Zeta_toxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AAA domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B5A0_LEIMU

TriTrypDb:

LmxM.33.3110

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9B5A0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5A0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.560
CLV_NRD_NRD_1	85	87	PF00675	0.720
CLV_PCSK_KEX2_1	10	12	PF00082	0.463
CLV_PCSK_KEX2_1	112	114	PF00082	0.598
CLV_PCSK_KEX2_1	162	164	PF00082	0.560
CLV_PCSK_KEX2_1	51	53	PF00082	0.745
CLV_PCSK_KEX2_1	85	87	PF00082	0.637
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.423
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.598
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.799
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.637
CLV_PCSK_SKI1_1	193	197	PF00082	0.588
CLV_PCSK_SKI1_1	37	41	PF00082	0.406
CLV_PCSK_SKI1_1	59	63	PF00082	0.793
DEG_APCC_DBOX_1	178	186	PF00400	0.398
DEG_ODPH_VHL_1	185	197	PF01847	0.342
DOC_MAPK_DCC_7	88	98	PF00069	0.404
DOC_MAPK_gen_1	19	27	PF00069	0.566
DOC_MAPK_MEF2A_6	19	27	PF00069	0.550
DOC_PP1_RVXF_1	35	41	PF00149	0.415
DOC_USP7_MATH_1	129	133	PF00917	0.360
DOC_USP7_UBL2_3	65	69	PF12436	0.564
DOC_WW_Pin1_4	43	48	PF00397	0.388
LIG_14-3-3_CanoR_1	19	24	PF00244	0.546
LIG_14-3-3_CanoR_1	86	91	PF00244	0.499
LIG_Actin_WH2_2	148	164	PF00022	0.360
LIG_BIR_II_1	1	5	PF00653	0.690
LIG_BRCT_BRCA1_1	174	178	PF00533	0.360
LIG_FHA_1	113	119	PF00498	0.380
LIG_FHA_1	133	139	PF00498	0.162
LIG_FHA_1	156	162	PF00498	0.288
LIG_FHA_1	20	26	PF00498	0.453
LIG_FHA_1	4	10	PF00498	0.760
LIG_FHA_1	48	54	PF00498	0.519
LIG_FHA_2	221	227	PF00498	0.303
LIG_FHA_2	238	244	PF00498	0.516
LIG_LIR_Gen_1	121	130	PF02991	0.333
LIG_LIR_Gen_1	203	209	PF02991	0.398
LIG_LIR_Gen_1	26	36	PF02991	0.353
LIG_LIR_Nem_3	121	125	PF02991	0.333
LIG_LIR_Nem_3	26	31	PF02991	0.358
LIG_Pex14_1	110	114	PF04695	0.301
LIG_SH2_CRK	42	46	PF00017	0.461
LIG_SH2_PTP2	122	125	PF00017	0.374
LIG_SH2_SRC	122	125	PF00017	0.344
LIG_SH2_STAP1	114	118	PF00017	0.398
LIG_SH2_STAT5	114	117	PF00017	0.325
LIG_SH2_STAT5	122	125	PF00017	0.325
LIG_SH2_STAT5	141	144	PF00017	0.360
LIG_SH3_1	88	94	PF00018	0.445
LIG_SH3_3	88	94	PF00018	0.422
LIG_SUMO_SIM_anti_2	95	101	PF11976	0.360
LIG_SUMO_SIM_par_1	21	26	PF11976	0.542
LIG_SUMO_SIM_par_1	223	228	PF11976	0.360
LIG_UBA3_1	98	107	PF00899	0.357
MOD_CDK_SPK_2	43	48	PF00069	0.398
MOD_CK1_1	105	111	PF00069	0.297
MOD_CK1_1	132	138	PF00069	0.438
MOD_CK1_1	54	60	PF00069	0.677
MOD_CK1_1	92	98	PF00069	0.435
MOD_CK2_1	208	214	PF00069	0.406
MOD_CK2_1	220	226	PF00069	0.282
MOD_GlcNHglycan	1	4	PF01048	0.722
MOD_GlcNHglycan	104	107	PF01048	0.357
MOD_GlcNHglycan	53	56	PF01048	0.678
MOD_GlcNHglycan	75	78	PF01048	0.661
MOD_GSK3_1	15	22	PF00069	0.512
MOD_GSK3_1	196	203	PF00069	0.435
MOD_GSK3_1	43	50	PF00069	0.628
MOD_GSK3_1	51	58	PF00069	0.655
MOD_LATS_1	49	55	PF00433	0.477
MOD_N-GLC_1	139	144	PF02516	0.442
MOD_N-GLC_1	172	177	PF02516	0.438
MOD_N-GLC_1	81	86	PF02516	0.496
MOD_NEK2_1	102	107	PF00069	0.318
MOD_NEK2_1	134	139	PF00069	0.415
MOD_NEK2_1	15	20	PF00069	0.664
MOD_NEK2_1	161	166	PF00069	0.403
MOD_NEK2_1	237	242	PF00069	0.635
MOD_PIKK_1	71	77	PF00454	0.664
MOD_PK_1	196	202	PF00069	0.435
MOD_PKA_1	112	118	PF00069	0.492
MOD_PKA_1	51	57	PF00069	0.689
MOD_PKA_1	86	92	PF00069	0.613
MOD_PKA_2	112	118	PF00069	0.492
MOD_PKA_2	132	138	PF00069	0.162
MOD_PKA_2	161	167	PF00069	0.391
MOD_PKA_2	51	57	PF00069	0.658
MOD_Plk_1	172	178	PF00069	0.238
MOD_Plk_4	105	111	PF00069	0.280
MOD_Plk_4	118	124	PF00069	0.346
MOD_Plk_4	220	226	PF00069	0.397
MOD_Plk_4	23	29	PF00069	0.492
MOD_Plk_4	92	98	PF00069	0.477
MOD_ProDKin_1	43	49	PF00069	0.486
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.425
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.415
TRG_ENDOCYTIC_2	114	117	PF00928	0.438
TRG_ENDOCYTIC_2	122	125	PF00928	0.438
TRG_ENDOCYTIC_2	204	207	PF00928	0.444
TRG_ENDOCYTIC_2	42	45	PF00928	0.587
TRG_ER_diArg_1	130	133	PF00400	0.438
TRG_ER_diArg_1	161	163	PF00400	0.438
TRG_NLS_MonoCore_2	84	89	PF00514	0.605
TRG_NLS_MonoExtC_3	84	90	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	183	188	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F6	Leptomonas seymouri	57%	98%
A0A3R7RME9	Trypanosoma rangeli	30%	100%
A0A3S7X8C5	Leishmania donovani	88%	97%
A4HB30	Leishmania braziliensis	70%	100%
A4IA87	Leishmania infantum	89%	97%
C9ZM16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4Q2N3	Leishmania major	90%	100%