Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B599_LEIMU

TriTrypDb:

LmxM.33.3100

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B599

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B599

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.518
CLV_NRD_NRD_1	212	214	PF00675	0.497
CLV_PCSK_KEX2_1	212	214	PF00082	0.538
CLV_PCSK_SKI1_1	361	365	PF00082	0.413
CLV_PCSK_SKI1_1	382	386	PF00082	0.425
CLV_PCSK_SKI1_1	95	99	PF00082	0.399
DEG_APCC_DBOX_1	211	219	PF00400	0.438
DEG_Nend_UBRbox_2	1	3	PF02207	0.601
DOC_CKS1_1	338	343	PF01111	0.536
DOC_CYCLIN_RxL_1	358	367	PF00134	0.571
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.573
DOC_MAPK_gen_1	100	110	PF00069	0.467
DOC_MAPK_gen_1	118	128	PF00069	0.441
DOC_MAPK_gen_1	19	30	PF00069	0.407
DOC_MAPK_MEF2A_6	23	32	PF00069	0.404
DOC_MAPK_MEF2A_6	386	393	PF00069	0.394
DOC_MAPK_NFAT4_5	23	31	PF00069	0.420
DOC_MAPK_NFAT4_5	386	394	PF00069	0.452
DOC_PP1_RVXF_1	211	218	PF00149	0.497
DOC_PP2B_LxvP_1	296	299	PF13499	0.419
DOC_PP4_FxxP_1	114	117	PF00568	0.536
DOC_USP7_MATH_1	284	288	PF00917	0.484
DOC_USP7_MATH_1	31	35	PF00917	0.372
DOC_USP7_MATH_1	312	316	PF00917	0.721
DOC_USP7_MATH_1	317	321	PF00917	0.711
DOC_USP7_MATH_1	52	56	PF00917	0.658
DOC_USP7_MATH_1	63	67	PF00917	0.616
DOC_USP7_UBL2_3	103	107	PF12436	0.284
DOC_USP7_UBL2_3	382	386	PF12436	0.470
DOC_WW_Pin1_4	318	323	PF00397	0.724
DOC_WW_Pin1_4	337	342	PF00397	0.561
DOC_WW_Pin1_4	90	95	PF00397	0.389
LIG_14-3-3_CanoR_1	131	137	PF00244	0.499
LIG_14-3-3_CanoR_1	152	156	PF00244	0.463
LIG_14-3-3_CanoR_1	19	23	PF00244	0.474
LIG_14-3-3_CanoR_1	212	218	PF00244	0.425
LIG_14-3-3_CanoR_1	264	271	PF00244	0.565
LIG_14-3-3_CanoR_1	35	44	PF00244	0.371
LIG_Actin_WH2_2	371	388	PF00022	0.267
LIG_APCC_ABBA_1	96	101	PF00400	0.540
LIG_APCC_ABBAyCdc20_2	95	101	PF00400	0.538
LIG_BIR_III_2	57	61	PF00653	0.624
LIG_BRCT_BRCA1_1	286	290	PF00533	0.370
LIG_FHA_1	146	152	PF00498	0.488
LIG_FHA_1	243	249	PF00498	0.512
LIG_FHA_1	266	272	PF00498	0.480
LIG_FHA_1	289	295	PF00498	0.485
LIG_FHA_1	374	380	PF00498	0.477
LIG_FHA_1	81	87	PF00498	0.509
LIG_FHA_2	19	25	PF00498	0.403
LIG_Integrin_RGD_1	174	176	PF01839	0.564
LIG_IRF3_LxIS_1	86	93	PF10401	0.525
LIG_LIR_Apic_2	113	117	PF02991	0.531
LIG_LIR_Gen_1	176	183	PF02991	0.413
LIG_LIR_Gen_1	200	210	PF02991	0.387
LIG_LIR_Gen_1	87	97	PF02991	0.407
LIG_LIR_Nem_3	176	181	PF02991	0.410
LIG_LIR_Nem_3	200	205	PF02991	0.398
LIG_LIR_Nem_3	367	373	PF02991	0.498
LIG_LIR_Nem_3	87	92	PF02991	0.412
LIG_LRP6_Inhibitor_1	363	369	PF00058	0.521
LIG_Pex14_2	18	22	PF04695	0.399
LIG_REV1ctd_RIR_1	15	24	PF16727	0.402
LIG_RPA_C_Fungi	30	42	PF08784	0.549
LIG_SH2_CRK	178	182	PF00017	0.402
LIG_SH2_STAP1	112	116	PF00017	0.522
LIG_SH2_STAP1	37	41	PF00017	0.487
LIG_SH2_STAT5	10	13	PF00017	0.454
LIG_SH2_STAT5	231	234	PF00017	0.489
LIG_SH2_STAT5	85	88	PF00017	0.600
LIG_SH3_1	316	322	PF00018	0.627
LIG_SH3_3	316	322	PF00018	0.691
LIG_SH3_3	324	330	PF00018	0.566
LIG_SH3_4	382	389	PF00018	0.459
LIG_UBA3_1	28	33	PF00899	0.453
MOD_CDK_SPK_2	90	95	PF00069	0.387
MOD_CK1_1	154	160	PF00069	0.484
MOD_CK1_1	242	248	PF00069	0.404
MOD_CK1_1	266	272	PF00069	0.500
MOD_CK1_1	320	326	PF00069	0.663
MOD_CK2_1	136	142	PF00069	0.265
MOD_CK2_1	213	219	PF00069	0.409
MOD_GlcNHglycan	222	226	PF01048	0.546
MOD_GlcNHglycan	310	313	PF01048	0.682
MOD_GlcNHglycan	322	325	PF01048	0.522
MOD_GlcNHglycan	356	359	PF01048	0.466
MOD_GlcNHglycan	54	57	PF01048	0.634
MOD_GlcNHglycan	65	68	PF01048	0.613
MOD_GlcNHglycan	76	79	PF01048	0.630
MOD_GSK3_1	132	139	PF00069	0.499
MOD_GSK3_1	159	166	PF00069	0.444
MOD_GSK3_1	284	291	PF00069	0.386
MOD_GSK3_1	308	315	PF00069	0.731
MOD_GSK3_1	31	38	PF00069	0.383
MOD_GSK3_1	76	83	PF00069	0.642
MOD_GSK3_1	84	91	PF00069	0.575
MOD_N-GLC_1	239	244	PF02516	0.381
MOD_N-GLC_1	354	359	PF02516	0.440
MOD_N-GLC_1	364	369	PF02516	0.446
MOD_NEK2_1	18	23	PF00069	0.374
MOD_NEK2_1	188	193	PF00069	0.464
MOD_NEK2_1	265	270	PF00069	0.488
MOD_NEK2_1	279	284	PF00069	0.316
MOD_NEK2_1	288	293	PF00069	0.358
MOD_NEK2_1	301	306	PF00069	0.545
MOD_NEK2_1	364	369	PF00069	0.542
MOD_NEK2_2	197	202	PF00069	0.509
MOD_NEK2_2	356	361	PF00069	0.386
MOD_PIKK_1	288	294	PF00454	0.366
MOD_PKA_2	151	157	PF00069	0.445
MOD_PKA_2	18	24	PF00069	0.499
MOD_PKA_2	263	269	PF00069	0.515
MOD_Plk_1	112	118	PF00069	0.460
MOD_Plk_1	163	169	PF00069	0.469
MOD_Plk_1	239	245	PF00069	0.376
MOD_Plk_1	364	370	PF00069	0.403
MOD_Plk_4	132	138	PF00069	0.493
MOD_Plk_4	154	160	PF00069	0.573
MOD_Plk_4	213	219	PF00069	0.425
MOD_Plk_4	37	43	PF00069	0.590
MOD_Plk_4	81	87	PF00069	0.574
MOD_Plk_4	9	15	PF00069	0.538
MOD_ProDKin_1	318	324	PF00069	0.721
MOD_ProDKin_1	337	343	PF00069	0.560
MOD_ProDKin_1	90	96	PF00069	0.392
MOD_SUMO_for_1	348	351	PF00179	0.387
MOD_SUMO_rev_2	101	108	PF00179	0.531
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.458
TRG_ENDOCYTIC_2	10	13	PF00928	0.454
TRG_ENDOCYTIC_2	178	181	PF00928	0.396
TRG_NES_CRM1_1	278	292	PF08389	0.488
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P515	Leptomonas seymouri	66%	100%
A0A0S4J2A2	Bodo saltans	32%	100%
A0A1X0PA56	Trypanosomatidae	45%	100%
A0A3Q8IHQ1	Leishmania donovani	94%	100%
A0A3R7KID6	Trypanosoma rangeli	47%	100%
A4HB29	Leishmania braziliensis	80%	100%
A4IA86	Leishmania infantum	94%	100%
C9ZM18	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4Q2N4	Leishmania major	94%	100%
V5BKV3	Trypanosoma cruzi	46%	100%