Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B582_LEIMU

TriTrypDb:

LmxM.33.2930

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B582

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B582

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	81	83	PF00675	0.510
CLV_PCSK_SKI1_1	127	131	PF00082	0.369
CLV_PCSK_SKI1_1	174	178	PF00082	0.340
CLV_PCSK_SKI1_1	184	188	PF00082	0.399
CLV_PCSK_SKI1_1	9	13	PF00082	0.562
DEG_Nend_Nbox_1	1	3	PF02207	0.581
DEG_SPOP_SBC_1	90	94	PF00917	0.515
DOC_MAPK_gen_1	44	52	PF00069	0.353
DOC_MAPK_MEF2A_6	44	52	PF00069	0.375
DOC_USP7_MATH_1	62	66	PF00917	0.633
DOC_USP7_MATH_1	72	76	PF00917	0.680
DOC_USP7_MATH_1	78	82	PF00917	0.614
DOC_USP7_UBL2_3	12	16	PF12436	0.526
DOC_WW_Pin1_4	68	73	PF00397	0.652
LIG_14-3-3_CanoR_1	109	118	PF00244	0.410
LIG_14-3-3_CanoR_1	4	11	PF00244	0.579
LIG_BRCT_BRCA1_1	150	154	PF00533	0.361
LIG_eIF4E_1	148	154	PF01652	0.353
LIG_FHA_1	148	154	PF00498	0.314
LIG_FHA_1	166	172	PF00498	0.346
LIG_FHA_1	43	49	PF00498	0.376
LIG_FHA_1	98	104	PF00498	0.593
LIG_FHA_2	21	27	PF00498	0.578
LIG_LIR_Gen_1	141	149	PF02991	0.358
LIG_LIR_Gen_1	150	160	PF02991	0.320
LIG_LIR_Gen_1	38	43	PF02991	0.353
LIG_LIR_Nem_3	141	146	PF02991	0.316
LIG_LIR_Nem_3	150	155	PF02991	0.237
LIG_LIR_Nem_3	38	42	PF02991	0.342
LIG_SH2_CRK	143	147	PF00017	0.318
LIG_SH2_CRK	161	165	PF00017	0.500
LIG_SH2_NCK_1	143	147	PF00017	0.417
LIG_SH2_NCK_1	25	29	PF00017	0.382
LIG_SH2_NCK_1	58	62	PF00017	0.616
LIG_SH2_SRC	25	28	PF00017	0.378
LIG_SH2_STAP1	58	62	PF00017	0.599
LIG_SH3_3	128	134	PF00018	0.373
LIG_SH3_3	14	20	PF00018	0.539
LIG_SUMO_SIM_par_1	48	54	PF11976	0.379
MOD_CK1_1	110	116	PF00069	0.399
MOD_CK1_1	172	178	PF00069	0.379
MOD_CK1_1	5	11	PF00069	0.613
MOD_CK1_1	54	60	PF00069	0.619
MOD_CK1_1	66	72	PF00069	0.599
MOD_CK1_1	77	83	PF00069	0.693
MOD_CK2_1	20	26	PF00069	0.458
MOD_GlcNHglycan	53	56	PF01048	0.368
MOD_GlcNHglycan	65	68	PF01048	0.521
MOD_GlcNHglycan	74	77	PF01048	0.702
MOD_GlcNHglycan	84	87	PF01048	0.729
MOD_GlcNHglycan	93	96	PF01048	0.646
MOD_GSK3_1	107	114	PF00069	0.399
MOD_GSK3_1	144	151	PF00069	0.389
MOD_GSK3_1	165	172	PF00069	0.382
MOD_GSK3_1	62	69	PF00069	0.591
MOD_GSK3_1	74	81	PF00069	0.679
MOD_GSK3_1	82	89	PF00069	0.542
MOD_GSK3_1	93	100	PF00069	0.505
MOD_NEK2_1	107	112	PF00069	0.381
MOD_NEK2_1	2	7	PF00069	0.517
MOD_NEK2_1	42	47	PF00069	0.362
MOD_PK_1	169	175	PF00069	0.355
MOD_PKA_1	82	88	PF00069	0.522
MOD_PKA_2	3	9	PF00069	0.424
MOD_PKA_2	81	87	PF00069	0.488
MOD_PKB_1	167	175	PF00069	0.357
MOD_Plk_1	169	175	PF00069	0.355
MOD_Plk_4	148	154	PF00069	0.300
MOD_Plk_4	172	178	PF00069	0.375
MOD_ProDKin_1	68	74	PF00069	0.656
MOD_SUMO_for_1	98	101	PF00179	0.664
MOD_SUMO_rev_2	124	129	PF00179	0.413
TRG_ENDOCYTIC_2	143	146	PF00928	0.316
TRG_ENDOCYTIC_2	161	164	PF00928	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXG2	Leptomonas seymouri	72%	96%
A0A0S4J1H8	Bodo saltans	39%	100%
A0A0S4J255	Bodo saltans	39%	98%
A0A1X0PAS6	Trypanosomatidae	51%	100%
A0A3Q8IHE2	Leishmania donovani	91%	100%
A0A3R7K5Q8	Trypanosoma rangeli	52%	100%
A4HB12	Leishmania braziliensis	80%	100%
A4IA69	Leishmania infantum	91%	100%
C9ZM37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
Q4Q2Q1	Leishmania major	93%	100%