Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleus and spindle associated protein 4, putative

Species:

Leishmania mexicana

UniProt:

E9B586_LEIMU

TriTrypDb:

LmxM.33.2970

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B586

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B586

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	76	80	PF00656	0.517
CLV_NRD_NRD_1	163	165	PF00675	0.513
CLV_NRD_NRD_1	183	185	PF00675	0.289
CLV_PCSK_KEX2_1	165	167	PF00082	0.520
CLV_PCSK_KEX2_1	174	176	PF00082	0.438
CLV_PCSK_KEX2_1	188	190	PF00082	0.501
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.570
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.579
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.600
CLV_PCSK_PC7_1	184	190	PF00082	0.586
CLV_PCSK_SKI1_1	185	189	PF00082	0.490
DEG_Nend_Nbox_1	1	3	PF02207	0.558
DOC_MAPK_gen_1	153	162	PF00069	0.536
DOC_MAPK_gen_1	164	173	PF00069	0.525
DOC_MAPK_MEF2A_6	164	173	PF00069	0.549
DOC_MAPK_NFAT4_5	166	174	PF00069	0.548
DOC_USP7_MATH_1	126	130	PF00917	0.530
DOC_USP7_MATH_1	132	136	PF00917	0.480
DOC_USP7_MATH_1	149	153	PF00917	0.298
LIG_14-3-3_CanoR_1	26	35	PF00244	0.468
LIG_BRCT_BRCA1_1	61	65	PF00533	0.634
LIG_CaM_IQ_9	85	100	PF13499	0.522
LIG_CtBP_PxDLS_1	7	11	PF00389	0.455
LIG_CtBP_PxDLS_1	74	78	PF00389	0.527
LIG_FAT_LD_1	78	86	PF03623	0.546
LIG_FHA_1	118	124	PF00498	0.534
LIG_FHA_2	17	23	PF00498	0.653
LIG_FHA_2	174	180	PF00498	0.556
LIG_LIR_Nem_3	140	144	PF02991	0.621
LIG_NRP_CendR_1	188	191	PF00754	0.665
LIG_SH2_NCK_1	2	6	PF00017	0.455
LIG_SH2_STAT3	144	147	PF00017	0.627
LIG_SH2_STAT5	144	147	PF00017	0.627
LIG_SH2_STAT5	84	87	PF00017	0.475
LIG_SUMO_SIM_anti_2	6	12	PF11976	0.747
LIG_SUMO_SIM_par_1	158	163	PF11976	0.528
LIG_SUMO_SIM_par_1	36	42	PF11976	0.525
LIG_SUMO_SIM_par_1	6	12	PF11976	0.455
MOD_CK1_1	131	137	PF00069	0.506
MOD_CK1_1	68	74	PF00069	0.631
MOD_CK2_1	131	137	PF00069	0.624
MOD_CK2_1	16	22	PF00069	0.487
MOD_CK2_1	173	179	PF00069	0.557
MOD_GlcNHglycan	130	133	PF01048	0.487
MOD_GlcNHglycan	134	137	PF01048	0.459
MOD_GlcNHglycan	149	152	PF01048	0.367
MOD_GlcNHglycan	59	62	PF01048	0.704
MOD_GlcNHglycan	68	71	PF01048	0.662
MOD_GSK3_1	128	135	PF00069	0.467
MOD_GSK3_1	59	66	PF00069	0.656
MOD_NEK2_1	65	70	PF00069	0.651
MOD_PKA_2	107	113	PF00069	0.495
MOD_PKA_2	27	33	PF00069	0.562
MOD_Plk_2-3	6	12	PF00069	0.705
MOD_Plk_4	6	12	PF00069	0.705
MOD_SUMO_rev_2	103	113	PF00179	0.432
MOD_SUMO_rev_2	131	141	PF00179	0.546
MOD_SUMO_rev_2	167	176	PF00179	0.492
TRG_DiLeu_BaEn_1	6	11	PF01217	0.744
TRG_ENDOCYTIC_2	2	5	PF00928	0.459
TRG_ER_diArg_1	175	178	PF00400	0.543
TRG_NLS_Bipartite_1	164	178	PF00514	0.587
TRG_NLS_MonoExtC_3	173	179	PF00514	0.603
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVR9	Leptomonas seymouri	65%	100%
A0A3Q8IEJ0	Leishmania donovani	86%	100%
A0A3R7NC13	Trypanosoma rangeli	30%	100%
A4HB16	Leishmania braziliensis	76%	100%
A4IA73	Leishmania infantum	86%	100%
C9ZM34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q2P7	Leishmania major	85%	95%
V5B5F2	Trypanosoma cruzi	32%	100%