CAP_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B593_LEIMU

TriTrypDb:

LmxM.33.3040

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B593

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B593

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	504	508	PF00656	0.421
CLV_C14_Caspase3-7	57	61	PF00656	0.474
CLV_C14_Caspase3-7	82	86	PF00656	0.655
CLV_NRD_NRD_1	108	110	PF00675	0.474
CLV_NRD_NRD_1	158	160	PF00675	0.405
CLV_NRD_NRD_1	247	249	PF00675	0.542
CLV_NRD_NRD_1	266	268	PF00675	0.519
CLV_NRD_NRD_1	359	361	PF00675	0.556
CLV_NRD_NRD_1	531	533	PF00675	0.410
CLV_PCSK_KEX2_1	108	110	PF00082	0.470
CLV_PCSK_KEX2_1	158	160	PF00082	0.405
CLV_PCSK_KEX2_1	266	268	PF00082	0.349
CLV_PCSK_KEX2_1	531	533	PF00082	0.455
CLV_PCSK_SKI1_1	15	19	PF00082	0.573
CLV_PCSK_SKI1_1	225	229	PF00082	0.685
CLV_PCSK_SKI1_1	266	270	PF00082	0.333
CLV_PCSK_SKI1_1	290	294	PF00082	0.528
CLV_PCSK_SKI1_1	323	327	PF00082	0.448
CLV_PCSK_SKI1_1	361	365	PF00082	0.352
CLV_PCSK_SKI1_1	441	445	PF00082	0.483
CLV_PCSK_SKI1_1	550	554	PF00082	0.291
DOC_ANK_TNKS_1	531	538	PF00023	0.417
DOC_CKS1_1	491	496	PF01111	0.559
DOC_CYCLIN_RxL_1	358	368	PF00134	0.360
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.638
DOC_CYCLIN_yCln2_LP_2	321	327	PF00134	0.333
DOC_CYCLIN_yCln2_LP_2	426	432	PF00134	0.496
DOC_MAPK_gen_1	158	166	PF00069	0.421
DOC_MAPK_RevD_3	236	250	PF00069	0.588
DOC_MAPK_RevD_3	517	532	PF00069	0.422
DOC_PP2B_LxvP_1	207	210	PF13499	0.620
DOC_PP2B_LxvP_1	73	76	PF13499	0.527
DOC_PP4_FxxP_1	278	281	PF00568	0.446
DOC_PP4_FxxP_1	294	297	PF00568	0.452
DOC_PP4_FxxP_1	341	344	PF00568	0.316
DOC_USP7_MATH_1	10	14	PF00917	0.660
DOC_USP7_MATH_1	218	222	PF00917	0.741
DOC_USP7_MATH_1	227	231	PF00917	0.603
DOC_USP7_MATH_1	303	307	PF00917	0.407
DOC_USP7_MATH_1	351	355	PF00917	0.425
DOC_USP7_MATH_1	387	391	PF00917	0.621
DOC_USP7_MATH_1	445	449	PF00917	0.420
DOC_USP7_UBL2_3	225	229	PF12436	0.645
DOC_USP7_UBL2_3	231	235	PF12436	0.593
DOC_USP7_UBL2_3	488	492	PF12436	0.557
DOC_USP7_UBL2_3	5	9	PF12436	0.642
DOC_WW_Pin1_4	236	241	PF00397	0.629
DOC_WW_Pin1_4	378	383	PF00397	0.556
DOC_WW_Pin1_4	405	410	PF00397	0.621
DOC_WW_Pin1_4	490	495	PF00397	0.587
LIG_14-3-3_CanoR_1	158	166	PF00244	0.523
LIG_14-3-3_CanoR_1	290	295	PF00244	0.443
LIG_14-3-3_CanoR_1	302	308	PF00244	0.440
LIG_14-3-3_CanoR_1	523	530	PF00244	0.360
LIG_14-3-3_CanoR_1	531	535	PF00244	0.412
LIG_APCC_ABBA_1	148	153	PF00400	0.580
LIG_BIR_III_4	58	62	PF00653	0.561
LIG_BRCT_BRCA1_1	507	511	PF00533	0.358
LIG_deltaCOP1_diTrp_1	282	289	PF00928	0.315
LIG_FHA_1	159	165	PF00498	0.531
LIG_FHA_1	28	34	PF00498	0.664
LIG_FHA_1	316	322	PF00498	0.422
LIG_FHA_1	366	372	PF00498	0.377
LIG_FHA_1	479	485	PF00498	0.543
LIG_FHA_1	562	568	PF00498	0.524
LIG_FHA_1	68	74	PF00498	0.456
LIG_FHA_2	502	508	PF00498	0.437
LIG_FHA_2	55	61	PF00498	0.466
LIG_IBAR_NPY_1	149	151	PF08397	0.561
LIG_LIR_Apic_2	277	281	PF02991	0.548
LIG_LIR_Apic_2	293	297	PF02991	0.449
LIG_LIR_Apic_2	340	344	PF02991	0.314
LIG_LIR_Apic_2	587	593	PF02991	0.503
LIG_LIR_Gen_1	282	292	PF02991	0.395
LIG_LIR_Gen_1	37	45	PF02991	0.495
LIG_LIR_Gen_1	466	475	PF02991	0.348
LIG_LIR_Gen_1	508	519	PF02991	0.398
LIG_LIR_Gen_1	579	585	PF02991	0.481
LIG_LIR_Nem_3	282	287	PF02991	0.359
LIG_LIR_Nem_3	329	334	PF02991	0.439
LIG_LIR_Nem_3	37	42	PF02991	0.520
LIG_LIR_Nem_3	466	470	PF02991	0.346
LIG_LIR_Nem_3	479	483	PF02991	0.493
LIG_LIR_Nem_3	508	514	PF02991	0.396
LIG_LIR_Nem_3	579	583	PF02991	0.514
LIG_MYND_1	236	240	PF01753	0.565
LIG_MYND_1	593	597	PF01753	0.479
LIG_Pex14_2	32	36	PF04695	0.617
LIG_PTB_Apo_2	306	313	PF02174	0.541
LIG_SH2_CRK	331	335	PF00017	0.436
LIG_SH2_CRK	350	354	PF00017	0.366
LIG_SH2_CRK	590	594	PF00017	0.536
LIG_SH2_GRB2like	590	593	PF00017	0.460
LIG_SH2_NCK_1	350	354	PF00017	0.426
LIG_SH2_NCK_1	39	43	PF00017	0.565
LIG_SH2_SRC	151	154	PF00017	0.533
LIG_SH2_SRC	392	395	PF00017	0.465
LIG_SH2_SRC	534	537	PF00017	0.404
LIG_SH2_SRC	590	593	PF00017	0.460
LIG_SH2_STAP1	151	155	PF00017	0.552
LIG_SH2_STAP1	160	164	PF00017	0.516
LIG_SH2_STAP1	480	484	PF00017	0.543
LIG_SH2_STAT3	257	260	PF00017	0.540
LIG_SH2_STAT5	160	163	PF00017	0.521
LIG_SH2_STAT5	274	277	PF00017	0.673
LIG_SH2_STAT5	331	334	PF00017	0.381
LIG_SH2_STAT5	392	395	PF00017	0.465
LIG_SH2_STAT5	475	478	PF00017	0.437
LIG_SH2_STAT5	480	483	PF00017	0.532
LIG_SH2_STAT5	534	537	PF00017	0.438
LIG_SH2_STAT5	558	561	PF00017	0.435
LIG_SH3_1	144	150	PF00018	0.440
LIG_SH3_1	488	494	PF00018	0.604
LIG_SH3_2	194	199	PF14604	0.521
LIG_SH3_3	122	128	PF00018	0.672
LIG_SH3_3	135	141	PF00018	0.696
LIG_SH3_3	144	150	PF00018	0.530
LIG_SH3_3	188	194	PF00018	0.471
LIG_SH3_3	403	409	PF00018	0.598
LIG_SH3_3	488	494	PF00018	0.622
LIG_SH3_3	60	66	PF00018	0.491
LIG_SH3_3	86	92	PF00018	0.638
LIG_SUMO_SIM_anti_2	70	79	PF11976	0.498
LIG_SUMO_SIM_par_1	322	329	PF11976	0.381
LIG_SUMO_SIM_par_1	70	79	PF11976	0.537
LIG_SUMO_SIM_par_1	93	99	PF11976	0.474
LIG_TRAF2_1	143	146	PF00917	0.623
LIG_TRAF2_1	268	271	PF00917	0.445
LIG_TRAF2_1	412	415	PF00917	0.482
LIG_TRAF2_1	76	79	PF00917	0.602
LIG_WRC_WIRS_1	275	280	PF05994	0.555
MOD_CK1_1	38	44	PF00069	0.547
MOD_CK1_1	46	52	PF00069	0.461
MOD_CK1_1	505	511	PF00069	0.363
MOD_CK2_1	10	16	PF00069	0.688
MOD_CK2_1	530	536	PF00069	0.415
MOD_GlcNHglycan	353	356	PF01048	0.418
MOD_GlcNHglycan	397	402	PF01048	0.716
MOD_GlcNHglycan	414	419	PF01048	0.476
MOD_GlcNHglycan	446	450	PF01048	0.409
MOD_GlcNHglycan	536	540	PF01048	0.499
MOD_GlcNHglycan	85	88	PF01048	0.579
MOD_GSK3_1	113	120	PF00069	0.583
MOD_GSK3_1	158	165	PF00069	0.455
MOD_GSK3_1	227	234	PF00069	0.594
MOD_GSK3_1	34	41	PF00069	0.592
MOD_GSK3_1	378	385	PF00069	0.394
MOD_GSK3_1	5	12	PF00069	0.702
MOD_GSK3_1	501	508	PF00069	0.430
MOD_GSK3_1	522	529	PF00069	0.425
MOD_N-GLC_1	10	15	PF02516	0.623
MOD_NEK2_1	326	331	PF00069	0.431
MOD_NEK2_1	521	526	PF00069	0.484
MOD_NEK2_2	27	32	PF00069	0.674
MOD_NEK2_2	387	392	PF00069	0.448
MOD_NEK2_2	478	483	PF00069	0.548
MOD_NEK2_2	561	566	PF00069	0.433
MOD_PIKK_1	158	164	PF00454	0.633
MOD_PIKK_1	326	332	PF00454	0.388
MOD_PIKK_1	365	371	PF00454	0.337
MOD_PIKK_1	43	49	PF00454	0.396
MOD_PIKK_1	522	528	PF00454	0.257
MOD_PKA_1	158	164	PF00069	0.633
MOD_PKA_1	225	231	PF00069	0.604
MOD_PKA_1	4	10	PF00069	0.639
MOD_PKA_2	158	164	PF00069	0.536
MOD_PKA_2	522	528	PF00069	0.419
MOD_PKA_2	530	536	PF00069	0.352
MOD_Plk_1	162	168	PF00069	0.505
MOD_Plk_1	502	508	PF00069	0.448
MOD_Plk_1	561	567	PF00069	0.441
MOD_Plk_1	586	592	PF00069	0.484
MOD_Plk_2-3	203	209	PF00069	0.600
MOD_Plk_4	113	119	PF00069	0.488
MOD_Plk_4	27	33	PF00069	0.668
MOD_Plk_4	387	393	PF00069	0.449
MOD_Plk_4	478	484	PF00069	0.508
MOD_ProDKin_1	236	242	PF00069	0.623
MOD_ProDKin_1	378	384	PF00069	0.568
MOD_ProDKin_1	405	411	PF00069	0.622
MOD_ProDKin_1	490	496	PF00069	0.591
MOD_SUMO_for_1	143	146	PF00179	0.593
MOD_SUMO_for_1	268	271	PF00179	0.461
MOD_SUMO_rev_2	241	251	PF00179	0.489
MOD_SUMO_rev_2	414	423	PF00179	0.533
TRG_DiLeu_BaEn_1	271	276	PF01217	0.473
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.450
TRG_ENDOCYTIC_2	331	334	PF00928	0.362
TRG_ENDOCYTIC_2	39	42	PF00928	0.506
TRG_ER_diArg_1	158	160	PF00400	0.405
TRG_ER_diArg_1	265	267	PF00400	0.398
TRG_ER_diArg_1	530	532	PF00400	0.454
TRG_ER_diArg_1	565	568	PF00400	0.420
TRG_NLS_MonoCore_2	222	227	PF00514	0.656
TRG_NLS_MonoExtC_3	230	235	PF00514	0.709
TRG_NLS_MonoExtN_4	2	8	PF00514	0.642
TRG_NLS_MonoExtN_4	223	228	PF00514	0.717
TRG_NLS_MonoExtN_4	229	236	PF00514	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5J9	Leptomonas seymouri	58%	100%
A0A1X0PAQ0	Trypanosomatidae	29%	100%
A0A3S5H7X4	Leishmania donovani	93%	100%
A4HB23	Leishmania braziliensis	76%	100%
A4IA80	Leishmania infantum	92%	100%
C9ZM29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4Q2P0	Leishmania major	92%	100%