UBP-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zn-finger in ubiquitin-hydrolases and other protein, putative

Species:

Leishmania mexicana

UniProt:

E9B5B7_LEIMU

TriTrypDb:

LmxM.33.3280

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5B7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5B7

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007165	signal transduction	2	1
GO:0007264	small GTPase mediated signal transduction	4	1
GO:0007265	Ras protein signal transduction	5	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.551
CLV_C14_Caspase3-7	67	71	PF00656	0.601
CLV_NRD_NRD_1	127	129	PF00675	0.528
CLV_NRD_NRD_1	357	359	PF00675	0.568
CLV_NRD_NRD_1	431	433	PF00675	0.565
CLV_NRD_NRD_1	466	468	PF00675	0.678
CLV_PCSK_KEX2_1	127	129	PF00082	0.528
CLV_PCSK_KEX2_1	292	294	PF00082	0.494
CLV_PCSK_KEX2_1	356	358	PF00082	0.559
CLV_PCSK_KEX2_1	431	433	PF00082	0.597
CLV_PCSK_KEX2_1	465	467	PF00082	0.698
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.537
CLV_PCSK_SKI1_1	272	276	PF00082	0.614
CLV_PCSK_SKI1_1	292	296	PF00082	0.269
CLV_PCSK_SKI1_1	30	34	PF00082	0.265
CLV_PCSK_SKI1_1	368	372	PF00082	0.565
CLV_PCSK_SKI1_1	392	396	PF00082	0.533
CLV_PCSK_SKI1_1	414	418	PF00082	0.571
CLV_PCSK_SKI1_1	444	448	PF00082	0.707
DEG_Nend_UBRbox_2	1	3	PF02207	0.538
DEG_SPOP_SBC_1	49	53	PF00917	0.556
DOC_MAPK_MEF2A_6	158	166	PF00069	0.514
DOC_USP7_MATH_1	12	16	PF00917	0.615
DOC_USP7_MATH_1	145	149	PF00917	0.517
DOC_USP7_MATH_1	25	29	PF00917	0.502
DOC_USP7_MATH_1	345	349	PF00917	0.593
DOC_USP7_MATH_1	394	398	PF00917	0.576
DOC_USP7_UBL2_3	260	264	PF12436	0.568
DOC_USP7_UBL2_3	269	273	PF12436	0.483
DOC_WW_Pin1_4	252	257	PF00397	0.719
DOC_WW_Pin1_4	322	327	PF00397	0.672
DOC_WW_Pin1_4	98	103	PF00397	0.571
LIG_14-3-3_CanoR_1	356	365	PF00244	0.505
LIG_14-3-3_CanoR_1	408	416	PF00244	0.476
LIG_14-3-3_CanoR_1	50	55	PF00244	0.571
LIG_Actin_WH2_2	381	398	PF00022	0.505
LIG_AP2alpha_2	161	163	PF02296	0.464
LIG_EH1_1	210	218	PF00400	0.611
LIG_FHA_1	114	120	PF00498	0.552
LIG_FHA_1	196	202	PF00498	0.452
LIG_FHA_1	358	364	PF00498	0.589
LIG_FHA_1	379	385	PF00498	0.550
LIG_FHA_2	374	380	PF00498	0.586
LIG_FHA_2	417	423	PF00498	0.449
LIG_FHA_2	65	71	PF00498	0.625
LIG_LIR_Apic_2	75	81	PF02991	0.505
LIG_LIR_Gen_1	161	171	PF02991	0.454
LIG_LIR_Gen_1	174	181	PF02991	0.455
LIG_LIR_Gen_1	223	230	PF02991	0.681
LIG_LIR_Gen_1	335	343	PF02991	0.630
LIG_LIR_Nem_3	161	166	PF02991	0.454
LIG_LIR_Nem_3	223	229	PF02991	0.677
LIG_LIR_Nem_3	335	339	PF02991	0.620
LIG_LIR_Nem_3	340	346	PF02991	0.574
LIG_LIR_Nem_3	75	80	PF02991	0.497
LIG_RPA_C_Fungi	453	465	PF08784	0.464
LIG_SH2_CRK	281	285	PF00017	0.581
LIG_SH2_STAP1	270	274	PF00017	0.547
LIG_SH2_STAP1	281	285	PF00017	0.425
LIG_SH2_STAP1	296	300	PF00017	0.476
LIG_SH2_STAT3	135	138	PF00017	0.535
LIG_SH2_STAT3	296	299	PF00017	0.592
LIG_SH2_STAT3	97	100	PF00017	0.630
LIG_SH2_STAT5	170	173	PF00017	0.360
LIG_SH2_STAT5	55	58	PF00017	0.583
LIG_SH2_STAT5	79	82	PF00017	0.471
LIG_SH3_1	78	84	PF00018	0.564
LIG_SH3_3	78	84	PF00018	0.564
LIG_SUMO_SIM_anti_2	31	37	PF11976	0.512
LIG_SUMO_SIM_anti_2	443	449	PF11976	0.624
LIG_SUMO_SIM_par_1	212	219	PF11976	0.486
LIG_TYR_ITSM	73	80	PF00017	0.527
MOD_CDK_SPK_2	322	327	PF00069	0.459
MOD_CK1_1	113	119	PF00069	0.604
MOD_CK1_1	390	396	PF00069	0.558
MOD_CK2_1	373	379	PF00069	0.557
MOD_CK2_1	409	415	PF00069	0.498
MOD_GlcNHglycan	108	111	PF01048	0.558
MOD_GlcNHglycan	147	150	PF01048	0.615
MOD_GlcNHglycan	16	19	PF01048	0.502
MOD_GlcNHglycan	244	247	PF01048	0.678
MOD_GlcNHglycan	266	269	PF01048	0.665
MOD_GlcNHglycan	94	97	PF01048	0.547
MOD_GSK3_1	102	109	PF00069	0.496
MOD_GSK3_1	216	223	PF00069	0.578
MOD_GSK3_1	390	397	PF00069	0.460
MOD_GSK3_1	92	99	PF00069	0.546
MOD_NEK2_1	118	123	PF00069	0.508
MOD_NEK2_1	216	221	PF00069	0.540
MOD_NEK2_1	274	279	PF00069	0.583
MOD_NEK2_1	295	300	PF00069	0.561
MOD_NEK2_1	337	342	PF00069	0.626
MOD_NEK2_1	407	412	PF00069	0.479
MOD_NEK2_1	416	421	PF00069	0.399
MOD_NEK2_1	90	95	PF00069	0.553
MOD_NEK2_2	25	30	PF00069	0.276
MOD_OFUCOSY	117	123	PF10250	0.431
MOD_PIKK_1	110	116	PF00454	0.401
MOD_PIKK_1	195	201	PF00454	0.309
MOD_PIKK_1	295	301	PF00454	0.599
MOD_PIKK_1	426	432	PF00454	0.581
MOD_PIKK_1	96	102	PF00454	0.650
MOD_PKA_1	272	278	PF00069	0.635
MOD_PKA_1	357	363	PF00069	0.560
MOD_PKA_1	465	471	PF00069	0.475
MOD_PKA_2	357	363	PF00069	0.508
MOD_PKA_2	407	413	PF00069	0.498
MOD_PKA_2	465	471	PF00069	0.760
MOD_PKA_2	49	55	PF00069	0.600
MOD_PKB_1	356	364	PF00069	0.331
MOD_Plk_1	379	385	PF00069	0.513
MOD_Plk_1	90	96	PF00069	0.568
MOD_Plk_4	222	228	PF00069	0.672
MOD_Plk_4	31	37	PF00069	0.482
MOD_Plk_4	345	351	PF00069	0.536
MOD_Plk_4	50	56	PF00069	0.602
MOD_Plk_4	73	79	PF00069	0.631
MOD_ProDKin_1	252	258	PF00069	0.716
MOD_ProDKin_1	322	328	PF00069	0.666
MOD_ProDKin_1	98	104	PF00069	0.562
MOD_SUMO_for_1	151	154	PF00179	0.511
MOD_SUMO_for_1	285	288	PF00179	0.549
MOD_SUMO_for_1	370	373	PF00179	0.522
MOD_SUMO_rev_2	257	266	PF00179	0.656
MOD_SUMO_rev_2	267	275	PF00179	0.579
MOD_SUMO_rev_2	287	294	PF00179	0.556
MOD_SUMO_rev_2	410	419	PF00179	0.524
TRG_DiLeu_BaEn_4	379	385	PF01217	0.596
TRG_ENDOCYTIC_2	176	179	PF00928	0.391
TRG_ENDOCYTIC_2	281	284	PF00928	0.572
TRG_ENDOCYTIC_2	336	339	PF00928	0.609
TRG_ENDOCYTIC_2	77	80	PF00928	0.482
TRG_ER_diArg_1	127	129	PF00400	0.528
TRG_ER_diArg_1	356	358	PF00400	0.333
TRG_ER_diArg_1	431	433	PF00400	0.568
TRG_ER_diArg_1	465	467	PF00400	0.666
TRG_NES_CRM1_1	27	41	PF08389	0.483
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	431	436	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAV0	Leptomonas seymouri	68%	80%
A0A0S4ILW6	Bodo saltans	31%	84%
A0A1X0PAX0	Trypanosomatidae	34%	94%
A0A3Q8IEL0	Leishmania donovani	94%	100%
A0A422NNH1	Trypanosoma rangeli	37%	97%
A4HB46	Leishmania braziliensis	84%	100%
A4IA95	Leishmania infantum	94%	82%
C9ZLZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	97%
O13747	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	88%
Q4Q2L6	Leishmania major	89%	99%
Q7Z569	Homo sapiens	23%	81%
Q95QN6	Caenorhabditis elegans	23%	81%
Q99MP8	Mus musculus	23%	81%
V5DLZ1	Trypanosoma cruzi	36%	95%