Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B591_LEIMU

TriTrypDb:

LmxM.33.3020

Length:

936

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B591

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B591

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	613	617	PF00656	0.655
CLV_C14_Caspase3-7	911	915	PF00656	0.599
CLV_MEL_PAP_1	698	704	PF00089	0.738
CLV_NRD_NRD_1	163	165	PF00675	0.532
CLV_NRD_NRD_1	305	307	PF00675	0.500
CLV_NRD_NRD_1	416	418	PF00675	0.415
CLV_NRD_NRD_1	479	481	PF00675	0.411
CLV_NRD_NRD_1	482	484	PF00675	0.411
CLV_NRD_NRD_1	537	539	PF00675	0.411
CLV_NRD_NRD_1	59	61	PF00675	0.727
CLV_NRD_NRD_1	597	599	PF00675	0.545
CLV_NRD_NRD_1	671	673	PF00675	0.742
CLV_NRD_NRD_1	84	86	PF00675	0.720
CLV_NRD_NRD_1	868	870	PF00675	0.736
CLV_PCSK_FUR_1	303	307	PF00082	0.589
CLV_PCSK_FUR_1	480	484	PF00082	0.411
CLV_PCSK_FUR_1	81	85	PF00082	0.677
CLV_PCSK_KEX2_1	163	165	PF00082	0.532
CLV_PCSK_KEX2_1	305	307	PF00082	0.500
CLV_PCSK_KEX2_1	415	417	PF00082	0.411
CLV_PCSK_KEX2_1	479	481	PF00082	0.411
CLV_PCSK_KEX2_1	482	484	PF00082	0.411
CLV_PCSK_KEX2_1	59	61	PF00082	0.727
CLV_PCSK_KEX2_1	597	599	PF00082	0.545
CLV_PCSK_KEX2_1	671	673	PF00082	0.798
CLV_PCSK_KEX2_1	83	85	PF00082	0.728
CLV_PCSK_KEX2_1	868	870	PF00082	0.733
CLV_PCSK_PC7_1	593	599	PF00082	0.523
CLV_PCSK_SKI1_1	251	255	PF00082	0.657
CLV_PCSK_SKI1_1	368	372	PF00082	0.352
CLV_PCSK_SKI1_1	450	454	PF00082	0.411
CLV_PCSK_SKI1_1	685	689	PF00082	0.679
CLV_Separin_Metazoa	787	791	PF03568	0.550
DEG_Nend_UBRbox_3	1	3	PF02207	0.722
DEG_SCF_FBW7_1	461	468	PF00400	0.394
DEG_SPOP_SBC_1	144	148	PF00917	0.722
DOC_CKS1_1	192	197	PF01111	0.663
DOC_CKS1_1	462	467	PF01111	0.394
DOC_MAPK_gen_1	303	310	PF00069	0.576
DOC_MAPK_gen_1	81	90	PF00069	0.675
DOC_MAPK_MEF2A_6	356	363	PF00069	0.499
DOC_PIKK_1	342	350	PF02985	0.642
DOC_PP1_RVXF_1	602	609	PF00149	0.549
DOC_PP2B_LxvP_1	179	182	PF13499	0.687
DOC_PP2B_LxvP_1	666	669	PF13499	0.764
DOC_PP2B_LxvP_1	903	906	PF13499	0.551
DOC_USP7_MATH_1	150	154	PF00917	0.763
DOC_USP7_MATH_1	431	435	PF00917	0.512
DOC_USP7_MATH_1	725	729	PF00917	0.594
DOC_USP7_MATH_1	791	795	PF00917	0.737
DOC_USP7_MATH_1	826	830	PF00917	0.785
DOC_USP7_UBL2_3	539	543	PF12436	0.411
DOC_USP7_UBL2_3	922	926	PF12436	0.711
DOC_WW_Pin1_4	119	124	PF00397	0.742
DOC_WW_Pin1_4	145	150	PF00397	0.803
DOC_WW_Pin1_4	191	196	PF00397	0.771
DOC_WW_Pin1_4	201	206	PF00397	0.681
DOC_WW_Pin1_4	211	216	PF00397	0.613
DOC_WW_Pin1_4	461	466	PF00397	0.394
DOC_WW_Pin1_4	552	557	PF00397	0.498
DOC_WW_Pin1_4	763	768	PF00397	0.625
DOC_WW_Pin1_4	834	839	PF00397	0.707
LIG_14-3-3_CanoR_1	116	126	PF00244	0.627
LIG_14-3-3_CanoR_1	145	149	PF00244	0.759
LIG_14-3-3_CanoR_1	172	182	PF00244	0.674
LIG_14-3-3_CanoR_1	415	423	PF00244	0.512
LIG_14-3-3_CanoR_1	502	507	PF00244	0.411
LIG_14-3-3_CanoR_1	732	738	PF00244	0.830
LIG_14-3-3_CanoR_1	83	89	PF00244	0.735
LIG_14-3-3_CanoR_1	98	102	PF00244	0.745
LIG_Actin_WH2_2	366	381	PF00022	0.411
LIG_APCC_ABBAyCdc20_2	685	691	PF00400	0.549
LIG_APCC_ABBAyCdc20_2	926	932	PF00400	0.510
LIG_BIR_III_4	620	624	PF00653	0.756
LIG_BIR_III_4	649	653	PF00653	0.778
LIG_BIR_III_4	914	918	PF00653	0.566
LIG_BRCT_BRCA1_1	521	525	PF00533	0.411
LIG_deltaCOP1_diTrp_1	518	525	PF00928	0.411
LIG_EVH1_1	666	670	PF00568	0.537
LIG_FHA_1	192	198	PF00498	0.625
LIG_FHA_1	334	340	PF00498	0.412
LIG_FHA_1	420	426	PF00498	0.411
LIG_FHA_1	467	473	PF00498	0.387
LIG_FHA_1	530	536	PF00498	0.396
LIG_FHA_1	728	734	PF00498	0.728
LIG_FHA_1	776	782	PF00498	0.786
LIG_FHA_1	898	904	PF00498	0.691
LIG_FHA_2	321	327	PF00498	0.469
LIG_FHA_2	343	349	PF00498	0.368
LIG_FHA_2	857	863	PF00498	0.733
LIG_FHA_2	905	911	PF00498	0.603
LIG_Integrin_RGD_1	263	265	PF01839	0.563
LIG_LIR_Apic_2	138	142	PF02991	0.517
LIG_LIR_Apic_2	810	816	PF02991	0.696
LIG_LIR_Gen_1	320	330	PF02991	0.533
LIG_LIR_Gen_1	500	507	PF02991	0.411
LIG_LIR_Gen_1	518	528	PF02991	0.249
LIG_LIR_Gen_1	581	591	PF02991	0.472
LIG_LIR_Nem_3	320	325	PF02991	0.387
LIG_LIR_Nem_3	422	426	PF02991	0.411
LIG_LIR_Nem_3	500	506	PF02991	0.411
LIG_LIR_Nem_3	518	524	PF02991	0.249
LIG_LIR_Nem_3	534	540	PF02991	0.305
LIG_LIR_Nem_3	565	569	PF02991	0.472
LIG_LIR_Nem_3	581	587	PF02991	0.471
LIG_MYND_1	126	130	PF01753	0.757
LIG_NRBOX	519	525	PF00104	0.411
LIG_Pex14_1	521	525	PF04695	0.411
LIG_Pex14_2	318	322	PF04695	0.497
LIG_RPA_C_Fungi	301	313	PF08784	0.357
LIG_SH2_CRK	426	430	PF00017	0.411
LIG_SH2_CRK	503	507	PF00017	0.411
LIG_SH2_CRK	584	588	PF00017	0.473
LIG_SH2_CRK	813	817	PF00017	0.751
LIG_SH2_NCK_1	503	507	PF00017	0.411
LIG_SH2_PTP2	139	142	PF00017	0.519
LIG_SH2_STAP1	503	507	PF00017	0.411
LIG_SH2_STAP1	584	588	PF00017	0.574
LIG_SH2_STAT3	762	765	PF00017	0.549
LIG_SH2_STAT5	139	142	PF00017	0.519
LIG_SH2_STAT5	390	393	PF00017	0.383
LIG_SH2_STAT5	401	404	PF00017	0.314
LIG_SH2_STAT5	426	429	PF00017	0.411
LIG_SH2_STAT5	471	474	PF00017	0.375
LIG_SH3_1	664	670	PF00018	0.543
LIG_SH3_1	813	819	PF00018	0.642
LIG_SH3_2	667	672	PF14604	0.546
LIG_SH3_3	120	126	PF00018	0.759
LIG_SH3_3	178	184	PF00018	0.702
LIG_SH3_3	189	195	PF00018	0.601
LIG_SH3_3	324	330	PF00018	0.543
LIG_SH3_3	459	465	PF00018	0.394
LIG_SH3_3	599	605	PF00018	0.542
LIG_SH3_3	623	629	PF00018	0.699
LIG_SH3_3	662	668	PF00018	0.776
LIG_SH3_3	813	819	PF00018	0.704
LIG_SUMO_SIM_anti_2	341	348	PF11976	0.360
LIG_SUMO_SIM_par_1	332	342	PF11976	0.426
LIG_SxIP_EBH_1	163	176	PF03271	0.661
LIG_TRAF2_1	18	21	PF00917	0.500
LIG_TRAF2_1	330	333	PF00917	0.735
LIG_TRAF2_1	352	355	PF00917	0.593
LIG_WW_3	489	493	PF00397	0.411
LIG_WW_3	668	672	PF00397	0.776
MOD_CAAXbox	933	936	PF01239	0.659
MOD_CDK_SPxK_1	211	217	PF00069	0.720
MOD_CDK_SPxxK_3	145	152	PF00069	0.538
MOD_CK1_1	117	123	PF00069	0.792
MOD_CK1_1	15	21	PF00069	0.647
MOD_CK1_1	173	179	PF00069	0.650
MOD_CK1_1	393	399	PF00069	0.352
MOD_CK1_1	434	440	PF00069	0.512
MOD_CK1_1	505	511	PF00069	0.411
MOD_CK1_1	697	703	PF00069	0.776
MOD_CK1_1	836	842	PF00069	0.583
MOD_CK1_1	91	97	PF00069	0.737
MOD_CK2_1	15	21	PF00069	0.647
MOD_CK2_1	314	320	PF00069	0.516
MOD_CK2_1	342	348	PF00069	0.371
MOD_CK2_1	481	487	PF00069	0.411
MOD_CK2_1	71	77	PF00069	0.598
MOD_CK2_1	791	797	PF00069	0.784
MOD_CK2_1	801	807	PF00069	0.668
MOD_CK2_1	843	849	PF00069	0.723
MOD_CK2_1	856	862	PF00069	0.683
MOD_GlcNHglycan	116	119	PF01048	0.766
MOD_GlcNHglycan	167	170	PF01048	0.696
MOD_GlcNHglycan	227	231	PF01048	0.612
MOD_GlcNHglycan	265	270	PF01048	0.810
MOD_GlcNHglycan	392	395	PF01048	0.352
MOD_GlcNHglycan	616	619	PF01048	0.570
MOD_GlcNHglycan	661	664	PF01048	0.816
MOD_GlcNHglycan	703	706	PF01048	0.794
MOD_GlcNHglycan	715	718	PF01048	0.644
MOD_GlcNHglycan	727	730	PF01048	0.711
MOD_GlcNHglycan	740	743	PF01048	0.744
MOD_GlcNHglycan	770	773	PF01048	0.686
MOD_GlcNHglycan	794	797	PF01048	0.782
MOD_GlcNHglycan	809	812	PF01048	0.558
MOD_GlcNHglycan	828	831	PF01048	0.597
MOD_GlcNHglycan	845	848	PF01048	0.717
MOD_GlcNHglycan	93	96	PF01048	0.725
MOD_GSK3_1	12	19	PF00069	0.671
MOD_GSK3_1	207	214	PF00069	0.777
MOD_GSK3_1	314	321	PF00069	0.514
MOD_GSK3_1	338	345	PF00069	0.467
MOD_GSK3_1	415	422	PF00069	0.411
MOD_GSK3_1	452	459	PF00069	0.411
MOD_GSK3_1	461	468	PF00069	0.411
MOD_GSK3_1	498	505	PF00069	0.411
MOD_GSK3_1	610	617	PF00069	0.592
MOD_GSK3_1	697	704	PF00069	0.795
MOD_GSK3_1	727	734	PF00069	0.830
MOD_GSK3_1	807	814	PF00069	0.759
MOD_GSK3_1	84	91	PF00069	0.725
MOD_N-GLC_1	12	17	PF02516	0.655
MOD_N-GLC_1	150	155	PF02516	0.812
MOD_N-GLC_1	157	162	PF02516	0.719
MOD_N-GLC_1	165	170	PF02516	0.594
MOD_N-GLC_1	247	252	PF02516	0.747
MOD_N-GLC_1	342	347	PF02516	0.351
MOD_N-GLC_1	6	11	PF02516	0.720
MOD_N-GLC_1	77	82	PF02516	0.773
MOD_N-GLC_1	807	812	PF02516	0.756
MOD_N-GLC_1	851	856	PF02516	0.719
MOD_N-GLC_1	88	93	PF02516	0.642
MOD_N-GLC_2	877	879	PF02516	0.800
MOD_NEK2_1	135	140	PF00069	0.752
MOD_NEK2_1	293	298	PF00069	0.584
MOD_NEK2_1	318	323	PF00069	0.495
MOD_NEK2_1	481	486	PF00069	0.411
MOD_NEK2_1	497	502	PF00069	0.411
MOD_NEK2_1	586	591	PF00069	0.472
MOD_NEK2_1	614	619	PF00069	0.700
MOD_NEK2_1	738	743	PF00069	0.575
MOD_NEK2_1	843	848	PF00069	0.723
MOD_NEK2_1	88	93	PF00069	0.711
MOD_NEK2_2	6	11	PF00069	0.671
MOD_NEK2_2	744	749	PF00069	0.733
MOD_PIKK_1	109	115	PF00454	0.778
MOD_PIKK_1	117	123	PF00454	0.782
MOD_PIKK_1	415	421	PF00454	0.411
MOD_PIKK_1	818	824	PF00454	0.514
MOD_PIKK_1	851	857	PF00454	0.646
MOD_PK_1	502	508	PF00069	0.411
MOD_PK_1	550	556	PF00069	0.515
MOD_PKA_1	415	421	PF00069	0.411
MOD_PKA_1	83	89	PF00069	0.719
MOD_PKA_2	144	150	PF00069	0.757
MOD_PKA_2	151	157	PF00069	0.676
MOD_PKA_2	415	421	PF00069	0.411
MOD_PKA_2	481	487	PF00069	0.411
MOD_PKA_2	497	503	PF00069	0.411
MOD_PKA_2	731	737	PF00069	0.832
MOD_PKA_2	83	89	PF00069	0.733
MOD_PKA_2	856	862	PF00069	0.685
MOD_PKA_2	91	97	PF00069	0.740
MOD_PKB_1	81	89	PF00069	0.670
MOD_Plk_1	333	339	PF00069	0.559
MOD_Plk_1	342	348	PF00069	0.512
MOD_Plk_1	550	556	PF00069	0.515
MOD_Plk_1	6	12	PF00069	0.718
MOD_Plk_1	610	616	PF00069	0.675
MOD_Plk_1	756	762	PF00069	0.729
MOD_Plk_1	77	83	PF00069	0.771
MOD_Plk_1	801	807	PF00069	0.766
MOD_Plk_1	851	857	PF00069	0.713
MOD_Plk_2-3	342	348	PF00069	0.356
MOD_Plk_2-3	904	910	PF00069	0.552
MOD_Plk_4	135	141	PF00069	0.525
MOD_Plk_4	342	348	PF00069	0.356
MOD_Plk_4	586	592	PF00069	0.479
MOD_ProDKin_1	119	125	PF00069	0.741
MOD_ProDKin_1	145	151	PF00069	0.804
MOD_ProDKin_1	191	197	PF00069	0.772
MOD_ProDKin_1	201	207	PF00069	0.679
MOD_ProDKin_1	211	217	PF00069	0.675
MOD_ProDKin_1	461	467	PF00069	0.394
MOD_ProDKin_1	552	558	PF00069	0.491
MOD_ProDKin_1	763	769	PF00069	0.627
MOD_ProDKin_1	834	840	PF00069	0.711
MOD_SUMO_for_1	361	364	PF00179	0.475
MOD_SUMO_rev_2	364	370	PF00179	0.411
MOD_SUMO_rev_2	656	662	PF00179	0.562
MOD_SUMO_rev_2	914	924	PF00179	0.812
TRG_DiLeu_BaEn_1	342	347	PF01217	0.640
TRG_DiLeu_BaEn_2	564	570	PF01217	0.478
TRG_DiLeu_BaEn_4	20	26	PF01217	0.492
TRG_DiLeu_BaEn_4	332	338	PF01217	0.701
TRG_ENDOCYTIC_2	401	404	PF00928	0.394
TRG_ENDOCYTIC_2	426	429	PF00928	0.411
TRG_ENDOCYTIC_2	503	506	PF00928	0.411
TRG_ENDOCYTIC_2	584	587	PF00928	0.474
TRG_ER_diArg_1	302	305	PF00400	0.491
TRG_ER_diArg_1	414	417	PF00400	0.411
TRG_ER_diArg_1	479	481	PF00400	0.411
TRG_ER_diArg_1	59	61	PF00400	0.710
TRG_ER_diArg_1	670	672	PF00400	0.787
TRG_ER_diArg_1	81	84	PF00400	0.676
TRG_NES_CRM1_1	518	529	PF08389	0.411
TRG_Pf-PMV_PEXEL_1	560	565	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK71	Leptomonas seymouri	50%	100%
A0A3Q8IFR1	Leishmania donovani	87%	99%
A4HB21	Leishmania braziliensis	62%	97%
A4IA78	Leishmania infantum	87%	99%
Q4Q2P2	Leishmania major	86%	100%