EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair, putative

Species:

Leishmania mexicana

UniProt:

E9B584_LEIMU

TriTrypDb:

LmxM.33.2950

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B584

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B584

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.459
CLV_C14_Caspase3-7	309	313	PF00656	0.328
CLV_C14_Caspase3-7	345	349	PF00656	0.470
CLV_NRD_NRD_1	103	105	PF00675	0.408
CLV_NRD_NRD_1	109	111	PF00675	0.418
CLV_NRD_NRD_1	151	153	PF00675	0.581
CLV_NRD_NRD_1	359	361	PF00675	0.593
CLV_NRD_NRD_1	57	59	PF00675	0.262
CLV_PCSK_KEX2_1	109	111	PF00082	0.370
CLV_PCSK_KEX2_1	19	21	PF00082	0.438
CLV_PCSK_KEX2_1	57	59	PF00082	0.262
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.522
CLV_PCSK_SKI1_1	19	23	PF00082	0.432
CLV_PCSK_SKI1_1	242	246	PF00082	0.489
CLV_PCSK_SKI1_1	332	336	PF00082	0.422
CLV_PCSK_SKI1_1	370	374	PF00082	0.457
CLV_PCSK_SKI1_1	57	61	PF00082	0.390
DEG_APCC_DBOX_1	241	249	PF00400	0.504
DEG_Nend_UBRbox_3	1	3	PF02207	0.698
DOC_CYCLIN_RxL_1	16	26	PF00134	0.459
DOC_CYCLIN_RxL_1	262	270	PF00134	0.432
DOC_MAPK_gen_1	109	116	PF00069	0.273
DOC_PP2B_LxvP_1	323	326	PF13499	0.455
DOC_USP7_MATH_1	183	187	PF00917	0.507
DOC_USP7_MATH_1	202	206	PF00917	0.505
DOC_USP7_MATH_1	240	244	PF00917	0.555
DOC_USP7_MATH_1	326	330	PF00917	0.427
DOC_WW_Pin1_4	23	28	PF00397	0.652
DOC_WW_Pin1_4	324	329	PF00397	0.488
DOC_WW_Pin1_4	363	368	PF00397	0.583
DOC_WW_Pin1_4	98	103	PF00397	0.390
LIG_14-3-3_CanoR_1	25	31	PF00244	0.563
LIG_Actin_WH2_2	88	106	PF00022	0.487
LIG_BRCT_BRCA1_1	204	208	PF00533	0.530
LIG_BRCT_BRCA1_1	340	344	PF00533	0.506
LIG_eIF4E_1	319	325	PF01652	0.479
LIG_FHA_1	291	297	PF00498	0.495
LIG_FHA_1	299	305	PF00498	0.509
LIG_FHA_1	88	94	PF00498	0.382
LIG_FHA_2	145	151	PF00498	0.558
LIG_FHA_2	161	167	PF00498	0.456
LIG_FHA_2	307	313	PF00498	0.331
LIG_FHA_2	373	379	PF00498	0.475
LIG_FHA_2	50	56	PF00498	0.351
LIG_FHA_2	75	81	PF00498	0.449
LIG_LIR_Apic_2	348	354	PF02991	0.507
LIG_LIR_Gen_1	188	198	PF02991	0.419
LIG_LIR_Gen_1	312	320	PF02991	0.184
LIG_LIR_Gen_1	406	413	PF02991	0.462
LIG_LIR_Gen_1	90	100	PF02991	0.470
LIG_LIR_Nem_3	173	177	PF02991	0.379
LIG_LIR_Nem_3	188	194	PF02991	0.376
LIG_LIR_Nem_3	312	317	PF02991	0.207
LIG_LIR_Nem_3	406	412	PF02991	0.483
LIG_LIR_Nem_3	90	95	PF02991	0.470
LIG_Pex14_1	340	344	PF04695	0.480
LIG_Pex14_2	155	159	PF04695	0.432
LIG_Pex14_2	373	377	PF04695	0.390
LIG_SH2_CRK	178	182	PF00017	0.388
LIG_SH2_CRK	351	355	PF00017	0.497
LIG_SH2_PTP2	314	317	PF00017	0.184
LIG_SH2_SRC	314	317	PF00017	0.184
LIG_SH2_STAP1	320	324	PF00017	0.477
LIG_SH2_STAT3	396	399	PF00017	0.466
LIG_SH2_STAT5	297	300	PF00017	0.416
LIG_SH2_STAT5	314	317	PF00017	0.210
LIG_SH2_STAT5	396	399	PF00017	0.430
LIG_SUMO_SIM_anti_2	186	196	PF11976	0.403
LIG_SUMO_SIM_anti_2	90	97	PF11976	0.475
LIG_TRAF2_1	170	173	PF00917	0.402
LIG_TRAF2_1	228	231	PF00917	0.463
LIG_TRAF2_1	52	55	PF00917	0.448
LIG_TRAF2_1	59	62	PF00917	0.402
LIG_TRAF2_1	66	69	PF00917	0.377
LIG_UBA3_1	75	84	PF00899	0.475
LIG_WRC_WIRS_1	33	38	PF05994	0.554
MOD_CDC14_SPxK_1	101	104	PF00782	0.476
MOD_CDK_SPxK_1	98	104	PF00069	0.383
MOD_CDK_SPxxK_3	363	370	PF00069	0.578
MOD_CDK_SPxxK_3	98	105	PF00069	0.424
MOD_CK1_1	184	190	PF00069	0.308
MOD_CK1_1	222	228	PF00069	0.633
MOD_CK1_1	26	32	PF00069	0.542
MOD_CK2_1	144	150	PF00069	0.546
MOD_CK2_1	167	173	PF00069	0.411
MOD_CK2_1	183	189	PF00069	0.415
MOD_CK2_1	225	231	PF00069	0.564
MOD_CK2_1	299	305	PF00069	0.526
MOD_CK2_1	49	55	PF00069	0.396
MOD_CK2_1	63	69	PF00069	0.308
MOD_GlcNHglycan	156	159	PF01048	0.521
MOD_GlcNHglycan	169	172	PF01048	0.506
MOD_GlcNHglycan	181	184	PF01048	0.424
MOD_GlcNHglycan	242	245	PF01048	0.554
MOD_GlcNHglycan	259	262	PF01048	0.379
MOD_GlcNHglycan	278	281	PF01048	0.493
MOD_GlcNHglycan	328	331	PF01048	0.526
MOD_GlcNHglycan	399	402	PF01048	0.494
MOD_GSK3_1	179	186	PF00069	0.546
MOD_GSK3_1	202	209	PF00069	0.456
MOD_GSK3_1	240	247	PF00069	0.501
MOD_GSK3_1	276	283	PF00069	0.462
MOD_GSK3_1	32	39	PF00069	0.494
MOD_GSK3_1	45	52	PF00069	0.400
MOD_GSK3_1	83	90	PF00069	0.444
MOD_N-GLC_1	159	164	PF02516	0.489
MOD_N-GLC_1	299	304	PF02516	0.471
MOD_N-GLC_1	63	68	PF02516	0.437
MOD_NEK2_1	11	16	PF00069	0.472
MOD_NEK2_1	159	164	PF00069	0.480
MOD_NEK2_1	208	213	PF00069	0.454
MOD_NEK2_1	267	272	PF00069	0.493
MOD_NEK2_1	299	304	PF00069	0.440
MOD_NEK2_1	36	41	PF00069	0.523
MOD_NEK2_1	46	51	PF00069	0.453
MOD_PIKK_1	46	52	PF00454	0.579
MOD_PK_1	206	212	PF00069	0.392
MOD_Plk_1	187	193	PF00069	0.396
MOD_Plk_1	206	212	PF00069	0.318
MOD_Plk_1	225	231	PF00069	0.563
MOD_Plk_1	299	305	PF00069	0.516
MOD_Plk_1	63	69	PF00069	0.421
MOD_Plk_4	187	193	PF00069	0.395
MOD_Plk_4	244	250	PF00069	0.448
MOD_Plk_4	299	305	PF00069	0.493
MOD_ProDKin_1	23	29	PF00069	0.648
MOD_ProDKin_1	324	330	PF00069	0.488
MOD_ProDKin_1	363	369	PF00069	0.578
MOD_ProDKin_1	98	104	PF00069	0.383
MOD_SUMO_for_1	213	216	PF00179	0.523
MOD_SUMO_rev_2	161	170	PF00179	0.566
MOD_SUMO_rev_2	226	233	PF00179	0.557
MOD_SUMO_rev_2	341	349	PF00179	0.414
TRG_DiLeu_BaEn_1	388	393	PF01217	0.447
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.418
TRG_ENDOCYTIC_2	178	181	PF00928	0.389
TRG_ENDOCYTIC_2	314	317	PF00928	0.333
TRG_ENDOCYTIC_2	320	323	PF00928	0.357
TRG_ER_diArg_1	108	110	PF00400	0.416
TRG_ER_diArg_1	56	58	PF00400	0.262
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2R2	Leptomonas seymouri	65%	100%
A0A0S4J207	Bodo saltans	35%	97%
A0A1X0PAP2	Trypanosomatidae	41%	100%
A0A3Q8IHP2	Leishmania donovani	93%	100%
A0A422N4H8	Trypanosoma rangeli	41%	100%
A4HB14	Leishmania braziliensis	82%	100%
A4IA71	Leishmania infantum	94%	100%
C9ZM35	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q2P9	Leishmania major	92%	100%
V5B5A3	Trypanosoma cruzi	40%	100%