Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B589_LEIMU

TriTrypDb:

LmxM.33.3000

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B589

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B589

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.485
CLV_C14_Caspase3-7	464	468	PF00656	0.527
CLV_C14_Caspase3-7	48	52	PF00656	0.543
CLV_C14_Caspase3-7	569	573	PF00656	0.645
CLV_C14_Caspase3-7	595	599	PF00656	0.601
CLV_NRD_NRD_1	168	170	PF00675	0.474
CLV_NRD_NRD_1	241	243	PF00675	0.621
CLV_NRD_NRD_1	35	37	PF00675	0.572
CLV_NRD_NRD_1	462	464	PF00675	0.686
CLV_NRD_NRD_1	486	488	PF00675	0.761
CLV_NRD_NRD_1	618	620	PF00675	0.684
CLV_PCSK_KEX2_1	168	170	PF00082	0.516
CLV_PCSK_KEX2_1	241	243	PF00082	0.551
CLV_PCSK_KEX2_1	35	37	PF00082	0.572
CLV_PCSK_KEX2_1	462	464	PF00082	0.613
CLV_PCSK_KEX2_1	618	620	PF00082	0.684
CLV_PCSK_SKI1_1	619	623	PF00082	0.703
DEG_Nend_UBRbox_1	1	4	PF02207	0.714
DEG_SCF_FBW7_1	291	296	PF00400	0.778
DOC_CKS1_1	13	18	PF01111	0.704
DOC_CKS1_1	336	341	PF01111	0.762
DOC_CYCLIN_yCln2_LP_2	519	525	PF00134	0.709
DOC_MAPK_gen_1	35	43	PF00069	0.601
DOC_MAPK_gen_1	618	626	PF00069	0.683
DOC_MAPK_MEF2A_6	618	626	PF00069	0.683
DOC_MAPK_RevD_3	473	488	PF00069	0.623
DOC_PP2B_LxvP_1	156	159	PF13499	0.615
DOC_PP2B_LxvP_1	355	358	PF13499	0.690
DOC_PP2B_LxvP_1	513	516	PF13499	0.780
DOC_PP4_FxxP_1	254	257	PF00568	0.737
DOC_PP4_FxxP_1	492	495	PF00568	0.524
DOC_USP7_MATH_1	107	111	PF00917	0.632
DOC_USP7_MATH_1	126	130	PF00917	0.268
DOC_USP7_MATH_1	261	265	PF00917	0.698
DOC_USP7_MATH_1	293	297	PF00917	0.785
DOC_USP7_MATH_1	315	319	PF00917	0.766
DOC_USP7_MATH_1	420	424	PF00917	0.725
DOC_USP7_MATH_1	428	432	PF00917	0.638
DOC_USP7_MATH_1	551	555	PF00917	0.704
DOC_USP7_MATH_1	577	581	PF00917	0.760
DOC_USP7_MATH_1	594	598	PF00917	0.468
DOC_USP7_MATH_1	605	609	PF00917	0.625
DOC_USP7_MATH_2	261	267	PF00917	0.641
DOC_USP7_UBL2_3	298	302	PF12436	0.776
DOC_USP7_UBL2_3	91	95	PF12436	0.472
DOC_WW_Pin1_4	12	17	PF00397	0.720
DOC_WW_Pin1_4	253	258	PF00397	0.763
DOC_WW_Pin1_4	26	31	PF00397	0.608
DOC_WW_Pin1_4	289	294	PF00397	0.695
DOC_WW_Pin1_4	332	337	PF00397	0.733
DOC_WW_Pin1_4	356	361	PF00397	0.608
DOC_WW_Pin1_4	4	9	PF00397	0.717
DOC_WW_Pin1_4	521	526	PF00397	0.712
DOC_WW_Pin1_4	541	546	PF00397	0.573
DOC_WW_Pin1_4	563	568	PF00397	0.598
DOC_WW_Pin1_4	584	589	PF00397	0.594
DOC_WW_Pin1_4	68	73	PF00397	0.548
DOC_WW_Pin1_4	81	86	PF00397	0.534
LIG_14-3-3_CanoR_1	128	137	PF00244	0.497
LIG_14-3-3_CanoR_1	317	326	PF00244	0.675
LIG_APCC_ABBA_1	453	458	PF00400	0.818
LIG_BRCT_BRCA1_1	263	267	PF00533	0.713
LIG_BRCT_BRCA1_1	310	314	PF00533	0.617
LIG_BRCT_BRCA1_1	596	600	PF00533	0.638
LIG_Clathr_ClatBox_1	363	367	PF01394	0.797
LIG_EVH1_1	585	589	PF00568	0.695
LIG_FHA_1	233	239	PF00498	0.633
LIG_FHA_1	450	456	PF00498	0.714
LIG_FHA_1	479	485	PF00498	0.738
LIG_FHA_2	137	143	PF00498	0.502
LIG_FHA_2	149	155	PF00498	0.499
LIG_FHA_2	199	205	PF00498	0.482
LIG_FHA_2	245	251	PF00498	0.565
LIG_FHA_2	270	276	PF00498	0.580
LIG_FHA_2	370	376	PF00498	0.758
LIG_FHA_2	43	49	PF00498	0.534
LIG_FHA_2	469	475	PF00498	0.818
LIG_FHA_2	564	570	PF00498	0.537
LIG_FHA_2	57	63	PF00498	0.432
LIG_FHA_2	590	596	PF00498	0.623
LIG_Integrin_RGD_1	242	244	PF01839	0.763
LIG_Integrin_RGD_1	465	467	PF01839	0.532
LIG_LIR_Apic_2	252	257	PF02991	0.741
LIG_LIR_Apic_2	580	586	PF02991	0.501
LIG_LIR_Gen_1	116	127	PF02991	0.520
LIG_LIR_Gen_1	350	360	PF02991	0.712
LIG_LIR_Gen_1	54	65	PF02991	0.681
LIG_LIR_Gen_1	620	628	PF02991	0.471
LIG_LIR_Nem_3	116	122	PF02991	0.509
LIG_LIR_Nem_3	256	262	PF02991	0.737
LIG_LIR_Nem_3	350	355	PF02991	0.723
LIG_LIR_Nem_3	54	60	PF02991	0.664
LIG_LIR_Nem_3	597	603	PF02991	0.646
LIG_LIR_Nem_3	620	624	PF02991	0.467
LIG_MLH1_MIPbox_1	310	314	PF16413	0.651
LIG_PCNA_yPIPBox_3	141	155	PF02747	0.509
LIG_PDZ_Class_2	623	628	PF00595	0.662
LIG_Pex14_1	53	57	PF04695	0.539
LIG_PTB_Apo_2	307	314	PF02174	0.631
LIG_PTB_Phospho_1	307	313	PF10480	0.628
LIG_SH2_CRK	119	123	PF00017	0.489
LIG_SH2_CRK	21	25	PF00017	0.658
LIG_SH2_GRB2like	21	24	PF00017	0.707
LIG_SH2_GRB2like	504	507	PF00017	0.668
LIG_SH2_SRC	202	205	PF00017	0.663
LIG_SH2_SRC	21	24	PF00017	0.707
LIG_SH2_SRC	277	280	PF00017	0.501
LIG_SH2_STAT5	307	310	PF00017	0.672
LIG_SH2_STAT5	313	316	PF00017	0.725
LIG_SH2_STAT5	504	507	PF00017	0.690
LIG_SH2_STAT5	603	606	PF00017	0.658
LIG_SH2_STAT5	9	12	PF00017	0.622
LIG_SH3_1	61	67	PF00018	0.689
LIG_SH3_3	297	303	PF00018	0.672
LIG_SH3_3	333	339	PF00018	0.784
LIG_SH3_3	519	525	PF00018	0.781
LIG_SH3_3	583	589	PF00018	0.711
LIG_SH3_3	60	66	PF00018	0.593
LIG_SUMO_SIM_anti_2	399	404	PF11976	0.735
LIG_SUMO_SIM_anti_2	407	414	PF11976	0.667
LIG_SUMO_SIM_par_1	362	367	PF11976	0.794
LIG_SUMO_SIM_par_1	372	379	PF11976	0.562
LIG_SUMO_SIM_par_1	39	45	PF11976	0.433
LIG_TRAF2_1	139	142	PF00917	0.453
LIG_TRAF2_1	151	154	PF00917	0.397
LIG_TRAF2_1	45	48	PF00917	0.536
LIG_WRC_WIRS_1	127	132	PF05994	0.478
MOD_CDK_SPK_2	253	258	PF00069	0.741
MOD_CDK_SPK_2	68	73	PF00069	0.548
MOD_CDK_SPxxK_3	291	298	PF00069	0.784
MOD_CDK_SPxxK_3	541	548	PF00069	0.711
MOD_CK1_1	196	202	PF00069	0.640
MOD_CK1_1	233	239	PF00069	0.632
MOD_CK1_1	31	37	PF00069	0.697
MOD_CK1_1	318	324	PF00069	0.647
MOD_CK1_1	335	341	PF00069	0.707
MOD_CK1_1	369	375	PF00069	0.759
MOD_CK1_1	378	384	PF00069	0.629
MOD_CK1_1	401	407	PF00069	0.723
MOD_CK1_1	418	424	PF00069	0.703
MOD_CK1_1	449	455	PF00069	0.690
MOD_CK1_1	480	486	PF00069	0.729
MOD_CK1_1	71	77	PF00069	0.525
MOD_CK1_1	84	90	PF00069	0.521
MOD_CK2_1	126	132	PF00069	0.459
MOD_CK2_1	136	142	PF00069	0.532
MOD_CK2_1	148	154	PF00069	0.493
MOD_CK2_1	221	227	PF00069	0.636
MOD_CK2_1	244	250	PF00069	0.640
MOD_CK2_1	257	263	PF00069	0.709
MOD_CK2_1	405	411	PF00069	0.694
MOD_CK2_1	418	424	PF00069	0.651
MOD_CK2_1	42	48	PF00069	0.532
MOD_CK2_1	468	474	PF00069	0.819
MOD_CK2_1	480	486	PF00069	0.742
MOD_CK2_1	563	569	PF00069	0.537
MOD_CK2_1	589	595	PF00069	0.627
MOD_Cter_Amidation	616	619	PF01082	0.684
MOD_DYRK1A_RPxSP_1	26	30	PF00069	0.673
MOD_DYRK1A_RPxSP_1	521	525	PF00069	0.595
MOD_GlcNHglycan	124	127	PF01048	0.555
MOD_GlcNHglycan	196	199	PF01048	0.662
MOD_GlcNHglycan	2	5	PF01048	0.714
MOD_GlcNHglycan	263	266	PF01048	0.544
MOD_GlcNHglycan	295	298	PF01048	0.679
MOD_GlcNHglycan	326	329	PF01048	0.554
MOD_GlcNHglycan	393	396	PF01048	0.662
MOD_GlcNHglycan	430	433	PF01048	0.609
MOD_GlcNHglycan	572	575	PF01048	0.818
MOD_GlcNHglycan	579	582	PF01048	0.677
MOD_GSK3_1	122	129	PF00069	0.390
MOD_GSK3_1	189	196	PF00069	0.727
MOD_GSK3_1	22	29	PF00069	0.641
MOD_GSK3_1	226	233	PF00069	0.714
MOD_GSK3_1	249	256	PF00069	0.697
MOD_GSK3_1	257	264	PF00069	0.709
MOD_GSK3_1	289	296	PF00069	0.667
MOD_GSK3_1	331	338	PF00069	0.817
MOD_GSK3_1	343	350	PF00069	0.611
MOD_GSK3_1	362	369	PF00069	0.801
MOD_GSK3_1	401	408	PF00069	0.592
MOD_GSK3_1	415	422	PF00069	0.703
MOD_GSK3_1	559	566	PF00069	0.552
MOD_GSK3_1	607	614	PF00069	0.640
MOD_GSK3_1	81	88	PF00069	0.557
MOD_N-GLC_1	22	27	PF02516	0.656
MOD_N-GLC_1	233	238	PF02516	0.739
MOD_N-GLC_1	309	314	PF02516	0.743
MOD_N-GLC_1	315	320	PF02516	0.682
MOD_N-GLC_1	405	410	PF02516	0.684
MOD_N-GLC_1	81	86	PF02516	0.558
MOD_NEK2_1	122	127	PF00069	0.462
MOD_NEK2_1	221	226	PF00069	0.696
MOD_NEK2_1	308	313	PF00069	0.641
MOD_NEK2_1	347	352	PF00069	0.607
MOD_NEK2_1	405	410	PF00069	0.662
MOD_NEK2_1	560	565	PF00069	0.635
MOD_NEK2_1	622	627	PF00069	0.761
MOD_NEK2_2	315	320	PF00069	0.706
MOD_PIKK_1	137	143	PF00454	0.480
MOD_PIKK_1	405	411	PF00454	0.739
MOD_PIKK_1	490	496	PF00454	0.826
MOD_PIKK_1	589	595	PF00454	0.605
MOD_PIKK_1	9	15	PF00454	0.716
MOD_PKA_2	461	467	PF00069	0.525
MOD_Plk_1	226	232	PF00069	0.749
MOD_Plk_1	233	239	PF00069	0.573
MOD_Plk_1	249	255	PF00069	0.562
MOD_Plk_1	309	315	PF00069	0.674
MOD_Plk_1	366	372	PF00069	0.768
MOD_Plk_1	378	384	PF00069	0.576
MOD_Plk_1	398	404	PF00069	0.705
MOD_Plk_1	405	411	PF00069	0.685
MOD_Plk_2-3	42	48	PF00069	0.532
MOD_Plk_4	309	315	PF00069	0.601
MOD_Plk_4	369	375	PF00069	0.780
MOD_Plk_4	398	404	PF00069	0.691
MOD_Plk_4	451	457	PF00069	0.749
MOD_Plk_4	509	515	PF00069	0.777
MOD_Plk_4	607	613	PF00069	0.741
MOD_ProDKin_1	12	18	PF00069	0.720
MOD_ProDKin_1	253	259	PF00069	0.763
MOD_ProDKin_1	26	32	PF00069	0.609
MOD_ProDKin_1	289	295	PF00069	0.695
MOD_ProDKin_1	332	338	PF00069	0.732
MOD_ProDKin_1	356	362	PF00069	0.608
MOD_ProDKin_1	4	10	PF00069	0.717
MOD_ProDKin_1	521	527	PF00069	0.712
MOD_ProDKin_1	541	547	PF00069	0.573
MOD_ProDKin_1	563	569	PF00069	0.599
MOD_ProDKin_1	584	590	PF00069	0.592
MOD_ProDKin_1	68	74	PF00069	0.538
MOD_ProDKin_1	81	87	PF00069	0.536
MOD_SUMO_rev_2	480	489	PF00179	0.730
MOD_SUMO_rev_2	524	532	PF00179	0.614
TRG_DiLeu_BaEn_1	118	123	PF01217	0.496
TRG_DiLeu_BaEn_3	595	601	PF01217	0.733
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.786
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.666
TRG_ENDOCYTIC_2	119	122	PF00928	0.496
TRG_ENDOCYTIC_2	21	24	PF00928	0.661
TRG_ENDOCYTIC_2	259	262	PF00928	0.514
TRG_ENDOCYTIC_2	57	60	PF00928	0.567
TRG_ER_diArg_1	167	169	PF00400	0.501
TRG_ER_diArg_1	35	37	PF00400	0.574
TRG_ER_diArg_1	462	465	PF00400	0.522
TRG_Pf-PMV_PEXEL_1	165	170	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P512	Leptomonas seymouri	39%	99%
A0A3Q8IIC9	Leishmania donovani	82%	100%
A4HB19	Leishmania braziliensis	57%	100%
A4IA76	Leishmania infantum	82%	100%
Q4Q2P4	Leishmania major	82%	100%