DRMBL domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA repair metallo-beta-lactamase, putative

Species:

Leishmania mexicana

UniProt:

E9B5B5_LEIMU

TriTrypDb:

LmxM.33.3260

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

E9B5B5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5B5

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0009987	cellular process	1	11
GO:0033554	cellular response to stress	3	11
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0000723	telomere maintenance	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006303	double-strand break repair via nonhomologous end joining	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0016043	cellular component organization	3	1
GO:0031848	protection from non-homologous end joining at telomere	6	1
GO:0032200	telomere organization	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0036297	interstrand cross-link repair	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043247	telomere maintenance in response to DNA damage	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0051276	chromosome organization	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003684	damaged DNA binding	5	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0005488	binding	1	1
GO:0008409	5'-3' exonuclease activity	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0035312	5'-3' DNA exonuclease activity	7	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.441
CLV_C14_Caspase3-7	308	312	PF00656	0.543
CLV_C14_Caspase3-7	375	379	PF00656	0.584
CLV_C14_Caspase3-7	556	560	PF00656	0.527
CLV_MEL_PAP_1	512	518	PF00089	0.509
CLV_NRD_NRD_1	211	213	PF00675	0.356
CLV_NRD_NRD_1	343	345	PF00675	0.614
CLV_NRD_NRD_1	540	542	PF00675	0.685
CLV_NRD_NRD_1	589	591	PF00675	0.674
CLV_PCSK_KEX2_1	116	118	PF00082	0.733
CLV_PCSK_KEX2_1	211	213	PF00082	0.469
CLV_PCSK_KEX2_1	450	452	PF00082	0.281
CLV_PCSK_KEX2_1	540	542	PF00082	0.692
CLV_PCSK_KEX2_1	591	593	PF00082	0.772
CLV_PCSK_KEX2_1	630	632	PF00082	0.629
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.553
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.289
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.551
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.772
CLV_PCSK_PC1ET2_1	630	632	PF00082	0.666
CLV_PCSK_SKI1_1	155	159	PF00082	0.481
CLV_PCSK_SKI1_1	189	193	PF00082	0.390
CLV_PCSK_SKI1_1	229	233	PF00082	0.342
CLV_PCSK_SKI1_1	235	239	PF00082	0.374
CLV_PCSK_SKI1_1	276	280	PF00082	0.357
CLV_PCSK_SKI1_1	56	60	PF00082	0.233
CLV_Separin_Metazoa	186	190	PF03568	0.464
DEG_APCC_DBOX_1	154	162	PF00400	0.386
DEG_APCC_DBOX_1	639	647	PF00400	0.708
DEG_Nend_UBRbox_2	1	3	PF02207	0.348
DEG_SPOP_SBC_1	36	40	PF00917	0.463
DOC_CKS1_1	21	26	PF01111	0.366
DOC_CYCLIN_RxL_1	150	159	PF00134	0.389
DOC_MAPK_gen_1	211	220	PF00069	0.416
DOC_MAPK_gen_1	227	234	PF00069	0.235
DOC_MAPK_MEF2A_6	155	162	PF00069	0.468
DOC_MAPK_MEF2A_6	227	234	PF00069	0.361
DOC_MAPK_MEF2A_6	367	374	PF00069	0.581
DOC_PP2B_LxvP_1	33	36	PF13499	0.503
DOC_PP2B_LxvP_1	464	467	PF13499	0.436
DOC_PP4_FxxP_1	167	170	PF00568	0.346
DOC_PP4_FxxP_1	400	403	PF00568	0.347
DOC_PP4_FxxP_1	483	486	PF00568	0.436
DOC_PP4_FxxP_1	71	74	PF00568	0.332
DOC_USP7_MATH_1	202	206	PF00917	0.718
DOC_USP7_MATH_1	36	40	PF00917	0.652
DOC_USP7_MATH_1	362	366	PF00917	0.786
DOC_USP7_MATH_1	403	407	PF00917	0.319
DOC_USP7_MATH_1	491	495	PF00917	0.449
DOC_USP7_MATH_1	613	617	PF00917	0.749
DOC_USP7_UBL2_3	542	546	PF12436	0.715
DOC_WW_Pin1_4	20	25	PF00397	0.467
DOC_WW_Pin1_4	270	275	PF00397	0.362
DOC_WW_Pin1_4	301	306	PF00397	0.747
DOC_WW_Pin1_4	355	360	PF00397	0.513
DOC_WW_Pin1_4	549	554	PF00397	0.731
DOC_WW_Pin1_4	634	639	PF00397	0.774
DOC_WW_Pin1_4	70	75	PF00397	0.391
LIG_14-3-3_CanoR_1	104	108	PF00244	0.479
LIG_14-3-3_CanoR_1	265	269	PF00244	0.372
LIG_14-3-3_CanoR_1	297	305	PF00244	0.530
LIG_14-3-3_CanoR_1	465	474	PF00244	0.477
LIG_14-3-3_CanoR_1	524	529	PF00244	0.548
LIG_14-3-3_CanoR_1	580	586	PF00244	0.483
LIG_BIR_III_2	236	240	PF00653	0.473
LIG_BRCT_BRCA1_1	281	285	PF00533	0.417
LIG_BRCT_BRCA1_1	72	76	PF00533	0.336
LIG_deltaCOP1_diTrp_1	92	97	PF00928	0.401
LIG_EH1_1	52	60	PF00400	0.214
LIG_EVH1_2	134	138	PF00568	0.267
LIG_FHA_1	179	185	PF00498	0.378
LIG_FHA_1	293	299	PF00498	0.436
LIG_FHA_1	318	324	PF00498	0.588
LIG_FHA_1	337	343	PF00498	0.610
LIG_FHA_1	607	613	PF00498	0.714
LIG_FHA_2	306	312	PF00498	0.670
LIG_FHA_2	490	496	PF00498	0.531
LIG_FHA_2	554	560	PF00498	0.543
LIG_Integrin_isoDGR_2	102	104	PF01839	0.380
LIG_LIR_Apic_2	106	110	PF02991	0.393
LIG_LIR_Apic_2	164	170	PF02991	0.329
LIG_LIR_Apic_2	398	403	PF02991	0.389
LIG_LIR_Apic_2	482	486	PF02991	0.446
LIG_LIR_Gen_1	275	285	PF02991	0.370
LIG_LIR_Gen_1	435	445	PF02991	0.582
LIG_LIR_Gen_1	458	468	PF02991	0.483
LIG_LIR_Gen_1	479	487	PF02991	0.465
LIG_LIR_Gen_1	523	534	PF02991	0.659
LIG_LIR_Gen_1	623	634	PF02991	0.696
LIG_LIR_Gen_1	92	98	PF02991	0.471
LIG_LIR_Nem_3	236	241	PF02991	0.395
LIG_LIR_Nem_3	275	280	PF02991	0.374
LIG_LIR_Nem_3	287	293	PF02991	0.383
LIG_LIR_Nem_3	406	412	PF02991	0.460
LIG_LIR_Nem_3	435	440	PF02991	0.482
LIG_LIR_Nem_3	458	464	PF02991	0.483
LIG_LIR_Nem_3	479	483	PF02991	0.465
LIG_LIR_Nem_3	495	501	PF02991	0.359
LIG_LIR_Nem_3	523	529	PF02991	0.615
LIG_LIR_Nem_3	623	629	PF02991	0.685
LIG_LIR_Nem_3	73	79	PF02991	0.326
LIG_LIR_Nem_3	92	97	PF02991	0.489
LIG_MYND_1	327	331	PF01753	0.419
LIG_NRBOX	157	163	PF00104	0.323
LIG_Pex14_2	138	142	PF04695	0.238
LIG_Pex14_2	174	178	PF04695	0.467
LIG_Pex14_2	286	290	PF04695	0.416
LIG_SH2_CRK	172	176	PF00017	0.442
LIG_SH2_CRK	277	281	PF00017	0.432
LIG_SH2_CRK	409	413	PF00017	0.492
LIG_SH2_CRK	437	441	PF00017	0.531
LIG_SH2_CRK	461	465	PF00017	0.435
LIG_SH2_PTP2	107	110	PF00017	0.504
LIG_SH2_SRC	107	110	PF00017	0.432
LIG_SH2_STAP1	139	143	PF00017	0.455
LIG_SH2_STAP1	437	441	PF00017	0.531
LIG_SH2_STAP1	501	505	PF00017	0.408
LIG_SH2_STAT5	107	110	PF00017	0.504
LIG_SH2_STAT5	223	226	PF00017	0.396
LIG_SH2_STAT5	461	464	PF00017	0.511
LIG_SH2_STAT5	7	10	PF00017	0.302
LIG_SH3_3	106	112	PF00018	0.529
LIG_SH3_3	123	129	PF00018	0.466
LIG_SH3_3	131	137	PF00018	0.501
LIG_SH3_3	18	24	PF00018	0.467
LIG_SH3_3	198	204	PF00018	0.583
LIG_SH3_3	325	331	PF00018	0.370
LIG_SH3_3	568	574	PF00018	0.571
LIG_SH3_3	599	605	PF00018	0.579
LIG_SUMO_SIM_anti_2	159	164	PF11976	0.319
LIG_SUMO_SIM_anti_2	438	444	PF11976	0.513
LIG_SUMO_SIM_par_1	159	164	PF11976	0.319
LIG_SUMO_SIM_par_1	330	336	PF11976	0.462
LIG_SUMO_SIM_par_1	438	444	PF11976	0.513
LIG_SUMO_SIM_par_1	662	670	PF11976	0.581
LIG_TRAF2_1	570	573	PF00917	0.507
LIG_TYR_ITIM	407	412	PF00017	0.335
LIG_WRC_WIRS_1	8	13	PF05994	0.230
LIG_WW_2	109	112	PF00397	0.411
MOD_CDC14_SPxK_1	273	276	PF00782	0.355
MOD_CDC14_SPxK_1	637	640	PF00782	0.579
MOD_CDK_SPxK_1	270	276	PF00069	0.329
MOD_CDK_SPxK_1	634	640	PF00069	0.578
MOD_CK1_1	10	16	PF00069	0.489
MOD_CK1_1	124	130	PF00069	0.656
MOD_CK1_1	244	250	PF00069	0.631
MOD_CK1_1	296	302	PF00069	0.637
MOD_CK1_1	38	44	PF00069	0.671
MOD_CK1_1	514	520	PF00069	0.630
MOD_CK1_1	561	567	PF00069	0.676
MOD_CK1_1	90	96	PF00069	0.471
MOD_CK2_1	173	179	PF00069	0.353
MOD_CK2_1	381	387	PF00069	0.696
MOD_CK2_1	489	495	PF00069	0.393
MOD_Cter_Amidation	538	541	PF01082	0.482
MOD_GlcNHglycan	360	363	PF01048	0.779
MOD_GlcNHglycan	383	386	PF01048	0.712
MOD_GSK3_1	240	247	PF00069	0.573
MOD_GSK3_1	253	260	PF00069	0.657
MOD_GSK3_1	292	299	PF00069	0.379
MOD_GSK3_1	3	10	PF00069	0.369
MOD_GSK3_1	301	308	PF00069	0.714
MOD_GSK3_1	311	318	PF00069	0.690
MOD_GSK3_1	358	365	PF00069	0.641
MOD_GSK3_1	455	462	PF00069	0.345
MOD_GSK3_1	520	527	PF00069	0.510
MOD_GSK3_1	545	552	PF00069	0.660
MOD_GSK3_1	603	610	PF00069	0.673
MOD_GSK3_1	614	621	PF00069	0.620
MOD_GSK3_1	75	82	PF00069	0.319
MOD_N-GLC_1	260	265	PF02516	0.590
MOD_N-GLC_1	381	386	PF02516	0.596
MOD_N-GLC_1	87	92	PF02516	0.416
MOD_N-GLC_2	14	16	PF02516	0.270
MOD_N-GLC_2	61	63	PF02516	0.344
MOD_NEK2_1	163	168	PF00069	0.298
MOD_NEK2_1	219	224	PF00069	0.232
MOD_NEK2_1	279	284	PF00069	0.545
MOD_NEK2_1	293	298	PF00069	0.520
MOD_NEK2_1	3	8	PF00069	0.331
MOD_NEK2_1	558	563	PF00069	0.681
MOD_NEK2_1	607	612	PF00069	0.620
MOD_NEK2_1	9	14	PF00069	0.382
MOD_NEK2_1	97	102	PF00069	0.454
MOD_PIKK_1	173	179	PF00454	0.471
MOD_PIKK_1	253	259	PF00454	0.635
MOD_PIKK_1	455	461	PF00454	0.189
MOD_PIKK_1	592	598	PF00454	0.516
MOD_PK_1	524	530	PF00069	0.642
MOD_PKA_2	264	270	PF00069	0.322
MOD_PKA_2	296	302	PF00069	0.560
MOD_PKA_2	366	372	PF00069	0.731
MOD_PKA_2	514	520	PF00069	0.544
MOD_PKA_2	90	96	PF00069	0.421
MOD_PKA_2	98	104	PF00069	0.450
MOD_PKB_1	590	598	PF00069	0.468
MOD_Plk_1	121	127	PF00069	0.546
MOD_Plk_1	163	169	PF00069	0.296
MOD_Plk_2-3	373	379	PF00069	0.486
MOD_Plk_4	103	109	PF00069	0.527
MOD_Plk_4	3	9	PF00069	0.324
MOD_Plk_4	395	401	PF00069	0.363
MOD_Plk_4	459	465	PF00069	0.273
MOD_Plk_4	553	559	PF00069	0.481
MOD_Plk_4	75	81	PF00069	0.333
MOD_ProDKin_1	20	26	PF00069	0.474
MOD_ProDKin_1	270	276	PF00069	0.358
MOD_ProDKin_1	301	307	PF00069	0.747
MOD_ProDKin_1	355	361	PF00069	0.512
MOD_ProDKin_1	549	555	PF00069	0.730
MOD_ProDKin_1	634	640	PF00069	0.777
MOD_ProDKin_1	70	76	PF00069	0.395
MOD_SUMO_rev_2	543	548	PF00179	0.577
TRG_DiLeu_BaEn_1	392	397	PF01217	0.490
TRG_DiLeu_BaEn_2	475	481	PF01217	0.271
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.387
TRG_ENDOCYTIC_2	139	142	PF00928	0.460
TRG_ENDOCYTIC_2	277	280	PF00928	0.361
TRG_ENDOCYTIC_2	409	412	PF00928	0.356
TRG_ENDOCYTIC_2	437	440	PF00928	0.399
TRG_ENDOCYTIC_2	461	464	PF00928	0.375
TRG_ENDOCYTIC_2	501	504	PF00928	0.409
TRG_ER_diArg_1	268	271	PF00400	0.405
TRG_ER_diArg_1	510	513	PF00400	0.371
TRG_ER_diArg_1	640	643	PF00400	0.538
TRG_NLS_MonoExtC_3	589	594	PF00514	0.782
TRG_NLS_MonoExtN_4	590	595	PF00514	0.780
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB91	Leptomonas seymouri	42%	77%
A0A1X0P9Y1	Trypanosomatidae	32%	90%
A0A3Q8IHR3	Leishmania donovani	85%	100%
A0A3R7MJM0	Trypanosoma rangeli	31%	94%
A4HB44	Leishmania braziliensis	66%	98%
A4IA93	Leishmania infantum	85%	83%
C9ZM02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	93%
Q4Q2L8	Leishmania major	85%	99%
V5BQH0	Trypanosoma cruzi	34%	94%