Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 28

Species:

Leishmania mexicana

UniProt:

E9B5A2_LEIMU

TriTrypDb:

LmxM.33.3130

Length:

436

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5A2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.375
CLV_C14_Caspase3-7	191	195	PF00656	0.505
CLV_C14_Caspase3-7	60	64	PF00656	0.663
CLV_NRD_NRD_1	81	83	PF00675	0.450
CLV_PCSK_KEX2_1	179	181	PF00082	0.477
CLV_PCSK_KEX2_1	80	82	PF00082	0.448
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.511
CLV_PCSK_SKI1_1	124	128	PF00082	0.488
CLV_PCSK_SKI1_1	224	228	PF00082	0.364
CLV_PCSK_SKI1_1	336	340	PF00082	0.336
CLV_PCSK_SKI1_1	364	368	PF00082	0.444
DEG_APCC_DBOX_1	71	79	PF00400	0.430
DEG_Nend_UBRbox_2	1	3	PF02207	0.649
DOC_CDC14_PxL_1	231	239	PF14671	0.426
DOC_MAPK_DCC_7	302	312	PF00069	0.347
DOC_MAPK_gen_1	364	374	PF00069	0.482
DOC_MAPK_gen_1	80	91	PF00069	0.537
DOC_MAPK_MEF2A_6	283	290	PF00069	0.337
DOC_MAPK_MEF2A_6	85	93	PF00069	0.562
DOC_PP2B_LxvP_1	145	148	PF13499	0.359
DOC_PP4_FxxP_1	113	116	PF00568	0.325
DOC_SPAK_OSR1_1	417	421	PF12202	0.433
DOC_USP7_MATH_1	12	16	PF00917	0.590
DOC_USP7_MATH_1	165	169	PF00917	0.697
DOC_USP7_MATH_1	300	304	PF00917	0.440
DOC_USP7_MATH_1	326	330	PF00917	0.514
DOC_USP7_MATH_1	406	410	PF00917	0.533
DOC_USP7_MATH_1	432	436	PF00917	0.399
DOC_USP7_UBL2_3	332	336	PF12436	0.430
DOC_WW_Pin1_4	139	144	PF00397	0.351
DOC_WW_Pin1_4	215	220	PF00397	0.371
DOC_WW_Pin1_4	291	296	PF00397	0.377
LIG_14-3-3_CanoR_1	122	131	PF00244	0.552
LIG_14-3-3_CanoR_1	172	176	PF00244	0.424
LIG_14-3-3_CanoR_1	283	289	PF00244	0.355
LIG_14-3-3_CanoR_1	392	399	PF00244	0.401
LIG_Actin_WH2_2	270	285	PF00022	0.364
LIG_Actin_WH2_2	354	369	PF00022	0.404
LIG_eIF4E_1	242	248	PF01652	0.289
LIG_FHA_1	140	146	PF00498	0.367
LIG_FHA_1	414	420	PF00498	0.381
LIG_FHA_2	15	21	PF00498	0.693
LIG_FHA_2	326	332	PF00498	0.537
LIG_FHA_2	395	401	PF00498	0.461
LIG_FHA_2	48	54	PF00498	0.792
LIG_GBD_Chelix_1	69	77	PF00786	0.305
LIG_Integrin_isoDGR_2	354	356	PF01839	0.322
LIG_LIR_Gen_1	181	191	PF02991	0.495
LIG_LIR_Nem_3	139	144	PF02991	0.485
LIG_LIR_Nem_3	181	187	PF02991	0.459
LIG_LIR_Nem_3	348	352	PF02991	0.271
LIG_LIR_Nem_3	97	103	PF02991	0.416
LIG_PDZ_Class_1	431	436	PF00595	0.343
LIG_Pex14_2	341	345	PF04695	0.432
LIG_PTB_Apo_2	236	243	PF02174	0.389
LIG_PTB_Phospho_1	236	242	PF10480	0.391
LIG_REV1ctd_RIR_1	338	348	PF16727	0.388
LIG_SH2_GRB2like	267	270	PF00017	0.294
LIG_SH2_PTP2	359	362	PF00017	0.400
LIG_SH2_SRC	267	270	PF00017	0.325
LIG_SH2_STAP1	87	91	PF00017	0.469
LIG_SH2_STAT3	347	350	PF00017	0.473
LIG_SH2_STAT5	242	245	PF00017	0.422
LIG_SH2_STAT5	267	270	PF00017	0.344
LIG_SH2_STAT5	323	326	PF00017	0.524
LIG_SH2_STAT5	359	362	PF00017	0.341
LIG_SH2_STAT5	7	10	PF00017	0.651
LIG_SH3_1	359	365	PF00018	0.425
LIG_SH3_2	362	367	PF14604	0.439
LIG_SH3_3	359	365	PF00018	0.359
LIG_SUMO_SIM_par_1	142	150	PF11976	0.347
LIG_TRAF2_1	368	371	PF00917	0.269
LIG_TRAF2_1	410	413	PF00917	0.514
LIG_UBA3_1	226	233	PF00899	0.452
LIG_WRC_WIRS_1	337	342	PF05994	0.335
MOD_CK1_1	163	169	PF00069	0.705
MOD_CK1_1	218	224	PF00069	0.387
MOD_CK1_1	251	257	PF00069	0.468
MOD_CK1_1	291	297	PF00069	0.370
MOD_CK1_1	394	400	PF00069	0.431
MOD_CK1_1	64	70	PF00069	0.640
MOD_CK2_1	325	331	PF00069	0.427
MOD_CK2_1	382	388	PF00069	0.491
MOD_CK2_1	394	400	PF00069	0.382
MOD_GlcNHglycan	124	127	PF01048	0.510
MOD_GlcNHglycan	164	168	PF01048	0.561
MOD_GlcNHglycan	331	335	PF01048	0.478
MOD_GlcNHglycan	404	407	PF01048	0.482
MOD_GlcNHglycan	408	411	PF01048	0.448
MOD_GlcNHglycan	66	69	PF01048	0.406
MOD_GSK3_1	12	19	PF00069	0.536
MOD_GSK3_1	159	166	PF00069	0.615
MOD_GSK3_1	186	193	PF00069	0.524
MOD_GSK3_1	207	214	PF00069	0.326
MOD_GSK3_1	229	236	PF00069	0.554
MOD_GSK3_1	284	291	PF00069	0.337
MOD_GSK3_1	326	333	PF00069	0.484
MOD_GSK3_1	394	401	PF00069	0.477
MOD_GSK3_1	402	409	PF00069	0.434
MOD_GSK3_1	427	434	PF00069	0.297
MOD_GSK3_1	43	50	PF00069	0.713
MOD_GSK3_1	57	64	PF00069	0.755
MOD_N-GLC_1	251	256	PF02516	0.470
MOD_NEK2_1	201	206	PF00069	0.349
MOD_NEK2_1	290	295	PF00069	0.337
MOD_NEK2_1	89	94	PF00069	0.578
MOD_PKA_2	171	177	PF00069	0.432
MOD_PKA_2	326	332	PF00069	0.428
MOD_PKA_2	391	397	PF00069	0.386
MOD_PKA_2	61	67	PF00069	0.697
MOD_Plk_1	251	257	PF00069	0.527
MOD_Plk_1	89	95	PF00069	0.490
MOD_Plk_2-3	171	177	PF00069	0.432
MOD_Plk_2-3	382	388	PF00069	0.507
MOD_Plk_4	171	177	PF00069	0.508
MOD_Plk_4	336	342	PF00069	0.337
MOD_Plk_4	398	404	PF00069	0.541
MOD_Plk_4	61	67	PF00069	0.544
MOD_Plk_4	89	95	PF00069	0.538
MOD_Plk_4	96	102	PF00069	0.472
MOD_ProDKin_1	139	145	PF00069	0.347
MOD_ProDKin_1	215	221	PF00069	0.378
MOD_ProDKin_1	291	297	PF00069	0.390
MOD_SUMO_for_1	178	181	PF00179	0.497
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.341
TRG_ENDOCYTIC_2	100	103	PF00928	0.351
TRG_ER_diArg_1	121	124	PF00400	0.349
TRG_ER_diArg_1	80	82	PF00400	0.468
TRG_ER_diLys_1	431	436	PF00400	0.391
TRG_NES_CRM1_1	196	211	PF08389	0.443
TRG_Pf-PMV_PEXEL_1	224	229	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	81	86	PF00026	0.534
TRG_PTS1	433	436	PF00515	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1E1	Leptomonas seymouri	65%	92%
A0A0S4INK9	Bodo saltans	44%	99%
A0A1X0PAR0	Trypanosomatidae	60%	100%
A0A3S7X876	Leishmania donovani	92%	100%
A0A422NNH0	Trypanosoma rangeli	60%	87%
A4HB32	Leishmania braziliensis	85%	100%
A4IAN7	Leishmania infantum	92%	100%
C9ZM15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
Q4Q2N1	Leishmania major	93%	100%
V5DLX6	Trypanosoma cruzi	61%	100%