DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379), putative

Species:

Leishmania mexicana

UniProt:

E9B5B6_LEIMU

TriTrypDb:

LmxM.33.3270

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5B6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	46	48	PF00675	0.506
CLV_PCSK_FUR_1	172	176	PF00082	0.520
CLV_PCSK_KEX2_1	114	116	PF00082	0.300
CLV_PCSK_KEX2_1	174	176	PF00082	0.539
CLV_PCSK_KEX2_1	56	58	PF00082	0.554
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.300
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.539
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.554
DOC_CKS1_1	31	36	PF01111	0.658
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.555
DOC_MAPK_gen_1	172	181	PF00069	0.519
DOC_MAPK_gen_1	36	44	PF00069	0.529
DOC_MAPK_gen_1	47	54	PF00069	0.512
DOC_MAPK_RevD_3	160	175	PF00069	0.602
DOC_USP7_MATH_1	158	162	PF00917	0.420
DOC_USP7_MATH_1	17	21	PF00917	0.618
DOC_WW_Pin1_4	156	161	PF00397	0.562
DOC_WW_Pin1_4	18	23	PF00397	0.509
DOC_WW_Pin1_4	30	35	PF00397	0.607
LIG_14-3-3_CanoR_1	103	109	PF00244	0.376
LIG_14-3-3_CanoR_1	172	181	PF00244	0.637
LIG_14-3-3_CanoR_1	36	44	PF00244	0.509
LIG_APCC_ABBA_1	82	87	PF00400	0.325
LIG_BRCT_BRCA1_1	132	136	PF00533	0.493
LIG_FHA_1	157	163	PF00498	0.719
LIG_FHA_1	174	180	PF00498	0.578
LIG_FHA_1	39	45	PF00498	0.606
LIG_LIR_Apic_2	90	96	PF02991	0.394
LIG_LYPXL_S_1	84	88	PF13949	0.300
LIG_LYPXL_yS_3	85	88	PF13949	0.300
LIG_MAD2	115	123	PF02301	0.300
LIG_MYND_1	160	164	PF01753	0.604
LIG_MYND_1	169	173	PF01753	0.526
LIG_SH2_CRK	58	62	PF00017	0.578
LIG_SH2_STAP1	108	112	PF00017	0.184
LIG_SH3_3	16	22	PF00018	0.513
LIG_SH3_3	63	69	PF00018	0.511
MOD_CDK_SPxK_1	30	36	PF00069	0.559
MOD_CK1_1	18	24	PF00069	0.603
MOD_Cter_Amidation	54	57	PF01082	0.574
MOD_GlcNHglycan	144	147	PF01048	0.625
MOD_GlcNHglycan	154	157	PF01048	0.534
MOD_GSK3_1	104	111	PF00069	0.308
MOD_GSK3_1	152	159	PF00069	0.490
MOD_NEK2_1	130	135	PF00069	0.501
MOD_NEK2_1	23	28	PF00069	0.598
MOD_NEK2_2	6	11	PF00069	0.583
MOD_PIKK_1	24	30	PF00454	0.596
MOD_PKA_1	174	180	PF00069	0.633
MOD_PKA_2	174	180	PF00069	0.642
MOD_Plk_1	108	114	PF00069	0.258
MOD_Plk_4	158	164	PF00069	0.673
MOD_Plk_4	174	180	PF00069	0.626
MOD_ProDKin_1	156	162	PF00069	0.558
MOD_ProDKin_1	18	24	PF00069	0.511
MOD_ProDKin_1	30	36	PF00069	0.608
TRG_ENDOCYTIC_2	85	88	PF00928	0.322
TRG_ER_diArg_1	63	66	PF00400	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU88	Leptomonas seymouri	65%	92%
A0A1X0PA15	Trypanosomatidae	54%	100%
A0A3R7NSK5	Trypanosoma rangeli	57%	100%
A0A3S7X894	Leishmania donovani	87%	100%
A4HB45	Leishmania braziliensis	76%	100%
A4IA94	Leishmania infantum	88%	100%
C9ZM00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
Q4Q2L7	Leishmania major	90%	99%