Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5A4_LEIMU

TriTrypDb:

LmxM.33.3150

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B5A4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5A4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	366	370	PF00656	0.449
CLV_C14_Caspase3-7	97	101	PF00656	0.436
CLV_NRD_NRD_1	305	307	PF00675	0.724
CLV_PCSK_KEX2_1	145	147	PF00082	0.741
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.741
CLV_PCSK_SKI1_1	168	172	PF00082	0.686
CLV_PCSK_SKI1_1	265	269	PF00082	0.694
CLV_PCSK_SKI1_1	308	312	PF00082	0.613
CLV_PCSK_SKI1_1	337	341	PF00082	0.470
CLV_PCSK_SKI1_1	90	94	PF00082	0.499
DEG_Nend_UBRbox_2	1	3	PF02207	0.598
DEG_SCF_FBW7_1	35	41	PF00400	0.472
DEG_SPOP_SBC_1	39	43	PF00917	0.435
DOC_CKS1_1	35	40	PF01111	0.465
DOC_CYCLIN_RxL_1	303	315	PF00134	0.358
DOC_CYCLIN_RxL_1	331	343	PF00134	0.279
DOC_CYCLIN_RxL_1	84	97	PF00134	0.295
DOC_CYCLIN_yClb5_NLxxxL_5	198	205	PF00134	0.277
DOC_MAPK_FxFP_2	187	190	PF00069	0.371
DOC_MAPK_gen_1	196	205	PF00069	0.496
DOC_MAPK_gen_1	304	312	PF00069	0.506
DOC_MAPK_gen_1	377	385	PF00069	0.455
DOC_MAPK_MEF2A_6	145	154	PF00069	0.343
DOC_MAPK_MEF2A_6	196	205	PF00069	0.429
DOC_MAPK_MEF2A_6	282	291	PF00069	0.479
DOC_PP2B_PxIxI_1	174	180	PF00149	0.430
DOC_PP4_FxxP_1	187	190	PF00568	0.329
DOC_USP7_MATH_1	148	152	PF00917	0.445
DOC_USP7_MATH_1	166	170	PF00917	0.549
DOC_USP7_MATH_1	251	255	PF00917	0.643
DOC_USP7_MATH_1	39	43	PF00917	0.422
DOC_WW_Pin1_4	171	176	PF00397	0.531
DOC_WW_Pin1_4	257	262	PF00397	0.415
DOC_WW_Pin1_4	270	275	PF00397	0.379
DOC_WW_Pin1_4	316	321	PF00397	0.405
DOC_WW_Pin1_4	34	39	PF00397	0.378
DOC_WW_Pin1_4	340	345	PF00397	0.410
LIG_14-3-3_CanoR_1	136	142	PF00244	0.418
LIG_14-3-3_CanoR_1	168	177	PF00244	0.430
LIG_14-3-3_CanoR_1	263	268	PF00244	0.438
LIG_14-3-3_CanoR_1	353	363	PF00244	0.359
LIG_14-3-3_CanoR_1	63	72	PF00244	0.576
LIG_14-3-3_CanoR_1	94	99	PF00244	0.460
LIG_BIR_III_2	147	151	PF00653	0.343
LIG_BRCT_BRCA1_1	150	154	PF00533	0.357
LIG_BRCT_BRCA1_1	399	403	PF00533	0.374
LIG_deltaCOP1_diTrp_1	262	268	PF00928	0.330
LIG_eIF4E_1	204	210	PF01652	0.482
LIG_EVH1_1	34	38	PF00568	0.399
LIG_FHA_1	282	288	PF00498	0.330
LIG_FHA_1	334	340	PF00498	0.293
LIG_FHA_1	360	366	PF00498	0.319
LIG_FHA_1	419	425	PF00498	0.620
LIG_FHA_2	159	165	PF00498	0.574
LIG_FHA_2	35	41	PF00498	0.525
LIG_LIR_Apic_2	315	320	PF02991	0.406
LIG_LIR_Gen_1	379	390	PF02991	0.410
LIG_LIR_Nem_3	104	109	PF02991	0.398
LIG_LIR_Nem_3	262	267	PF02991	0.410
LIG_LIR_Nem_3	290	296	PF02991	0.395
LIG_LIR_Nem_3	311	317	PF02991	0.402
LIG_LIR_Nem_3	379	385	PF02991	0.428
LIG_PDZ_Class_2	421	426	PF00595	0.661
LIG_Pex14_1	184	188	PF04695	0.325
LIG_Pex14_1	264	268	PF04695	0.514
LIG_Pex14_2	384	388	PF04695	0.378
LIG_SH2_CRK	20	24	PF00017	0.501
LIG_SH2_CRK	317	321	PF00017	0.406
LIG_SH2_PTP2	382	385	PF00017	0.428
LIG_SH2_STAP1	185	189	PF00017	0.252
LIG_SH2_STAT3	141	144	PF00017	0.482
LIG_SH2_STAT5	204	207	PF00017	0.411
LIG_SH2_STAT5	270	273	PF00017	0.379
LIG_SH2_STAT5	317	320	PF00017	0.409
LIG_SH2_STAT5	382	385	PF00017	0.401
LIG_SH3_1	317	323	PF00018	0.401
LIG_SH3_1	32	38	PF00018	0.414
LIG_SH3_3	238	244	PF00018	0.583
LIG_SH3_3	268	274	PF00018	0.384
LIG_SH3_3	317	323	PF00018	0.401
LIG_SH3_3	32	38	PF00018	0.385
LIG_SH3_3	338	344	PF00018	0.407
LIG_SH3_3	7	13	PF00018	0.478
LIG_SUMO_SIM_anti_2	336	343	PF11976	0.273
LIG_SUMO_SIM_par_1	336	343	PF11976	0.273
LIG_TYR_ITIM	267	272	PF00017	0.387
MOD_CDK_SPK_2	316	321	PF00069	0.405
MOD_CDK_SPxK_1	257	263	PF00069	0.413
MOD_CDK_SPxxK_3	171	178	PF00069	0.517
MOD_CK1_1	254	260	PF00069	0.540
MOD_CK1_1	5	11	PF00069	0.553
MOD_CK1_1	67	73	PF00069	0.520
MOD_CK2_1	107	113	PF00069	0.387
MOD_CK2_1	158	164	PF00069	0.570
MOD_CK2_1	166	172	PF00069	0.488
MOD_CK2_1	277	283	PF00069	0.310
MOD_GlcNHglycan	168	171	PF01048	0.742
MOD_GlcNHglycan	25	28	PF01048	0.585
MOD_GlcNHglycan	257	260	PF01048	0.763
MOD_GlcNHglycan	392	396	PF01048	0.665
MOD_GlcNHglycan	53	57	PF01048	0.751
MOD_GlcNHglycan	59	62	PF01048	0.659
MOD_GlcNHglycan	66	69	PF01048	0.679
MOD_GlcNHglycan	7	10	PF01048	0.824
MOD_GlcNHglycan	79	82	PF01048	0.531
MOD_GSK3_1	125	132	PF00069	0.376
MOD_GSK3_1	166	173	PF00069	0.519
MOD_GSK3_1	251	258	PF00069	0.508
MOD_GSK3_1	277	284	PF00069	0.349
MOD_GSK3_1	308	315	PF00069	0.456
MOD_GSK3_1	34	41	PF00069	0.485
MOD_GSK3_1	372	379	PF00069	0.438
MOD_GSK3_1	57	64	PF00069	0.608
MOD_GSK3_1	67	74	PF00069	0.432
MOD_N-GLC_1	308	313	PF02516	0.552
MOD_N-GLC_2	131	133	PF02516	0.688
MOD_NEK2_1	292	297	PF00069	0.484
MOD_NEK2_1	312	317	PF00069	0.381
MOD_NEK2_1	397	402	PF00069	0.540
MOD_NEK2_1	93	98	PF00069	0.424
MOD_PIKK_1	123	129	PF00454	0.408
MOD_PIKK_1	71	77	PF00454	0.510
MOD_PKA_2	137	143	PF00069	0.397
MOD_PKA_2	281	287	PF00069	0.503
MOD_PKA_2	376	382	PF00069	0.439
MOD_PKA_2	93	99	PF00069	0.485
MOD_Plk_1	308	314	PF00069	0.349
MOD_Plk_1	397	403	PF00069	0.515
MOD_Plk_4	263	269	PF00069	0.517
MOD_Plk_4	287	293	PF00069	0.414
MOD_Plk_4	308	314	PF00069	0.421
MOD_Plk_4	398	404	PF00069	0.290
MOD_Plk_4	94	100	PF00069	0.499
MOD_ProDKin_1	171	177	PF00069	0.520
MOD_ProDKin_1	257	263	PF00069	0.413
MOD_ProDKin_1	270	276	PF00069	0.386
MOD_ProDKin_1	316	322	PF00069	0.403
MOD_ProDKin_1	34	40	PF00069	0.390
MOD_ProDKin_1	340	346	PF00069	0.410
MOD_SUMO_rev_2	343	350	PF00179	0.497
MOD_SUMO_rev_2	366	373	PF00179	0.515
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.287
TRG_DiLeu_LyEn_5	172	177	PF01217	0.462
TRG_ENDOCYTIC_2	185	188	PF00928	0.339
TRG_ENDOCYTIC_2	269	272	PF00928	0.379
TRG_ENDOCYTIC_2	382	385	PF00928	0.439
TRG_ER_diArg_1	135	138	PF00400	0.406
TRG_ER_diArg_1	29	32	PF00400	0.352
TRG_NLS_MonoExtN_4	304	310	PF00514	0.469
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHK0	Leptomonas seymouri	49%	96%
A0A3S7X898	Leishmania donovani	86%	100%
A4HB34	Leishmania braziliensis	71%	100%
A4IAN5	Leishmania infantum	86%	100%
Q4Q2M9	Leishmania major	85%	100%