LeishMANIAdb
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DM10 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DM10 domain-containing protein
Gene product:
Nucleoside diphosphate kinase 3
Species:
Leishmania mexicana
UniProt:
E9B587_LEIMU
TriTrypDb:
LmxM.33.2980
Length:
343

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0005813 centrosome 3 2
GO:0005815 microtubule organizing center 2 2
GO:0005929 cilium 4 1
GO:0005930 axoneme 2 2
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0110165 cellular anatomical entity 1 2
GO:0120025 plasma membrane bounded cell projection 3 1

Expansion

Sequence features

E9B587
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B587

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 16
GO:0006796 phosphate-containing compound metabolic process 4 16
GO:0008152 metabolic process 1 16
GO:0009987 cellular process 1 16
GO:0016310 phosphorylation 5 16
GO:0044237 cellular metabolic process 2 16
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 16
GO:0016301 kinase activity 4 16
GO:0016740 transferase activity 2 16
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 16
GO:0004550 nucleoside diphosphate kinase activity 5 9
GO:0016776 phosphotransferase activity, phosphate group as acceptor 4 9
GO:0019205 nucleobase-containing compound kinase activity 5 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 176 180 PF00656 0.460
CLV_NRD_NRD_1 156 158 PF00675 0.509
CLV_PCSK_KEX2_1 51 53 PF00082 0.366
CLV_PCSK_PC1ET2_1 51 53 PF00082 0.386
CLV_PCSK_PC7_1 47 53 PF00082 0.403
CLV_PCSK_SKI1_1 256 260 PF00082 0.213
CLV_PCSK_SKI1_1 338 342 PF00082 0.305
DEG_APCC_DBOX_1 255 263 PF00400 0.507
DOC_MAPK_gen_1 51 57 PF00069 0.318
DOC_MAPK_RevD_3 38 52 PF00069 0.486
DOC_PP4_FxxP_1 139 142 PF00568 0.311
DOC_USP7_MATH_1 204 208 PF00917 0.367
DOC_USP7_MATH_1 90 94 PF00917 0.412
DOC_USP7_UBL2_3 159 163 PF12436 0.278
DOC_USP7_UBL2_3 305 309 PF12436 0.523
LIG_14-3-3_CanoR_1 9 13 PF00244 0.271
LIG_BIR_II_1 1 5 PF00653 0.448
LIG_FHA_1 1 7 PF00498 0.609
LIG_FHA_1 136 142 PF00498 0.325
LIG_FHA_1 146 152 PF00498 0.331
LIG_FHA_1 204 210 PF00498 0.321
LIG_FHA_1 270 276 PF00498 0.438
LIG_FHA_1 282 288 PF00498 0.452
LIG_FHA_1 35 41 PF00498 0.398
LIG_FHA_1 83 89 PF00498 0.305
LIG_FHA_1 94 100 PF00498 0.321
LIG_FHA_2 120 126 PF00498 0.406
LIG_FHA_2 174 180 PF00498 0.454
LIG_LIR_Apic_2 137 142 PF02991 0.436
LIG_LIR_Gen_1 162 171 PF02991 0.440
LIG_LIR_Gen_1 223 233 PF02991 0.372
LIG_LIR_Nem_3 102 108 PF02991 0.383
LIG_LIR_Nem_3 162 168 PF02991 0.432
LIG_LIR_Nem_3 223 228 PF02991 0.372
LIG_LIR_Nem_3 253 258 PF02991 0.454
LIG_MYND_3 259 263 PF01753 0.413
LIG_SH2_CRK 255 259 PF00017 0.434
LIG_SH2_CRK 298 302 PF00017 0.523
LIG_SH2_STAP1 298 302 PF00017 0.523
LIG_SH2_STAP1 336 340 PF00017 0.434
LIG_SH2_STAT5 111 114 PF00017 0.336
LIG_SH2_STAT5 31 34 PF00017 0.380
LIG_SH2_STAT5 336 339 PF00017 0.452
LIG_SH2_STAT5 49 52 PF00017 0.317
LIG_SH3_3 16 22 PF00018 0.561
LIG_SH3_3 207 213 PF00018 0.428
LIG_SH3_3 52 58 PF00018 0.349
LIG_SUMO_SIM_anti_2 148 154 PF11976 0.440
LIG_SUMO_SIM_anti_2 206 212 PF11976 0.280
LIG_SUMO_SIM_anti_2 282 290 PF11976 0.427
LIG_SUMO_SIM_anti_2 37 42 PF11976 0.466
LIG_SUMO_SIM_par_1 150 156 PF11976 0.441
LIG_SUMO_SIM_par_1 282 290 PF11976 0.456
LIG_SUMO_SIM_par_1 34 42 PF11976 0.462
LIG_SUMO_SIM_par_1 93 103 PF11976 0.405
LIG_WRC_WIRS_1 136 141 PF05994 0.219
LIG_WRC_WIRS_1 266 271 PF05994 0.382
MOD_CK1_1 60 66 PF00069 0.374
MOD_CK1_1 93 99 PF00069 0.357
MOD_CK2_1 121 127 PF00069 0.420
MOD_CK2_1 277 283 PF00069 0.492
MOD_GlcNHglycan 222 225 PF01048 0.284
MOD_GlcNHglycan 244 247 PF01048 0.273
MOD_GlcNHglycan 3 6 PF01048 0.580
MOD_GlcNHglycan 34 37 PF01048 0.424
MOD_GlcNHglycan 44 47 PF01048 0.476
MOD_GlcNHglycan 59 62 PF01048 0.353
MOD_GlcNHglycan 65 68 PF01048 0.428
MOD_GSK3_1 169 176 PF00069 0.391
MOD_GSK3_1 233 240 PF00069 0.486
MOD_GSK3_1 265 272 PF00069 0.496
MOD_GSK3_1 277 284 PF00069 0.433
MOD_GSK3_1 90 97 PF00069 0.458
MOD_N-GLC_1 204 209 PF02516 0.338
MOD_NEK2_1 1 6 PF00069 0.455
MOD_NEK2_1 145 150 PF00069 0.347
MOD_NEK2_1 215 220 PF00069 0.391
MOD_NEK2_1 262 267 PF00069 0.454
MOD_NEK2_1 269 274 PF00069 0.438
MOD_NEK2_1 32 37 PF00069 0.505
MOD_NEK2_2 8 13 PF00069 0.342
MOD_PKA_2 169 175 PF00069 0.407
MOD_PKA_2 8 14 PF00069 0.436
MOD_Plk_1 204 210 PF00069 0.278
MOD_Plk_1 281 287 PF00069 0.445
MOD_Plk_1 93 99 PF00069 0.362
MOD_Plk_2-3 34 40 PF00069 0.364
MOD_Plk_4 204 210 PF00069 0.279
MOD_Plk_4 265 271 PF00069 0.497
MOD_Plk_4 297 303 PF00069 0.506
MOD_Plk_4 94 100 PF00069 0.320
TRG_DiLeu_LyEn_5 103 108 PF01217 0.185
TRG_ENDOCYTIC_2 111 114 PF00928 0.346
TRG_ENDOCYTIC_2 255 258 PF00928 0.428
TRG_ENDOCYTIC_2 298 301 PF00928 0.523
TRG_ENDOCYTIC_2 336 339 PF00928 0.448
TRG_NES_CRM1_1 277 289 PF08389 0.471
TRG_NLS_MonoExtC_3 156 162 PF00514 0.287
TRG_Pf-PMV_PEXEL_1 86 91 PF00026 0.416

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJQ8 Leptomonas seymouri 70% 100%
A0A0N1PC23 Leptomonas seymouri 26% 100%
A0A0S4IXH2 Bodo saltans 28% 100%
A0A1X0P5C0 Trypanosomatidae 29% 100%
A0A1X0PAT4 Trypanosomatidae 44% 98%
A0A3Q8IJQ8 Leishmania donovani 28% 100%
A0A3R7M6K1 Trypanosoma rangeli 46% 99%
A0A3R7N390 Trypanosoma rangeli 29% 100%
A0A3S7X855 Leishmania donovani 94% 100%
A4HB17 Leishmania braziliensis 82% 100%
A4HN58 Leishmania braziliensis 28% 100%
A4IA74 Leishmania infantum 94% 100%
A4IBS5 Leishmania infantum 28% 100%
C9ZM33 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 98%
C9ZYU7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AFL1 Leishmania major 27% 100%
E9B6R5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
Q4Q2P6 Leishmania major 91% 100%
Q5E9Y9 Bos taurus 25% 91%
Q9QXL7 Rattus norvegicus 25% 87%
Q9QXL8 Mus musculus 24% 87%
Q9Y5B8 Homo sapiens 25% 91%
V5BXY9 Trypanosoma cruzi 27% 99%
V5DLW4 Trypanosoma cruzi 44% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS