Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B594_LEIMU

TriTrypDb:

LmxM.33.3050

Length:

178


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0012505	endomembrane system	2	2
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1

E9B594

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B594


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	31	35	PF00082	0.602
DOC_MAPK_gen_1	87	95	PF00069	0.291
DOC_MAPK_MEF2A_6	6	14	PF00069	0.455
DOC_MAPK_MEF2A_6	90	97	PF00069	0.258
DOC_PP4_FxxP_1	106	109	PF00568	0.321
DOC_USP7_MATH_1	13	17	PF00917	0.374
DOC_USP7_MATH_1	20	24	PF00917	0.374
DOC_USP7_UBL2_3	156	160	PF12436	0.355
DOC_USP7_UBL2_3	31	35	PF12436	0.476
LIG_14-3-3_CanoR_1	90	96	PF00244	0.308
LIG_BIR_II_1	1	5	PF00653	0.707
LIG_FHA_1	19	25	PF00498	0.412
LIG_FHA_1	32	38	PF00498	0.411
LIG_LIR_Gen_1	89	100	PF02991	0.316
LIG_LIR_Nem_3	159	164	PF02991	0.349
LIG_LIR_Nem_3	170	176	PF02991	0.369
LIG_LIR_Nem_3	81	86	PF02991	0.312
LIG_LIR_Nem_3	89	95	PF02991	0.319
LIG_LYPXL_yS_3	161	164	PF13949	0.338
LIG_PCNA_yPIPBox_3	6	15	PF02747	0.400
LIG_SH2_CRK	83	87	PF00017	0.297
LIG_SH2_GRB2like	134	137	PF00017	0.273
LIG_SH2_NCK_1	100	104	PF00017	0.263
LIG_SH2_STAT3	134	137	PF00017	0.273
LIG_SH2_STAT5	134	137	PF00017	0.273
LIG_SH2_STAT5	153	156	PF00017	0.190
LIG_SH2_STAT5	167	170	PF00017	0.330
LIG_SH2_STAT5	26	29	PF00017	0.593
LIG_SH2_STAT5	75	78	PF00017	0.378
LIG_SUMO_SIM_anti_2	143	152	PF11976	0.346
LIG_SUMO_SIM_par_1	10	16	PF11976	0.269
LIG_TRAF2_1	143	146	PF00917	0.324
MOD_CK1_1	52	58	PF00069	0.501
MOD_CK2_1	140	146	PF00069	0.325
MOD_CK2_1	52	58	PF00069	0.565
MOD_GlcNHglycan	15	18	PF01048	0.354
MOD_GlcNHglycan	54	57	PF01048	0.743
MOD_GlcNHglycan	61	64	PF01048	0.666
MOD_GlcNHglycan	67	70	PF01048	0.579
MOD_N-GLC_1	140	145	PF02516	0.546
MOD_NEK2_2	20	25	PF00069	0.279
MOD_PIKK_1	78	84	PF00454	0.315
MOD_Plk_4	20	26	PF00069	0.404
MOD_SUMO_for_1	86	89	PF00179	0.346
TRG_DiLeu_BaEn_4	145	151	PF01217	0.279
TRG_ENDOCYTIC_2	113	116	PF00928	0.352
TRG_ENDOCYTIC_2	161	164	PF00928	0.324
TRG_ENDOCYTIC_2	83	86	PF00928	0.290


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I427	Leptomonas seymouri	73%	95%
A0A0S4KHZ8	Bodo saltans	39%	100%
A0A1X0P9U9	Trypanosomatidae	51%	100%
A0A3Q8IGX1	Leishmania donovani	41%	100%
A0A3R7RC54	Trypanosoma rangeli	41%	99%
A0A3S7X865	Leishmania donovani	95%	100%
A4H7Y9	Leishmania braziliensis	40%	100%
A4HB24	Leishmania braziliensis	85%	100%
A4HQJ0	Leishmania braziliensis	37%	100%
A4IA81	Leishmania infantum	95%	100%
E9AHZ9	Leishmania infantum	41%	100%
E9AUA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
O00264	Homo sapiens	32%	91%
O55022	Mus musculus	32%	91%
Q12091	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q17QC0	Bos taurus	32%	92%
Q1JQA5	Bos taurus	34%	100%
Q4Q088	Leishmania major	40%	100%
Q4Q2N9	Leishmania major	96%	100%
Q5RED0	Pongo abelii	32%	91%
Q5XIU9	Rattus norvegicus	31%	82%
Q80UU9	Mus musculus	31%	82%
Q95250	Sus scrofa	33%	92%
V5DM24	Trypanosoma cruzi	54%	99%