Phosphatidylinositol-4-phosphate-5-kinase-likep ro tein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol phosphate kinase alpha

Species:

Leishmania mexicana

UniProt:

E9B598_LEIMU

TriTrypDb:

LmxM.33.3090

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0020016	ciliary pocket	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B598

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B598

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0044237	cellular metabolic process	2	9
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006661	phosphatidylinositol biosynthetic process	6	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046488	phosphatidylinositol metabolic process	6	1
GO:0046854	phosphatidylinositol phosphate biosynthetic process	7	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016307	phosphatidylinositol phosphate kinase activity	5	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.394
CLV_C14_Caspase3-7	450	454	PF00656	0.149
CLV_C14_Caspase3-7	455	459	PF00656	0.330
CLV_C14_Caspase3-7	467	471	PF00656	0.175
CLV_NRD_NRD_1	186	188	PF00675	0.717
CLV_NRD_NRD_1	285	287	PF00675	0.401
CLV_NRD_NRD_1	356	358	PF00675	0.413
CLV_NRD_NRD_1	377	379	PF00675	0.332
CLV_NRD_NRD_1	507	509	PF00675	0.360
CLV_NRD_NRD_1	521	523	PF00675	0.332
CLV_PCSK_FUR_1	184	188	PF00082	0.684
CLV_PCSK_KEX2_1	186	188	PF00082	0.717
CLV_PCSK_KEX2_1	355	357	PF00082	0.413
CLV_PCSK_KEX2_1	377	379	PF00082	0.332
CLV_PCSK_KEX2_1	393	395	PF00082	0.332
CLV_PCSK_KEX2_1	523	525	PF00082	0.419
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.413
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.413
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.419
CLV_PCSK_SKI1_1	102	106	PF00082	0.666
CLV_PCSK_SKI1_1	190	194	PF00082	0.740
CLV_PCSK_SKI1_1	233	237	PF00082	0.388
CLV_PCSK_SKI1_1	275	279	PF00082	0.332
CLV_PCSK_SKI1_1	286	290	PF00082	0.317
CLV_PCSK_SKI1_1	378	382	PF00082	0.334
CLV_PCSK_SKI1_1	430	434	PF00082	0.468
CLV_PCSK_SKI1_1	472	476	PF00082	0.332
CLV_PCSK_SKI1_1	5	9	PF00082	0.619
CLV_PCSK_SKI1_1	508	512	PF00082	0.468
CLV_PCSK_SKI1_1	65	69	PF00082	0.421
CLV_PCSK_SKI1_1	70	74	PF00082	0.465
DEG_APCC_DBOX_1	4	12	PF00400	0.645
DEG_APCC_DBOX_1	507	515	PF00400	0.345
DEG_SCF_FBW7_1	255	261	PF00400	0.335
DOC_CDC14_PxL_1	406	414	PF14671	0.173
DOC_CKS1_1	255	260	PF01111	0.413
DOC_CYCLIN_RxL_1	2	10	PF00134	0.689
DOC_PP1_RVXF_1	534	541	PF00149	0.332
DOC_USP7_MATH_1	128	132	PF00917	0.696
DOC_USP7_MATH_1	188	192	PF00917	0.670
DOC_USP7_MATH_1	258	262	PF00917	0.332
DOC_USP7_MATH_1	37	41	PF00917	0.762
DOC_USP7_MATH_1	452	456	PF00917	0.379
DOC_USP7_MATH_1	457	461	PF00917	0.340
DOC_USP7_MATH_1	539	543	PF00917	0.398
DOC_USP7_UBL2_3	338	342	PF12436	0.332
DOC_WW_Pin1_4	222	227	PF00397	0.366
DOC_WW_Pin1_4	254	259	PF00397	0.338
DOC_WW_Pin1_4	366	371	PF00397	0.368
LIG_14-3-3_CanoR_1	149	158	PF00244	0.569
LIG_14-3-3_CanoR_1	187	193	PF00244	0.711
LIG_14-3-3_CanoR_1	194	199	PF00244	0.652
LIG_14-3-3_CanoR_1	356	361	PF00244	0.385
LIG_14-3-3_CanoR_1	430	437	PF00244	0.439
LIG_14-3-3_CanoR_1	472	481	PF00244	0.366
LIG_14-3-3_CanoR_1	522	530	PF00244	0.411
LIG_14-3-3_CanoR_1	70	78	PF00244	0.509
LIG_Actin_WH2_1	270	288	PF00022	0.345
LIG_Actin_WH2_2	301	316	PF00022	0.468
LIG_BRCT_BRCA1_1	217	221	PF00533	0.506
LIG_EH_1	298	302	PF12763	0.468
LIG_EVH1_2	215	219	PF00568	0.571
LIG_FHA_1	303	309	PF00498	0.374
LIG_FHA_1	330	336	PF00498	0.397
LIG_FHA_1	427	433	PF00498	0.416
LIG_FHA_1	55	61	PF00498	0.462
LIG_FHA_2	158	164	PF00498	0.470
LIG_FHA_2	195	201	PF00498	0.727
LIG_FHA_2	218	224	PF00498	0.396
LIG_FHA_2	274	280	PF00498	0.338
LIG_FHA_2	332	338	PF00498	0.332
LIG_FHA_2	359	365	PF00498	0.370
LIG_FHA_2	429	435	PF00498	0.448
LIG_LIR_Gen_1	195	205	PF02991	0.533
LIG_LIR_Gen_1	218	229	PF02991	0.460
LIG_LIR_Gen_1	250	258	PF02991	0.397
LIG_LIR_Gen_1	298	308	PF02991	0.332
LIG_LIR_Gen_1	319	330	PF02991	0.416
LIG_LIR_Gen_1	399	408	PF02991	0.332
LIG_LIR_Nem_3	195	201	PF02991	0.660
LIG_LIR_Nem_3	218	224	PF02991	0.410
LIG_LIR_Nem_3	234	238	PF02991	0.328
LIG_LIR_Nem_3	250	255	PF02991	0.397
LIG_LIR_Nem_3	298	304	PF02991	0.318
LIG_LIR_Nem_3	399	403	PF02991	0.332
LIG_LIR_Nem_3	492	498	PF02991	0.332
LIG_PDZ_Class_2	541	546	PF00595	0.332
LIG_Pex14_1	516	520	PF04695	0.394
LIG_Pex14_2	178	182	PF04695	0.461
LIG_REV1ctd_RIR_1	264	274	PF16727	0.332
LIG_SH2_CRK	189	193	PF00017	0.539
LIG_SH2_CRK	400	404	PF00017	0.332
LIG_SH2_PTP2	495	498	PF00017	0.332
LIG_SH2_STAP1	400	404	PF00017	0.332
LIG_SH2_STAT5	243	246	PF00017	0.424
LIG_SH2_STAT5	445	448	PF00017	0.474
LIG_SH2_STAT5	495	498	PF00017	0.332
LIG_SH3_1	80	86	PF00018	0.493
LIG_SH3_2	83	88	PF14604	0.497
LIG_SH3_3	80	86	PF00018	0.493
LIG_TRAF2_1	278	281	PF00917	0.366
LIG_TYR_ITIM	493	498	PF00017	0.332
LIG_UBA3_1	381	387	PF00899	0.330
MOD_CDK_SPxK_1	254	260	PF00069	0.332
MOD_CK1_1	254	260	PF00069	0.332
MOD_CK1_1	417	423	PF00069	0.412
MOD_CK1_1	460	466	PF00069	0.419
MOD_CK1_1	91	97	PF00069	0.574
MOD_CK2_1	200	206	PF00069	0.636
MOD_CK2_1	273	279	PF00069	0.341
MOD_CK2_1	331	337	PF00069	0.332
MOD_CK2_1	348	354	PF00069	0.332
MOD_CK2_1	73	79	PF00069	0.550
MOD_GlcNHglycan	173	176	PF01048	0.713
MOD_GlcNHglycan	260	263	PF01048	0.332
MOD_GlcNHglycan	33	36	PF01048	0.755
MOD_GlcNHglycan	420	423	PF01048	0.343
MOD_GlcNHglycan	453	457	PF01048	0.426
MOD_GlcNHglycan	98	101	PF01048	0.548
MOD_GSK3_1	145	152	PF00069	0.712
MOD_GSK3_1	188	195	PF00069	0.713
MOD_GSK3_1	215	222	PF00069	0.564
MOD_GSK3_1	247	254	PF00069	0.332
MOD_GSK3_1	275	282	PF00069	0.332
MOD_GSK3_1	408	415	PF00069	0.454
MOD_GSK3_1	417	424	PF00069	0.417
MOD_GSK3_1	426	433	PF00069	0.366
MOD_GSK3_1	460	467	PF00069	0.464
MOD_GSK3_1	88	95	PF00069	0.505
MOD_N-GLC_1	464	469	PF02516	0.440
MOD_NEK2_1	171	176	PF00069	0.747
MOD_NEK2_1	178	183	PF00069	0.643
MOD_NEK2_1	192	197	PF00069	0.714
MOD_NEK2_1	247	252	PF00069	0.332
MOD_NEK2_1	329	334	PF00069	0.374
MOD_NEK2_1	341	346	PF00069	0.257
MOD_NEK2_1	392	397	PF00069	0.341
MOD_NEK2_1	398	403	PF00069	0.320
MOD_NEK2_1	412	417	PF00069	0.137
MOD_NEK2_1	428	433	PF00069	0.325
MOD_NEK2_1	443	448	PF00069	0.259
MOD_NEK2_1	540	545	PF00069	0.332
MOD_NEK2_1	7	12	PF00069	0.696
MOD_NEK2_1	96	101	PF00069	0.491
MOD_NEK2_2	37	42	PF00069	0.709
MOD_PIKK_1	120	126	PF00454	0.543
MOD_PIKK_1	192	198	PF00454	0.742
MOD_PIKK_1	316	322	PF00454	0.394
MOD_PIKK_1	358	364	PF00454	0.332
MOD_PK_1	251	257	PF00069	0.413
MOD_PK_1	88	94	PF00069	0.545
MOD_PKA_1	355	361	PF00069	0.370
MOD_PKA_1	523	529	PF00069	0.413
MOD_PKA_2	120	126	PF00069	0.673
MOD_PKA_2	128	134	PF00069	0.664
MOD_PKA_2	137	143	PF00069	0.653
MOD_PKA_2	247	253	PF00069	0.394
MOD_PKA_2	355	361	PF00069	0.383
MOD_PKA_2	523	529	PF00069	0.413
MOD_Plk_1	145	151	PF00069	0.715
MOD_Plk_1	178	184	PF00069	0.716
MOD_Plk_1	398	404	PF00069	0.332
MOD_Plk_1	88	94	PF00069	0.464
MOD_Plk_2-3	200	206	PF00069	0.701
MOD_Plk_4	128	134	PF00069	0.700
MOD_Plk_4	194	200	PF00069	0.600
MOD_Plk_4	398	404	PF00069	0.339
MOD_Plk_4	515	521	PF00069	0.413
MOD_Plk_4	540	546	PF00069	0.344
MOD_ProDKin_1	222	228	PF00069	0.363
MOD_ProDKin_1	254	260	PF00069	0.338
MOD_ProDKin_1	366	372	PF00069	0.368
MOD_SUMO_for_1	11	14	PF00179	0.700
MOD_SUMO_rev_2	234	242	PF00179	0.475
MOD_SUMO_rev_2	337	344	PF00179	0.332
MOD_SUMO_rev_2	518	525	PF00179	0.468
TRG_DiLeu_BaEn_1	376	381	PF01217	0.413
TRG_ENDOCYTIC_2	189	192	PF00928	0.542
TRG_ENDOCYTIC_2	229	232	PF00928	0.381
TRG_ENDOCYTIC_2	243	246	PF00928	0.391
TRG_ENDOCYTIC_2	293	296	PF00928	0.313
TRG_ENDOCYTIC_2	400	403	PF00928	0.332
TRG_ENDOCYTIC_2	495	498	PF00928	0.332
TRG_ER_diArg_1	184	187	PF00400	0.691
TRG_ER_diArg_1	522	525	PF00400	0.482
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	378	383	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT9	Leptomonas seymouri	66%	100%
A0A0N1PE70	Leptomonas seymouri	24%	100%
A0A1X0P9B0	Trypanosomatidae	24%	100%
A0A1X0PB79	Trypanosomatidae	46%	100%
A0A381MTN1	Leishmania infantum	93%	100%
A0A3Q8ILB5	Leishmania donovani	93%	100%
A4HB28	Leishmania braziliensis	77%	100%
A4HNP5	Leishmania braziliensis	22%	100%
C9ZM20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
O48709	Arabidopsis thaliana	31%	77%
Q4Q2N5	Leishmania major	90%	100%
Q6EX42	Oryza sativa subsp. japonica	30%	68%
Q8RY89	Arabidopsis thaliana	32%	71%
Q9LMN1	Arabidopsis thaliana	25%	100%
Q9M149	Arabidopsis thaliana	26%	100%
Q9SLG9	Arabidopsis thaliana	31%	71%
Q9SUI2	Arabidopsis thaliana	31%	72%
V5BA13	Trypanosoma cruzi	27%	100%