RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5B3_LEIMU

TriTrypDb:

LmxM.33.3240

Length:

637

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	1
GO:0020016	ciliary pocket	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B5B3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5B3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	471	475	PF00656	0.390
CLV_NRD_NRD_1	502	504	PF00675	0.454
CLV_NRD_NRD_1	526	528	PF00675	0.290
CLV_PCSK_KEX2_1	279	281	PF00082	0.371
CLV_PCSK_KEX2_1	502	504	PF00082	0.454
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.382
CLV_PCSK_SKI1_1	502	506	PF00082	0.363
CLV_PCSK_SKI1_1	79	83	PF00082	0.544
CLV_Separin_Metazoa	190	194	PF03568	0.369
CLV_Separin_Metazoa	422	426	PF03568	0.338
DEG_Nend_UBRbox_2	1	3	PF02207	0.675
DOC_CDC14_PxL_1	26	34	PF14671	0.529
DOC_CKS1_1	152	157	PF01111	0.361
DOC_CKS1_1	337	342	PF01111	0.419
DOC_CYCLIN_yCln2_LP_2	337	343	PF00134	0.419
DOC_MAPK_gen_1	527	536	PF00069	0.490
DOC_MAPK_MEF2A_6	125	132	PF00069	0.591
DOC_PP1_RVXF_1	446	452	PF00149	0.392
DOC_PP1_RVXF_1	507	513	PF00149	0.621
DOC_PP1_RVXF_1	84	90	PF00149	0.264
DOC_PP2B_LxvP_1	417	420	PF13499	0.521
DOC_PP2B_LxvP_1	596	599	PF13499	0.548
DOC_USP7_MATH_1	462	466	PF00917	0.424
DOC_USP7_MATH_1	609	613	PF00917	0.624
DOC_USP7_MATH_2	624	630	PF00917	0.578
DOC_WW_Pin1_4	12	17	PF00397	0.730
DOC_WW_Pin1_4	151	156	PF00397	0.407
DOC_WW_Pin1_4	336	341	PF00397	0.419
DOC_WW_Pin1_4	518	523	PF00397	0.502
LIG_14-3-3_CanoR_1	177	185	PF00244	0.451
LIG_14-3-3_CanoR_1	249	258	PF00244	0.398
LIG_14-3-3_CanoR_1	298	308	PF00244	0.541
LIG_14-3-3_CanoR_1	5	9	PF00244	0.582
LIG_14-3-3_CanoR_1	502	510	PF00244	0.669
LIG_14-3-3_CanoR_1	79	84	PF00244	0.351
LIG_14-3-3_CanoR_1	86	92	PF00244	0.254
LIG_Actin_WH2_2	410	427	PF00022	0.420
LIG_Actin_WH2_2	437	455	PF00022	0.415
LIG_APCC_ABBA_1	319	324	PF00400	0.403
LIG_BRCT_BRCA1_1	118	122	PF00533	0.424
LIG_BRCT_BRCA1_1	263	267	PF00533	0.391
LIG_BRCT_BRCA1_1	373	377	PF00533	0.419
LIG_BRCT_BRCA1_1	632	636	PF00533	0.639
LIG_BRCT_BRCA1_1	8	12	PF00533	0.585
LIG_CSL_BTD_1	337	340	PF09270	0.277
LIG_deltaCOP1_diTrp_1	254	258	PF00928	0.272
LIG_FHA_1	109	115	PF00498	0.573
LIG_FHA_1	181	187	PF00498	0.346
LIG_FHA_1	288	294	PF00498	0.565
LIG_FHA_1	337	343	PF00498	0.322
LIG_FHA_1	393	399	PF00498	0.556
LIG_FHA_1	444	450	PF00498	0.380
LIG_FHA_1	519	525	PF00498	0.498
LIG_FHA_1	52	58	PF00498	0.362
LIG_FHA_1	530	536	PF00498	0.450
LIG_FHA_1	556	562	PF00498	0.430
LIG_FHA_1	82	88	PF00498	0.402
LIG_FHA_2	469	475	PF00498	0.361
LIG_FHA_2	80	86	PF00498	0.378
LIG_GBD_Chelix_1	52	60	PF00786	0.542
LIG_LIR_Gen_1	256	266	PF02991	0.318
LIG_LIR_Gen_1	348	358	PF02991	0.534
LIG_LIR_Gen_1	369	380	PF02991	0.243
LIG_LIR_Gen_1	401	410	PF02991	0.486
LIG_LIR_Gen_1	54	60	PF02991	0.378
LIG_LIR_LC3C_4	311	314	PF02991	0.250
LIG_LIR_LC3C_4	54	58	PF02991	0.368
LIG_LIR_Nem_3	256	261	PF02991	0.338
LIG_LIR_Nem_3	264	270	PF02991	0.394
LIG_LIR_Nem_3	348	353	PF02991	0.528
LIG_LIR_Nem_3	369	375	PF02991	0.402
LIG_LIR_Nem_3	457	461	PF02991	0.399
LIG_LIR_Nem_3	54	58	PF02991	0.419
LIG_PCNA_yPIPBox_3	48	56	PF02747	0.425
LIG_Pex14_1	263	267	PF04695	0.419
LIG_Pex14_1	70	74	PF04695	0.336
LIG_Pex14_2	185	189	PF04695	0.342
LIG_Pex14_2	382	386	PF04695	0.355
LIG_PTB_Apo_2	269	276	PF02174	0.292
LIG_PTB_Phospho_1	269	275	PF10480	0.419
LIG_RPA_C_Fungi	498	510	PF08784	0.523
LIG_SH2_CRK	33	37	PF00017	0.314
LIG_SH2_PTP2	552	555	PF00017	0.521
LIG_SH2_SRC	273	276	PF00017	0.499
LIG_SH2_STAT3	195	198	PF00017	0.357
LIG_SH2_STAT5	18	21	PF00017	0.415
LIG_SH2_STAT5	195	198	PF00017	0.369
LIG_SH2_STAT5	247	250	PF00017	0.530
LIG_SH2_STAT5	273	276	PF00017	0.410
LIG_SH2_STAT5	403	406	PF00017	0.419
LIG_SH2_STAT5	552	555	PF00017	0.521
LIG_SH2_STAT5	589	592	PF00017	0.409
LIG_SUMO_SIM_anti_2	311	316	PF11976	0.336
LIG_SUMO_SIM_anti_2	323	329	PF11976	0.277
LIG_SUMO_SIM_anti_2	333	339	PF11976	0.286
LIG_SUMO_SIM_anti_2	532	537	PF11976	0.371
LIG_SUMO_SIM_par_1	317	324	PF11976	0.501
LIG_UBA3_1	560	567	PF00899	0.558
LIG_WW_1	30	33	PF00397	0.511
MOD_CK1_1	6	12	PF00069	0.637
MOD_CK1_1	617	623	PF00069	0.661
MOD_CK1_1	63	69	PF00069	0.414
MOD_CK2_1	317	323	PF00069	0.514
MOD_CK2_1	426	432	PF00069	0.569
MOD_CK2_1	79	85	PF00069	0.391
MOD_CMANNOS	252	255	PF00535	0.525
MOD_CMANNOS	412	415	PF00535	0.419
MOD_GlcNHglycan	116	119	PF01048	0.407
MOD_GlcNHglycan	428	431	PF01048	0.588
MOD_GlcNHglycan	518	521	PF01048	0.460
MOD_GlcNHglycan	541	544	PF01048	0.347
MOD_GlcNHglycan	632	635	PF01048	0.755
MOD_GlcNHglycan	8	11	PF01048	0.596
MOD_GSK3_1	110	117	PF00069	0.340
MOD_GSK3_1	176	183	PF00069	0.561
MOD_GSK3_1	283	290	PF00069	0.469
MOD_GSK3_1	367	374	PF00069	0.369
MOD_GSK3_1	404	411	PF00069	0.355
MOD_GSK3_1	59	66	PF00069	0.432
MOD_GSK3_1	614	621	PF00069	0.683
MOD_GSK3_1	622	629	PF00069	0.750
MOD_N-GLC_1	392	397	PF02516	0.382
MOD_NEK2_1	116	121	PF00069	0.286
MOD_NEK2_1	287	292	PF00069	0.528
MOD_NEK2_1	308	313	PF00069	0.323
MOD_NEK2_1	317	322	PF00069	0.311
MOD_NEK2_1	330	335	PF00069	0.292
MOD_NEK2_1	398	403	PF00069	0.360
MOD_NEK2_1	4	9	PF00069	0.526
MOD_NEK2_1	413	418	PF00069	0.428
MOD_NEK2_1	529	534	PF00069	0.370
MOD_NEK2_1	568	573	PF00069	0.389
MOD_NEK2_1	584	589	PF00069	0.393
MOD_NEK2_1	60	65	PF00069	0.428
MOD_NEK2_1	615	620	PF00069	0.596
MOD_NEK2_1	87	92	PF00069	0.311
MOD_NEK2_2	392	397	PF00069	0.332
MOD_NEK2_2	74	79	PF00069	0.413
MOD_PIKK_1	116	122	PF00454	0.251
MOD_PIKK_1	468	474	PF00454	0.523
MOD_PIKK_1	555	561	PF00454	0.574
MOD_PKA_1	502	508	PF00069	0.423
MOD_PKA_2	176	182	PF00069	0.425
MOD_PKA_2	4	10	PF00069	0.406
MOD_PKA_2	502	508	PF00069	0.473
MOD_Plk_1	253	259	PF00069	0.389
MOD_Plk_1	392	398	PF00069	0.342
MOD_Plk_4	280	286	PF00069	0.539
MOD_Plk_4	308	314	PF00069	0.309
MOD_Plk_4	330	336	PF00069	0.362
MOD_Plk_4	367	373	PF00069	0.547
MOD_Plk_4	386	392	PF00069	0.374
MOD_Plk_4	408	414	PF00069	0.316
MOD_Plk_4	462	468	PF00069	0.477
MOD_Plk_4	51	57	PF00069	0.581
MOD_Plk_4	573	579	PF00069	0.333
MOD_Plk_4	584	590	PF00069	0.456
MOD_ProDKin_1	12	18	PF00069	0.673
MOD_ProDKin_1	151	157	PF00069	0.505
MOD_ProDKin_1	336	342	PF00069	0.419
MOD_ProDKin_1	518	524	PF00069	0.363
MOD_SUMO_rev_2	119	128	PF00179	0.281
MOD_SUMO_rev_2	167	174	PF00179	0.524
MOD_SUMO_rev_2	621	629	PF00179	0.539
MOD_SUMO_rev_2	67	77	PF00179	0.468
TRG_DiLeu_BaEn_1	323	328	PF01217	0.419
TRG_ENDOCYTIC_2	213	216	PF00928	0.391
TRG_ENDOCYTIC_2	33	36	PF00928	0.304
TRG_ENDOCYTIC_2	350	353	PF00928	0.419
TRG_ENDOCYTIC_2	403	406	PF00928	0.314
TRG_ER_diArg_1	502	504	PF00400	0.484
TRG_ER_diArg_1	512	515	PF00400	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ84	Leptomonas seymouri	63%	100%
A0A0S4IIE9	Bodo saltans	23%	87%
A0A1X0PA84	Trypanosomatidae	37%	97%
A0A3R7KG27	Trypanosoma rangeli	34%	100%
A0A3S7X8A1	Leishmania donovani	94%	100%
A4HB42	Leishmania braziliensis	79%	100%
A4IA91	Leishmania infantum	94%	100%
C9ZM03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4Q2M0	Leishmania major	94%	100%
V5DLY6	Trypanosoma cruzi	33%	100%