Mitochondrial carrier protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein-like protein

Species:

Leishmania mexicana

UniProt:

E9B595_LEIMU

TriTrypDb:

LmxM.33.3060

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B595

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B595

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0000295	adenine nucleotide transmembrane transporter activity	6	1
GO:0005215	transporter activity	1	1
GO:0005346	purine ribonucleotide transmembrane transporter activity	4	1
GO:0005347	ATP transmembrane transporter activity	5	1
GO:0008509	monoatomic anion transmembrane transporter activity	4	1
GO:0008514	organic anion transmembrane transporter activity	5	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015215	nucleotide transmembrane transporter activity	4	1
GO:0015216	purine nucleotide transmembrane transporter activity	5	1
GO:0015605	organophosphate ester transmembrane transporter activity	3	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	97	101	PF00656	0.603
CLV_NRD_NRD_1	210	212	PF00675	0.187
CLV_NRD_NRD_1	33	35	PF00675	0.390
CLV_NRD_NRD_1	49	51	PF00675	0.505
CLV_PCSK_KEX2_1	258	260	PF00082	0.483
CLV_PCSK_KEX2_1	33	35	PF00082	0.387
CLV_PCSK_KEX2_1	80	82	PF00082	0.503
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.483
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.453
CLV_PCSK_PC7_1	76	82	PF00082	0.437
CLV_PCSK_SKI1_1	255	259	PF00082	0.457
CLV_PCSK_SKI1_1	320	324	PF00082	0.348
CLV_PCSK_SKI1_1	51	55	PF00082	0.635
CLV_Separin_Metazoa	204	208	PF03568	0.319
DEG_APCC_DBOX_1	32	40	PF00400	0.438
DEG_Nend_Nbox_1	1	3	PF02207	0.554
DOC_CDC14_PxL_1	156	164	PF14671	0.425
DOC_CKS1_1	145	150	PF01111	0.509
DOC_MAPK_gen_1	133	141	PF00069	0.534
DOC_MAPK_gen_1	211	218	PF00069	0.187
DOC_MAPK_gen_1	46	55	PF00069	0.451
DOC_PP2B_LxvP_1	146	149	PF13499	0.494
DOC_USP7_MATH_1	108	112	PF00917	0.517
DOC_USP7_MATH_1	119	123	PF00917	0.600
DOC_USP7_MATH_1	243	247	PF00917	0.281
DOC_USP7_UBL2_3	48	52	PF12436	0.398
DOC_WW_Pin1_4	115	120	PF00397	0.611
DOC_WW_Pin1_4	144	149	PF00397	0.509
LIG_14-3-3_CanoR_1	107	117	PF00244	0.541
LIG_14-3-3_CanoR_1	137	142	PF00244	0.492
LIG_14-3-3_CanoR_1	34	40	PF00244	0.382
LIG_Actin_WH2_2	322	337	PF00022	0.281
LIG_deltaCOP1_diTrp_1	5	12	PF00928	0.429
LIG_FHA_1	122	128	PF00498	0.565
LIG_FHA_1	186	192	PF00498	0.281
LIG_FHA_1	341	347	PF00498	0.281
LIG_FHA_1	73	79	PF00498	0.475
LIG_FHA_2	126	132	PF00498	0.592
LIG_GBD_Chelix_1	28	36	PF00786	0.432
LIG_Integrin_isoDGR_2	300	302	PF01839	0.281
LIG_LIR_Gen_1	147	156	PF02991	0.498
LIG_LIR_Gen_1	25	32	PF02991	0.364
LIG_LIR_Gen_1	343	350	PF02991	0.281
LIG_LIR_Gen_1	92	99	PF02991	0.487
LIG_LIR_Nem_3	147	153	PF02991	0.512
LIG_LIR_Nem_3	217	222	PF02991	0.281
LIG_LIR_Nem_3	25	29	PF02991	0.333
LIG_LIR_Nem_3	323	329	PF02991	0.281
LIG_LIR_Nem_3	343	347	PF02991	0.158
LIG_LIR_Nem_3	5	11	PF02991	0.426
LIG_LIR_Nem_3	92	98	PF02991	0.498
LIG_PCNA_yPIPBox_3	315	326	PF02747	0.281
LIG_Pex14_2	218	222	PF04695	0.281
LIG_Pex14_2	26	30	PF04695	0.368
LIG_SH2_NCK_1	240	244	PF00017	0.281
LIG_SH2_SRC	40	43	PF00017	0.304
LIG_SH2_STAT3	250	253	PF00017	0.395
LIG_SH2_STAT5	333	336	PF00017	0.281
LIG_SH2_STAT5	35	38	PF00017	0.456
LIG_SH3_3	110	116	PF00018	0.589
LIG_SH3_3	280	286	PF00018	0.281
LIG_TYR_ITIM	230	235	PF00017	0.281
LIG_UBA3_1	179	187	PF00899	0.281
LIG_UBA3_1	248	256	PF00899	0.467
MOD_CK1_1	118	124	PF00069	0.621
MOD_CK1_1	144	150	PF00069	0.509
MOD_CK1_1	324	330	PF00069	0.281
MOD_CK1_1	340	346	PF00069	0.281
MOD_CK2_1	125	131	PF00069	0.535
MOD_CK2_1	35	41	PF00069	0.389
MOD_GlcNHglycan	110	113	PF01048	0.511
MOD_GlcNHglycan	241	244	PF01048	0.348
MOD_GlcNHglycan	306	309	PF01048	0.348
MOD_GlcNHglycan	326	329	PF01048	0.158
MOD_GlcNHglycan	339	342	PF01048	0.281
MOD_GlcNHglycan	62	67	PF01048	0.499
MOD_GSK3_1	115	122	PF00069	0.599
MOD_GSK3_1	137	144	PF00069	0.480
MOD_GSK3_1	239	246	PF00069	0.281
MOD_GSK3_1	275	282	PF00069	0.281
MOD_GSK3_1	289	296	PF00069	0.281
MOD_GSK3_1	320	327	PF00069	0.281
MOD_GSK3_1	90	97	PF00069	0.773
MOD_N-GLC_1	164	169	PF02516	0.281
MOD_NEK2_1	239	244	PF00069	0.281
MOD_NEK2_1	274	279	PF00069	0.281
MOD_NEK2_2	321	326	PF00069	0.281
MOD_NEK2_2	35	40	PF00069	0.372
MOD_PIKK_1	121	127	PF00454	0.455
MOD_PIKK_1	293	299	PF00454	0.281
MOD_PK_1	137	143	PF00069	0.536
MOD_PK_1	64	70	PF00069	0.505
MOD_PKA_1	304	310	PF00069	0.304
MOD_PKA_1	80	86	PF00069	0.463
MOD_PKA_2	80	86	PF00069	0.559
MOD_PKB_1	135	143	PF00069	0.492
MOD_PKB_1	291	299	PF00069	0.281
MOD_Plk_1	141	147	PF00069	0.515
MOD_Plk_1	164	170	PF00069	0.281
MOD_Plk_1	260	266	PF00069	0.421
MOD_Plk_4	141	147	PF00069	0.515
MOD_Plk_4	243	249	PF00069	0.281
MOD_Plk_4	321	327	PF00069	0.281
MOD_Plk_4	340	346	PF00069	0.281
MOD_Plk_4	35	41	PF00069	0.384
MOD_Plk_4	94	100	PF00069	0.607
MOD_ProDKin_1	115	121	PF00069	0.611
MOD_ProDKin_1	144	150	PF00069	0.509
TRG_DiLeu_BaEn_1	74	79	PF01217	0.419
TRG_DiLeu_BaLyEn_6	349	354	PF01217	0.261
TRG_ENDOCYTIC_2	219	222	PF00928	0.281
TRG_ENDOCYTIC_2	232	235	PF00928	0.281
TRG_ENDOCYTIC_2	306	309	PF00928	0.281
TRG_ER_diArg_1	132	135	PF00400	0.533
TRG_ER_diArg_1	290	293	PF00400	0.281
TRG_ER_diArg_1	32	34	PF00400	0.376
TRG_ER_diArg_1	86	89	PF00400	0.568
TRG_NLS_Bipartite_1	33	54	PF00514	0.469
TRG_NLS_MonoExtC_3	254	259	PF00514	0.453
TRG_NLS_MonoExtN_4	48	54	PF00514	0.455
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.261

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXG6	Leptomonas seymouri	69%	68%
A0A3Q8INL3	Leishmania donovani	93%	100%
A4H8E6	Leishmania braziliensis	25%	100%
A4HB25	Leishmania braziliensis	80%	100%
A4IA82	Leishmania infantum	93%	100%
A5PJZ1	Bos taurus	27%	75%
E9AQH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
O04619	Arabidopsis thaliana	28%	100%
O94502	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	84%
Q4Q2N8	Leishmania major	89%	100%
Q54VS7	Dictyostelium discoideum	25%	100%
Q5PQ27	Xenopus laevis	27%	100%
Q86AV5	Dictyostelium discoideum	25%	100%
Q8BMD8	Mus musculus	28%	75%
Q94AG6	Arabidopsis thaliana	27%	100%