Putative exosome subunit rrp6p homologue

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exosome subunit rrp6p homologue, putative

Species:

Leishmania mexicana

UniProt:

E9B597_LEIMU

TriTrypDb:

LmxM.33.3080

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000176	nuclear exosome (RNase complex)	3	12
GO:0000178	exosome (RNase complex)	4	12
GO:0032991	protein-containing complex	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1905354	exoribonuclease complex	3	12
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B597

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B597

Function

Biological processes
Term	Name	Level	Count
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	12
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	12
GO:0000469	cleavage involved in rRNA processing	7	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0031123	RNA 3'-end processing	7	12
GO:0031125	rRNA 3'-end processing	9	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043628	regulatory ncRNA 3'-end processing	8	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	12
GO:0090501	RNA phosphodiester bond hydrolysis	6	12
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006399	tRNA metabolic process	7	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0008334	histone mRNA metabolic process	7	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016071	mRNA metabolic process	6	1
GO:0016073	snRNA metabolic process	7	1
GO:0016074	sno(s)RNA metabolic process	7	1
GO:0016075	rRNA catabolic process	7	1
GO:0016076	snRNA catabolic process	7	1
GO:0016077	sno(s)RNA catabolic process	7	1
GO:0016078	tRNA catabolic process	7	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0031126	sno(s)RNA 3'-end processing	9	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034661	ncRNA catabolic process	6	1
GO:0042868	antisense RNA metabolic process	7	1
GO:0043144	sno(s)RNA processing	8	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0043633	polyadenylation-dependent RNA catabolic process	6	1
GO:0043634	polyadenylation-dependent ncRNA catabolic process	7	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071025	RNA surveillance	6	1
GO:0071027	nuclear RNA surveillance	7	1
GO:0071029	nuclear ncRNA surveillance	7	1
GO:0071034	CUT catabolic process	7	1
GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process	8	1
GO:0071036	nuclear polyadenylation-dependent snoRNA catabolic process	8	1
GO:0071037	nuclear polyadenylation-dependent snRNA catabolic process	8	1
GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process	8	1
GO:0071039	nuclear polyadenylation-dependent CUT catabolic process	8	1
GO:0071040	nuclear polyadenylation-dependent antisense transcript catabolic process	8	1
GO:0071041	antisense RNA transcript catabolic process	7	1
GO:0071043	CUT metabolic process	7	1
GO:0071044	histone mRNA catabolic process	8	1
GO:0071046	nuclear polyadenylation-dependent ncRNA catabolic process	8	1
GO:0071051	polyadenylation-dependent snoRNA 3'-end processing	10	1
GO:0106354	tRNA surveillance	7	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0000175	3'-5'-RNA exonuclease activity	7	12
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004527	exonuclease activity	5	12
GO:0004532	RNA exonuclease activity	5	12
GO:0004540	RNA nuclease activity	4	12
GO:0005488	binding	1	12
GO:0008408	3'-5' exonuclease activity	6	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	12
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	12
GO:0036094	small molecule binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003723	RNA binding	4	1
GO:0003727	single-stranded RNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.295
CLV_C14_Caspase3-7	108	112	PF00656	0.295
CLV_C14_Caspase3-7	691	695	PF00656	0.704
CLV_NRD_NRD_1	120	122	PF00675	0.552
CLV_NRD_NRD_1	165	167	PF00675	0.547
CLV_NRD_NRD_1	48	50	PF00675	0.388
CLV_NRD_NRD_1	664	666	PF00675	0.446
CLV_NRD_NRD_1	74	76	PF00675	0.282
CLV_NRD_NRD_1	740	742	PF00675	0.558
CLV_PCSK_KEX2_1	120	122	PF00082	0.493
CLV_PCSK_KEX2_1	165	167	PF00082	0.547
CLV_PCSK_KEX2_1	714	716	PF00082	0.584
CLV_PCSK_KEX2_1	72	74	PF00082	0.330
CLV_PCSK_KEX2_1	740	742	PF00082	0.553
CLV_PCSK_PC1ET2_1	714	716	PF00082	0.594
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.313
CLV_PCSK_PC7_1	68	74	PF00082	0.420
CLV_PCSK_SKI1_1	248	252	PF00082	0.325
CLV_PCSK_SKI1_1	396	400	PF00082	0.243
CLV_PCSK_SKI1_1	439	443	PF00082	0.402
CLV_PCSK_SKI1_1	496	500	PF00082	0.304
CLV_PCSK_SKI1_1	573	577	PF00082	0.634
CLV_PCSK_SKI1_1	599	603	PF00082	0.722
CLV_PCSK_SKI1_1	714	718	PF00082	0.689
CLV_Separin_Metazoa	497	501	PF03568	0.390
DEG_ODPH_VHL_1	297	309	PF01847	0.467
DEG_SIAH_1	218	226	PF03145	0.526
DOC_CKS1_1	171	176	PF01111	0.496
DOC_CYCLIN_RxL_1	245	254	PF00134	0.548
DOC_CYCLIN_RxL_1	392	403	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	341	347	PF00134	0.512
DOC_MAPK_DCC_7	220	228	PF00069	0.513
DOC_MAPK_gen_1	165	171	PF00069	0.509
DOC_MAPK_MEF2A_6	14	21	PF00069	0.530
DOC_MAPK_MEF2A_6	220	228	PF00069	0.442
DOC_MAPK_MEF2A_6	510	519	PF00069	0.544
DOC_PP1_SILK_1	304	309	PF00149	0.521
DOC_PP2B_LxvP_1	341	344	PF13499	0.443
DOC_PP4_FxxP_1	171	174	PF00568	0.421
DOC_PP4_FxxP_1	210	213	PF00568	0.476
DOC_PP4_FxxP_1	301	304	PF00568	0.454
DOC_USP7_MATH_1	102	106	PF00917	0.311
DOC_USP7_MATH_1	202	206	PF00917	0.490
DOC_USP7_MATH_1	648	652	PF00917	0.624
DOC_USP7_MATH_1	655	659	PF00917	0.624
DOC_USP7_UBL2_3	25	29	PF12436	0.283
DOC_USP7_UBL2_3	358	362	PF12436	0.454
DOC_USP7_UBL2_3	451	455	PF12436	0.525
DOC_USP7_UBL2_3	728	732	PF12436	0.705
DOC_USP7_UBL2_3	738	742	PF12436	0.734
DOC_WW_Pin1_4	170	175	PF00397	0.453
DOC_WW_Pin1_4	471	476	PF00397	0.433
DOC_WW_Pin1_4	604	609	PF00397	0.638
LIG_14-3-3_CanoR_1	291	295	PF00244	0.454
LIG_14-3-3_CanoR_1	371	380	PF00244	0.548
LIG_14-3-3_CanoR_1	675	682	PF00244	0.760
LIG_14-3-3_CanoR_1	73	79	PF00244	0.341
LIG_14-3-3_CanoR_1	96	100	PF00244	0.407
LIG_APCC_ABBA_1	413	418	PF00400	0.437
LIG_BIR_III_2	229	233	PF00653	0.465
LIG_BIR_III_4	188	192	PF00653	0.517
LIG_BRCT_BRCA1_1	128	132	PF00533	0.606
LIG_BRCT_BRCA1_1	17	21	PF00533	0.565
LIG_BRCT_BRCA1_1	345	349	PF00533	0.454
LIG_BRCT_BRCA1_1	608	612	PF00533	0.488
LIG_BRCT_BRCA1_1	85	89	PF00533	0.439
LIG_deltaCOP1_diTrp_1	315	324	PF00928	0.443
LIG_deltaCOP1_diTrp_1	559	562	PF00928	0.709
LIG_FHA_1	11	17	PF00498	0.495
LIG_FHA_1	207	213	PF00498	0.303
LIG_FHA_1	383	389	PF00498	0.433
LIG_FHA_1	435	441	PF00498	0.428
LIG_FHA_1	504	510	PF00498	0.513
LIG_FHA_1	574	580	PF00498	0.599
LIG_FHA_1	65	71	PF00498	0.397
LIG_FHA_2	171	177	PF00498	0.485
LIG_FHA_2	232	238	PF00498	0.315
LIG_FHA_2	276	282	PF00498	0.454
LIG_FHA_2	492	498	PF00498	0.484
LIG_FHA_2	658	664	PF00498	0.629
LIG_FHA_2	96	102	PF00498	0.395
LIG_LIR_Apic_2	209	213	PF02991	0.367
LIG_LIR_Gen_1	26	35	PF02991	0.326
LIG_LIR_Gen_1	352	359	PF02991	0.454
LIG_LIR_Gen_1	609	618	PF02991	0.507
LIG_LIR_Gen_1	86	95	PF02991	0.148
LIG_LIR_Nem_3	18	24	PF02991	0.458
LIG_LIR_Nem_3	26	30	PF02991	0.257
LIG_LIR_Nem_3	263	267	PF02991	0.437
LIG_LIR_Nem_3	323	327	PF02991	0.443
LIG_LIR_Nem_3	352	357	PF02991	0.443
LIG_LIR_Nem_3	384	390	PF02991	0.434
LIG_LIR_Nem_3	557	563	PF02991	0.673
LIG_LIR_Nem_3	86	92	PF02991	0.148
LIG_NRBOX	394	400	PF00104	0.443
LIG_PCNA_yPIPBox_3	303	314	PF02747	0.504
LIG_RPA_C_Fungi	150	162	PF08784	0.528
LIG_RPA_C_Fungi	636	648	PF08784	0.584
LIG_SH2_CRK	27	31	PF00017	0.311
LIG_SH2_CRK	563	567	PF00017	0.700
LIG_SH2_NCK_1	345	349	PF00017	0.392
LIG_SH2_NCK_1	427	431	PF00017	0.405
LIG_SH2_SRC	39	42	PF00017	0.311
LIG_SH2_STAP1	345	349	PF00017	0.392
LIG_SH2_STAP1	39	43	PF00017	0.311
LIG_SH2_STAT3	265	268	PF00017	0.311
LIG_SH2_STAT3	380	383	PF00017	0.295
LIG_SH2_STAT5	327	330	PF00017	0.295
LIG_SH2_STAT5	390	393	PF00017	0.297
LIG_SH3_3	178	184	PF00018	0.545
LIG_SH3_3	221	227	PF00018	0.458
LIG_SH3_3	534	540	PF00018	0.441
LIG_SH3_3	568	574	PF00018	0.612
LIG_SH3_3	627	633	PF00018	0.581
LIG_SH3_3	705	711	PF00018	0.656
LIG_SH3_5	35	39	PF00018	0.330
LIG_SUMO_SIM_anti_2	15	21	PF11976	0.524
LIG_SUMO_SIM_anti_2	511	518	PF11976	0.433
LIG_SUMO_SIM_anti_2	54	64	PF11976	0.382
LIG_SUMO_SIM_par_1	482	489	PF11976	0.304
LIG_SUMO_SIM_par_1	54	64	PF11976	0.336
LIG_SUMO_SIM_par_1	590	595	PF11976	0.393
LIG_TRAF2_1	278	281	PF00917	0.415
LIG_TRAF2_1	595	598	PF00917	0.645
LIG_TRAF2_1	661	664	PF00917	0.674
LIG_TRAF2_2	626	631	PF00917	0.540
LIG_UBA3_1	515	521	PF00899	0.407
LIG_UBA3_1	709	714	PF00899	0.660
LIG_Vh1_VBS_1	99	117	PF01044	0.289
LIG_WRC_WIRS_1	207	212	PF05994	0.244
MOD_CK1_1	109	115	PF00069	0.369
MOD_CK1_1	28	34	PF00069	0.377
MOD_CK1_1	407	413	PF00069	0.574
MOD_CK1_1	483	489	PF00069	0.369
MOD_CK1_1	581	587	PF00069	0.707
MOD_CK1_1	604	610	PF00069	0.642
MOD_CK1_1	658	664	PF00069	0.537
MOD_CK1_1	680	686	PF00069	0.722
MOD_CK2_1	102	108	PF00069	0.279
MOD_CK2_1	131	137	PF00069	0.504
MOD_CK2_1	20	26	PF00069	0.514
MOD_CK2_1	208	214	PF00069	0.425
MOD_CK2_1	274	280	PF00069	0.315
MOD_CK2_1	491	497	PF00069	0.295
MOD_CK2_1	592	598	PF00069	0.667
MOD_CK2_1	657	663	PF00069	0.652
MOD_CK2_1	675	681	PF00069	0.671
MOD_CK2_1	95	101	PF00069	0.326
MOD_Cter_Amidation	118	121	PF01082	0.533
MOD_GlcNHglycan	152	155	PF01048	0.632
MOD_GlcNHglycan	176	180	PF01048	0.491
MOD_GlcNHglycan	188	192	PF01048	0.520
MOD_GlcNHglycan	30	33	PF01048	0.458
MOD_GlcNHglycan	373	376	PF01048	0.443
MOD_GlcNHglycan	446	449	PF01048	0.495
MOD_GlcNHglycan	465	468	PF01048	0.154
MOD_GlcNHglycan	543	546	PF01048	0.655
MOD_GlcNHglycan	597	602	PF01048	0.626
MOD_GlcNHglycan	667	670	PF01048	0.719
MOD_GlcNHglycan	677	680	PF01048	0.721
MOD_GlcNHglycan	78	81	PF01048	0.396
MOD_GlcNHglycan	85	88	PF01048	0.344
MOD_GSK3_1	102	109	PF00069	0.278
MOD_GSK3_1	202	209	PF00069	0.539
MOD_GSK3_1	231	238	PF00069	0.429
MOD_GSK3_1	416	423	PF00069	0.359
MOD_GSK3_1	479	486	PF00069	0.364
MOD_GSK3_1	581	588	PF00069	0.676
MOD_GSK3_1	597	604	PF00069	0.621
MOD_GSK3_1	606	613	PF00069	0.508
MOD_GSK3_1	671	678	PF00069	0.716
MOD_GSK3_1	689	696	PF00069	0.776
MOD_GSK3_1	91	98	PF00069	0.409
MOD_LATS_1	51	57	PF00433	0.314
MOD_N-GLC_1	416	421	PF02516	0.360
MOD_NEK2_1	128	133	PF00069	0.604
MOD_NEK2_1	136	141	PF00069	0.610
MOD_NEK2_1	235	240	PF00069	0.343
MOD_NEK2_1	274	279	PF00069	0.291
MOD_NEK2_1	290	295	PF00069	0.335
MOD_NEK2_1	331	336	PF00069	0.293
MOD_NEK2_1	442	447	PF00069	0.404
MOD_NEK2_1	479	484	PF00069	0.295
MOD_NEK2_1	575	580	PF00069	0.496
MOD_NEK2_1	603	608	PF00069	0.641
MOD_NEK2_2	337	342	PF00069	0.330
MOD_PIKK_1	136	142	PF00454	0.558
MOD_PIKK_1	212	218	PF00454	0.560
MOD_PIKK_1	592	598	PF00454	0.682
MOD_PK_1	208	214	PF00069	0.475
MOD_PK_1	715	721	PF00069	0.637
MOD_PKA_1	665	671	PF00069	0.453
MOD_PKA_1	73	79	PF00069	0.332
MOD_PKA_2	290	296	PF00069	0.333
MOD_PKA_2	404	410	PF00069	0.463
MOD_PKA_2	463	469	PF00069	0.374
MOD_PKA_2	535	541	PF00069	0.514
MOD_PKA_2	73	79	PF00069	0.364
MOD_PKA_2	95	101	PF00069	0.407
MOD_PKB_1	369	377	PF00069	0.443
MOD_Plk_1	322	328	PF00069	0.400
MOD_Plk_1	434	440	PF00069	0.413
MOD_Plk_1	597	603	PF00069	0.643
MOD_Plk_1	94	100	PF00069	0.369
MOD_Plk_2-3	95	101	PF00069	0.369
MOD_Plk_4	102	108	PF00069	0.267
MOD_Plk_4	109	115	PF00069	0.248
MOD_Plk_4	15	21	PF00069	0.524
MOD_Plk_4	202	208	PF00069	0.538
MOD_Plk_4	231	237	PF00069	0.411
MOD_Plk_4	302	308	PF00069	0.352
MOD_Plk_4	407	413	PF00069	0.549
MOD_Plk_4	480	486	PF00069	0.380
MOD_Plk_4	55	61	PF00069	0.306
MOD_Plk_4	581	587	PF00069	0.598
MOD_Plk_4	95	101	PF00069	0.325
MOD_ProDKin_1	170	176	PF00069	0.451
MOD_ProDKin_1	471	477	PF00069	0.282
MOD_ProDKin_1	604	610	PF00069	0.635
MOD_SUMO_for_1	540	543	PF00179	0.549
MOD_SUMO_for_1	719	722	PF00179	0.632
MOD_SUMO_rev_2	658	668	PF00179	0.564
TRG_DiLeu_BaEn_1	598	603	PF01217	0.675
TRG_ENDOCYTIC_2	267	270	PF00928	0.311
TRG_ENDOCYTIC_2	27	30	PF00928	0.295
TRG_ENDOCYTIC_2	563	566	PF00928	0.679
TRG_ER_diArg_1	120	122	PF00400	0.533
TRG_ER_diArg_1	164	166	PF00400	0.562
TRG_ER_diArg_1	368	371	PF00400	0.295
TRG_ER_diArg_1	73	75	PF00400	0.332
TRG_NES_CRM1_1	126	140	PF08389	0.421
TRG_NLS_MonoCore_2	71	76	PF00514	0.380
TRG_NLS_MonoExtN_4	71	76	PF00514	0.352
TRG_Pf-PMV_PEXEL_1	120	125	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	318	323	PF00026	0.295
TRG_Pf-PMV_PEXEL_1	371	376	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2R9	Leptomonas seymouri	69%	100%
A0A0S4JND8	Bodo saltans	48%	100%
A0A1X0P9Z3	Trypanosomatidae	54%	100%
A0A381MTM9	Leishmania infantum	91%	100%
A0A3R7LLL0	Trypanosoma rangeli	54%	100%
A0A3S7X869	Leishmania donovani	92%	100%
A4HB27	Leishmania braziliensis	79%	99%
C9ZM21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
P56960	Mus musculus	34%	84%
Q01780	Homo sapiens	33%	84%
Q4Q2N6	Leishmania major	90%	100%
V5BQF7	Trypanosoma cruzi	52%	100%