Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B596_LEIMU

TriTrypDb:

LmxM.33.3070

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	22

Expansion

Sequence features

E9B596

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B596

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.800
CLV_NRD_NRD_1	339	341	PF00675	0.332
CLV_NRD_NRD_1	403	405	PF00675	0.401
CLV_PCSK_KEX2_1	339	341	PF00082	0.334
CLV_PCSK_KEX2_1	393	395	PF00082	0.408
CLV_PCSK_KEX2_1	403	405	PF00082	0.396
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.420
CLV_PCSK_PC7_1	335	341	PF00082	0.318
CLV_PCSK_SKI1_1	124	128	PF00082	0.350
CLV_PCSK_SKI1_1	176	180	PF00082	0.453
CLV_PCSK_SKI1_1	262	266	PF00082	0.406
CLV_PCSK_SKI1_1	390	394	PF00082	0.406
CLV_PCSK_SKI1_1	404	408	PF00082	0.349
CLV_PCSK_SKI1_1	508	512	PF00082	0.284
DEG_APCC_DBOX_1	175	183	PF00400	0.511
DEG_APCC_DBOX_1	378	386	PF00400	0.563
DEG_SCF_FBW7_2	30	36	PF00400	0.617
DOC_CKS1_1	30	35	PF01111	0.618
DOC_CYCLIN_yCln2_LP_2	104	110	PF00134	0.535
DOC_MAPK_DCC_7	596	604	PF00069	0.300
DOC_MAPK_MEF2A_6	152	160	PF00069	0.511
DOC_MAPK_MEF2A_6	596	604	PF00069	0.289
DOC_MAPK_RevD_3	383	399	PF00069	0.505
DOC_PP1_RVXF_1	122	129	PF00149	0.532
DOC_PP1_RVXF_1	304	310	PF00149	0.614
DOC_PP1_RVXF_1	41	48	PF00149	0.598
DOC_PP4_FxxP_1	321	324	PF00568	0.596
DOC_USP7_MATH_1	17	21	PF00917	0.623
DOC_USP7_MATH_1	4	8	PF00917	0.633
DOC_USP7_MATH_1	563	567	PF00917	0.434
DOC_USP7_MATH_1	585	589	PF00917	0.275
DOC_USP7_MATH_1	60	64	PF00917	0.759
DOC_USP7_MATH_1	75	79	PF00917	0.769
DOC_USP7_UBL2_3	393	397	PF12436	0.556
DOC_WW_Pin1_4	112	117	PF00397	0.602
DOC_WW_Pin1_4	29	34	PF00397	0.629
LIG_14-3-3_CanoR_1	124	129	PF00244	0.543
LIG_14-3-3_CanoR_1	162	170	PF00244	0.584
LIG_14-3-3_CanoR_1	357	367	PF00244	0.548
LIG_14-3-3_CanoR_1	43	48	PF00244	0.726
LIG_14-3-3_CanoR_1	493	497	PF00244	0.527
LIG_14-3-3_CanoR_1	508	514	PF00244	0.477
LIG_14-3-3_CanoR_1	529	533	PF00244	0.276
LIG_14-3-3_CanoR_1	68	73	PF00244	0.670
LIG_Actin_WH2_2	104	122	PF00022	0.650
LIG_APCC_ABBAyCdc20_2	99	105	PF00400	0.490
LIG_BIR_III_4	59	63	PF00653	0.602
LIG_Clathr_ClatBox_1	385	389	PF01394	0.540
LIG_EH1_1	518	526	PF00400	0.178
LIG_EH1_1	622	630	PF00400	0.583
LIG_eIF4E_1	593	599	PF01652	0.274
LIG_eIF4E_1	617	623	PF01652	0.528
LIG_EVH1_2	313	317	PF00568	0.521
LIG_FHA_1	152	158	PF00498	0.547
LIG_FHA_1	3	9	PF00498	0.628
LIG_FHA_1	418	424	PF00498	0.554
LIG_FHA_1	430	436	PF00498	0.496
LIG_FHA_1	441	447	PF00498	0.250
LIG_FHA_1	450	456	PF00498	0.228
LIG_FHA_1	474	480	PF00498	0.378
LIG_FHA_1	50	56	PF00498	0.709
LIG_FHA_1	67	73	PF00498	0.702
LIG_FHA_2	162	168	PF00498	0.552
LIG_FHA_2	210	216	PF00498	0.664
LIG_FHA_2	270	276	PF00498	0.723
LIG_FHA_2	30	36	PF00498	0.622
LIG_FHA_2	375	381	PF00498	0.537
LIG_GBD_Chelix_1	625	633	PF00786	0.423
LIG_LIR_Apic_2	319	324	PF02991	0.584
LIG_LIR_Gen_1	315	324	PF02991	0.524
LIG_LIR_Gen_1	531	539	PF02991	0.301
LIG_LIR_Gen_1	615	625	PF02991	0.392
LIG_LIR_Nem_3	140	146	PF02991	0.604
LIG_LIR_Nem_3	315	321	PF02991	0.535
LIG_LIR_Nem_3	531	535	PF02991	0.295
LIG_LIR_Nem_3	580	584	PF02991	0.352
LIG_LIR_Nem_3	6	12	PF02991	0.599
LIG_LIR_Nem_3	611	617	PF02991	0.377
LIG_LYPXL_S_1	469	473	PF13949	0.378
LIG_LYPXL_yS_3	470	473	PF13949	0.378
LIG_PCNA_yPIPBox_3	587	596	PF02747	0.264
LIG_Pex14_2	317	321	PF04695	0.567
LIG_Pex14_2	609	613	PF04695	0.455
LIG_PTAP_UEV_1	76	81	PF05743	0.638
LIG_SH2_CRK	410	414	PF00017	0.621
LIG_SH2_SRC	341	344	PF00017	0.573
LIG_SH2_STAP1	532	536	PF00017	0.353
LIG_SH2_STAT3	552	555	PF00017	0.359
LIG_SH2_STAT3	584	587	PF00017	0.261
LIG_SH2_STAT5	163	166	PF00017	0.557
LIG_SH2_STAT5	296	299	PF00017	0.632
LIG_SH2_STAT5	341	344	PF00017	0.531
LIG_SH2_STAT5	465	468	PF00017	0.291
LIG_SH2_STAT5	472	475	PF00017	0.265
LIG_SH2_STAT5	593	596	PF00017	0.465
LIG_SH2_STAT5	617	620	PF00017	0.523
LIG_SH3_3	110	116	PF00018	0.596
LIG_SH3_3	229	235	PF00018	0.662
LIG_SH3_3	27	33	PF00018	0.675
LIG_SH3_3	308	314	PF00018	0.465
LIG_SH3_3	71	77	PF00018	0.714
LIG_SH3_3	79	85	PF00018	0.685
LIG_SUMO_SIM_anti_2	153	159	PF11976	0.511
LIG_SUMO_SIM_anti_2	434	439	PF11976	0.277
LIG_SUMO_SIM_anti_2	443	449	PF11976	0.261
LIG_SUMO_SIM_par_1	475	480	PF11976	0.276
LIG_TRAF2_1	213	216	PF00917	0.678
LIG_TRAF2_1	378	381	PF00917	0.502
LIG_TRAF2_1	92	95	PF00917	0.557
LIG_UBA3_1	146	152	PF00899	0.456
LIG_UBA3_1	385	393	PF00899	0.528
LIG_WRC_WIRS_1	296	301	PF05994	0.575
LIG_WRC_WIRS_1	44	49	PF05994	0.631
LIG_WRC_WIRS_1	535	540	PF05994	0.379
LIG_WRC_WIRS_1	609	614	PF05994	0.276
MOD_CK1_1	252	258	PF00069	0.599
MOD_CK1_1	316	322	PF00069	0.523
MOD_CK1_1	558	564	PF00069	0.341
MOD_CK1_1	61	67	PF00069	0.750
MOD_CK2_1	112	118	PF00069	0.571
MOD_CK2_1	196	202	PF00069	0.707
MOD_CK2_1	209	215	PF00069	0.710
MOD_CK2_1	265	271	PF00069	0.718
MOD_CK2_1	374	380	PF00069	0.546
MOD_CK2_1	534	540	PF00069	0.368
MOD_CK2_1	89	95	PF00069	0.584
MOD_GlcNHglycan	19	22	PF01048	0.505
MOD_GlcNHglycan	198	201	PF01048	0.555
MOD_GlcNHglycan	513	516	PF01048	0.429
MOD_GlcNHglycan	552	555	PF01048	0.522
MOD_GlcNHglycan	557	560	PF01048	0.492
MOD_GlcNHglycan	59	63	PF01048	0.532
MOD_GlcNHglycan	77	80	PF01048	0.585
MOD_GSK3_1	192	199	PF00069	0.717
MOD_GSK3_1	234	241	PF00069	0.737
MOD_GSK3_1	250	257	PF00069	0.672
MOD_GSK3_1	265	272	PF00069	0.608
MOD_GSK3_1	295	302	PF00069	0.569
MOD_GSK3_1	312	319	PF00069	0.545
MOD_GSK3_1	449	456	PF00069	0.393
MOD_GSK3_1	473	480	PF00069	0.373
MOD_GSK3_1	481	488	PF00069	0.319
MOD_GSK3_1	49	56	PF00069	0.688
MOD_GSK3_1	509	516	PF00069	0.353
MOD_GSK3_1	534	541	PF00069	0.320
MOD_GSK3_1	558	565	PF00069	0.360
MOD_N-GLC_1	28	33	PF02516	0.585
MOD_N-GLC_1	97	102	PF02516	0.410
MOD_NEK2_1	146	151	PF00069	0.537
MOD_NEK2_1	185	190	PF00069	0.747
MOD_NEK2_1	265	270	PF00069	0.608
MOD_NEK2_1	299	304	PF00069	0.566
MOD_NEK2_1	359	364	PF00069	0.561
MOD_NEK2_1	374	379	PF00069	0.469
MOD_NEK2_1	417	422	PF00069	0.556
MOD_NEK2_1	423	428	PF00069	0.540
MOD_NEK2_1	440	445	PF00069	0.327
MOD_NEK2_1	450	455	PF00069	0.318
MOD_NEK2_1	482	487	PF00069	0.270
MOD_NEK2_1	503	508	PF00069	0.543
MOD_NEK2_1	511	516	PF00069	0.369
MOD_NEK2_1	608	613	PF00069	0.393
MOD_NEK2_2	563	568	PF00069	0.454
MOD_PIKK_1	185	191	PF00454	0.696
MOD_PIKK_1	238	244	PF00454	0.629
MOD_PIKK_1	343	349	PF00454	0.525
MOD_PK_1	68	74	PF00069	0.598
MOD_PKA_2	161	167	PF00069	0.547
MOD_PKA_2	375	381	PF00069	0.626
MOD_PKA_2	417	423	PF00069	0.526
MOD_PKA_2	492	498	PF00069	0.602
MOD_PKA_2	528	534	PF00069	0.335
MOD_PKA_2	555	561	PF00069	0.355
MOD_Plk_1	130	136	PF00069	0.547
MOD_Plk_1	275	281	PF00069	0.792
MOD_Plk_1	89	95	PF00069	0.594
MOD_Plk_1	97	103	PF00069	0.571
MOD_Plk_4	137	143	PF00069	0.564
MOD_Plk_4	151	157	PF00069	0.520
MOD_Plk_4	313	319	PF00069	0.530
MOD_Plk_4	4	10	PF00069	0.651
MOD_Plk_4	440	446	PF00069	0.357
MOD_Plk_4	450	456	PF00069	0.313
MOD_Plk_4	473	479	PF00069	0.342
MOD_Plk_4	534	540	PF00069	0.339
MOD_Plk_4	563	569	PF00069	0.370
MOD_Plk_4	585	591	PF00069	0.352
MOD_Plk_4	608	614	PF00069	0.350
MOD_Plk_4	68	74	PF00069	0.598
MOD_ProDKin_1	112	118	PF00069	0.601
MOD_ProDKin_1	29	35	PF00069	0.629
MOD_SUMO_rev_2	115	122	PF00179	0.609
MOD_SUMO_rev_2	389	395	PF00179	0.604
MOD_SUMO_rev_2	566	573	PF00179	0.247
TRG_DiLeu_BaEn_1	153	158	PF01217	0.589
TRG_DiLeu_BaEn_1	261	266	PF01217	0.727
TRG_DiLeu_BaEn_1	381	386	PF01217	0.533
TRG_DiLeu_BaEn_4	165	171	PF01217	0.633
TRG_DiLeu_BaEn_4	86	92	PF01217	0.566
TRG_ENDOCYTIC_2	143	146	PF00928	0.520
TRG_ENDOCYTIC_2	296	299	PF00928	0.620
TRG_ENDOCYTIC_2	318	321	PF00928	0.560
TRG_ENDOCYTIC_2	470	473	PF00928	0.303
TRG_ENDOCYTIC_2	532	535	PF00928	0.355
TRG_ENDOCYTIC_2	617	620	PF00928	0.450
TRG_ER_diArg_1	280	283	PF00400	0.789
TRG_ER_diArg_1	338	340	PF00400	0.517
TRG_NLS_MonoExtC_3	392	397	PF00514	0.619
TRG_NLS_MonoExtN_4	390	397	PF00514	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2M1	Leptomonas seymouri	30%	100%
A0A0N1HRT9	Leptomonas seymouri	30%	100%
A0A0N1P9A0	Leptomonas seymouri	30%	100%
A0A0N1PBU6	Leptomonas seymouri	55%	100%
A0A1X0P9W4	Trypanosomatidae	38%	100%
A0A3Q8IFF3	Leishmania donovani	33%	98%
A0A3Q8ISH4	Leishmania donovani	34%	100%
A0A3R7KFP4	Trypanosoma rangeli	37%	100%
A0A3S7X483	Leishmania donovani	32%	98%
A0A3S7X888	Leishmania donovani	86%	100%
A4HB26	Leishmania braziliensis	65%	100%
A4HJ59	Leishmania braziliensis	31%	100%
A4HJ60	Leishmania braziliensis	33%	100%
A4I6H4	Leishmania infantum	32%	98%
A4I6H5	Leishmania infantum	34%	100%
A4IA83	Leishmania infantum	85%	100%
C9ZM24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B1N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B1N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4Q6I2	Leishmania major	33%	100%
Q4Q6I3	Leishmania major	32%	99%
V5B5A9	Trypanosoma cruzi	37%	100%