Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B588_LEIMU

TriTrypDb:

LmxM.33.2990

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

E9B588

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B588

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.588
CLV_C14_Caspase3-7	3	7	PF00656	0.505
CLV_MEL_PAP_1	235	241	PF00089	0.628
CLV_NRD_NRD_1	106	108	PF00675	0.611
CLV_NRD_NRD_1	113	115	PF00675	0.613
CLV_NRD_NRD_1	218	220	PF00675	0.628
CLV_NRD_NRD_1	237	239	PF00675	0.403
CLV_NRD_NRD_1	31	33	PF00675	0.788
CLV_NRD_NRD_1	361	363	PF00675	0.599
CLV_NRD_NRD_1	415	417	PF00675	0.530
CLV_PCSK_FUR_1	111	115	PF00082	0.699
CLV_PCSK_KEX2_1	106	108	PF00082	0.708
CLV_PCSK_KEX2_1	113	115	PF00082	0.593
CLV_PCSK_KEX2_1	217	219	PF00082	0.650
CLV_PCSK_KEX2_1	237	239	PF00082	0.373
CLV_PCSK_KEX2_1	31	33	PF00082	0.731
CLV_PCSK_KEX2_1	361	363	PF00082	0.501
CLV_PCSK_KEX2_1	372	374	PF00082	0.498
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.479
CLV_PCSK_PC7_1	357	363	PF00082	0.511
CLV_PCSK_SKI1_1	372	376	PF00082	0.588
CLV_PCSK_SKI1_1	74	78	PF00082	0.478
DEG_APCC_DBOX_1	356	364	PF00400	0.507
DOC_MAPK_gen_1	106	112	PF00069	0.583
DOC_MAPK_gen_1	217	229	PF00069	0.581
DOC_MAPK_gen_1	361	368	PF00069	0.579
DOC_MAPK_gen_1	372	380	PF00069	0.487
DOC_MAPK_MEF2A_6	331	339	PF00069	0.601
DOC_MAPK_MEF2A_6	373	382	PF00069	0.447
DOC_USP7_MATH_1	169	173	PF00917	0.739
DOC_USP7_MATH_1	175	179	PF00917	0.723
DOC_WW_Pin1_4	140	145	PF00397	0.585
DOC_WW_Pin1_4	149	154	PF00397	0.663
DOC_WW_Pin1_4	259	264	PF00397	0.702
DOC_WW_Pin1_4	267	272	PF00397	0.697
DOC_WW_Pin1_4	274	279	PF00397	0.698
DOC_WW_Pin1_4	37	42	PF00397	0.657
DOC_WW_Pin1_4	386	391	PF00397	0.597
LIG_14-3-3_CanoR_1	106	112	PF00244	0.578
LIG_14-3-3_CanoR_1	15	22	PF00244	0.620
LIG_14-3-3_CanoR_1	281	287	PF00244	0.624
LIG_14-3-3_CanoR_1	331	335	PF00244	0.541
LIG_14-3-3_CanoR_1	373	381	PF00244	0.470
LIG_14-3-3_CanoR_1	394	398	PF00244	0.538
LIG_14-3-3_CanoR_1	404	408	PF00244	0.500
LIG_Actin_WH2_2	115	132	PF00022	0.458
LIG_Actin_WH2_2	283	299	PF00022	0.639
LIG_BIR_II_1	1	5	PF00653	0.681
LIG_BRCT_BRCA1_1	122	126	PF00533	0.459
LIG_BRCT_BRCA1_1	7	11	PF00533	0.503
LIG_DLG_GKlike_1	398	406	PF00625	0.519
LIG_FHA_1	141	147	PF00498	0.706
LIG_FHA_1	197	203	PF00498	0.626
LIG_FHA_1	270	276	PF00498	0.656
LIG_FHA_1	287	293	PF00498	0.580
LIG_FHA_1	373	379	PF00498	0.477
LIG_FHA_2	1	7	PF00498	0.510
LIG_FHA_2	126	132	PF00498	0.812
LIG_FHA_2	137	143	PF00498	0.728
LIG_FHA_2	178	184	PF00498	0.737
LIG_FHA_2	64	70	PF00498	0.707
LIG_FHA_2	79	85	PF00498	0.567
LIG_LIR_Gen_1	282	291	PF02991	0.619
LIG_LIR_Gen_1	8	16	PF02991	0.674
LIG_LIR_Nem_3	123	129	PF02991	0.488
LIG_LIR_Nem_3	282	286	PF02991	0.636
LIG_LIR_Nem_3	8	14	PF02991	0.685
LIG_SH2_STAP1	301	305	PF00017	0.541
LIG_SH2_STAT3	200	203	PF00017	0.624
LIG_SH2_STAT5	145	148	PF00017	0.626
LIG_SH2_STAT5	154	157	PF00017	0.559
LIG_SH2_STAT5	200	203	PF00017	0.578
LIG_SH2_STAT5	220	223	PF00017	0.402
LIG_SH2_STAT5	359	362	PF00017	0.604
LIG_SH3_2	263	268	PF14604	0.503
LIG_SH3_3	260	266	PF00018	0.763
LIG_SUMO_SIM_par_1	289	295	PF11976	0.586
LIG_SUMO_SIM_par_1	364	369	PF11976	0.567
LIG_SUMO_SIM_par_1	46	53	PF11976	0.653
LIG_TRAF2_1	189	192	PF00917	0.685
LIG_TRAF2_1	81	84	PF00917	0.669
LIG_WRC_WIRS_1	251	256	PF05994	0.661
MOD_CDC14_SPxK_1	265	268	PF00782	0.549
MOD_CDK_SPxK_1	262	268	PF00069	0.581
MOD_CDK_SPxxK_3	274	281	PF00069	0.723
MOD_CK1_1	178	184	PF00069	0.708
MOD_CK1_1	249	255	PF00069	0.574
MOD_CK1_1	262	268	PF00069	0.684
MOD_CK1_1	4	10	PF00069	0.675
MOD_CK1_1	403	409	PF00069	0.476
MOD_CK1_1	64	70	PF00069	0.658
MOD_CK2_1	178	184	PF00069	0.770
MOD_CK2_1	342	348	PF00069	0.386
MOD_CK2_1	4	10	PF00069	0.504
MOD_CK2_1	78	84	PF00069	0.669
MOD_GlcNHglycan	157	160	PF01048	0.708
MOD_GlcNHglycan	170	174	PF01048	0.672
MOD_GlcNHglycan	231	234	PF01048	0.625
MOD_GlcNHglycan	254	257	PF01048	0.546
MOD_GlcNHglycan	306	310	PF01048	0.564
MOD_GlcNHglycan	367	371	PF01048	0.567
MOD_GlcNHglycan	6	10	PF01048	0.505
MOD_GlcNHglycan	63	66	PF01048	0.552
MOD_GSK3_1	1	8	PF00069	0.509
MOD_GSK3_1	125	132	PF00069	0.756
MOD_GSK3_1	136	143	PF00069	0.725
MOD_GSK3_1	144	151	PF00069	0.678
MOD_GSK3_1	243	250	PF00069	0.696
MOD_GSK3_1	270	277	PF00069	0.732
MOD_GSK3_1	282	289	PF00069	0.584
MOD_GSK3_1	393	400	PF00069	0.467
MOD_GSK3_1	402	409	PF00069	0.456
MOD_GSK3_1	60	67	PF00069	0.744
MOD_GSK3_1	74	81	PF00069	0.579
MOD_N-GLC_1	74	79	PF02516	0.693
MOD_NEK2_1	14	19	PF00069	0.682
MOD_NEK2_1	247	252	PF00069	0.657
MOD_NEK2_1	366	371	PF00069	0.563
MOD_NEK2_1	385	390	PF00069	0.270
MOD_NEK2_1	393	398	PF00069	0.467
MOD_NEK2_1	402	407	PF00069	0.307
MOD_PIKK_1	1	7	PF00454	0.724
MOD_PIKK_1	160	166	PF00454	0.628
MOD_PIKK_1	86	92	PF00454	0.601
MOD_PKA_1	237	243	PF00069	0.425
MOD_PKA_1	372	378	PF00069	0.375
MOD_PKA_2	105	111	PF00069	0.583
MOD_PKA_2	129	135	PF00069	0.654
MOD_PKA_2	14	20	PF00069	0.629
MOD_PKA_2	229	235	PF00069	0.557
MOD_PKA_2	237	243	PF00069	0.609
MOD_PKA_2	330	336	PF00069	0.538
MOD_PKA_2	372	378	PF00069	0.375
MOD_PKA_2	393	399	PF00069	0.545
MOD_PKA_2	403	409	PF00069	0.493
MOD_Plk_1	175	181	PF00069	0.635
MOD_Plk_1	74	80	PF00069	0.760
MOD_Plk_4	196	202	PF00069	0.662
MOD_Plk_4	270	276	PF00069	0.692
MOD_Plk_4	286	292	PF00069	0.532
MOD_Plk_4	330	336	PF00069	0.538
MOD_ProDKin_1	140	146	PF00069	0.584
MOD_ProDKin_1	149	155	PF00069	0.663
MOD_ProDKin_1	259	265	PF00069	0.702
MOD_ProDKin_1	267	273	PF00069	0.697
MOD_ProDKin_1	274	280	PF00069	0.695
MOD_ProDKin_1	37	43	PF00069	0.655
MOD_ProDKin_1	386	392	PF00069	0.591
MOD_SUMO_rev_2	252	261	PF00179	0.504
MOD_SUMO_rev_2	68	76	PF00179	0.482
TRG_DiLeu_BaEn_4	192	198	PF01217	0.696
TRG_DiLeu_BaLyEn_6	387	392	PF01217	0.497
TRG_ER_diArg_1	110	113	PF00400	0.631
TRG_ER_diArg_1	216	219	PF00400	0.635
TRG_ER_diArg_1	237	239	PF00400	0.500
TRG_ER_diArg_1	30	32	PF00400	0.692
TRG_ER_diArg_1	360	362	PF00400	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBH6	Leptomonas seymouri	43%	100%
A0A3Q8IIQ7	Leishmania donovani	87%	100%
A4HB18	Leishmania braziliensis	68%	100%
A4IA75	Leishmania infantum	87%	100%
Q4Q2P5	Leishmania major	89%	100%