069	0.605
MOD_PKA_2	75	81	PF00069	0.364
MOD_Plk_1	216	222	PF00069	0.390
MOD_Plk_1	382	388	PF00069	0.677
MOD_Plk_2-3	26	32	PF00069	0.454
MOD_Plk_4	136	142	PF00069	0.347
MOD_Plk_4	155	161	PF00069	0.383
MOD_Plk_4	424	430	PF00069	0.658
MOD_Plk_4	66	72	PF00069	0.360
MOD_ProDKin_1	173	179	PF00069	0.441
MOD_ProDKin_1	401	407	PF00069	0.600
MOD_ProDKin_1	434	440	PF00069	0.667
MOD_ProDKin_1	83	89	PF00069	0.490
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.438
TRG_ENDOCYTIC_2	191	194	PF00928	0.413
TRG_ENDOCYTIC_2	44	47	PF00928	0.361
TRG_ER_diArg_1	204	206	PF00400	0.349
TRG_ER_diArg_1	289	292	PF00400	0.394
TRG_NES_CRM1_1	321	335	PF08389	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P448	Leptomonas seymouri	33%	96%
A0A3S7X8E6	Leishmania donovani	85%	100%
A4HB48	Leishmania braziliensis	67%	100%
A4IA96	Leishmania infantum	85%	100%
Q4Q2L5	Leishmania major	84%	100%