Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tir chaperone protein (CesT) family, putative

Species:

Leishmania mexicana

UniProt:

E9B5A6_LEIMU

TriTrypDb:

LmxM.33.3170

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5A6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0008104	protein localization	4	7
GO:0009306	protein secretion	4	7
GO:0009987	cellular process	1	7
GO:0015031	protein transport	4	7
GO:0030254	protein secretion by the type III secretion system	4	7
GO:0032940	secretion by cell	3	7
GO:0033036	macromolecule localization	2	7
GO:0035592	establishment of protein localization to extracellular region	4	7
GO:0045184	establishment of protein localization	3	7
GO:0046903	secretion	4	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0051641	cellular localization	2	7
GO:0055085	transmembrane transport	2	7
GO:0070727	cellular macromolecule localization	3	7
GO:0071692	protein localization to extracellular region	5	7
GO:0071702	organic substance transport	4	7
GO:0071705	nitrogen compound transport	4	7
GO:0071806	protein transmembrane transport	3	7
GO:0140352	export from cell	2	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.572
CLV_C14_Caspase3-7	300	304	PF00656	0.387
CLV_C14_Caspase3-7	70	74	PF00656	0.444
CLV_NRD_NRD_1	136	138	PF00675	0.568
CLV_NRD_NRD_1	175	177	PF00675	0.527
CLV_NRD_NRD_1	331	333	PF00675	0.452
CLV_NRD_NRD_1	38	40	PF00675	0.537
CLV_NRD_NRD_1	391	393	PF00675	0.588
CLV_PCSK_KEX2_1	136	138	PF00082	0.522
CLV_PCSK_KEX2_1	175	177	PF00082	0.551
CLV_PCSK_KEX2_1	288	290	PF00082	0.551
CLV_PCSK_KEX2_1	330	332	PF00082	0.453
CLV_PCSK_KEX2_1	391	393	PF00082	0.535
CLV_PCSK_KEX2_1	42	44	PF00082	0.411
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.466
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.411
CLV_PCSK_PC7_1	132	138	PF00082	0.520
CLV_PCSK_PC7_1	327	333	PF00082	0.447
CLV_PCSK_SKI1_1	288	292	PF00082	0.527
CLV_PCSK_SKI1_1	356	360	PF00082	0.562
CLV_PCSK_SKI1_1	39	43	PF00082	0.440
DEG_APCC_DBOX_1	263	271	PF00400	0.465
DEG_APCC_DBOX_1	372	380	PF00400	0.452
DEG_APCC_DBOX_1	496	504	PF00400	0.475
DEG_Nend_UBRbox_2	1	3	PF02207	0.658
DEG_SPOP_SBC_1	87	91	PF00917	0.507
DOC_CYCLIN_RxL_1	315	329	PF00134	0.432
DOC_MAPK_gen_1	262	269	PF00069	0.488
DOC_MAPK_gen_1	288	296	PF00069	0.391
DOC_MAPK_MEF2A_6	465	473	PF00069	0.458
DOC_MAPK_MEF2A_6	475	484	PF00069	0.520
DOC_PP2B_LxvP_1	119	122	PF13499	0.494
DOC_PP2B_LxvP_1	149	152	PF13499	0.536
DOC_PP2B_LxvP_1	170	173	PF13499	0.600
DOC_USP7_MATH_1	105	109	PF00917	0.543
DOC_USP7_MATH_1	219	223	PF00917	0.599
DOC_USP7_MATH_1	297	301	PF00917	0.397
DOC_USP7_MATH_1	443	447	PF00917	0.459
DOC_WW_Pin1_4	101	106	PF00397	0.588
DOC_WW_Pin1_4	131	136	PF00397	0.701
DOC_WW_Pin1_4	143	148	PF00397	0.756
DOC_WW_Pin1_4	163	168	PF00397	0.581
DOC_WW_Pin1_4	175	180	PF00397	0.684
DOC_WW_Pin1_4	206	211	PF00397	0.605
DOC_WW_Pin1_4	220	225	PF00397	0.707
LIG_14-3-3_CanoR_1	148	152	PF00244	0.662
LIG_14-3-3_CanoR_1	373	377	PF00244	0.514
LIG_14-3-3_CanoR_1	537	544	PF00244	0.434
LIG_Actin_WH2_2	523	539	PF00022	0.529
LIG_BRCT_BRCA1_1	402	406	PF00533	0.542
LIG_Clathr_ClatBox_1	470	474	PF01394	0.475
LIG_CtBP_PxDLS_1	210	214	PF00389	0.612
LIG_eIF4E_1	481	487	PF01652	0.495
LIG_FHA_1	456	462	PF00498	0.464
LIG_FHA_1	475	481	PF00498	0.383
LIG_FHA_1	557	563	PF00498	0.553
LIG_FHA_1	9	15	PF00498	0.510
LIG_FHA_2	336	342	PF00498	0.462
LIG_LIR_Gen_1	385	394	PF02991	0.431
LIG_LIR_Gen_1	478	487	PF02991	0.559
LIG_LIR_Gen_1	59	65	PF02991	0.483
LIG_LIR_Nem_3	385	389	PF02991	0.454
LIG_LIR_Nem_3	478	484	PF02991	0.559
LIG_LIR_Nem_3	59	63	PF02991	0.491
LIG_SH2_CRK	207	211	PF00017	0.613
LIG_SH2_CRK	25	29	PF00017	0.379
LIG_SH2_NCK_1	191	195	PF00017	0.563
LIG_SH2_PTP2	483	486	PF00017	0.529
LIG_SH2_SRC	481	484	PF00017	0.495
LIG_SH2_STAP1	501	505	PF00017	0.596
LIG_SH2_STAT3	439	442	PF00017	0.418
LIG_SH2_STAT5	15	18	PF00017	0.488
LIG_SH2_STAT5	245	248	PF00017	0.423
LIG_SH2_STAT5	439	442	PF00017	0.418
LIG_SH2_STAT5	44	47	PF00017	0.410
LIG_SH2_STAT5	481	484	PF00017	0.526
LIG_SH3_3	155	161	PF00018	0.556
LIG_SH3_3	402	408	PF00018	0.666
LIG_SUMO_SIM_anti_2	322	329	PF11976	0.435
LIG_SUMO_SIM_anti_2	524	531	PF11976	0.466
LIG_SUMO_SIM_anti_2	561	566	PF11976	0.394
LIG_SUMO_SIM_par_1	208	214	PF11976	0.479
LIG_SUMO_SIM_par_1	448	453	PF11976	0.455
LIG_SUMO_SIM_par_1	469	474	PF11976	0.475
LIG_TRAF2_1	338	341	PF00917	0.530
LIG_WRC_WIRS_1	57	62	PF05994	0.472
LIG_WW_3	121	125	PF00397	0.559
MOD_CDC14_SPxK_1	134	137	PF00782	0.561
MOD_CDK_SPK_2	131	136	PF00069	0.701
MOD_CDK_SPK_2	143	148	PF00069	0.550
MOD_CDK_SPK_2	163	168	PF00069	0.513
MOD_CDK_SPxK_1	131	137	PF00069	0.568
MOD_CK1_1	117	123	PF00069	0.595
MOD_CK1_1	195	201	PF00069	0.483
MOD_CK1_1	217	223	PF00069	0.651
MOD_CK1_1	522	528	PF00069	0.500
MOD_CK1_1	539	545	PF00069	0.434
MOD_CK1_1	88	94	PF00069	0.566
MOD_CK2_1	206	212	PF00069	0.661
MOD_CK2_1	335	341	PF00069	0.464
MOD_CK2_1	372	378	PF00069	0.513
MOD_CK2_1	425	431	PF00069	0.468
MOD_GlcNHglycan	149	152	PF01048	0.647
MOD_GlcNHglycan	217	220	PF01048	0.658
MOD_GlcNHglycan	232	235	PF01048	0.650
MOD_GlcNHglycan	425	428	PF01048	0.457
MOD_GlcNHglycan	445	448	PF01048	0.481
MOD_GlcNHglycan	492	495	PF01048	0.200
MOD_GlcNHglycan	538	541	PF01048	0.291
MOD_GlcNHglycan	69	72	PF01048	0.474
MOD_GlcNHglycan	90	93	PF01048	0.485
MOD_GlcNHglycan	98	101	PF01048	0.509
MOD_GSK3_1	101	108	PF00069	0.617
MOD_GSK3_1	143	150	PF00069	0.609
MOD_GSK3_1	211	218	PF00069	0.721
MOD_GSK3_1	378	385	PF00069	0.500
MOD_GSK3_1	455	462	PF00069	0.400
MOD_N-GLC_1	455	460	PF02516	0.275
MOD_NEK2_1	1	6	PF00069	0.585
MOD_NEK2_1	106	111	PF00069	0.644
MOD_NEK2_1	142	147	PF00069	0.567
MOD_NEK2_1	205	210	PF00069	0.578
MOD_NEK2_1	211	216	PF00069	0.600
MOD_NEK2_1	432	437	PF00069	0.487
MOD_NEK2_1	482	487	PF00069	0.495
MOD_NEK2_1	530	535	PF00069	0.555
MOD_NEK2_1	536	541	PF00069	0.561
MOD_NEK2_1	65	70	PF00069	0.496
MOD_NEK2_2	297	302	PF00069	0.388
MOD_PIKK_1	438	444	PF00454	0.423
MOD_PKA_2	147	153	PF00069	0.644
MOD_PKA_2	372	378	PF00069	0.518
MOD_PKA_2	411	417	PF00069	0.514
MOD_PKA_2	474	480	PF00069	0.616
MOD_PKA_2	536	542	PF00069	0.529
MOD_Plk_1	455	461	PF00069	0.492
MOD_Plk_2-3	382	388	PF00069	0.442
MOD_Plk_4	114	120	PF00069	0.493
MOD_Plk_4	137	143	PF00069	0.597
MOD_Plk_4	435	441	PF00069	0.275
MOD_Plk_4	482	488	PF00069	0.520
MOD_ProDKin_1	101	107	PF00069	0.590
MOD_ProDKin_1	131	137	PF00069	0.701
MOD_ProDKin_1	143	149	PF00069	0.756
MOD_ProDKin_1	163	169	PF00069	0.582
MOD_ProDKin_1	175	181	PF00069	0.681
MOD_ProDKin_1	206	212	PF00069	0.605
MOD_ProDKin_1	220	226	PF00069	0.709
MOD_SUMO_for_1	314	317	PF00179	0.431
MOD_SUMO_for_1	358	361	PF00179	0.525
MOD_SUMO_rev_2	248	254	PF00179	0.446
MOD_SUMO_rev_2	280	290	PF00179	0.531
MOD_SUMO_rev_2	335	344	PF00179	0.526
TRG_DiLeu_BaEn_4	285	291	PF01217	0.441
TRG_ENDOCYTIC_2	25	28	PF00928	0.381
TRG_ENDOCYTIC_2	481	484	PF00928	0.492
TRG_ENDOCYTIC_2	501	504	PF00928	0.578
TRG_ER_diArg_1	135	137	PF00400	0.511
TRG_ER_diArg_1	174	176	PF00400	0.524
TRG_ER_diArg_1	261	264	PF00400	0.508
TRG_ER_diArg_1	330	332	PF00400	0.453
TRG_NES_CRM1_1	248	259	PF08389	0.503
TRG_NES_CRM1_1	55	67	PF08389	0.469
TRG_NLS_MonoExtC_3	38	43	PF00514	0.456
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	356	361	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIE0	Leishmania donovani	86%	100%
A4HB36	Leishmania braziliensis	72%	100%
A4IAN3	Leishmania infantum	86%	100%
Q4Q2M7	Leishmania major	85%	100%
V5BKV7	Trypanosoma cruzi	34%	100%