Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B585_LEIMU

TriTrypDb:

LmxM.33.2960

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B585

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B585

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	70	72	PF00675	0.551
CLV_PCSK_KEX2_1	70	72	PF00082	0.551
CLV_PCSK_SKI1_1	71	75	PF00082	0.497
DEG_Nend_Nbox_1	1	3	PF02207	0.769
DOC_AGCK_PIF_2	100	105	PF00069	0.584
DOC_MAPK_MEF2A_6	120	129	PF00069	0.727
DOC_SPAK_OSR1_1	89	93	PF12202	0.786
DOC_USP7_MATH_1	63	67	PF00917	0.797
DOC_USP7_UBL2_3	74	78	PF12436	0.687
LIG_14-3-3_CanoR_1	188	193	PF00244	0.754
LIG_14-3-3_CanoR_1	207	211	PF00244	0.599
LIG_14-3-3_CanoR_1	89	93	PF00244	0.731
LIG_Actin_WH2_2	105	122	PF00022	0.707
LIG_DCNL_PONY_1	1	4	PF03556	0.729
LIG_EH1_1	89	97	PF00400	0.785
LIG_eIF4E_1	146	152	PF01652	0.774
LIG_eIF4E_1	21	27	PF01652	0.436
LIG_eIF4E_1	45	51	PF01652	0.513
LIG_FHA_1	114	120	PF00498	0.733
LIG_FHA_2	207	213	PF00498	0.769
LIG_GBD_Chelix_1	46	54	PF00786	0.425
LIG_NRBOX	22	28	PF00104	0.513
LIG_NRBOX	50	56	PF00104	0.319
LIG_PTB_Apo_2	144	151	PF02174	0.654
LIG_PTB_Phospho_1	144	150	PF10480	0.653
LIG_SH2_NCK_1	146	150	PF00017	0.771
LIG_SH2_PTP2	128	131	PF00017	0.715
LIG_SH2_STAT5	113	116	PF00017	0.721
LIG_SH2_STAT5	128	131	PF00017	0.715
LIG_SH2_STAT5	150	153	PF00017	0.674
LIG_SH2_STAT5	45	48	PF00017	0.411
LIG_SH2_STAT5	81	84	PF00017	0.746
LIG_SH3_3	10	16	PF00018	0.580
LIG_SH3_3	119	125	PF00018	0.790
LIG_SUMO_SIM_par_1	25	30	PF11976	0.513
LIG_TYR_ITIM	126	131	PF00017	0.734
MOD_CK1_1	134	140	PF00069	0.732
MOD_CK2_1	224	230	PF00069	0.602
MOD_CK2_1	88	94	PF00069	0.769
MOD_GlcNHglycan	133	136	PF01048	0.535
MOD_GlcNHglycan	164	167	PF01048	0.526
MOD_GlcNHglycan	175	178	PF01048	0.579
MOD_GlcNHglycan	183	186	PF01048	0.388
MOD_GlcNHglycan	199	202	PF01048	0.538
MOD_GlcNHglycan	29	32	PF01048	0.222
MOD_GlcNHglycan	67	70	PF01048	0.534
MOD_GSK3_1	134	141	PF00069	0.750
MOD_GSK3_1	158	165	PF00069	0.771
MOD_GSK3_1	188	195	PF00069	0.751
MOD_N-GLC_1	217	222	PF02516	0.523
MOD_N-GLC_2	206	208	PF02516	0.568
MOD_NEK2_1	131	136	PF00069	0.733
MOD_NEK2_1	217	222	PF00069	0.733
MOD_NEK2_1	27	32	PF00069	0.513
MOD_NEK2_1	88	93	PF00069	0.711
MOD_PIKK_1	7	13	PF00454	0.719
MOD_PKA_2	141	147	PF00069	0.669
MOD_PKA_2	187	193	PF00069	0.748
MOD_PKA_2	206	212	PF00069	0.751
MOD_PKA_2	218	224	PF00069	0.645
MOD_PKA_2	88	94	PF00069	0.730
MOD_Plk_4	206	212	PF00069	0.795
TRG_DiLeu_BaLyEn_6	32	37	PF01217	0.604
TRG_ENDOCYTIC_2	128	131	PF00928	0.749
TRG_ENDOCYTIC_2	45	48	PF00928	0.411
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS2	Leptomonas seymouri	52%	100%
A0A3Q8IUS4	Leishmania donovani	90%	100%
A4HB15	Leishmania braziliensis	69%	100%
A4IA72	Leishmania infantum	90%	100%
Q4Q2P8	Leishmania major	89%	100%