Cilia- and flagella-associated protein 418

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Retinal Maintenance, putative

Species:

Leishmania mexicana

UniProt:

E9B592_LEIMU

TriTrypDb:

LmxM.33.3030

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0001917	photoreceptor inner segment	2	9
GO:0005737	cytoplasm	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9B592

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B592

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.736
CLV_C14_Caspase3-7	98	102	PF00656	0.699
CLV_NRD_NRD_1	192	194	PF00675	0.325
CLV_NRD_NRD_1	31	33	PF00675	0.840
CLV_NRD_NRD_1	338	340	PF00675	0.621
CLV_PCSK_KEX2_1	30	32	PF00082	0.842
CLV_PCSK_KEX2_1	317	319	PF00082	0.494
CLV_PCSK_KEX2_1	338	340	PF00082	0.624
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.494
CLV_PCSK_SKI1_1	120	124	PF00082	0.733
CLV_PCSK_SKI1_1	127	131	PF00082	0.676
CLV_PCSK_SKI1_1	194	198	PF00082	0.317
CLV_PCSK_SKI1_1	278	282	PF00082	0.360
CLV_PCSK_SKI1_1	300	304	PF00082	0.334
CLV_PCSK_SKI1_1	46	50	PF00082	0.721
DEG_APCC_DBOX_1	149	157	PF00400	0.709
DOC_CKS1_1	156	161	PF01111	0.649
DOC_MAPK_DCC_7	127	135	PF00069	0.714
DOC_MAPK_gen_1	338	344	PF00069	0.624
DOC_MAPK_HePTP_8	224	236	PF00069	0.560
DOC_MAPK_MEF2A_6	227	236	PF00069	0.560
DOC_PP1_RVXF_1	125	132	PF00149	0.666
DOC_PP4_FxxP_1	131	134	PF00568	0.710
DOC_USP7_MATH_1	134	138	PF00917	0.679
DOC_USP7_MATH_1	146	150	PF00917	0.572
DOC_USP7_MATH_1	26	30	PF00917	0.763
DOC_USP7_MATH_1	274	278	PF00917	0.591
DOC_USP7_MATH_1	69	73	PF00917	0.701
DOC_WW_Pin1_4	155	160	PF00397	0.639
DOC_WW_Pin1_4	21	26	PF00397	0.656
DOC_WW_Pin1_4	263	268	PF00397	0.560
LIG_14-3-3_CanoR_1	120	129	PF00244	0.653
LIG_14-3-3_CanoR_1	261	270	PF00244	0.499
LIG_14-3-3_CanoR_1	282	286	PF00244	0.598
LIG_14-3-3_CanoR_1	309	315	PF00244	0.720
LIG_14-3-3_CanoR_1	59	65	PF00244	0.699
LIG_BIR_II_1	1	5	PF00653	0.609
LIG_BIR_III_4	94	98	PF00653	0.791
LIG_BRCT_BRCA1_1	127	131	PF00533	0.570
LIG_FHA_1	183	189	PF00498	0.707
LIG_LIR_Apic_2	128	134	PF02991	0.650
LIG_LIR_Gen_1	258	267	PF02991	0.523
LIG_LIR_Gen_1	295	304	PF02991	0.501
LIG_LIR_Nem_3	258	262	PF02991	0.523
LIG_LIR_Nem_3	295	299	PF02991	0.485
LIG_Pex14_2	131	135	PF04695	0.707
LIG_SH2_CRK	231	235	PF00017	0.501
LIG_SH2_NCK_1	145	149	PF00017	0.720
LIG_SH2_STAT3	290	293	PF00017	0.501
LIG_SH2_STAT5	152	155	PF00017	0.620
LIG_SH2_STAT5	249	252	PF00017	0.501
LIG_SH2_STAT5	290	293	PF00017	0.498
LIG_SH3_2	25	30	PF14604	0.524
LIG_SH3_3	126	132	PF00018	0.632
LIG_SH3_3	22	28	PF00018	0.681
LIG_TRAF2_1	333	336	PF00917	0.456
LIG_WRC_WIRS_1	45	50	PF05994	0.603
MOD_CDK_SPxxK_3	155	162	PF00069	0.650
MOD_CK1_1	121	127	PF00069	0.731
MOD_CK1_1	141	147	PF00069	0.687
MOD_CK1_1	21	27	PF00069	0.650
MOD_CK1_1	295	301	PF00069	0.501
MOD_CK1_1	63	69	PF00069	0.762
MOD_CK2_1	136	142	PF00069	0.666
MOD_CK2_1	64	70	PF00069	0.736
MOD_GlcNHglycan	21	24	PF01048	0.715
MOD_GlcNHglycan	263	266	PF01048	0.398
MOD_GlcNHglycan	83	86	PF01048	0.803
MOD_GSK3_1	121	128	PF00069	0.733
MOD_GSK3_1	134	141	PF00069	0.654
MOD_GSK3_1	151	158	PF00069	0.446
MOD_GSK3_1	26	33	PF00069	0.776
MOD_GSK3_1	276	283	PF00069	0.597
MOD_GSK3_1	58	65	PF00069	0.767
MOD_GSK3_1	69	76	PF00069	0.697
MOD_GSK3_1	81	88	PF00069	0.667
MOD_N-GLC_1	59	64	PF02516	0.699
MOD_N-GLC_2	18	20	PF02516	0.693
MOD_N-GLC_2	206	208	PF02516	0.325
MOD_NEK2_1	183	188	PF00069	0.673
MOD_NEK2_1	248	253	PF00069	0.501
MOD_NEK2_1	281	286	PF00069	0.598
MOD_NEK2_1	334	339	PF00069	0.709
MOD_PKA_1	30	36	PF00069	0.832
MOD_PKA_2	281	287	PF00069	0.598
MOD_PKA_2	30	36	PF00069	0.778
MOD_PKA_2	308	314	PF00069	0.718
MOD_PKA_2	58	64	PF00069	0.510
MOD_PKA_2	81	87	PF00069	0.723
MOD_Plk_1	183	189	PF00069	0.615
MOD_Plk_1	213	219	PF00069	0.598
MOD_Plk_1	311	317	PF00069	0.778
MOD_Plk_1	59	65	PF00069	0.679
MOD_Plk_2-3	3	9	PF00069	0.741
MOD_Plk_2-3	36	42	PF00069	0.744
MOD_Plk_4	125	131	PF00069	0.540
MOD_Plk_4	292	298	PF00069	0.516
MOD_Plk_4	3	9	PF00069	0.741
MOD_ProDKin_1	155	161	PF00069	0.643
MOD_ProDKin_1	21	27	PF00069	0.655
MOD_ProDKin_1	263	269	PF00069	0.560
TRG_DiLeu_BaEn_1	3	8	PF01217	0.741
TRG_ENDOCYTIC_2	231	234	PF00928	0.501
TRG_ENDOCYTIC_2	249	252	PF00928	0.362
TRG_ER_diArg_1	30	32	PF00400	0.842
TRG_ER_diArg_1	338	340	PF00400	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P513	Leptomonas seymouri	53%	95%
A0A3S7X892	Leishmania donovani	88%	100%
A0A422N4K3	Trypanosoma rangeli	40%	100%
A4HB22	Leishmania braziliensis	72%	100%
A4IA79	Leishmania infantum	87%	100%
C9ZM30	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4Q2P1	Leishmania major	88%	100%