LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B583_LEIMU
TriTrypDb:
LmxM.33.2940
Length:
294

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B583
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B583

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 214 216 PF00675 0.538
CLV_NRD_NRD_1 36 38 PF00675 0.535
CLV_NRD_NRD_1 51 53 PF00675 0.638
CLV_NRD_NRD_1 9 11 PF00675 0.725
CLV_PCSK_KEX2_1 120 122 PF00082 0.667
CLV_PCSK_KEX2_1 151 153 PF00082 0.643
CLV_PCSK_KEX2_1 265 267 PF00082 0.533
CLV_PCSK_KEX2_1 35 37 PF00082 0.553
CLV_PCSK_KEX2_1 51 53 PF00082 0.652
CLV_PCSK_KEX2_1 9 11 PF00082 0.725
CLV_PCSK_PC1ET2_1 120 122 PF00082 0.690
CLV_PCSK_PC1ET2_1 151 153 PF00082 0.668
CLV_PCSK_PC1ET2_1 265 267 PF00082 0.533
CLV_PCSK_SKI1_1 171 175 PF00082 0.443
CLV_PCSK_SKI1_1 191 195 PF00082 0.565
CLV_PCSK_SKI1_1 41 45 PF00082 0.666
DOC_PP4_FxxP_1 65 68 PF00568 0.674
DOC_USP7_MATH_1 115 119 PF00917 0.627
DOC_USP7_MATH_1 226 230 PF00917 0.616
DOC_WW_Pin1_4 284 289 PF00397 0.743
LIG_14-3-3_CanoR_1 114 124 PF00244 0.624
LIG_14-3-3_CanoR_1 215 221 PF00244 0.351
LIG_14-3-3_CanoR_1 280 285 PF00244 0.728
LIG_BIR_II_1 1 5 PF00653 0.664
LIG_BRCT_BRCA1_1 275 279 PF00533 0.579
LIG_BRCT_BRCA1_1 280 284 PF00533 0.691
LIG_FHA_1 192 198 PF00498 0.676
LIG_FHA_1 27 33 PF00498 0.626
LIG_FHA_1 92 98 PF00498 0.601
LIG_FHA_2 160 166 PF00498 0.661
LIG_FHA_2 215 221 PF00498 0.466
LIG_FHA_2 56 62 PF00498 0.710
LIG_IBAR_NPY_1 273 275 PF08397 0.561
LIG_LIR_Apic_2 198 204 PF02991 0.560
LIG_LIR_Gen_1 94 104 PF02991 0.634
LIG_LIR_Nem_3 101 107 PF02991 0.517
LIG_LIR_Nem_3 20 26 PF02991 0.510
LIG_LIR_Nem_3 249 254 PF02991 0.489
LIG_LIR_Nem_3 74 80 PF02991 0.643
LIG_Pex14_2 104 108 PF04695 0.393
LIG_SH2_CRK 205 209 PF00017 0.566
LIG_SH2_CRK 275 279 PF00017 0.612
LIG_SH2_NCK_1 275 279 PF00017 0.612
LIG_SH2_PTP2 201 204 PF00017 0.565
LIG_SH2_STAP1 275 279 PF00017 0.579
LIG_SH2_STAT3 234 237 PF00017 0.652
LIG_SH2_STAT5 201 204 PF00017 0.587
LIG_SH3_1 21 27 PF00018 0.544
LIG_SH3_3 21 27 PF00018 0.583
LIG_SH3_3 285 291 PF00018 0.553
LIG_SUMO_SIM_par_1 255 260 PF11976 0.582
LIG_TYR_ITSM 73 80 PF00017 0.709
LIG_UBA3_1 263 271 PF00899 0.549
LIG_WW_3 287 291 PF00397 0.676
MOD_CDK_SPxK_1 284 290 PF00069 0.673
MOD_CK1_1 2 8 PF00069 0.684
MOD_CK1_1 214 220 PF00069 0.510
MOD_CK1_1 229 235 PF00069 0.552
MOD_CK2_1 159 165 PF00069 0.665
MOD_CK2_1 214 220 PF00069 0.599
MOD_CK2_1 55 61 PF00069 0.713
MOD_Cter_Amidation 49 52 PF01082 0.699
MOD_Cter_Amidation 7 10 PF01082 0.668
MOD_GlcNHglycan 197 200 PF01048 0.699
MOD_GSK3_1 116 123 PF00069 0.650
MOD_GSK3_1 134 141 PF00069 0.645
MOD_GSK3_1 191 198 PF00069 0.685
MOD_GSK3_1 210 217 PF00069 0.316
MOD_GSK3_1 229 236 PF00069 0.572
MOD_GSK3_1 26 33 PF00069 0.591
MOD_GSK3_1 274 281 PF00069 0.580
MOD_GSK3_1 87 94 PF00069 0.573
MOD_N-GLC_1 189 194 PF02516 0.587
MOD_N-GLC_1 211 216 PF02516 0.573
MOD_N-GLC_1 70 75 PF02516 0.651
MOD_NEK2_1 1 6 PF00069 0.673
MOD_NEK2_1 138 143 PF00069 0.591
MOD_NEK2_1 181 186 PF00069 0.554
MOD_NEK2_1 189 194 PF00069 0.596
MOD_NEK2_1 211 216 PF00069 0.574
MOD_NEK2_1 233 238 PF00069 0.534
MOD_NEK2_1 243 248 PF00069 0.446
MOD_NEK2_1 70 75 PF00069 0.696
MOD_NEK2_1 99 104 PF00069 0.653
MOD_NEK2_2 274 279 PF00069 0.583
MOD_PIKK_1 214 220 PF00454 0.473
MOD_PIKK_1 233 239 PF00454 0.606
MOD_PKA_1 120 126 PF00069 0.621
MOD_PKA_2 120 126 PF00069 0.652
MOD_PKA_2 195 201 PF00069 0.704
MOD_PKA_2 214 220 PF00069 0.314
MOD_Plk_1 189 195 PF00069 0.665
MOD_Plk_4 134 140 PF00069 0.585
MOD_Plk_4 226 232 PF00069 0.641
MOD_Plk_4 274 280 PF00069 0.589
MOD_Plk_4 99 105 PF00069 0.641
MOD_ProDKin_1 284 290 PF00069 0.745
MOD_SUMO_rev_2 268 272 PF00179 0.528
TRG_DiLeu_BaEn_2 37 43 PF01217 0.678
TRG_ENDOCYTIC_2 205 208 PF00928 0.608
TRG_ENDOCYTIC_2 275 278 PF00928 0.604
TRG_ENDOCYTIC_2 77 80 PF00928 0.639
TRG_ER_diArg_1 34 37 PF00400 0.541
TRG_ER_diArg_1 9 11 PF00400 0.713
TRG_Pf-PMV_PEXEL_1 41 46 PF00026 0.696

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAU8 Leptomonas seymouri 60% 100%
A0A1X0PA38 Trypanosomatidae 29% 100%
A0A3Q8ILA3 Leishmania donovani 91% 96%
A0A3R7KSA4 Trypanosoma rangeli 31% 100%
A4HB13 Leishmania braziliensis 75% 100%
A4IA70 Leishmania infantum 91% 100%
C9ZM36 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
Q4Q2Q0 Leishmania major 91% 100%
V5BV16 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2026 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS